메뉴 건너뛰기




Volumn 71, Issue 7, 2011, Pages 2718-2727

Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; BETA CATENIN; CD133 ANTIGEN; PROTEIN KINASE B;

EID: 79953313217     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-2705     Document Type: Article
Times cited : (71)

References (40)
  • 2
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 2006;116:1582-95.
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 3
    • 50849122701 scopus 로고    scopus 로고
    • PTEN at the crossroad of metabolic diseases and cancer in the liver
    • Vinciguerra M, Foti M. PTEN at the crossroad of metabolic diseases and cancer in the liver. Ann Hepatol 2008;7:192-9.
    • (2008) Ann Hepatol , vol.7 , pp. 192-199
    • Vinciguerra, M.1    Foti, M.2
  • 4
    • 12344289067 scopus 로고    scopus 로고
    • Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma
    • DOI 10.1002/cncr.20774
    • Nakanishi K, Sakamoto M, Yamasaki S, Todo S, Hirohashi S. Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer 2005;103:307-12. (Pubitemid 40129290)
    • (2005) Cancer , vol.103 , Issue.2 , pp. 307-312
    • Nakanishi, K.1    Sakamoto, M.2    Yamasaki, S.3    Todo, S.4    Hirohashi, S.5
  • 7
    • 29144509972 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma
    • DOI 10.1016/j.hepres.2005.09.026, PII S138663460500313X
    • Watanabe S, Horie Y, Suzuki A. Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. Hepatol Res 2005;33:161-6. (Pubitemid 41799796)
    • (2005) Hepatology Research , vol.33 , Issue.2 , pp. 161-166
    • Watanabe, S.1    Horie, Y.2    Suzuki, A.3
  • 8
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal Lipid and Glucose Metabolism in Obesity: Implications for Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.03.055, PII S0016508507005811
    • Parekh S, Anania FA. Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 2007;132:2191-207. (Pubitemid 46693752)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 9
    • 69949089784 scopus 로고    scopus 로고
    • Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program
    • Radonjic M, de Haan JR, van Erk MJ, van Dijk KW, van den Berg SA, de Groot PJ, et al. Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program. PLoS One 2009;4:e6646.
    • (2009) PLoS One , vol.4
    • Radonjic, M.1    De Haan, J.R.2    Van Erk, M.J.3    Van Dijk, K.W.4    Van Den Berg, S.A.5    De Groot, P.J.6
  • 10
    • 77950509620 scopus 로고    scopus 로고
    • A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
    • Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, Bulyk M, et al. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 2010;17:348-61.
    • (2010) Cancer Cell , vol.17 , pp. 348-361
    • Hirsch, H.A.1    Iliopoulos, D.2    Joshi, A.3    Zhang, Y.4    Jaeger, S.A.5    Bulyk, M.6
  • 12
  • 13
    • 0036463949 scopus 로고    scopus 로고
    • Induction of ovarian cancer by defined multiple genetic changes in a mouse model system
    • DOI 10.1016/S1535-6108(01)00002-2
    • Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 2002;1:53-62. (Pubitemid 41039176)
    • (2002) Cancer Cell , vol.1 , Issue.1 , pp. 53-62
    • Orsulic, S.1    Li, Y.2    Soslow, R.A.3    Vitale-Cross, L.A.4    Gutkind, J.S.5    Varmus, H.E.6
  • 14
    • 58249117627 scopus 로고    scopus 로고
    • Role of cyclin D1 as a mediator of c-Met- And beta-catenin-induced hepatocarcinogenesis
    • Patil MA, Lee SA, Macias E, Lam ET, Xu C, Jones KD, et al. Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis. Cancer Res 2009;69:253-61.
    • (2009) Cancer Res , vol.69 , pp. 253-261
    • Patil, M.A.1    Lee, S.A.2    Macias, E.3    Lam, E.T.4    Xu, C.5    Jones, K.D.6
  • 16
    • 79953307171 scopus 로고    scopus 로고
    • WHO International Agency for Research on Cancer. Mohr U, editor. New York: Springer-Verlag
    • International Classification of Rodent Tumors The Mouse. WHO International Agency for Research on Cancer. In:Mohr U, editor. New York: Springer-Verlag 2001; p. 64-8.
    • (2001) International Classification of Rodent Tumors the Mouse , pp. 64-68
  • 21
    • 63349098247 scopus 로고    scopus 로고
    • Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    • Cieply B, Zeng G, Proverbs-Singh T, Geller DA, Monga SP. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology 2009;49:821-31.
