Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: A potential target for cancer therapy

Journal of Controlled Release

Volumn 171, Issue 2, 2013, Pages 251-257

  Maynadier, Marie ^a   Vezenkov, Lubomir L ^a   Amblard, Muriel ^a   Martin, Vincent ^a   Gandreuil, Céline ^a   Vaillant, Ophélie ^a   Gary Bobo, Magali ^a   Basile, Ilaria ^a   Hernandez, Jean François ^a   Garcia, Marcel ^a   Martinez, Jean ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Apoptosis; Cancer; Cathepsin D inhibitors; Cell penetrating compounds; Pepstatin bioconjugate

Indexed keywords

BIOMOLECULES; CELL CULTURE; CELL DEATH; CELLS; CYTOLOGY; DISEASES; TUMORS;

ANTIPROLIFERATIVE EFFECT; BIOCONJUGATES; BREAST CANCER CELLS; CANCER; CATHEPSIN D; INTRACELLULAR DELIVERY; PROTEOLYTIC ACTIVITIES; THERAPEUTIC MOLECULES;

ENZYME ACTIVITY;

ANTINEOPLASTIC AGENT; CASPASE 9; CATHEPSIN D; CYCLIN DEPENDENT KINASE 2; CYCLINE; DIPEPTIDE; JMV 4463; OLIGOMER; PEPSTATIN DERIVATIVE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL CYCLE ARREST; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPLICATION; DRUG CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOGENICITY; INTERNALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

APOPTOSIS; CANCER; CATHEPSIN D INHIBITORS; CELL PENETRATING COMPOUNDS; PEPSTATIN BIOCONJUGATE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; CASPASE 9; CATHEPSIN D; CELL CYCLE; CELL LINE, TUMOR; DIPEPTIDES; FEMALE; HUMANS; MICE; MICE, NUDE; NEOPLASMS; PEPSTATINS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84882788073     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.07.017     Document Type: Article

References (31)

