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Volumn 95, Issue 12, 2016, Pages 598-610

Autophagy and the invisible line between life and death

Author keywords

Apoptosis; Autophagic cell death; Autophagy; Cell death modalities; Necrosis

Indexed keywords

APOPTOSIS; AUTOPHAGY; CELL DEATH; CELL FATE; CELL SURVIVAL; NECROSIS; PRIORITY JOURNAL; REVIEW; ANIMAL; HUMAN; PHYSIOLOGY; SIGNAL TRANSDUCTION;

EID: 85005949293     PISSN: 01719335     EISSN: 16181298     Source Type: Journal    
DOI: 10.1016/j.ejcb.2016.10.005     Document Type: Review
Times cited : (33)

References (162)
  • 1
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: multiple pathways to apoptosis
    • Adams, J.M., Ways of dying: multiple pathways to apoptosis. Genes Dev. 17 (2003), 2481–2495.
    • (2003) Genes Dev. , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 4
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate, M., Mitra, S., Schweitzer, E.S., Segal, M.R., Finkbeiner, S., Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431 (2004), 805–810.
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 5
    • 20444375511 scopus 로고    scopus 로고
    • Proteolytic mechanisms in necrotic cell death and neurodegeneration
    • Artal-Sanz, M., Tavernarakis, N., Proteolytic mechanisms in necrotic cell death and neurodegeneration. FEBS Lett. 579 (2005), 3287–3296.
    • (2005) FEBS Lett. , vol.579 , pp. 3287-3296
    • Artal-Sanz, M.1    Tavernarakis, N.2
  • 6
    • 61649122814 scopus 로고    scopus 로고
    • Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death
    • Baek, S.-H., Kim, E.-K., Goudreau, J.L., Lookingland, K.J., Kim, S.W., Yu, S.-W., Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death. Autophagy 5 (2009), 277–279.
    • (2009) Autophagy , vol.5 , pp. 277-279
    • Baek, S.-H.1    Kim, E.-K.2    Goudreau, J.L.3    Lookingland, K.J.4    Kim, S.W.5    Yu, S.-W.6
  • 8
    • 36849006989 scopus 로고    scopus 로고
    • Autophagy and cell death: no longer at odds
    • Bergmann, A., Autophagy and cell death: no longer at odds. Cell 131 (2007), 1032–1034.
    • (2007) Cell , vol.131 , pp. 1032-1034
    • Bergmann, A.1
  • 9
    • 36849088609 scopus 로고    scopus 로고
    • Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila
    • Berry, D.L., Baehrecke, E.H., Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 131 (2007), 1137–1148.
    • (2007) Cell , vol.131 , pp. 1137-1148
    • Berry, D.L.1    Baehrecke, E.H.2
  • 10
    • 0033635904 scopus 로고    scopus 로고
    • Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
    • Bibel, M., Barde, Y.A., Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14 (2000), 2919–2937.
    • (2000) Genes Dev. , vol.14 , pp. 2919-2937
    • Bibel, M.1    Barde, Y.A.2
  • 11
    • 8044257699 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
    • Blommaart, E.F., Krause, U., Schellens, J.P., Vreeling-Sindelárová, H., Meijer, A.J., The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. FEBS 243 (1997), 240–246.
    • (1997) Eur. J. Biochem. FEBS , vol.243 , pp. 240-246
    • Blommaart, E.F.1    Krause, U.2    Schellens, J.P.3    Vreeling-Sindelárová, H.4    Meijer, A.J.5
  • 12
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: two distinct events induced respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., Lipton, S.A., Apoptosis and necrosis: two distinct events induced respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. U. S. A. 92 (1995), 7162–7166.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Krainc, D.2    Ankarcrona, M.3    Nicotera, P.4    Lipton, S.A.5
  • 15
    • 70349479251 scopus 로고    scopus 로고
    • Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death
    • Byun, J.-Y., Kim, M.-J., Yoon, C.-H., Cha, H., Yoon, G., Lee, S.-J., Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death. Mol. Cancer Res. 7 (2009), 1534–1542.
    • (2009) Mol. Cancer Res. , vol.7 , pp. 1534-1542
    • Byun, J.-Y.1    Kim, M.-J.2    Yoon, C.-H.3    Cha, H.4    Yoon, G.5    Lee, S.-J.6
  • 16
    • 70849093011 scopus 로고    scopus 로고
    • The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras
    • Byun, J.-Y., Yoon, C.-H., An, S., Park, I.-C., Kang, C.-M., Kim, M.-J., Lee, S.-J., The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras. Carcinogenesis 30 (2009), 1880–1888.
