메뉴 건너뛰기




Volumn 28, Issue 1, 2017, Pages 46-62

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

Author keywords

cancer; cellular instability; inflammation; microenvironment; obesity

Indexed keywords

AROMATASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LEPTIN; PROGESTERONE; PROGESTERONE RECEPTOR; PROSTAGLANDIN E2; PROTEIN P53;

EID: 84994908897     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2016.08.004     Document Type: Review
Times cited : (100)

References (125)
  • 1
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    • 1 Renehan, A.G., et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371 (2008), 569–578.
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1
  • 2
    • 85027951435 scopus 로고    scopus 로고
    • Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults
    • 2 Bhaskaran, K., et al. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults. Lancet 384 (2014), 755–765.
    • (2014) Lancet , vol.384 , pp. 755-765
    • Bhaskaran, K.1
  • 3
    • 84924910144 scopus 로고    scopus 로고
    • Global burden of cancer attributable to high body-mass index in 2012: a population-based study
    • 3 Arnold, M., et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 16 (2015), 36–46.
    • (2015) Lancet Oncol. , vol.16 , pp. 36-46
    • Arnold, M.1
  • 4
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013
    • 4 Ng, M., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384 (2014), 766–781.
    • (2014) Lancet , vol.384 , pp. 766-781
    • Ng, M.1
  • 5
    • 84905388767 scopus 로고    scopus 로고
    • 2) and mortality: a pooled analysis of 20 prospective studies
    • 2) and mortality: a pooled analysis of 20 prospective studies. PLoS Med., 11, 2014, e1001673.
    • (2014) PLoS Med. , vol.11 , pp. e1001673
    • Kitahara, C.M.1
  • 6
    • 84907481822 scopus 로고    scopus 로고
    • Metabolic health reduces risk of obesity-related cancer in Framingham study adults
    • 6 Moore, L.L., et al. Metabolic health reduces risk of obesity-related cancer in Framingham study adults. Cancer Epidemiol. Biomarkers Prev. 23 (2014), 2057–2065.
    • (2014) Cancer Epidemiol. Biomarkers Prev. , vol.23 , pp. 2057-2065
    • Moore, L.L.1
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 7 Hanahan, D., Weinberg, R.A., The hallmarks of cancer. Cell 100 (2000), 57–70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 8 Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 84867055650 scopus 로고    scopus 로고
    • Diet-induced metabolic change induces estrogen-independent allometric mammary growth
    • 9 Berryhill, G.E., et al. Diet-induced metabolic change induces estrogen-independent allometric mammary growth. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 16294–16299.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 16294-16299
    • Berryhill, G.E.1
  • 10
    • 84949196726 scopus 로고    scopus 로고
    • Estrogen deprivation and excess energy supply accelerate 7, 12-dimethylbenz (a) anthracene-induced mammary tumor growth in C3H/HeN mice
    • 10 Kim, J., et al. Estrogen deprivation and excess energy supply accelerate 7, 12-dimethylbenz (a) anthracene-induced mammary tumor growth in C3H/HeN mice. Nutr. Res. Pract. 9 (2015), 628–636.
    • (2015) Nutr. Res. Pract. , vol.9 , pp. 628-636
    • Kim, J.1
  • 11
    • 84936766416 scopus 로고    scopus 로고
    • High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-PyMT mouse model of breast cancer
    • 11 Cowen, S., et al. High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-PyMT mouse model of breast cancer. Cancers 7 (2015), 1125–1142.
    • (2015) Cancers , vol.7 , pp. 1125-1142
    • Cowen, S.1
  • 12
    • 84925033103 scopus 로고    scopus 로고
    • Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice
    • 12 Gahete, M.D., et al. Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice. Carcinogenesis 35 (2014), 2467–2473.
    • (2014) Carcinogenesis , vol.35 , pp. 2467-2473
    • Gahete, M.D.1
  • 13
    • 84908568810 scopus 로고    scopus 로고
    • Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice
    • 13 Sundaram, S., et al. Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice. PLoS One, 9, 2014, e111394.
    • (2014) PLoS One , vol.9 , pp. e111394
    • Sundaram, S.1
  • 14
    • 79955862214 scopus 로고    scopus 로고
    • Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland
    • 14 Subbaramaiah, K., et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev. Res. 4 (2011), 329–346.
    • (2011) Cancer Prev. Res. , vol.4 , pp. 329-346
    • Subbaramaiah, K.1
  • 15
    • 84879549514 scopus 로고    scopus 로고
    • Obesity, independent of p53 gene dosage, promotes mammary tumor progression and upregulates the p53 regulator MicroRNA-504
    • 15 Ford, N.A., et al. Obesity, independent of p53 gene dosage, promotes mammary tumor progression and upregulates the p53 regulator MicroRNA-504. PLoS One, 8, 2013, e68089.
