Metabolic health reduces risk of obesity-related cancer in framingham study adults

Cancer Epidemiology Biomarkers and Prevention

Volumn 23, Issue 10, 2014, Pages 2057-2065

  Moore, Lynn L ^a,b   Chadid, Susan ^a   Singer, Martha R ^a   Kreger, Bernard E ^a,b   Denis, Gerald V ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE BLOOD LEVEL;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; BREAST CANCER; CANCER RISK; COLON CANCER; ENDOMETRIUM CANCER; ESOPHAGEAL ADENOCARCINOMA; FEMALE; GALLBLADDER CANCER; GLUCOSE BLOOD LEVEL; HUMAN; KIDNEY CANCER; LIVER CANCER; MAJOR CLINICAL STUDY; MALE; NEOPLASM; OBESITY; OBESITY RELATED CANCER; PANCREAS CANCER; PHYSICAL ACTIVITY; RISK REDUCTION; SMOKING; UTERINE CERVIX CANCER; UTERUS CANCER; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ANALYSIS; BLOOD; COMPLICATION; METABOLISM; MIDDLE AGED; NEOPLASMS; PROPORTIONAL HAZARDS MODEL; WAIST TO HEIGHT RATIO;

AGED; BLOOD GLUCOSE; BODY MASS INDEX; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OBESITY; PROPORTIONAL HAZARDS MODELS; WAIST-HEIGHT RATIO;

EID: 84907481822     PISSN: 10559965     EISSN: 15387755     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-14-0240     Document Type: Article

References (33)

1. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011;377:557-67.
2. American Cancer Society. Cancer prevention & early detection facts & figures 2012. Atlanta, GA: American Cancer Society; 2012. p. 1-60.
3. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625-38.
4. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579-91.
5. Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci 2012;1271:37-43.
6. Moore LL, Bradlee ML, Singer MR, Splansky GL, Proctor MH, Ellison RC, et al. BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults. Int J Obes Relat Metab Disord 2004;28:559-67.
7. Parekh N, Lin Y, Vadiveloo M, Hayes RB, Lu-Yao GL. Metabolic dysregulation of the insulin-glucose axis and risk of obesity-related cancers in the Framingham heart study-offspring cohort (1971-2008). Cancer Epidemiol Biomarkers Prev 2013;22:1825-36.
8. Shea JL, Randell EW, Sun G. The prevalence of metabolically healthy obese subjects defined by BMI and dual-energy X-ray absorptiometry. Obesity (Silver Spring) 2011;19:624-30.
9. Stefan N, Haring H-U. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 2013;1:152-62.
10. Kloting N, Fasshauer M, Dietrich A, Kovacs P, Schon MR, Kern M, et al. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 2010;299: E506-15.
11. Bluher M. The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 2010;21:38-43.
12. Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV. The outliers become a stampede as immunometabolism reaches a tipping point. Immunol Rev 2012;249:253-75.
13. Browning LM, Hsieh SD, Ashwell M. A systematic review of waist-toheight ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0.5 could be a suitable global boundary value. Nutr Res Rev 2010;23:247-69.
14. Ziemer DC, Kolm P, Foster JK, Weintraub WS, Vaccarino V, Rhee MK, et al. Random plasma glucose in serendipitous screening for glucose intolerance: screening for impaired glucose tolerance study 7. J Gen Intern Med 2008;23:528-35
15. Fox CS, Coady S, Sorlie PD, D'Agostino RB Sr, Pencina MJ, Vasan RS, et al. Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study. Circulation 2007;115: 1544-50.
16. Kannel WB, Sorlie P. Some health benefits of physical activity. The Framingham Study. Arch Intern Med 1979;139:857-61.
17. Kreger BE, Splansky GL, Schatzkin A. The cancer experience in the Framingham Heart Study cohort. Cancer 1991;67:1-6.
18. McMillan DC, Sattar N, McArdle CS. ABC of obesity. Obesity and cancer. BMJ 2006;333:1109-11.
19. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and metaanalysis of prospective observational studies. Lancet 2008;371: 569-78.
20. International Classification of Disease for Oncology. Morphology of Neoplasms, 2nd ed. Geneva: World Health Organization; 1990.
21. Marini MA, Succurro E, Frontoni S, Hribal ML, Andreozzi F, Lauro R, et al. Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women. Diabetes Care 2007;30:2145-7.
22. Denis GV, Obin MS. 'Metabolically healthy obesity': origins and implications. Mol Aspects Med 2013 ;34:59-70.
23. Iyer A, Fairlie DP, Prins JB, Hammock BD, Brown L. Inflammatory lipid mediators in adipocyte function and obesity. Nat Rev Endocrinol 2010; 6:71-82.
24. Kim CS, Park HS, Kawada T, Kim JH, Lim D, Hubbard NE, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond) 2006;30:1347-55.
25. Lemieux I, Pascot A, Prud'homme D, Almeras N, Bogaty P, Nadeau A, et al. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 2001;21:961-7.
26. Pi-Sunyer FX. The epidemiology of central fat distribution in relation to disease. Nutr Rev 2004;62:S120-6.
27. Lee MJ, Wu Y, Fried SK. Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med 2013;34:1-11.
28. Farooqi IS, O'Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009;89:980S-4S.
29. Housa D, Housova J, Vernerova Z, Haluzik M. Adipocytokines and cancer. Physiol Res 2006;55:233-44.
30. Sharma D, Saxena NK, Vertino PM, Anania FA. Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr Relat Cancer 2006;13:629-40.
31. Cohen DH, LeRoith D. Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocr Relat Cancer 2012;19:F27-45.
32. Kabat GC, Kim MY, Strickler HD, Shikany JM, Lane D, Luo J, et al. A longitudinal study of serum insulin and glucose levels in relation to colorectal cancer risk among postmenopausal women. Br J Cancer 2012;106:227-32.
33. Ashwell M, Gunn P, Gibson S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev 2012; 13:275-86.