    • (2009) Carcinogenesis , vol.30 , pp. 1880-1888
    • Byun, J.-Y.1    Yoon, C.-H.2    An, S.3    Park, I.-C.4    Kang, C.-M.5    Kim, M.-J.6    Lee, S.-J.7
  • 17
    • 0033539141 scopus 로고    scopus 로고
    • Interdigital cell death can occur through a necrotic and caspase-independent pathway
    • Chautan, M., Chazal, G., Cecconi, F., Gruss, P., Golstein, P., Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr. Biol. 9 (1999), 967–970.
    • (1999) Curr. Biol. , vol.9 , pp. 967-970
    • Chautan, M.1    Chazal, G.2    Cecconi, F.3    Gruss, P.4    Golstein, P.5
  • 18
    • 38349043984 scopus 로고    scopus 로고
    • Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
    • Chen, Y., McMillan-Ward, E., Kong, J., Israels, S.J., Gibson, S.B., Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J. Cell Sci. 120 (2007), 4155–4166.
    • (2007) J. Cell Sci. , vol.120 , pp. 4155-4166
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 19
    • 14644412456 scopus 로고    scopus 로고
    • Do inducers of apoptosis trigger caspase-independent cell death?
    • Chipuk, J.E., Green, D.R., Do inducers of apoptosis trigger caspase-independent cell death?. Nat. Rev. Mol. Cell Biol. 6 (2005), 268–275.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 268-275
    • Chipuk, J.E.1    Green, D.R.2
  • 20
    • 57749089665 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells
    • Cho, D.-H., Jo, Y.K., Hwang, J.J., Lee, Y.M., Roh, S.A., Kim, J.C., Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells. Cancer Lett. 274 (2009), 95–100.
    • (2009) Cancer Lett. , vol.274 , pp. 95-100
    • Cho, D.-H.1    Jo, Y.K.2    Hwang, J.J.3    Lee, Y.M.4    Roh, S.A.5    Kim, J.C.6
  • 21
    • 35848947235 scopus 로고    scopus 로고
    • Beclin 1-independent pathway of damage-Induced mitophagy and autophagic stress: implications for neurodegeneration and cell death
    • Chu, C.T., Zhu, J., Dagda, R., Beclin 1-independent pathway of damage-Induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy 3 (2007), 663–666.
    • (2007) Autophagy , vol.3 , pp. 663-666
    • Chu, C.T.1    Zhu, J.2    Dagda, R.3
  • 22
    • 84864886861 scopus 로고    scopus 로고
    • Autophagic cell death exists
    • Clarke, P.G.H., Puyal, J., Autophagic cell death exists. Autophagy 8 (2012), 867–869.
    • (2012) Autophagy , vol.8 , pp. 867-869
    • Clarke, P.G.H.1    Puyal, J.2
  • 23
    • 0025283961 scopus 로고
    • Developmental cell death: morphological diversity and multiple mechanisms
    • Clarke, P.G.H., Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol. (Berl.) 181 (1990), 195–213.
    • (1990) Anat. Embryol. (Berl.) , vol.181 , pp. 195-213
    • Clarke, P.G.H.1
  • 24
    • 22344444616 scopus 로고    scopus 로고
    • Does autophagy contribute to cell death?
    • Debnath, J., Baehrecke, E.H., Kroemer, G., Does autophagy contribute to cell death?. Autophagy 1 (2005), 66–74.
    • (2005) Autophagy , vol.1 , pp. 66-74
    • Debnath, J.1    Baehrecke, E.H.2    Kroemer, G.3
  • 27
    • 84856748733 scopus 로고    scopus 로고
    • Cell death by autophagy: facts and apparent artefacts
    • Denton, D., Nicolson, S., Kumar, S., Cell death by autophagy: facts and apparent artefacts. Cell Death Differ. 19 (2012), 87–95.
    • (2012) Cell Death Differ. , vol.19 , pp. 87-95
    • Denton, D.1    Nicolson, S.2    Kumar, S.3
  • 29
    • 53249100208 scopus 로고    scopus 로고
    • Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila
    • Dutta, S., Baehrecke, E.H., Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr. Biol. 18 (2008), 1466–1475.
    • (2008) Curr. Biol. , vol.18 , pp. 1466-1475
    • Dutta, S.1    Baehrecke, E.H.2
  • 30
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: apoptosis, necrosis and autophagy
    • Edinger, A.L., Thompson, C.B., Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 16 (2004), 663–669.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 31
    • 0030915587 scopus 로고    scopus 로고
    • Intracellular ATP levels determine cell death fate by apoptosis or necrosis
    • Eguchi, Y., Shimizu, S., Tsujimoto, Y., Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 57 (1997), 1835–1840.