    • (2013) PLoS One , vol.8 , pp. e68089
    • Ford, N.A.1
  • 16
    • 84877263616 scopus 로고    scopus 로고
    • Caloric restriction reverses obesity-induced mammary gland inflammation in mice
    • 16 Bhardwaj, P., et al. Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer Prev. Res. 6 (2013), 282–289.
    • (2013) Cancer Prev. Res. , vol.6 , pp. 282-289
    • Bhardwaj, P.1
  • 17
    • 84883386133 scopus 로고    scopus 로고
    • Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1
    • 17 Nogueira, L.M., et al. Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1. Cancer Med. 1 (2012), 275–288.
    • (2012) Cancer Med. , vol.1 , pp. 275-288
    • Nogueira, L.M.1
  • 18
    • 84874103653 scopus 로고    scopus 로고
    • IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression
    • 18 Ford, N.A., et al. IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression. Endocr. Relat. Cancer 20 (2013), 39–51.
    • (2013) Endocr. Relat. Cancer , vol.20 , pp. 39-51
    • Ford, N.A.1
  • 19
    • 84867434944 scopus 로고    scopus 로고
    • Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer
    • 19 Chen, C-T., et al. Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol. Cancer Ther. 11 (2012), 2212–2221.
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 2212-2221
    • Chen, C.-T.1
  • 20
    • 84876438500 scopus 로고    scopus 로고
    • The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001
    • 20 De Angel, R.E., et al. The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001. Mol. Carcinog. 52 (2013), 446–458.
    • (2013) Mol. Carcinog. , vol.52 , pp. 446-458
    • De Angel, R.E.1
  • 21
    • 84947042966 scopus 로고    scopus 로고
    • E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice
    • 21 Stark, A.P., et al. E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice. Surgery 158 (2015), 1564–1572.
    • (2015) Surgery , vol.158 , pp. 1564-1572
    • Stark, A.P.1
  • 22
    • 84888267890 scopus 로고    scopus 로고
    • A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice
    • 22 Philip, B., et al. A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology 145 (2013), 1449–1458.
    • (2013) Gastroenterology , vol.145 , pp. 1449-1458
    • Philip, B.1
  • 23
    • 84887898693 scopus 로고    scopus 로고
    • High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model
    • 23 Dawson, D.W., et al. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev. Res. 6 (2013), 1064–1073.
    • (2013) Cancer Prev. Res. , vol.6 , pp. 1064-1073
    • Dawson, D.W.1
  • 24
    • 84959341863 scopus 로고    scopus 로고
    • Robust early inflammation of the peripancreatic visceral adipose tissue during diet-induced obesity in the KrasG12D model of pancreatic cancer
    • 24 Hertzer, K.M., et al. Robust early inflammation of the peripancreatic visceral adipose tissue during diet-induced obesity in the KrasG12D model of pancreatic cancer. Pancreas 45 (2016), 458–465.
    • (2016) Pancreas , vol.45 , pp. 458-465
    • Hertzer, K.M.1
  • 25
    • 84900523546 scopus 로고    scopus 로고
    • Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner
    • 25 Harvey, A.E., et al. Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner. PLoS One, 9, 2014, e94151.
    • (2014) PLoS One , vol.9 , pp. e94151
    • Harvey, A.E.1
  • 26
    • 79960085339 scopus 로고    scopus 로고
    • Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer
    • 26 Lashinger, L.M., et al. Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer. Cancer Prev. Res. 4 (2011), 1041–1051.
    • (2011) Cancer Prev. Res. , vol.4 , pp. 1041-1051
    • Lashinger, L.M.1
  • 27
    • 79955817191 scopus 로고    scopus 로고
    • Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2–driven pancreatic neoplasia
    • 27 Lashinger, L.M., et al. Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2–driven pancreatic neoplasia. Cancer Prev. Res. 4 (2011), 1030–1040.
    • (2011) Cancer Prev. Res. , vol.4 , pp. 1030-1040
    • Lashinger, L.M.1
  • 28
    • 84953449453 scopus 로고    scopus 로고
    • Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model
    • 28 Park, J.W., et al. Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model. Endocr. Relat. Cancer 23 (2016), 53–63.
    • (2016) Endocr. Relat. Cancer , vol.23 , pp. 53-63
    • Park, J.W.1
  • 29
    • 84880676059 scopus 로고    scopus 로고
    • Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model
    • 29 Kim, W.G., et al. Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model. Endocrinology 154 (2013), 2936–2947.
    • (2013) Endocrinology , vol.154 , pp. 2936-2947
    • Kim, W.G.1
  • 30
    • 84885057969 scopus 로고    scopus 로고
    • Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop
    • 30 Li, H-J., et al. Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop. Oncol. Rep. 30 (2013), 2153–2160.
