Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

Autophagy

Volumn 5, Issue 6, 2009, Pages 824-834

  Wu, You Tong ^a   Tan, Hui Ling ^a   Huang, Qing ^a   Ong, Choon Nam ^a   Shen, Han Ming ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Autophagy; Insulin; mTOR; Necrosis; PI3K

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; EPIDERMAL GROWTH FACTOR; HYDROGEN PEROXIDE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; METHYLNITRONITROSOGUANIDINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 69449092724     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.9099     Document Type: Article

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