    • (1997) Cancer Res. , vol.57 , pp. 1835-1840
    • Eguchi, Y.1    Shimizu, S.2    Tsujimoto, Y.3
  • 32
    • 79953306808 scopus 로고    scopus 로고
    • Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
    • Elgendy, M., Sheridan, C., Brumatti, G., Martin, S.J., Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol. Cell 42 (2011), 23–35.
    • (2011) Mol. Cell , vol.42 , pp. 23-35
    • Elgendy, M.1    Sheridan, C.2    Brumatti, G.3    Martin, S.J.4
  • 33
    • 80655144753 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy
    • Farkas, T., Daugaard, M., Jäättelä, M., Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy. J. Biol. Chem. 286 (2011), 38904–38912.
    • (2011) J. Biol. Chem. , vol.286 , pp. 38904-38912
    • Farkas, T.1    Daugaard, M.2    Jäättelä, M.3
  • 35
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng, Z., Zhang, H., Levine, A.J., Jin, S., The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005), 8204–8209.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 41
    • 33947532301 scopus 로고    scopus 로고
    • A new technique for real-time analysis of caspase-3 dependent neuronal cell death
    • Golbs, A., Heck, N., Luhmann, H.J., A new technique for real-time analysis of caspase-3 dependent neuronal cell death. J. Neurosci. Methods 161 (2007), 234–243.
    • (2007) J. Neurosci. Methods , vol.161 , pp. 234-243
    • Golbs, A.1    Heck, N.2    Luhmann, H.J.3
  • 42
    • 27644585945 scopus 로고    scopus 로고
    • Redundant cell death mechanisms as relics and backups
    • Golstein, P., Kroemer, G., Redundant cell death mechanisms as relics and backups. Cell Death Differ. 12:Suppl. 2 (2005), 1490–1496.
    • (2005) Cell Death Differ. , vol.12 , pp. 1490-1496
    • Golstein, P.1    Kroemer, G.2
  • 43
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: towards a molecular definition
    • Golstein, P., Kroemer, G., Cell death by necrosis: towards a molecular definition. Trends Biochem. Sci. 32 (2007), 37–43.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 44
    • 73449085813 scopus 로고    scopus 로고
    • Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies
    • Grandér, D., Kharaziha, P., Laane, E., Pokrovskaja, K., Panaretakis, T., Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies. Autophagy 5 (2009), 1198–1200.
    • (2009) Autophagy , vol.5 , pp. 1198-1200
    • Grandér, D.1    Kharaziha, P.2    Laane, E.3    Pokrovskaja, K.4    Panaretakis, T.5
  • 45
    • 65949083750 scopus 로고    scopus 로고
    • Cytoplasmic functions of the tumour suppressor p53
    • Green, D.R., Kroemer, G., Cytoplasmic functions of the tumour suppressor p53. Nature 458 (2009), 1127–1130.
    • (2009) Nature , vol.458 , pp. 1127-1130
    • Green, D.R.1    Kroemer, G.2
  • 46
    • 84907212907 scopus 로고    scopus 로고
    • Metabolic control of cell death
    • Green, D.R., Galluzzi, L., Kroemer, G., Metabolic control of cell death. Science, 345, 2014, 1250256.
    • (2014) Science , vol.345 , pp. 1250256
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 47
    • 20444430478 scopus 로고    scopus 로고
    • Apoptotic pathways: ten minutes to dead
    • Green, D.R., Apoptotic pathways: ten minutes to dead. Cell 121 (2005), 671–674.
    • (2005) Cell , vol.121 , pp. 671-674
    • Green, D.R.1
  • 48
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., Deretic, V., Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119 (2004), 753–766.
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 49
    • 84863101514 scopus 로고    scopus 로고
    • Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells
    • Hah, Y.-S., Noh, H.S., Ha, J.H., Ahn, J.S., Hahm, J.R., Cho, H.Y., Kim, D.R., Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells. Cancer Lett. 323 (2012), 208–214.
    • (2012) Cancer Lett. , vol.323 , pp. 208-214
    • Hah, Y.-S.1    Noh, H.S.2    Ha, J.H.3    Ahn, J.S.4    Hahm, J.R.5    Cho, H.Y.6    Kim, D.R.7
  • 50
    • 0030698810 scopus 로고    scopus 로고
    • The apoptosis-necrosis paradox: apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
    • Hirsch, T., Marchetti, P., Susin, S.A., Dallaporta, B., Zamzami, N., Marzo, I., Geuskens, M., Kroemer, G., The apoptosis-necrosis paradox: apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene 15 (1997), 1573–1581.