    • (2013) Oncol. Rep. , vol.30 , pp. 2153-2160
    • Li, H.-J.1
  • 31
    • 84864119774 scopus 로고    scopus 로고
    • Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth
    • 31 James, B.R., et al. Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J. Immunol. 189 (2012), 1311–1321.
    • (2012) J. Immunol. , vol.189 , pp. 1311-1321
    • James, B.R.1
  • 32
    • 84893762040 scopus 로고    scopus 로고
    • Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response
    • 32 Ericksen, R.E., et al. Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response. Gut 63 (2013), 385–394.
    • (2013) Gut , vol.63 , pp. 385-394
    • Ericksen, R.E.1
  • 33
    • 84865375235 scopus 로고    scopus 로고
    • Diet-induced obesity potentiates the growth of gastric cancer in mice
    • 33 Li, H-J., et al. Diet-induced obesity potentiates the growth of gastric cancer in mice. Exp. Ther. Med. 4 (2012), 615–620.
    • (2012) Exp. Ther. Med. , vol.4 , pp. 615-620
    • Li, H.-J.1
  • 34
    • 84929497622 scopus 로고    scopus 로고
    • Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2
    • 34 Hale, M., et al. Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2. PLoS One, 10, 2015, e0118784.
    • (2015) PLoS One , vol.10 , pp. e0118784
    • Hale, M.1
  • 35
    • 84899630749 scopus 로고    scopus 로고
    • Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression
    • 35 Olivo-Marston, S.E., et al. Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression. PLoS One, 9, 2014, e94765.
    • (2014) PLoS One , vol.9 , pp. e94765
    • Olivo-Marston, S.E.1
  • 36
    • 84945281525 scopus 로고    scopus 로고
    • Obesity promotes colonic stem cell expansion during cancer initiation
    • 36 DeClercq, V., et al. Obesity promotes colonic stem cell expansion during cancer initiation. Cancer Lett. 369 (2015), 336–343.
    • (2015) Cancer Lett. , vol.369 , pp. 336-343
    • DeClercq, V.1
  • 37
    • 79953772541 scopus 로고    scopus 로고
    • Energy balance modulates colon tumor growth: interactive roles of insulin and estrogen
    • 37 Rondini, E.A., et al. Energy balance modulates colon tumor growth: interactive roles of insulin and estrogen. Mol. Carcinog. 50 (2011), 370–382.
    • (2011) Mol. Carcinog. , vol.50 , pp. 370-382
    • Rondini, E.A.1
  • 38
    • 80052580981 scopus 로고    scopus 로고
    • Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis
    • 38 Endo, H., et al. Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut 60 (2011), 1363–1371.
    • (2011) Gut , vol.60 , pp. 1363-1371
    • Endo, H.1
  • 39
    • 84883552728 scopus 로고    scopus 로고
    • Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer
    • 39 Day, S.D., et al. Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer. Cytokine 64 (2013), 454–462.
    • (2013) Cytokine , vol.64 , pp. 454-462
    • Day, S.D.1
  • 40
    • 84875738655 scopus 로고    scopus 로고
    • Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice
    • 40 Tuominen, I., et al. Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice. PLoS One, 8, 2013, e60939.
    • (2013) PLoS One , vol.8 , pp. e60939
    • Tuominen, I.1
  • 41
    • 84888038812 scopus 로고    scopus 로고
    • Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression
    • 41 Harvey, A.E., et al. Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression. Mol. Carcinog. 52 (2013), 997–1006.
    • (2013) Mol. Carcinog. , vol.52 , pp. 997-1006
    • Harvey, A.E.1
  • 42
    • 79955115318 scopus 로고    scopus 로고
    • Leptin up-regulates pro-inflammatory cytokines in discrete cells within mouse colon
    • 42 Padidar, S., et al. Leptin up-regulates pro-inflammatory cytokines in discrete cells within mouse colon. J. Cell. Physiol. 226 (2011), 2123–2130.
    • (2011) J. Cell. Physiol. , vol.226 , pp. 2123-2130
    • Padidar, S.1
  • 43
    • 84866328666 scopus 로고    scopus 로고
    • Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer
    • 43 Liu, Z., et al. Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J. Nutr. Biochem. 23 (2012), 1207–1213.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 1207-1213
    • Liu, Z.1
  • 44
    • 84959449210 scopus 로고    scopus 로고
    • TLR4 signaling via NANOG cooperates with STAT3 to activate Twist1 and promote formation of tumor-initiating stem-like cells in livers of mice
    • 44 Kumar, D.B.U., et al. TLR4 signaling via NANOG cooperates with STAT3 to activate Twist1 and promote formation of tumor-initiating stem-like cells in livers of mice. Gastroenterology 150 (2016), 707–719.
    • (2016) Gastroenterology , vol.150 , pp. 707-719
    • Kumar, D.B.U.1
  • 45
    • 79953313217 scopus 로고    scopus 로고
    • Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors
    • 45 Stauffer, J.K., et al. Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors. Cancer Res. 71 (2011), 2718–2727.
