Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients

Oncotarget

Volumn 6, Issue 2, 2015, Pages 1327-1339

  Berg, Anna ^a,b   Hoivik, Erling A ^a,b   Mjøs, Siv ^a,b   Holst, Frederik ^a,b   Werner, Henrica M J ^a,b   Tangen, Ingvild L ^a,b   Taylor Weiner, Amaro ^c,d,e   Gibson, William J ^c,d,e   Kusonmano, Kanthida ^a,b   Wik, Elisabeth ^a,b   Trovik, Jone ^a,b   Halle, Mari K ^a,b   Øyan, Anne M ^a,b   Kalland, Karl Henning ^a,b   Cherniack, Andrew D ^c   Beroukhim, Rameen ^c,d,e   Stefansson, Ingunn ^a,b   Mills, Gordon B ^f   Krakstad, Camilla ^a,b   Salvesen, Helga B ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Body mass index; Endometrial carcinoma; Endometrial hyperplasia; Metastasis; PI3Kinase

Indexed keywords

ESTROGEN RECEPTOR ALPHA; FORMALDEHYDE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; STATHMIN; KRAS PROTEIN, HUMAN; MESSENGER RNA; ONCOPROTEIN; PIK3CA PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; RAS PROTEIN; TUMOR MARKER;

ARTICLE; BODY MASS; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER LOCALIZATION; CANCER RISK; CARCINOGENESIS; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; ENDOMETRIOID COMPLEX ATYPICAL HYPERPLASIA; ENDOMETRIOID ENDOMETRIAL CANCER; ENDOMETRIUM CARCINOMA; EPITHELIAL MESENCHYMAL TRANSITION; ERALPHA GENE; EXOME; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FREEZING; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE INTERACTION; GENE LOSS; GENE SEQUENCE; GENETIC MARKER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAJOR CLINICAL STUDY; METASTASIS; MISSENSE MUTATION; MUTATIONAL ANALYSIS; OBESITY; ONCOGENE; ONCOGENE K RAS; PI3K GENE; POSTOPERATIVE PERIOD; PR GENE; PRECANCER; PREOPERATIVE EVALUATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN MICROARRAY; PTEN GENE; REVERSE PHASE PROTEIN ARRAY; STATHMIN GENE; TISSUE FIXATION; VALIDATION STUDY; COMPARATIVE STUDY; COMPLICATION; DNA MICROARRAY; DNA SEQUENCE; ENDOMETRIAL NEOPLASMS; GENETICS; METABOLISM; MUTATION; PROCEDURES; PROTEOMICS;

BIOMARKERS, TUMOR; BODY MASS INDEX; COHORT STUDIES; ENDOMETRIAL NEOPLASMS; EXOME; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MUTATION; NEOPLASM METASTASIS; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEOMICS; PROTO-ONCOGENE PROTEINS; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

EID: 84921744960     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2675     Document Type: Article

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