    • (1997) Oncogene , vol.15 , pp. 1573-1581
    • Hirsch, T.1    Marchetti, P.2    Susin, S.A.3    Dallaporta, B.4    Zamzami, N.5    Marzo, I.6    Geuskens, M.7    Kroemer, G.8
  • 51
    • 52249085861 scopus 로고    scopus 로고
    • Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis
    • Hou, Y.-C.C., Chittaranjan, S., Barbosa, S.G., McCall, K., Gorski, S.M., Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 (2008), 1127–1139.
    • (2008) J. Cell Biol. , vol.182 , pp. 1127-1139
    • Hou, Y.-C.C.1    Chittaranjan, S.2    Barbosa, S.G.3    McCall, K.4    Gorski, S.M.5
  • 52
    • 61649093766 scopus 로고    scopus 로고
    • To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
    • Huang, Q., Shen, H.-M., To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage. Autophagy 5 (2009), 273–276.
    • (2009) Autophagy , vol.5 , pp. 273-276
    • Huang, Q.1    Shen, H.-M.2
  • 55
    • 0030681298 scopus 로고    scopus 로고
    • Steroid regulated programmed cell death during Drosophila metamorphosis
    • Jiang, C., Baehrecke, E.H., Thummel, C.S., Steroid regulated programmed cell death during Drosophila metamorphosis. Dev. Camb. Engl. 124 (1997), 4673–4683.
    • (1997) Dev. Camb. Engl. , vol.124 , pp. 4673-4683
    • Jiang, C.1    Baehrecke, E.H.2    Thummel, C.S.3
  • 57
    • 0028878716 scopus 로고
    • Expression of bcl-2 inhibits necrotic neural cell death
    • Kane, D.J., Örd, T., Anton, R., Bredesen, D.E.1, Expression of bcl-2 inhibits necrotic neural cell death. J. Neurosci. Res. 40 (1995), 269–275.
    • (1995) J. Neurosci. Res. , vol.40 , pp. 269-275
    • Kane, D.J.1    Örd, T.2    Anton, R.3    Bredesen, D.E.4
  • 59
    • 1242307475 scopus 로고    scopus 로고
    • Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
    • Karbowski, M., Arnoult, D., Chen, H., Chan, D.C., Smith, C.L., Youle, R.J., Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J. Cell Biol. 164 (2004), 493–499.
    • (2004) J. Cell Biol. , vol.164 , pp. 493-499
    • Karbowski, M.1    Arnoult, D.2    Chen, H.3    Chan, D.C.4    Smith, C.L.5    Youle, R.J.6
  • 60
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F.R., Wyllie, A.H., Currie, A.R., Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972), 239–257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 61
    • 85013763791 scopus 로고    scopus 로고
    • Acevedo Arozena, A., Adachi, H., Adams, C.M., Adams, P.D., Adeli, K., et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1–222
    • Klionsky, D.J., Abdelmohsen, K., Abe, A., Abedin, M.J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C.M., Adams, P.D., Adeli, K., et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1–222.
    • Klionsky, D.J.1    Abdelmohsen, K.2    Abe, A.3    Abedin, M.J.4    Abeliovich, H.5
  • 63
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: the story of a misnomer
    • Kroemer, G., Levine, B., Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol. 9 (2008), 1004–1010.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 64
    • 22544444514 scopus 로고    scopus 로고
    • Caspase-independent cell death
    • Kroemer, G., Martin, S.J., Caspase-independent cell death. Nat. Med. 11 (2005), 725–730.
    • (2005) Nat. Med. , vol.11 , pp. 725-730
    • Kroemer, G.1    Martin, S.J.2
  • 65
    • 0034068601 scopus 로고    scopus 로고
    • Mitochondrial control of cell death
    • Kroemer, G., Reed, J.C., Mitochondrial control of cell death. Nat. Med. 6 (2000), 513–519.
    • (2000) Nat. Med. , vol.6 , pp. 513-519
    • Kroemer, G.1    Reed, J.C.2
  • 67
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer, G., Galluzzi, L., Brenner, C., Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87 (2007), 99–163.
    • (2007) Physiol. Rev. , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 69
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer, G., Mariño, G., Levine, B., Autophagy and the integrated stress response. Mol. Cell 40 (2010), 280–293.
    • (2010) Mol. Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 71
    • 1842813931 scopus 로고    scopus 로고
    • Transcriptional control of the core cell-death machinery
    • Kumar, S., Cakouros, D., Transcriptional control of the core cell-death machinery. Trends Biochem. Sci. 29 (2004), 193–199.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 193-199
    • Kumar, S.1    Cakouros, D.2
  • 72
    • 34548068863 scopus 로고    scopus 로고
    • Apoptosis and autophagy in photoreceptors exposed to oxidative stress
    • Kunchithapautham, K., Rohrer, B., Apoptosis and autophagy in photoreceptors exposed to oxidative stress. Autophagy 3 (2007), 433–441.
