Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery

Molecular Nutrition and Food Research

Volumn 53, Issue 1, 2009, Pages 104-114

  Kagan, Valerian E ^a,g   Bayir, Ayse ^a   Bayir, Hulya ^a,b   Stoyanovsky, Detcho ^a,c   Borisenko, Grigory G ^a,d   Tyurina, Yulia Y ^a   Wipf, Peter ^a   Atkinson, Jeffrey ^e   Greenberger, Joel S ^a,b   Chapkin, Robert S ^f   Belikova, Natalia A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d FEDERAL RESEARCH AND CLINICAL CENTER OF PHYSICAL CHEMICAL MEDICINE OF FEDERAL MEDICAL BIOLOGICAL AGENCY   (Russian Federation)

^e BROCK UNIVERSITY   (Canada)

^f TEXAS A AND M UNIVERSITY   (United States)

^g UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Apoptosis; Cardiolipin; Cytochrome c; Drug delivery; Mitochondria targeting

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARDIOLIPIN; CYTOCHROME C; ENZYME INHIBITOR;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; AUTOPHAGY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MITOCHONDRION; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN CONFORMATION; REVIEW; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; CARDIOLIPINS; CONSERVED SEQUENCE; CYTOCHROMES C; ENZYME INHIBITORS; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

VASCONCELLEA CANDICANS;

EID: 58149350432     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700402     Document Type: Review

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