1. M. Garcia, N. Platet, E. Liaudet, V. Laurent, D. Derocq, J.P. Brouillet, H. Rochefort, Biological and clinical significance of cathepsin D in breast cancer metastasis, Stem Cells 14 (6) (1996) 642-650. (Pubitemid 26404616)
2. H. Rochefort, M. Garcia, M. Glondu, V. Laurent, E. Liaudet, J.M. Rey, P. Roger, Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview, Clin. Chim. Acta 291 (2) (2000) 157-170. (Pubitemid 30089762)
3. P. Benes,V. Vetvicka, M. Fusek, Cathepsin D-many functions of one aspartic protease, Crit. Rev. Oncol. Hematol. 68 (1) (2008) 12-28.
4. O. Masson, A.S. Bach, D. Derocq, C. Prébois, V. Laurent-Matha, S. Pattingre, E. Liaudet-Coopman, Pathophysiological functions of cathepsin D: targeting its catalytic activity versus its protein binding activity? Biochimie 92 (11) (2010) 1635-1643.
5. G. Ferrandina, G. Scambia, F. Bardelli, P. Benedetti Panici, S. Mancuso, A. Messori, Relationship between cathepsin-D content and disease-free survival in node-negative breast cancer patients: a meta-analysis, Br. J. Cancer 76 (5) (1997) 661-666. (Pubitemid 27354682)
6. J.A. Foekens, M.P. Look, J. Bolt-de Vries, M.E. Meijer-van Gelder, W.L. van Putten, J.G. Klijn, Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients, Br. J. Cancer 79 (2) (1999) 300-307. (Pubitemid 29002300)
7. G. Leto, F.M. Tumminello, M. Crescimanno, C. Flandina, N. Gebbia, Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications, Clin. Exp. Metastasis 21 (2) (2004) 91-106. (Pubitemid 38988083)
8. M. Garcia, D. Derocq, P. Pujol, H. Rochefort, Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency, Oncogene 5 (12) (1990) 1809-1814. (Pubitemid 120034707)
9. M. Glondu, E. Liaudet-Coopman, D. Derocq, N. Platet, H. Rochefort, M. Garcia, Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells, Oncogene 21 (33) (2002) 5127-5134.
10. C. Tardy, J. Tyynela, A. Hasilik, T. Levade, N. Andrieu-Abadie, Stress-induced apopto-sis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D, Cell Death Differ. 10 (9) (2003) 1090-1100. (Pubitemid 37069486)
11. V. Sagulenko, D. Muth, E. Sagulenko, T. Paffhausen, M. Schwab, F. Westermann, Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death, Carcinogenesis 29 (10) (2008) 1869-1877.
12. I.M. Melzer, S.B.M. Fernandez, S. Bosser, K. Lohrig, U. Lewandrowski, D. Wolters, S. Kehrloesser, M.L. Brezniceanu, A.C. Theos, P.M. Irusta, F. Impens, K. Gevaert, M. Zornig, The Apaf-1-binding protein Aven is cleaved by Cathep-sin D to unleash its anti-apoptotic potential, Cell Death Differ. 19 (9) (2012) 1435-1445.
13. C.G. Knight, A.J. Barrett, Interaction of human cathepsin-D with inhibitor pepstatin, Biochem. J. 155 (1) (1976) 117-125.
14. P. Free, C.A. Hurley, T. Kageyama, B.M. Chain, A.B. Tabor, Mannose-pepstatin conjugates as targeted inhibitors of antigen processing, Org. Biomol. Chem. 4 (9) (2006) 1817-1830. (Pubitemid 43835202)
15. S.S. Abdel-Meguid, Inhibition of aspartyl proteinases, Med. Res. Rev. 13 (1993) 731-778.
16. M. Bessodes, K. Antonakis, J. Herscovici, M. Garcia, H. Rochefort, F. Capony, Y. Lelievre, D. Scherman, Inhibition of cathepsin D by tripeptides containing statine analogs, Biochem. Pharmacol. 58 (2) (1999) 329-333. (Pubitemid 29255952)
17. A. Joliot, A. Prochiantz, Transduction peptides: from technology to physiology, Nat. Cell Biol. 6 (3) (2004) 189-196. (Pubitemid 38344356)
18. E. Vives, P. Brodin, B. Lebleu, A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus, J. Biol. Chem. 272 (25) (1997) 16010-16017. (Pubitemid 27265584)
19. P.A. Wender, D.J. Mitchell, K. Pattabiraman, E.T. Pelkey, L. Steinman, J.B. Rothbard, The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters, Proc. Natl. Acad. Sci. U. S. A. 97 (24) (2000) 13003-13008.
20. N. Zaidi, T. Burster, V. Sommandas, T. Herrmann, B.O. Boehm, C. Driessen, W. Voelter, H. Kalbacher, A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A, Biochem. Biophys. Res. Commun. 364 (2) (2007) 243-249. (Pubitemid 47633408)
21. L.L. Vezenkov, M. Maynadier, J.F. Hernandez, M.C. Averlant-Petit, O. Fabre, E. Benedetti, M. Garcia, J. Martinez, M. Amblard, Noncationic dipeptide mimic oligomers as cell penetrating nonpeptides (CPNP), Bioconjug. Chem. 21 (10) (2010) 1850-1854.
22. M. Amblard, J. Martinez, L.L. Vezenkov, J.F. Hernandez, M. Garcia, M. Maynadier, Use of Constrained Dipeptide and Tripeptide Mimic Oligomers as Vectorization Agents, 2011. (WO/2011/012729).
23. D. Paramelle, G. Subra, L.L. Vezenkov, M. Maynadier, C. André, C. Enjalbal, M. Calmès, M. Garcia, J. Martinez, M. Amblard, A straightforward approach for cellular-uptake quantification, Angew. Chem. Int. Ed. Engl. 49 (44) (2010) 8240-8243.
24. P.E. Scarborough, K. Guruprasad, C. Topham, G.R. Richo, G.E. Conner, T.L. Blundell, B.M. Dunn, Exploration of subsite binding-specificity of human cathepsin-D through kinetics and rule-based molecular modeling, Protein Sci. 2 (2) (1993) 264-276. (Pubitemid 23045479)
25. E.M. Manders, J. Stap, G.J. Brakenhoff, R. van Driel, J.A. Aten, Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy, J. Cell Sci. 103 (Pt 3) (1992) 857-862. (Pubitemid 23023255)
26. M. Koike, M. Shibata, Y. Ohsawa, H. Nakanishi, T. Koga, S. Kametaka, S. Waguri, T. Momoi, E. Kominami, C. Peters, K. von Figura, P. Saftig, Y. Uchiyama, Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice, Mol. Cell. Neurosci. 22 (2) (2003) 146-161. (Pubitemid 36379180)
27. I.L. Wapnir, D.E. Wartenberg, R.S. Greco, Three dimensional staging of breast cancer, Breast Cancer Res. Treat. 41 (1) (1996) 15-19. (Pubitemid 26360130)
28. M. Amblard, J.A. Fehrentz, J. Martinez, G. Subra, Methods and protocols of modern solid phase peptide synthesis, Mol. Biotechnol. 33 (3) (2006) 239-254. (Pubitemid 44337228)
29. C.S. Chen, W.N.U. Chen, M.J. Zhou, S. Arttamangkul, R.P. Haugland, Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy, J. Biochem. Biophys. Methods 42 (3) (2000) 137-151. (Pubitemid 30100551)
30. M. Jullian, A. Hernandez, A. Maurras, K. Puget, M. Amblard, J. Martinez, G. Subra, N-terminus FITC labeling of peptides on solid support: the truth behind the spacer, Tetrahedron Lett. 50 (3) (2009) 260-263.
31. G. Kroemer, W. El-Deiry, P. Golstein, M.E. Peter, D. Vaux, P. Vandenabeele, B. Zhivotovsky, M.V. Blagosklonny, W. Malorni, R.A. Knight, M. Piacentini, S. Nagata, G. Melino, Classification of cell death: recommendations of the Nomenclature Committee on Cell Death, Cell Death Differ. 12 (2005) 1463-1467. (Pubitemid 41553979)