    • (2007) Autophagy , vol.3 , pp. 433-441
    • Kunchithapautham, K.1    Rohrer, B.2
  • 74
    • 0023697978 scopus 로고
    • Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis
    • Laster, S.M., Wood, J.G., Gooding, L.R., Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J. Immunol. Baltim. Md 1950:141 (1988), 2629–2634.
    • (1988) J. Immunol. Baltim. Md , vol.1950 , Issue.141 , pp. 2629-2634
    • Laster, S.M.1    Wood, J.G.2    Gooding, L.R.3
  • 75
    • 0036434113 scopus 로고    scopus 로고
    • Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila
    • Lee, C.-Y., Simon, C.R., Woodard, C.T., Baehrecke, E.H., Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Dev. Biol. 252 (2002), 138–148.
    • (2002) Dev. Biol. , vol.252 , pp. 138-148
    • Lee, C.-Y.1    Simon, C.R.2    Woodard, C.T.3    Baehrecke, E.H.4
  • 77
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: from caspases to alternative mechanisms
    • Leist, M., Jäättelä, M., Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2 (2001), 589–598.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 589-598
    • Leist, M.1    Jäättelä, M.2
  • 79
    • 0030900980 scopus 로고    scopus 로고
    • Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis
    • Leist, M., Single, B., Castoldi, A.F., Kühnle, S., Nicotera, P., Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med. 185 (1997), 1481–1486.
    • (1997) J. Exp. Med. , vol.185 , pp. 1481-1486
    • Leist, M.1    Single, B.2    Castoldi, A.F.3    Kühnle, S.4    Nicotera, P.5
  • 80
    • 0033563776 scopus 로고    scopus 로고
    • Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis
    • Leist, M., Single, B., Naumann, H., Fava, E., Simon, B., Kühnle, S., Nicotera, P., Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis. Exp. Cell Res. 249 (1999), 396–403.
    • (1999) Exp. Cell Res. , vol.249 , pp. 396-403
    • Leist, M.1    Single, B.2    Naumann, H.3    Fava, E.4    Simon, B.5    Kühnle, S.6    Nicotera, P.7
  • 82
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine, B., Kroemer, G., Autophagy in the pathogenesis of disease. Cell 132 (2008), 27–42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 83
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: an innocent convict?
    • Levine, B., Yuan, J., Autophagy in cell death: an innocent convict?. J. Clin. Invest. 115 (2005), 2679–2688.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 84
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten, T., Ross, A.J., King, A., Zong, W.X., Rathmell, J.C., Shiels, H.A., Ulrich, E., Waymire, K.G., Mahar, P., Frauwirth, K., et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6 (2000), 1389–1399.
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1    Ross, A.J.2    King, A.3    Zong, W.X.4    Rathmell, J.C.5    Shiels, H.A.6    Ulrich, E.7    Waymire, K.G.8    Mahar, P.9    Frauwirth, K.10
  • 86
    • 0000031083 scopus 로고
    • Programmed cell death—II: Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths
    • Lockshin, R.A., Williams, C.M., Programmed cell death—II: Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths. J. Insect Physiol. 10 (1964), 643–649.
    • (1964) J. Insect Physiol. , vol.10 , pp. 643-649
    • Lockshin, R.A.1    Williams, C.M.2
  • 88
    • 67650261911 scopus 로고    scopus 로고
    • Cell death: a dynamic response concept
    • Loos, B., Engelbrecht, A.-M., Cell death: a dynamic response concept. Autophagy 5 (2009), 590–603.
    • (2009) Autophagy , vol.5 , pp. 590-603
    • Loos, B.1    Engelbrecht, A.-M.2
  • 89
    • 79955963895 scopus 로고    scopus 로고
    • At the core of survival: autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury
    • Loos, B., Genade, S., Ellis, B., Lochner, A., Engelbrecht, A.-M., At the core of survival: autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Exp. Cell Res. 317 (2011), 1437–1453.
    • (2011) Exp. Cell Res. , vol.317 , pp. 1437-1453
    • Loos, B.1    Genade, S.2    Ellis, B.3    Lochner, A.4    Engelbrecht, A.-M.5
  • 90
    • 84884332903 scopus 로고    scopus 로고
    • The variability of autophagy and cell death susceptibility: Unanswered questions
    • Loos, B., Engelbrecht, A.-M., Lockshin, R.A., Klionsky, D.J., Zakeri, Z., The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy 9 (2013), 1270–1285.
