Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway

Breast Cancer Research

Volumn 16, Issue 1, 2014, Pages

  Alshaker, Heba ^a,b   Krell, Jonathan ^a   Frampton, Adam E ^a   Waxman, Jonathan ^a   Blyuss, Oleg ^c   Zaikin, Alexey ^c   Winkler, Mathias ^a   Stebbing, Justin ^a   Yagüe, Ernesto ^a   Pchejetski, Dmitri ^d  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PETRA   (Jordan)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; JANUS KINASE 2; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1; JAK2 PROTEIN, HUMAN; LEPTIN; LEPTIN RECEPTOR, HUMAN; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; SPHINGOSINE KINASE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; BODY MASS; BREAST CANCER; BREAST CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTOPE LABELING; LIMIT OF QUANTITATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; BREAST NEOPLASMS; COMPLICATION; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MCF 7 CELL LINE; METABOLISM; OBESITY; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

BREAST NEOPLASMS; CELL PROLIFERATION; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; LEPTIN; LYMPHATIC METASTASIS; MCF-7 CELLS; OBESITY; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RECEPTORS, ESTROGEN; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84988857304     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/s13058-014-0426-6     Document Type: Article

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