Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer

International Journal of Colorectal Disease

Volumn 31, Issue 2, 2016, Pages 365-375

  Amor, S ^a   Iglesias de la Cruz, M C ^a   Ferrero, E ^b   Garcia Villar O ^b   Barrios, V ^c   Fernandez, N ^a   Monge, L ^a   Garcia Villalon A L ^a   Granado, M ^a,c  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c Instituto de Salud Carlos III   (Spain)

Author keywords

Adipose tissue; Colorectal cancer; Cytokines; Inflammation; Obesity; VEGF

Indexed keywords

ADIPONECTIN; ANGIOGENIC FACTOR; CYCLOOXYGENASE 2; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; NITRIC ACID DERIVATIVE; NITRITE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; CYCLOOXYGENASE 2 INHIBITOR; VASCULOTROPIN A;

ADIPOCYTE; ADIPOSE TISSUE; ARTICLE; BODY MASS; CANCER PATIENT; CANCER SIZE; CELL ISOLATION; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME INHIBITION; EXPLANT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; OBESITY; PERITUMORAL ADIPOSE TISSUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; BLOOD; COLONY FORMING UNIT GM; COLORECTAL TUMOR; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SECRETION (PROCESS);

ADIPOCYTES; ADIPONECTIN; ADIPOSE TISSUE; BODY MASS INDEX; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2 INHIBITORS; CYTOKINES; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE PROGENITOR CELLS; HUMANS; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; NEOVASCULARIZATION, PATHOLOGIC; NITRATES; NITRITES; OBESITY; PPAR GAMMA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84957441405     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-015-2420-6     Document Type: Article

References (59)

1. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62(1):10–29
2. Win AK et al (2012) Risk prediction models for colorectal cancer: a review. Cancer Epidemiol Biomarkers Prev 21(3):398–410
3. Frezza EE, Wachtel MS, Chiriva-Internati M (2006) Influence of obesity on the risk of developing colon cancer. Gut 55(2):285–291
4. Lee WM et al (2001) Susceptibility of lean and obese Zucker rats to tumorigenesis induced by N-methyl-N-nitrosourea. Cancer Lett 162(2):155–160
5. Giovannucci E et al (1996) Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control 7(2):253–263
6. Khan N, Afaq F, Mukhtar H (2010) Lifestyle as risk factor for cancer: evidence from human studies. Cancer Lett 293(2):133–143
7. Mai V et al (2003) Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms. Cancer Res 63(8):1752–1755
8. Balkwill F, Coussens LM (2004) Cancer: an inflammatory link. Nature 431(7007):405–406
9. Hauner H (2005) Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc 64(2):163–169
10. Grivennikov SI, Karin M (2011) Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis 70(Suppl 1):i104–i108
11. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115(5):1111–1119
12. McArdle MA et al (2013) Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne) 4:52
13. Harvey AE, Lashinger LM, Hursting SD (2011) The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci 1229:45–52
14. Fain JN et al (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145(5):2273–2282
15. Curat CA et al (2004) From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53(5):1285–1292
16. Nakarai H et al (2012) Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications. Innate Immun 18(1):164–170
17. de Vergueiro Lobo SM et al (2012) TNF-? modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes. Cytokine 60(1):150–156
18. Zhang QX et al (1997) Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J Surg Res 67(2):147–154
19. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407(6801):249–257
20. Park J, Euhus DM, Scherer PE (2011) Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev 32(4):550–570
21. Lijnen HR (2008) Angiogenesis and obesity. Cardiovasc Res 78(2):286–293
22. Hursting SD et al (2007) The obesity-cancer link: lessons learned from a fatless mouse. Cancer Res 67(6):2391–2393
23. Cho C-H et al (2007) Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res 100(4):e47–e57
24. Lijnen HR et al (2006) Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55(10):2698–2704
25. Rehman J et al (2004) Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109(10):1292–1298
26. Delage B et al (2007) The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. Nutr J 6:20
27. Schaffler A et al (2006) Vascular endothelial growth factor secretion from mesenteric adipose tissue and from creeping fat in Crohn’s disease. J Gastroenterol Hepatol 21(9):1419–1423
28. Miranda KM, Espey MG, Wink DA (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5(1):62–71
29. Chomczynski P (1993) A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15(3):532–534, 536-7
30. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402–408
31. Bland JM, Altman DG (1995) Multiple significance tests: the Bonferroni method. BMJ 310(6973):170
32. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591
33. Fontana L et al (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56(4):1010–1013
34. Catalán V et al (2011) Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. J Nutr Biochem 22(7):634–641
35. Hillenbrand A et al (2012) Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. BMC Cancer 12:545
36. Silha JV et al (2005) Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond) 29(11):1308–1314
37. Peterson JE et al (2012) VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. Angiogenesis 15(2):265–273
38. Andersson K et al (1999) A nitric oxide-mediated mechanism regulates lipolysis in human adipose tissue in vivo. Br J Pharmacol 126(7):1639–1645
39. Franco-Pons N, Gea-Sorlí S, Closa D (2010) Release of inflammatory mediators by adipose tissue during acute pancreatitis. J Pathol 221(2):175–182
40. Lumeng CN et al (2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56(1):16–23
41. Xu H et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821–1830
42. Wagner M et al (2012) Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis 15(3):481–495
43. Fried SK, Bunkin DA, Greenberg AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83(3):847–850
44. Sugiyama M et al (2009) Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. Int J Oncol 34(2):339–344
45. Granado M et al (2009) Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. Eur J Pharmacol 608(1-3):97–103
46. Gude MF et al (2012) The production and regulation of IGF and IGFBPs in human adipose tissue cultures. Growth Hormon IGF Res 22(6):200–205
47. O’Connor JC et al (2008) Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cell Immunol 252(1-2):91–110
48. DuBois RN et al (1998) The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis 19(1):49–53
49. Lefebvre AM et al (1998) Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 4(9):1053–1057
50. Papi A et al (2010) RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells. Cancer Lett 297(1):65–74
51. Dworzanski T et al (2010) Influence of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist, rosiglitazone and antagonist, biphenol-A-diglicydyl ether (BADGE) on the course of inflammation in the experimental model of colitis in rats. J Physiol Pharmacol 61(6):683–693
52. Sharma AM, Staels B (2007) Review: peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 92(2):386–395
53. Panigrahy D et al (2002) PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J Clin Invest 110(7):923–932
54. Gimble JM et al (1996) Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 50(5):1087–1094
55. Zhang Y et al (2012) Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res 72(20):5198–5208
56. Zhang Y et al (2009) White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Cancer Res 69(12):5259–5266
57. Klopp AH et al (2012) Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors. Clin Cancer Res 18(3):771–782
58. Ye J (2008) Regulation of PPARgamma function by TNF-alpha. Biochem Biophys Res Commun 374(3):405–408
59. Koumarianou A et al (2014) Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression. Anticancer Res 34(9):4949–4962