    • (2013) Autophagy , vol.9 , pp. 1270-1285
    • Loos, B.1    Engelbrecht, A.-M.2    Lockshin, R.A.3    Klionsky, D.J.4    Zakeri, Z.5
  • 91
    • 84919766968 scopus 로고    scopus 로고
    • Defining and measuring autophagosome flux—concept and reality
    • Loos, B., Toit, A., du Hofmeyr, J.-H.S., Defining and measuring autophagosome flux—concept and reality. Autophagy 10 (2014), 2087–2096.
    • (2014) Autophagy , vol.10 , pp. 2087-2096
    • Loos, B.1    Toit, A.2    du Hofmeyr, J.-H.S.3
  • 92
    • 0036196425 scopus 로고    scopus 로고
    • Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling
    • Los, M., Mozoluk, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z.-Q., Schulze-Osthoff, K., Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol. Biol. Cell 13 (2002), 978–988.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 978-988
    • Los, M.1    Mozoluk, M.2    Ferrari, D.3    Stepczynska, A.4    Stroh, C.5    Renz, A.6    Herceg, Z.7    Wang, Z.-Q.8    Schulze-Osthoff, K.9
  • 94
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum, J.J., Bauer, D.E., Kong, M., Harris, M.H., Li, C., Lindsten, T., Thompson, C.B., Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 (2005), 237–248.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 95
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: crosstalk between autophagy and apoptosis
    • Maiuri, M.C., Zalckvar, E., Kimchi, A., Kroemer, G., Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8 (2007), 741–752.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 96
    • 84896728489 scopus 로고    scopus 로고
    • Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms
    • Mansilla Pareja, M.E., Colombo, M.I., Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms. Front. Cell. Infect. Microbiol., 3, 2013.
    • (2013) Front. Cell. Infect. Microbiol. , vol.3
    • Mansilla Pareja, M.E.1    Colombo, M.I.2
  • 97
    • 0842279780 scopus 로고    scopus 로고
    • Caspases function in autophagic programmed cell death in Drosophila
    • Martin, D.N., Baehrecke, E.H., Caspases function in autophagic programmed cell death in Drosophila. Dev. Camb. Engl. 131 (2004), 275–284.
    • (2004) Dev. Camb. Engl. , vol.131 , pp. 275-284
    • Martin, D.N.1    Baehrecke, E.H.2
  • 100
    • 58149374227 scopus 로고    scopus 로고
    • Autophagy research: lessons from metabolism
    • Meijer, A.J., Autophagy research: lessons from metabolism. Autophagy 5 (2009), 3–5.
    • (2009) Autophagy , vol.5 , pp. 3-5
    • Meijer, A.J.1
  • 101
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D.H., Levine, B., Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301 (2003), 1387–1391.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Meléndez, A.1    Tallóczy, Z.2    Seaman, M.3    Eskelinen, E.-L.4    Hall, D.H.5    Levine, B.6
  • 102
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima, N., Yoshimori, T., How to interpret LC3 immunoblotting. Autophagy 3 (2007), 542–545.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 103
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J., Autophagy fights disease through cellular self-digestion. Nature 451 (2008), 1069–1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 105
    • 65249180897 scopus 로고    scopus 로고
    • Autophagy promotes caspase-dependent cell death during Drosophila development
    • Mohseni, N., McMillan, S.C., Chaudhary, R., Mok, J., Reed, B.H., Autophagy promotes caspase-dependent cell death during Drosophila development. Autophagy 5 (2009), 329–338.
    • (2009) Autophagy , vol.5 , pp. 329-338
    • Mohseni, N.1    McMillan, S.C.2    Chaudhary, R.3    Mok, J.4    Reed, B.H.5
  • 106
    • 40249091354 scopus 로고    scopus 로고
    • TNFalpha and reactive oxygen species in necrotic cell death
    • Morgan, M.J., Kim, Y.-S., Liu, Z., TNFalpha and reactive oxygen species in necrotic cell death. Cell Res. 18 (2008), 343–349.
    • (2008) Cell Res. , vol.18 , pp. 343-349
    • Morgan, M.J.1    Kim, Y.-S.2    Liu, Z.3
  • 108
    • 34548102440 scopus 로고    scopus 로고
    • Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survival
    • Neufeld, T.P., Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survival. Autophagy 3 (2007), 477–479.