    • (2011) Cancer Res. , vol.71 , pp. 2718-2727
    • Stauffer, J.K.1
  • 46
    • 84907976095 scopus 로고    scopus 로고
    • + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
    • + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26 (2014), 549–564.
    • (2014) Cancer Cell , vol.26 , pp. 549-564
    • Wolf, M.J.1
  • 47
    • 0026692795 scopus 로고
    • Dietary obesity in nine inbred mouse strains
    • 47 West, D.B., et al. Dietary obesity in nine inbred mouse strains. Am. J. Physiol. Regul. Integr. Comp. Physiol. 262 (1992), R1025–R1032.
    • (1992) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.262 , pp. R1025-R1032
    • West, D.B.1
  • 49
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • 49 Frese, K.K., Tuveson, D.A., Maximizing mouse cancer models. Nat. Rev. Cancer 7 (2007), 654–658.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 654-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 50
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    • 50 Paik, S., et al. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J. Clin. Oncol. 24 (2006), 3726–3734.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3726-3734
    • Paik, S.1
  • 51
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • 51 Cancer Genome Atlas Network, et al. Comprehensive molecular portraits of human breast tumours. Nature 490 (2012), 61–70.
    • (2012) Nature , vol.490 , pp. 61-70
    • Cancer Genome Atlas Network1
  • 52
    • 84865194273 scopus 로고    scopus 로고
    • A gene transcription signature of obesity in breast cancer
    • 52 Creighton, C.J., et al. A gene transcription signature of obesity in breast cancer. Breast Cancer Res. Treat. 132 (2012), 993–1000.
    • (2012) Breast Cancer Res. Treat. , vol.132 , pp. 993-1000
    • Creighton, C.J.1
  • 53
    • 79955781655 scopus 로고    scopus 로고
    • Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data
    • 53 Pilie, P.G., et al. Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data. Cancer Epidemiol. Biomarkers Prev. 20 (2011), 476–482.
    • (2011) Cancer Epidemiol. Biomarkers Prev. , vol.20 , pp. 476-482
    • Pilie, P.G.1
  • 54
    • 84921744960 scopus 로고    scopus 로고
    • Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients
    • 54 Berg, A., et al. Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. Oncotarget, 6, 2015, 1327.
    • (2015) Oncotarget , vol.6 , pp. 1327
    • Berg, A.1
  • 55
    • 84942197549 scopus 로고    scopus 로고
    • PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients
    • 55 Westin, S.N., et al. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Mol. Oncol. 9 (2015), 1694–1703.
    • (2015) Mol. Oncol. , vol.9 , pp. 1694-1703
    • Westin, S.N.1
  • 56
    • 84986910367 scopus 로고    scopus 로고
    • Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study
    • 56 Thrift, A.P., et al. Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study. J. Natl. Cancer Inst., 106, 2014, dju252.
    • (2014) J. Natl. Cancer Inst. , vol.106 , pp. dju252
    • Thrift, A.P.1
  • 57
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • 57 Medzhitov, R., Origin and physiological roles of inflammation. Nature 454 (2008), 428–435.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 58
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • 58 Coussens, L.M., Werb, Z., Inflammation and cancer. Nature 420 (2002), 860–867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 59
    • 84888633713 scopus 로고    scopus 로고
    • Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
    • 59 Elinav, E., et al. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat. Rev. Cancer 13 (2013), 759–771.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 759-771
    • Elinav, E.1
  • 60
    • 84896315632 scopus 로고    scopus 로고
    • Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy?
    • 60 O'Sullivan, K.E., et al. Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy?. J. Gastrointest. Cancer 45 (2014), 1–11.
    • (2014) J. Gastrointest. Cancer , vol.45 , pp. 1-11
    • O'Sullivan, K.E.1
  • 61
    • 80054789761 scopus 로고    scopus 로고
    • Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
    • 61 Chien, Y., et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 25 (2011), 2125–2136.
    • (2011) Genes Dev. , vol.25 , pp. 2125-2136
    • Chien, Y.1
  • 62
    • 4344612243 scopus 로고    scopus 로고
    • NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • 62 Huber, M.A., et al. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 114 (2004), 569–581.
    • (2004) J. Clin. Invest. , vol.114 , pp. 569-581
    • Huber, M.A.1
  • 63
    • 84897561550 scopus 로고    scopus 로고
    • IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
    • 63 Rokavec, M., et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Invest. 124 (2014), 1853–1867.
    • (2014) J. Clin. Invest. , vol.124 , pp. 1853-1867
    • Rokavec, M.1
  • 64
    • 84915803968 scopus 로고    scopus 로고
    • Interplay between the immune system and adipose tissue in obesity
    • 64 Exley, M.A., et al. Interplay between the immune system and adipose tissue in obesity. J. Endocrinol. 223 (2014), R41–R48.