    • (2009) Hepatology , vol.49 , pp. 821-831
    • Cieply, B.1    Zeng, G.2    Proverbs-Singh, T.3    Geller, D.A.4    Monga, S.P.5
  • 22
    • 0034495080 scopus 로고    scopus 로고
    • Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, Peng SY. Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000;157:763-70.
    • (2000) Am J Pathol , vol.157 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3    Chu, J.S.4    Lai, P.L.5    Peng, S.Y.6
  • 23
    • 0035395236 scopus 로고    scopus 로고
    • beta-catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance
    • DOI 10.1002/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R
    • Wong CM, Fan ST, Ng IO. beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001;92:136-45. (Pubitemid 32623050)
    • (2001) Cancer , vol.92 , Issue.1 , pp. 136-145
    • Wong, C.M.1    Fan, S.T.2    Ng, I.O.L.3
  • 25
    • 33645738114 scopus 로고    scopus 로고
    • Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors
    • Yamaoka H, Ohtsu K, Sueda T, Yokoyama T, Hiyama E. Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors. Oncol Rep 2006;15:551-6.
    • (2006) Oncol Rep , vol.15 , pp. 551-556
    • Yamaoka, H.1    Ohtsu, K.2    Sueda, T.3    Yokoyama, T.4    Hiyama, E.5
  • 26
    • 55249106920 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology
    • Cavard C, Colnot S, Audard V, Benhamouche S, Finzi L, Torre C, et al. Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology. Future Oncol 2008;4:647-60.
    • (2008) Future Oncol , vol.4 , pp. 647-660
    • Cavard, C.1    Colnot, S.2    Audard, V.3    Benhamouche, S.4    Finzi, L.5    Torre, C.6
  • 27
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009;136:1012-24.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.Y.6
  • 28
    • 77952324704 scopus 로고    scopus 로고
    • Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis
    • Liu L, Zhu XD, Wang WQ, Shen Y, Qin Y, Ren ZG, et al. Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res 2010;16:2740-50.
    • (2010) Clin Cancer Res , vol.16 , pp. 2740-2750
    • Liu, L.1    Zhu, X.D.2    Wang, W.Q.3    Shen, Y.4    Qin, Y.5    Ren, Z.G.6
  • 29
    • 43749120732 scopus 로고    scopus 로고
    • The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
    • DOI 10.2174/156800908784293659
    • Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008;8:187-98. (Pubitemid 351688437)
    • (2008) Current Cancer Drug Targets , vol.8 , Issue.3 , pp. 187-198
    • Carnero, A.1    Blanco-Aparicio, C.2    Renner, O.3    Link, W.4    Leal, J.F.M.5
  • 30
    • 60549111398 scopus 로고    scopus 로고
    • Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
    • Robey RB, Hay N. Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol 2009;19:25-31.
    • (2009) Semin Cancer Biol , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 32
    • 77349085585 scopus 로고    scopus 로고
    • Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma
    • Imbeaud S, Ladeiro Y, Zucman-Rossi J. Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma. Semin Liver Dis 2010;30:75-86.
    • (2010) Semin Liver Dis , vol.30 , pp. 75-86
    • Imbeaud, S.1    Ladeiro, Y.2    Zucman-Rossi, J.3
  • 36
    • 42249098060 scopus 로고    scopus 로고
    • Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer
    • DOI 10.1002/hep.22169
    • Lee SA, Ho C, Roy R, Kosinski C, Patil MA, Tward AD, et al. Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology 2008;47:1200-10. (Pubitemid 351547906)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1200-1210
    • Lee, S.A.1    Ho, C.2    Roy, R.3    Kosinski, C.4    Paul, M.A.5    Tward, A.D.6    Fridlyand, J.7    Chen, X.8
  • 38
    • 72149111966 scopus 로고    scopus 로고
    • Obesity is associated with a higher risk of clear-cell renal cell carcinoma than with other histologies
    • Lowrance WT, Thompson RH, Yee DS, Kaag M, Donat SM, Russo P. Obesity is associated with a higher risk of clear-cell renal cell carcinoma than with other histologies. BJU Int 2009;105:16-20.
    • (2009) BJU Int , vol.105 , pp. 16-20
    • Lowrance, W.T.1    Thompson, R.H.2    Yee, D.S.3    Kaag, M.4    Donat, S.M.5    Russo, P.6
  • 40
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010;140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.