    • (2007) Autophagy , vol.3 , pp. 477-479
    • Neufeld, T.P.1
  • 109
    • 41549151641 scopus 로고    scopus 로고
    • Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
    • Nezis, I.P., Simonsen, A., Sagona, A.P., Finley, K., Gaumer, S., Contamine, D., Rusten, T.E., Stenmark, H., Brech, A., Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J. Cell Biol. 180 (2008), 1065–1071.
    • (2008) J. Cell Biol. , vol.180 , pp. 1065-1071
    • Nezis, I.P.1    Simonsen, A.2    Sagona, A.P.3    Finley, K.4    Gaumer, S.5    Contamine, D.6    Rusten, T.E.7    Stenmark, H.8    Brech, A.9
  • 111
    • 78649297219 scopus 로고    scopus 로고
    • Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
    • Nezis, I.P., Shravage, B.V., Sagona, A.P., Johansen, T., Baehrecke, E.H., Stenmark, H., Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila. Autophagy 6 (2010), 1214–1215.
    • (2010) Autophagy , vol.6 , pp. 1214-1215
    • Nezis, I.P.1    Shravage, B.V.2    Sagona, A.P.3    Johansen, T.4    Baehrecke, E.H.5    Stenmark, H.6
  • 112
    • 0032881768 scopus 로고    scopus 로고
    • Execution of apoptosis: converging or diverging pathways?
    • Nicotera, P., Leist, M., Single, B., Volbracht, C., Execution of apoptosis: converging or diverging pathways?. Biol. Chem. 380 (1999), 1035–1040.
    • (1999) Biol. Chem. , vol.380 , pp. 1035-1040
    • Nicotera, P.1    Leist, M.2    Single, B.3    Volbracht, C.4
  • 115
    • 37349057040 scopus 로고    scopus 로고
    • Claude Bernard, the first systems biologist, and the future of physiology
    • Noble, D., Claude Bernard, the first systems biologist, and the future of physiology. Exp. Physiol. 93 (2008), 16–26.
    • (2008) Exp. Physiol. , vol.93 , pp. 16-26
    • Noble, D.1
  • 116
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: two ubiquitin-like systems
    • Ohsumi, Y., Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev. Mol. Cell Biol. 2 (2001), 211–216.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 117
  • 120
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death
    • Pyo, J.-O., Jang, M.-H., Kwon, Y.-K., Lee, H.-J., Jun, J.-I., Woo, H.-N., Cho, D.-H., Choi, B., Lee, H., Kim, J.-H., et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J. Biol. Chem. 280 (2005), 20722–20729.
    • (2005) J. Biol. Chem. , vol.280 , pp. 20722-20729
    • Pyo, J.-O.1    Jang, M.-H.2    Kwon, Y.-K.3    Lee, H.-J.4    Jun, J.-I.5    Woo, H.-N.6    Cho, D.-H.7    Choi, B.8    Lee, H.9    Kim, J.-H.10
  • 122
    • 0038364056 scopus 로고    scopus 로고
    • Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy
    • Ravikumar, B., Stewart, A., Kita, H., Kato, K., Duden, R., Rubinsztein, D.C., Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum. Mol. Genet. 12 (2003), 985–994.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 985-994
    • Ravikumar, B.1    Stewart, A.2    Kita, H.3    Kato, K.4    Duden, R.5    Rubinsztein, D.C.6
  • 125
    • 0034456628 scopus 로고    scopus 로고
    • Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells
    • Saldeen, J., Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells. Endocrinology 141 (2000), 2003–2010.
    • (2000) Endocrinology , vol.141 , pp. 2003-2010
    • Saldeen, J.1
  • 126
    • 0033613143 scopus 로고    scopus 로고
    • Caspase activation: the induced-proximity model
    • Salvesen, G.S., Dixit, V.M., Caspase activation: the induced-proximity model. Proc. Natl. Acad. Sci. U. S. A. 96 (1999), 10964–10967.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 10964-10967
    • Salvesen, G.S.1    Dixit, V.M.2
  • 127
    • 37349037902 scopus 로고    scopus 로고
    • Autophagy is required for necrotic cell death in Caenorhabditis elegans
    • Samara, C., Syntichaki, P., Tavernarakis, N., Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 15 (2008), 105–112.
    • (2008) Cell Death Differ. , vol.15 , pp. 105-112
    • Samara, C.1    Syntichaki, P.2    Tavernarakis, N.3
  • 128
    • 0015880897 scopus 로고
    • The morphology of various types of cell death in prenatal tissues
    • Schweichel, J.U., Merker, H.J., The morphology of various types of cell death in prenatal tissues. Teratology 7 (1973), 253–266.
    • (1973) Teratology , vol.7 , pp. 253-266
    • Schweichel, J.U.1    Merker, H.J.2
  • 129
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott, R.C., Schuldiner, O., Neufeld, T.P., Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7 (2004), 167–178.