    • (2014) J. Endocrinol. , vol.223 , pp. R41-R48
    • Exley, M.A.1
  • 65
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • 65 Weisberg, S.P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112 (2003), 1796–1808.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1
  • 66
    • 80053319523 scopus 로고    scopus 로고
    • Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue
    • 66 Lysaght, J., et al. Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue. Cancer Lett. 312 (2011), 62–72.
    • (2011) Cancer Lett. , vol.312 , pp. 62-72
    • Lysaght, J.1
  • 67
    • 84919337982 scopus 로고    scopus 로고
    • Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance
    • 67 Kitahara, C.M., et al. Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance. Cancer Epidemiol. Biomarkers Prev. 23 (2014), 2840–2849.
    • (2014) Cancer Epidemiol. Biomarkers Prev. , vol.23 , pp. 2840-2849
    • Kitahara, C.M.1
  • 68
    • 84919787912 scopus 로고    scopus 로고
    • Gene expression differences in adipose tissue associated with breast tumorigenesis
    • 68 Sturtz, L.A., et al. Gene expression differences in adipose tissue associated with breast tumorigenesis. Adipocyte 3 (2014), 107–114.
    • (2014) Adipocyte , vol.3 , pp. 107-114
    • Sturtz, L.A.1
  • 69
    • 84866532210 scopus 로고    scopus 로고
    • Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
    • 69 Ribeiro, R., et al. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med., 10, 2012, 1.
    • (2012) BMC Med. , vol.10 , pp. 1
    • Ribeiro, R.1
  • 70
    • 84859829669 scopus 로고    scopus 로고
    • Tumor cell-educated periprostatic adipose tissue acquires an aggressive cancer-promoting secretory profile
    • 70 Ribeiro, R.J., et al. Tumor cell-educated periprostatic adipose tissue acquires an aggressive cancer-promoting secretory profile. Cell. Physiol. Biochem. 29 (2012), 233–240.
    • (2012) Cell. Physiol. Biochem. , vol.29 , pp. 233-240
    • Ribeiro, R.J.1
  • 71
    • 84878830619 scopus 로고    scopus 로고
    • Elevated tumor expression of PAI-1 and SNAI2 in obese esophageal adenocarcinoma patients and impact on prognosis
    • 71 Allott, E.H., et al. Elevated tumor expression of PAI-1 and SNAI2 in obese esophageal adenocarcinoma patients and impact on prognosis. Clin. Transl. Gastroenterol., 3, 2012, e12.
    • (2012) Clin. Transl. Gastroenterol. , vol.3 , pp. e12
    • Allott, E.H.1
  • 72
    • 84957441405 scopus 로고    scopus 로고
    • Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer
    • 72 Amor, S., et al. Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer. Int. J. Colorectal Dis. 31 (2016), 365–375.
    • (2016) Int. J. Colorectal Dis. , vol.31 , pp. 365-375
    • Amor, S.1
  • 73
    • 84955321442 scopus 로고    scopus 로고
    • Obesity contributes to ovarian cancer metastatic success through increased lipogenesis, enhanced vascularity, and decreased infiltration of M1 macrophages
    • 73 Liu, Y., et al. Obesity contributes to ovarian cancer metastatic success through increased lipogenesis, enhanced vascularity, and decreased infiltration of M1 macrophages. Cancer Res. 75 (2015), 5046–5057.
    • (2015) Cancer Res. , vol.75 , pp. 5046-5057
    • Liu, Y.1
  • 74
    • 84885045471 scopus 로고    scopus 로고
    • Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis
    • 74 Arendt, L.M., et al. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res. 73 (2013), 6080–6093.
    • (2013) Cancer Res. , vol.73 , pp. 6080-6093
    • Arendt, L.M.1
  • 75
    • 84922328217 scopus 로고    scopus 로고
    • Paracrine interactions between adipocytes and tumor cells recruit and modify macrophages to the mammary tumor microenvironment: the role of obesity and inflammation in breast adipose tissue
    • 75 Santander, A.M., et al. Paracrine interactions between adipocytes and tumor cells recruit and modify macrophages to the mammary tumor microenvironment: the role of obesity and inflammation in breast adipose tissue. Cancers 7 (2015), 143–178.
    • (2015) Cancers , vol.7 , pp. 143-178
    • Santander, A.M.1
  • 76
    • 84862688466 scopus 로고    scopus 로고
    • Human adipose tissue macrophages display activation of cancer-related pathways
    • 76 Mayi, T.H., et al. Human adipose tissue macrophages display activation of cancer-related pathways. J. Biol. Chem. 287 (2012), 21904–21913.
    • (2012) J. Biol. Chem. , vol.287 , pp. 21904-21913
    • Mayi, T.H.1
  • 77
    • 68349150756 scopus 로고    scopus 로고
    • + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15 (2009), 914–920.
