TLR4 Signaling via NANOG Cooperates with STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice

Gastroenterology

Volumn 150, Issue 3, 2016, Pages 707-719

  Uthaya Kumar, Dinesh Babu ^a   Chen, Chia Lin ^a   Liu, Jian Chang ^a   Feldman, Douglas E ^a   Sher, Linda S ^a   French, Samuel ^b   Dinorcia, Joseph ^a   French, Samuel W ^b,c   Naini, Bita V ^b   Junrungsee, Sunhawit ^c   Agopian, Vatche Garen ^c   Zarrinpar, Ali ^c   Machida, Keigo ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Los Angeles School of Medicine ^*  (United States)

Author keywords

HCC; HCV; NASH; Obesity

Indexed keywords

CHOLESTEROL; MESSENGER RNA; NONSTRUCTURAL PROTEIN 5A; SATURATED FATTY ACID; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST 1; UNCLASSIFIED DRUG; APOLIPOPROTEIN E; HOMEODOMAIN PROTEIN; NANOG PROTEIN, MOUSE; NS-5 PROTEIN, HEPATITIS C VIRUS; NUCLEAR PROTEIN; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; TLR4 PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE; TWIST RELATED PROTEIN 1; TWIST1 PROTEIN, HUMAN; TWIST1 PROTEIN, MOUSE; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CELL MIGRATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR INITIATING STEM LIKE CELL; WESTERN DIET; ADULT; AGED; ANIMAL; C57BL MOUSE; CELL LINE; CELL MOTION; CELL SELF-RENEWAL; CELL TRANSFORMATION; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; LIPID DIET; LIVER; LIVER TUMOR; METABOLISM; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; PROMOTER REGION; SIGNAL TRANSDUCTION; TIME FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; APOLIPOPROTEINS E; CELL LINE; CELL MOVEMENT; CELL SELF RENEWAL; CELL TRANSFORMATION, NEOPLASTIC; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; NANOG HOMEOBOX PROTEIN; NEOPLASTIC STEM CELLS; NON-ALCOHOLIC FATTY LIVER DISEASE; NUCLEAR PROTEINS; PHENOTYPE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TWIST-RELATED PROTEIN 1; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84959449210     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.11.002     Document Type: Article

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