    • (2004) Dev. Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 130
    • 84856431622 scopus 로고    scopus 로고
    • The end of autophagic cell death?
    • Shen, S., Kepp, O., Kroemer, G., The end of autophagic cell death?. Autophagy 8 (2012), 1–3.
    • (2012) Autophagy , vol.8 , pp. 1-3
    • Shen, S.1    Kepp, O.2    Kroemer, G.3
  • 135
    • 70349919804 scopus 로고    scopus 로고
    • Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
    • Simonsen, A., Tooze, S.A., Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J. Cell Biol. 186 (2009), 773–782.
    • (2009) J. Cell Biol. , vol.186 , pp. 773-782
    • Simonsen, A.1    Tooze, S.A.2
  • 136
    • 0021112635 scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5’-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis
    • Sims, J.L., Berger, S.J., Berger, N.A., Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5’-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis. Biochemistry (Mosc.) 22 (1983), 5188–5194.
    • (1983) Biochemistry (Mosc.) , vol.22 , pp. 5188-5194
    • Sims, J.L.1    Berger, S.J.2    Berger, N.A.3
  • 138
    • 33646389796 scopus 로고    scopus 로고
    • Bioenergetic aspects of apoptosis, necrosis and mitoptosis
    • Skulachev, V.P., Bioenergetic aspects of apoptosis, necrosis and mitoptosis. Apoptosis Int. J. Program. Cell Death 11 (2006), 473–485.
    • (2006) Apoptosis Int. J. Program. Cell Death , vol.11 , pp. 473-485
    • Skulachev, V.P.1
  • 145
    • 0034849783 scopus 로고    scopus 로고
    • Autophagic cell death and its execution by lysosomal cathepsins
    • Uchiyama, Y., Autophagic cell death and its execution by lysosomal cathepsins. Arch. Histol. Cytol. 64 (2001), 233–246.
    • (2001) Arch. Histol. Cytol. , vol.64 , pp. 233-246
    • Uchiyama, Y.1
  • 149
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong, E., Cuervo, A.M., Autophagy gone awry in neurodegenerative diseases. Nat. Neurosci. 13 (2010), 805–811.
    • (2010) Nat. Neurosci. , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 151
    • 69449092724 scopus 로고    scopus 로고
    • Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
    • Wu, Y.-T., Tan, H.-L., Huang, Q., Ong, C.-N., Shen, H.-M., Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy 5 (2009), 824–834.
    • (2009) Autophagy , vol.5 , pp. 824-834
    • Wu, Y.-T.1    Tan, H.-L.2    Huang, Q.3    Ong, C.-N.4    Shen, H.-M.5
  • 152
    • 78650175369 scopus 로고    scopus 로고
    • zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway
    • Wu, Y.-T., Tan, H.-L., Huang, Q., Sun, X.-J., Zhu, X., Shen, H.-M., zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ. 18 (2011), 26–37.
    • (2011) Cell Death Differ. , vol.18 , pp. 26-37
    • Wu, Y.-T.1    Tan, H.-L.2    Huang, Q.3    Sun, X.-J.4    Zhu, X.5    Shen, H.-M.6
  • 153
    • 84922748610 scopus 로고    scopus 로고
    • Caspases: a molecular switch node in the crosstalk between autophagy and apoptosis
    • Wu, H., Che, X., Zheng, Q., Wu, A., Pan, K., Shao, A., Wu, Q., Zhang, J., Hong, Y., Caspases: a molecular switch node in the crosstalk between autophagy and apoptosis. Int. J. Biol. Sci. 10 (2014), 1072–1083.
    • (2014) Int. J. Biol. Sci. , vol.10 , pp. 1072-1083
    • Wu, H.1    Che, X.2    Zheng, Q.3    Wu, A.4    Pan, K.5    Shao, A.6    Wu, Q.7    Zhang, J.8    Hong, Y.9
  • 154
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • Youle, R.J., Strasser, A., The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9 (2008), 47–59.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 156
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E.H., Lenardo, M.J., Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304 (2004), 1500–1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6    Baehrecke, E.H.7    Lenardo, M.J.8
  • 157
  • 160
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue, Z., Jin, S., Yang, C., Levine, A.J., Heintz, N., Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 15077–15082.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 162
    • 29944438881 scopus 로고    scopus 로고
    • Necrotic death as a cell fate
    • Zong, W.-X., Thompson, C.B., Necrotic death as a cell fate. Genes Dev. 20 (2006), 1–15.
    • (2006) Genes Dev. , vol.20 , pp. 1-15
    • Zong, W.-X.1    Thompson, C.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.