Leptin and adiponectin modulate the self-renewal of normal human breast epithelial stem cells

Cancer Prevention Research

Volumn 8, Issue 12, 2015, Pages 1174-1183

  Esper, Raymond M ^a   Dame, Michael ^a   Mcclintock, Shannon ^a   Holt, Peter R ^b   Dannenberg, Andrew J ^c   S wicha, Max ^a   Brenner, Dean E ^a,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALDEHYDE DEHYDROGENASE; LEPTIN; ADIPOQ PROTEIN, HUMAN;

ADIPOCYTE; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIAL STEM CELL; BREAST EPITHELIUM CELL; CANCER RISK; CELL DIFFERENTIATION; CELL EXPANSION; CELL POPULATION; CELL SEPARATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MAMMARY GLAND FAT; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; STEM CELL SELF-RENEWAL; ADOLESCENT; ADULT; BLOOD; BREAST; BREAST TUMOR; CELL CULTURE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM; MIDDLE AGED; PHYSIOLOGY; STEM CELL; YOUNG ADULT;

ADIPONECTIN; ADOLESCENT; ADULT; BREAST; BREAST NEOPLASMS; CELL PROLIFERATION; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; HUMANS; LEPTIN; MICROSCOPY, CONFOCAL; MIDDLE AGED; OBESITY; STEM CELLS; YOUNG ADULT;

EID: 84951922542     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-14-0334     Document Type: Article

References (50)