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1
  • 78
    • 69249155107 scopus 로고    scopus 로고
    • + cells amass in human omentum and are depleted in patients with cancer and obesity
    • + cells amass in human omentum and are depleted in patients with cancer and obesity. Eur. J. Immunol. 39 (2009), 1893–1901.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1893-1901
    • Lynch, L.1
  • 79
    • 85003037438 scopus 로고    scopus 로고
    • The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function
    • Published online June 30, 2016
    • 79 Conroy, M.J., et al. The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function. J. Leukoc. Biol., 2016, 10.1189/jlb.5AB1115-493RR Published online June 30, 2016.
    • (2016) J. Leukoc. Biol.
    • Conroy, M.J.1
  • 80
    • 67449110963 scopus 로고    scopus 로고
    • White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models
    • 80 Zhang, Y., et al. White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Cancer Res. 69 (2009), 5259–5266.
    • (2009) Cancer Res. , vol.69 , pp. 5259-5266
    • Zhang, Y.1
  • 81
    • 84973333169 scopus 로고    scopus 로고
    • CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment
    • 81 Zhang, T., et al. CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment. Nat. Commun., 7, 2016, 11674.
    • (2016) Nat. Commun. , vol.7 , pp. 11674
    • Zhang, T.1
  • 82
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • 82 Greenberg, J.I., et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 456 (2008), 809–813.
    • (2008) Nature , vol.456 , pp. 809-813
    • Greenberg, J.I.1
  • 83
    • 84867546345 scopus 로고    scopus 로고
    • Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment
    • 83 Zhang, Y., et al. Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res. 72 (2012), 5198–5208.
    • (2012) Cancer Res. , vol.72 , pp. 5198-5208
    • Zhang, Y.1
  • 84
    • 84943339748 scopus 로고    scopus 로고
    • Stromal cells derived from visceral and obese adipose tissue promote growth of ovarian cancers
    • 84 Zhang, Y., et al. Stromal cells derived from visceral and obese adipose tissue promote growth of ovarian cancers. PLoS One, 10, 2015, e0136361.
    • (2015) PLoS One , vol.10 , pp. e0136361
    • Zhang, Y.1
  • 85
    • 84929026965 scopus 로고    scopus 로고
    • Adipocyte-derived monocyte chemotactic protein-1 (MCP-1) promotes prostate cancer progression through the induction of MMP-2 activity
    • 85 Ito, Y., et al. Adipocyte-derived monocyte chemotactic protein-1 (MCP-1) promotes prostate cancer progression through the induction of MMP-2 activity. Prostate 75 (2015), 1009–1019.
    • (2015) Prostate , vol.75 , pp. 1009-1019
    • Ito, Y.1
  • 86
    • 73249117062 scopus 로고    scopus 로고
    • Adipose tissue collagen VI in obesity
    • 86 Pasarica, M., et al. Adipose tissue collagen VI in obesity. J. Clin. Endocrinol. Metab. 94 (2009), 5155–5162.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 5155-5162
    • Pasarica, M.1
  • 87
    • 84868611621 scopus 로고    scopus 로고
    • Adipocyte-derived endotrophin promotes malignant tumor progression
    • 87 Park, J., Scherer, P.E., Adipocyte-derived endotrophin promotes malignant tumor progression. J. Clin. Invest., 122, 2012, 4243.
    • (2012) J. Clin. Invest. , vol.122 , pp. 4243
    • Park, J.1    Scherer, P.E.2
  • 88
    • 78649737455 scopus 로고    scopus 로고
    • The extracellular matrix at a glance
    • 88 Frantz, C., et al. The extracellular matrix at a glance. J. Cell Sci. 123 (2010), 4195–4200.
    • (2010) J. Cell Sci. , vol.123 , pp. 4195-4200
    • Frantz, C.1
  • 89
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: a dynamic niche in cancer progression
    • 89 Lu, P., et al. The extracellular matrix: a dynamic niche in cancer progression. J. Cell Biol. 196 (2012), 395–406.
    • (2012) J. Cell Biol. , vol.196 , pp. 395-406
    • Lu, P.1
  • 90
    • 70849099495 scopus 로고    scopus 로고
    • The extracellular matrix: not just pretty fibrils
    • 90 Hynes, R.O., The extracellular matrix: not just pretty fibrils. Science 326 (2009), 1216–1219.
    • (2009) Science , vol.326 , pp. 1216-1219
    • Hynes, R.O.1
  • 91
    • 84939817343 scopus 로고    scopus 로고
    • Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis
    • 91 Seo, B.R., et al. Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci. Transl. Med., 7, 2015, 301ra130.
