-
1
-
-
0033887693
-
Progression model for pancreatic cancer
-
Hruban, R. H., Goggins, M., Parsons, J., Kern, S. E. Progression model for pancreatic cancer. Cancer Res. 6, 2969-2972 (2000).
-
(2000)
Cancer Res.
, vol.6
, pp. 2969-2972
-
-
Hruban, R.H.1
Goggins, M.2
Parsons, J.3
Kern, S.E.4
-
2
-
-
0030988302
-
P16 and K-RAS gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
-
Moskaluk, C. A., Hruban, R. H., Kern, S. E. p16 and K-RAS gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 57, 2140-2143 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 2140-2143
-
-
Moskaluk, C.A.1
Hruban, R.H.2
Kern, S.E.3
-
3
-
-
0032532379
-
Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
-
Wilentz, R. E. et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res. 58, 4740-4744 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 4740-4744
-
-
Wilentz, R.E.1
-
4
-
-
0034032009
-
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
-
Wilentz, R. E. et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 60, 2002-2006 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 2002-2006
-
-
Wilentz, R.E.1
-
5
-
-
0035004797
-
Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis
-
Lüttges, J. et al. Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am. J. Pathol. 158, 1677-1683 (2001).
-
(2001)
Am. J. Pathol.
, vol.158
, pp. 1677-1683
-
-
Lüttges, J.1
-
6
-
-
84929991442
-
Tumor evolution High burden and pervasive positive selection of somatic mutations in normal human skin
-
Martincorena, I. et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348, 880-886 (2015).
-
(2015)
Science
, vol.348
, pp. 880-886
-
-
Martincorena, I.1
-
7
-
-
84930195799
-
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
-
Cooper, C. S. et al. Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat. Genet. 47, 367-372 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 367-372
-
-
Cooper, C.S.1
-
8
-
-
84940612958
-
Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma
-
Ross-Innes, C. S. et al. Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma. Nat. Genet. 47, 1038-1046 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1038-1046
-
-
Ross-Innes, C.S.1
-
9
-
-
84940587003
-
Paired exome analysis of Barrett's esophagus and adenocarcinoma
-
Stachler, M. D. et al. Paired exome analysis of Barrett's esophagus and adenocarcinoma. Nat. Genet. 47, 1047-1055 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1047-1055
-
-
Stachler, M.D.1
-
10
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida, S. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117 (2010).
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
-
11
-
-
84932617756
-
Early detection of sporadic pancreatic cancer: Summative review
-
Chari, S. T. et al. Early detection of sporadic pancreatic cancer: summative review. Pancreas 44, 693-712 (2015).
-
(2015)
Pancreas
, vol.44
, pp. 693-712
-
-
Chari, S.T.1
-
12
-
-
0002224909
-
-
(ed. Schopf, T. J. M. ) Freeman, Cooper and Company
-
Eldredge, N., Gould, S. J. in Models in Paleobiology (ed. Schopf, T. J. M. ) 82-115 (Freeman, Cooper and Company, 1972).
-
(1972)
Models in Paleobiology
, pp. 82-115
-
-
Eldredge, N.1
Gould, S.J.2
-
13
-
-
84924056345
-
Whole genomes redefine the mutational landscape of pancreatic cancer
-
Waddell, N. et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518, 495-501 (2015).
-
(2015)
Nature
, vol.518
, pp. 495-501
-
-
Waddell, N.1
-
14
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
Campbell, P. J. et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467, 1109-1113 (2010).
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
-
15
-
-
78650959663
-
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
-
Stephens, P. J. et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27-40 (2011).
-
(2011)
Cell
, vol.144
, pp. 27-40
-
-
Stephens, P.J.1
-
16
-
-
84885008220
-
Pan-cancer patterns of somatic copy number alteration
-
Zack, T. I. et al. Pan-cancer patterns of somatic copy number alteration. Nat. Genet. 45, 1134-1140 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 1134-1140
-
-
Zack, T.I.1
-
17
-
-
84862907577
-
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
-
Rausch, T. et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 148, 59-71 (2012).
-
(2012)
Cell
, vol.148
, pp. 59-71
-
-
Rausch, T.1
-
18
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
19
-
-
0037944148
-
Catastrophic hypothesis for pancreas cancer progression
-
Real, F. X. A. A "catastrophic hypothesis" for pancreas cancer progression. Gastroenterology 124, 1958-1964 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 1958-1964
-
-
Real, F.X.A.A.1
-
20
-
-
84930941966
-
Chromothripsis from DNA damage in micronuclei
-
Zhang, C.-Z. et al. Chromothripsis from DNA damage in micronuclei. Nature 522, 179-184 (2015).
-
(2015)
Nature
, vol.522
, pp. 179-184
-
-
Zhang, C.-Z.1
-
21
-
-
84950240143
-
Chromothripsis and kataegis induced by telomere crisis
-
Maciejowski, J., Li, Y., Bosco, N., Campbell, P. J., de Lange, T. Chromothripsis and kataegis induced by telomere crisis. Cell 163, 1641-1654 (2015).
-
(2015)
Cell
, vol.163
, pp. 1641-1654
-
-
MacIejowski, J.1
Li, Y.2
Bosco, N.3
Campbell, P.J.4
De Lange, T.5
-
22
-
-
84923952286
-
A Big Bang model of human colorectal tumor growth
-
Sottoriva, A. et al. A Big Bang model of human colorectal tumor growth. Nat. Genet. 47, 209-216 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 209-216
-
-
Sottoriva, A.1
-
23
-
-
84897528140
-
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
-
Li, Y. et al. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia. Nature 508, 98-102 (2014).
-
(2014)
Nature
, vol.508
, pp. 98-102
-
-
Li, Y.1
-
24
-
-
84886789716
-
Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor
-
Murphy, S. J. et al. Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor. Gastroenterology 145, 1098-1109. e1 (2013).
-
(2013)
Gastroenterology
, vol.145
, pp. 1098-1109
-
-
Murphy, S.J.1
-
25
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
Özdemir, B. C. et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25, 719-734 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Özdemir, B.C.1
-
26
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim, A. D. et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735-747 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
-
27
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469-483 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
-
28
-
-
84856082746
-
Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies
-
Haeno, H. et al. Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell 148, 362-375 (2012).
-
(2012)
Cell
, vol.148
, pp. 362-375
-
-
Haeno, H.1
-
29
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim, A. D. et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361 (2012).
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
-
30
-
-
84875135862
-
Criteria for inference of chromothripsis in cancer genomes
-
Korbel, J. O., Campbell, P. J. Criteria for inference of chromothripsis in cancer genomes. Cell 152, 1226-1236 (2013).
-
(2013)
Cell
, vol.152
, pp. 1226-1236
-
-
Korbel, J.O.1
Campbell, P.J.2
|