Transcriptional elongation requires DNA break-induced signalling

Nature Communications

Volumn 6, Issue , 2015, Pages

  Bunch, Heeyoun ^a   Lawney, Brian P ^b   Lin, Yu Fen ^c   Asaithamby, Aroumougame ^c   Murshid, Ayesha ^a   Wang, Yaoyu E ^b   Chen, Benjamin P C ^c   Calderwood, Stuart K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; HISTONE H2AX; PROTEIN; RNA POLYMERASE II; TRIM28 PROTEIN; UNCLASSIFIED DRUG; DNA DEPENDENT PROTEIN KINASE; HISTONE; NUCLEAR PROTEIN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PRKDC PROTEIN, HUMAN; REPRESSOR PROTEIN; TRIM28 PROTEIN, HUMAN;

DNA; ENZYME; GENE; INHIBITION; RNA; SIGNALING;

ARTICLE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; EMBRYO; ENZYME INHIBITION; ENZYME RELEASE; GENE INDUCTION; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION ELONGATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; CHROMATIN IMMUNOPRECIPITATION; COMET ASSAY; CONFOCAL MICROSCOPY; DNA DAMAGE; DNA STRAND BREAKAGE; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION;

CHROMATIN IMMUNOPRECIPITATION; COMET ASSAY; DNA BREAKS; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA-ACTIVATED PROTEIN KINASE; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HISTONES; HUMANS; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; RNA POLYMERASE II; SIGNAL TRANSDUCTION; TRANSCRIPTION ELONGATION, GENETIC; TRANSCRIPTION, GENETIC;

EID: 84950285123     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10191     Document Type: Article

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