    • (2015) Sci. Transl. Med. , vol.7 , pp. 301ra130
    • Seo, B.R.1
  • 92
    • 84856450751 scopus 로고    scopus 로고
    • Aromatase, breast cancer and obesity: a complex interaction
    • 92 Bulun, S.E., et al. Aromatase, breast cancer and obesity: a complex interaction. Trends Endocrinol. Metab. 23 (2012), 83–89.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 83-89
    • Bulun, S.E.1
  • 93
    • 84866250761 scopus 로고    scopus 로고
    • Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
    • 93 Subbaramaiah, K., et al. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2 (2012), 356–365.
    • (2012) Cancer Discov. , vol.2 , pp. 356-365
    • Subbaramaiah, K.1
  • 94
    • 0037561561 scopus 로고    scopus 로고
    • Role of CRE-binding protein (CREB) in aromatase expression in breast adipose
    • 94 Sofi, M., et al. Role of CRE-binding protein (CREB) in aromatase expression in breast adipose. Breast Cancer Res. Treat. 79 (2003), 399–407.
    • (2003) Breast Cancer Res. Treat. , vol.79 , pp. 399-407
    • Sofi, M.1
  • 95
    • 84923205376 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer
    • 95 Wang, X., et al. Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer. Cancer Res. 75 (2015), 645–655.
    • (2015) Cancer Res. , vol.75 , pp. 645-655
    • Wang, X.1
  • 96
    • 84875827863 scopus 로고    scopus 로고
    • HIF-1a stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma
    • 96 Samarajeewa, N.U., et al. HIF-1a stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma. Breast Cancer Res., 15, 2013, R30.
    • (2013) Breast Cancer Res. , vol.15 , pp. R30
    • Samarajeewa, N.U.1
  • 97
    • 84871252548 scopus 로고    scopus 로고
    • Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer
    • 97 Giles, E.D., et al. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Res. 72 (2012), 6490–6501.
    • (2012) Cancer Res. , vol.72 , pp. 6490-6501
    • Giles, E.D.1
  • 99
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • 99 La Cava, A., Matarese, G., The weight of leptin in immunity. Nat. Rev. Immunol. 4 (2004), 371–379.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 100
    • 2442475308 scopus 로고    scopus 로고
    • Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor α in MCF-7 cells
    • 100 Catalano, S., et al. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor α in MCF-7 cells. J. Biol. Chem. 279 (2004), 19908–19915.
    • (2004) J. Biol. Chem. , vol.279 , pp. 19908-19915
    • Catalano, S.1
  • 101
    • 84886744759 scopus 로고    scopus 로고
    • Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways
    • 101 Strong, A.L., et al. Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways. Breast Cancer Res., 15, 2013, R102.
    • (2013) Breast Cancer Res. , vol.15 , pp. R102
    • Strong, A.L.1
  • 102
    • 84910002431 scopus 로고    scopus 로고
    • Vitamin D suppresses leptin stimulation of cancer growth through microRNA
    • 102 Kasiappan, R., et al. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer Res. 74 (2014), 6194–6204.
    • (2014) Cancer Res. , vol.74 , pp. 6194-6204
    • Kasiappan, R.1
  • 103
    • 84951922542 scopus 로고    scopus 로고
    • Leptin and adiponectin modulate the self-renewal of normal human breast epithelial stem cells
    • 103 Esper, R.M., et al. Leptin and adiponectin modulate the self-renewal of normal human breast epithelial stem cells. Cancer Prev. Res. 8 (2015), 1174–1183.
    • (2015) Cancer Prev. Res. , vol.8 , pp. 1174-1183
    • Esper, R.M.1
  • 104
    • 84890115428 scopus 로고    scopus 로고
    • Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
    • 104 Zheng, Q., et al. Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr. Relat. Cancer 20 (2013), 797–808.
    • (2013) Endocr. Relat. Cancer , vol.20 , pp. 797-808
    • Zheng, Q.1
  • 105
    • 84957690410 scopus 로고    scopus 로고
    • Leptin as a mediator of tumor–stromal interactions promotes breast cancer stem cell activity
    • 105 Giordano, C., et al. Leptin as a mediator of tumor–stromal interactions promotes breast cancer stem cell activity. Oncotarget, 7, 2016, 1262.
    • (2016) Oncotarget , vol.7 , pp. 1262
    • Giordano, C.1
  • 106
    • 84939438451 scopus 로고    scopus 로고
    • Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression
    • 106 Chang, C.C., et al. Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression. Cancer Res. 75 (2015), 2375–2386.
    • (2015) Cancer Res. , vol.75 , pp. 2375-2386
    • Chang, C.C.1
  • 107
    • 84940746800 scopus 로고    scopus 로고
    • Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
    • 107 Kato, S., et al. Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women. Oncotarget 6 (2015), 21100–21119.
    • (2015) Oncotarget , vol.6 , pp. 21100-21119
    • Kato, S.1
  • 108
    • 84939963231 scopus 로고    scopus 로고
    • Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes
    • 108 Papanikolaou, V., et al. Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes. Cell. Oncol. 38 (2015), 155–164.