1. Bhaskaran K, Douglas I, Forbes H, Dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: A population-based cohort study of 5.24 million UK adults. Lancet 2014;384:755-65.
2. Renehan AG, Soerjomataram I, Tyson M, Egger M, Zwahlen M, Coebergh JW, et al. Incident cancer burden attributable to excess body mass index in 30 European countries. Int J Cancer 2010;126:692-702.
3. Sinicrope FA, Dannenberg AJ. Obesity and breast cancer prognosis: Weight of the evidence. J Clin Oncol 2011;29:4-7.
4. Brisken C, Duss S. Stem cells and the stem cell niche in the breast: An integrated hormonal and developmental perspective. Stem Cell Rev 2007;3:147-56.
5. Inadera H. The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int J Med Sci 2008;5:248-62.
6. Ricci R, Bevilacqua F. The potential role of leptin and adiponectin in obesity: A comparative review. Vet J 2012;191:292-8.
7. Gnerlich JL, Yao KA, Fitchev PS, Goldschmidt RA, Bond MC, Cornwell M, et al. Peritumoral expression of adipokines and fatty acids in breast cancer. Ann Surg Oncol 2013;20:S731-8.
8. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
9. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000;404:661-71.
10. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999;23:775-86.
11. Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 1999;22:221-32.
12. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 2006;12:1447-53.
13. Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, et al. High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patientswith high, but not low, serum leptin levels. Int J Cancer 2006;118:1414-9.
14. Ollberding NJ, Kim Y, Shvetsov YB, Wilkens LR, Franke AA, Cooney RV, et al. Prediagnostic leptin, adiponectin, C-reactive protein, and the risk of postmenopausal breast cancer. Cancer Prev Res 2013;6:188-95.
15. Zheng Q, Dunlap SM, Zhu J, Downs-Kelly E, Rich J, Hursting SD, et al. Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. Endoc Relat Cancer 2011;18:491-503.
16. Zheng Q, Hursting SD, Reizes O. Leptin regulates cyclin D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors. J Cancer Res Clin Oncol 2012;138:1607-12.
17. Zheng Q, Banaszak L, Fracci S, Basali D, Dunlap SM, Hursting SD, et al. Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr Relat Cancer 2013;20:797-808.
18. MantzorosC, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, et al. Adiponectin and breast cancer risk. J Clin Endocrinol Metab 2004;89:1102-7.
19. Gross AL, Newschaffer CJ, Hoffman-Bolton J, Rifai N, Visvanathan K. Adipocytokines, inflammation, and breast cancer risk in postmenopausal women: A prospective study. Cancer Epidemiol Biomarkers Prev 2013;22: 1319-24.
20. Tian YF, Chu CH, Wu MH, Chang CL, Yang T, Chou YC, et al. Anthropometric measures, plasma adiponectin, and breast cancer risk. Endocr Relat Cancer 2007;14:669-77.
21. Tworoger SS, Eliassen AH, Kelesidis T, Colditz GA, Willett WC, Mantzoros CS, et al. Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab 2007;92:1510-6.
22. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, et al. Association of serum adiponectin levels with breast cancer risk.Clin Cancer Res 2003;9:5699-704.
23. Jarde T, Caldefie-Chezet F, Goncalves-Mendes N, Mishellany F, Buechler C, Penault-Llorca F, et al. Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. Endocr Relat Cancer 2009;16:1197- 210.
24. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005;26:439-51.
25. Grossmann ME, Nkhata KJ, Mizuno NK, Ray A, Cleary MP. Effects of adiponectin on breast cancer cell growth and signaling. Br J Cancer 2008;98:370-9.
26. Lam JB, Chow KH, Xu A, Lam KS, Liu J, Wong NS, et al. Adiponectin haploinsufficiency promotes mammary tumor development in MMTVPyVT mice by modulation of phosphatase and tensin homolog activities. PloS One 2009;4:e4968.
27. Li Y, Rosen JM. Stem/progenitor cells in mouse mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2005;10: 17-24.
28. Fu N, Lindeman GJ, Visvader JE. The mammary stem cell hierarchy. Curr Top Dev Biol 2014;107:133-60.
29. Shah M, Allegrucci C. Keeping an openmind: highlights and controversies of the breast cancer stem cell theory. Breast Cancer 2012;4:155-66.
30. Li Y, Wicha MS, Schwartz SJ, Sun D. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem 2011;22:799-806.
31. Tu SM. Origin of cancers. Clinical perspectives and implications of a stemcell theory of cancer. Cancer Treat Res 2010;154:239.
32. Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS. Stem cells in normal breast development and breast cancer. Cell Prolif 2003;36:59-72.
33. Dontu G, Abdallah WM, Foley JM, Jackson KW, ClarkeMF, Kawamura MJ, et al. In vitro propagation and transcriptional profiling of humanmammary stem/progenitor cells. Genes Dev 2003;17:1253-70.
34. Shaw FL, Harrison H, Spence K, Ablett MP, Simoes BM, Farnie G, et al. A detailed mammosphere assay protocol for the quantification of breast stem cell activity. J Mammary Gland Biol Neoplasia 2012;17:111-7.
35. Dontu G, Liu S, Wicha MS. Stem cells in mammary development and carcinogenesis: implications for prevention and treatment. Stem Cell Rev 2005;1:207-13.
36. Dontu G, Wicha MS. Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia 2005;10:75-86.
37. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1: 555-67.
38. Liu S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Rep 2014;2:78-91.
39. Lee JH, Kirkham JC, McCormack MC, Medina MA, Nicholls AM, Randolph MA, et al. A novel approach to adipocyte analysis. Plast Reconstr Surg 2012;129:380-7.
40. Liuzzi A, Savia G, Tagliaferri M, Lucantoni R, Berselli ME, PetroniML, et al. Serum leptin concentration in moderate and severe obesity: Relationship with clinical, anthropometric andmetabolic factors. Int J Obes RelatMetab Disord 1999;23:1066-73.
41. Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: A secondary analysis of the women's health initiative randomized clinical trials. JAMA Oncol 2015;1:611-21.
42. Diehn M, Cho RW, Clarke MF. Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol 2009;19:78-86.
43. Croker AK, Goodale D, Chu J, Postenka C, Hedley BD, Hess DA, et al. High aldehyde dehydrogenase and expression of cancer stem cellmarkers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med 2009;13:2236-52.
44. Montales MT, Rahal OM, Kang J, Rogers TJ, Prior RL, Wu X, et al. Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis 2012;33:652-60.
45. Grudzien P, Lo S, Albain KS, Robinson P, Rajan P, Strack PR, et al. Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. Anticancer Res 2010;30:3853-67.
46. Santillan-Benitez JG, Mendieta-Zeron H, Gomez-Olivan LM, Torres-Juarez JJ, Gonzalez-Banales JM, Hernandez-Pena LV, et al. The tetrad BMI, leptin, leptin/adiponectin (L/A) ratio and CA 15-3 are reliable biomarkers of breast cancer. J Clin Lab Anal 2013;27:12-20.
47. Alikasifoglu A, Gonc N, Ozon ZA, Sen Y, Kandemir N. The relationship between serum adiponectin, tumor necrosis factor-alpha, leptin levels and insulin sensitivity in childhood and adolescent obesity: Adiponectin is a marker ofmetabolic syndrome. J Clin Res Pediatr Endocrinol 2009;1:233-9.
48. Otvos L Jr., Haspinger E, La Russa F, Maspero F, Graziano P, Kovalszky I, et al. Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotechnol 2011;11:90.
49. Otvos L Jr, Kovalszky I, Riolfi M, Ferla R, Olah J, Sztodola A, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer 2011;47:1578-84.
50. Otvos L Jr, Kovalszky I, Scolaro L, Sztodola A, Olah J, Cassone M, et al. Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation. Biopolymers 2011;96:117-25.