    • (2015) Cell. Oncol. , vol.38 , pp. 155-164
    • Papanikolaou, V.1
  • 109
    • 84988857304 scopus 로고    scopus 로고
    • Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, Janus kinase 2-independent pathway
    • 109 Alshaker, H., et al. Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, Janus kinase 2-independent pathway. Breast Cancer Res., 16, 2014, 426.
    • (2014) Breast Cancer Res. , vol.16 , pp. 426
    • Alshaker, H.1
  • 110
    • 84928893831 scopus 로고    scopus 로고
    • Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells
    • 110 Yao-Borengasser, A., et al. Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells. Oncol. Rep. 33 (2015), 2689–2694.
    • (2015) Oncol. Rep. , vol.33 , pp. 2689-2694
    • Yao-Borengasser, A.1
  • 111
    • 84939522108 scopus 로고    scopus 로고
    • Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers
    • 111 Strong, A.L., et al. Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers. Breast Cancer Res. 17 (2015), 1–16.
    • (2015) Breast Cancer Res. , vol.17 , pp. 1-16
    • Strong, A.L.1
  • 112
    • 77649175453 scopus 로고    scopus 로고
    • Genomic instability – an evolving hallmark of cancer
    • 112 Negrini, S., et al. Genomic instability – an evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 11 (2010), 220–228.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 220-228
    • Negrini, S.1
  • 113
    • 84890027933 scopus 로고    scopus 로고
    • Body mass index and microsatellite instability in colorectal cancer: a population-based study
    • 113 Hoffmeister, M., et al. Body mass index and microsatellite instability in colorectal cancer: a population-based study. Cancer Epidemiol. Biomarkers Prev. 22 (2013), 2303–2311.
    • (2013) Cancer Epidemiol. Biomarkers Prev. , vol.22 , pp. 2303-2311
    • Hoffmeister, M.1
  • 114
    • 84878838635 scopus 로고    scopus 로고
    • Anthropometric measures and the risk of endometrial cancer, overall and by tumor microsatellite status and histological subtype
    • 114 Amankwah, E.K., et al. Anthropometric measures and the risk of endometrial cancer, overall and by tumor microsatellite status and histological subtype. Am. J. Epidemiol. 177 (2013), 1378–1387.
    • (2013) Am. J. Epidemiol. , vol.177 , pp. 1378-1387
    • Amankwah, E.K.1
  • 115
    • 84877079243 scopus 로고    scopus 로고
    • High frequency of chromosome aberrations observed in lymphocytes in postmenopausal obese women
    • 115 Tafurt-Cardona, Y., et al. High frequency of chromosome aberrations observed in lymphocytes in postmenopausal obese women. Biomédica 32 (2012), 344–354.
    • (2012) Biomédica , vol.32 , pp. 344-354
    • Tafurt-Cardona, Y.1
  • 116
    • 84945206245 scopus 로고    scopus 로고
    • Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma
    • 116 Mongan, A., et al. Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma. Clin. Transl. Oncol. 18 (2016), 632–640.
    • (2016) Clin. Transl. Oncol. , vol.18 , pp. 632-640
    • Mongan, A.1
  • 117
  • 118
    • 77649338652 scopus 로고    scopus 로고
    • Mitochondrial gateways to cancer
    • 118 Galluzzi, L., et al. Mitochondrial gateways to cancer. Mol. Aspects Med. 31 (2010), 1–20.
    • (2010) Mol. Aspects Med. , vol.31 , pp. 1-20
    • Galluzzi, L.1
  • 119
    • 84924375901 scopus 로고    scopus 로고
    • Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma
    • 119 Lynam-Lennon, N., et al. Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma. BMC Cancer, 14, 2014, 907.
    • (2014) BMC Cancer , vol.14 , pp. 907
    • Lynam-Lennon, N.1
  • 120
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • 120 Ley, R.E., et al. Microbial ecology: human gut microbes associated with obesity. Nature 444 (2006), 1022–1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1
  • 121
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • 121 Tremaroli, V., Backhed, F., Functional interactions between the gut microbiota and host metabolism. Nature 489 (2012), 242–249.
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 122
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    • 122 Cani, P.D., et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58 (2009), 1091–1103.
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1
  • 123
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • 123 Ridlon, J.M., et al. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47 (2006), 241–259.
    • (2006) J. Lipid Res. , vol.47 , pp. 241-259
    • Ridlon, J.M.1
  • 124
    • 78349257844 scopus 로고    scopus 로고
    • The essence of senescence
    • 124 Kuilman, T., et al. The essence of senescence. Genes Dev. 24 (2010), 2463–2479.
    • (2010) Genes Dev. , vol.24 , pp. 2463-2479
    • Kuilman, T.1
  • 125
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • 125 Yoshimoto, S., et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499 (2013), 97–101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.