-
1
-
-
84881399206
-
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
-
COI: 1:CAS:528:DC%2BC3sXpsV2jt74%3D, PID: 23770676
-
Acosta JC, Banito A, Wuestefeld T et al (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15:978–90
-
(2013)
Nat Cell Biol
, vol.15
, pp. 978-990
-
-
Acosta, J.C.1
Banito, A.2
Wuestefeld, T.3
-
2
-
-
84928381028
-
Telomere dysfunction causes alveolar stem cell failure
-
COI: 1:CAS:528:DC%2BC2MXlvVGksrY%3D, PID: 25840590
-
Alder JK, Barkauskas CE, Limjunyawong N et al (2015) Telomere dysfunction causes alveolar stem cell failure. Proc Natl Acad Sci U S A 112:5099–5104
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 5099-5104
-
-
Alder, J.K.1
Barkauskas, C.E.2
Limjunyawong, N.3
-
3
-
-
84455207428
-
Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease
-
COI: 1:CAS:528:DC%2BC38XhtV2gtro%3D, PID: 21885626
-
Amsellem V, Gary-Bobo G, Marcos E et al (2011) Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 184:1358–1366
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 1358-1366
-
-
Amsellem, V.1
Gary-Bobo, G.2
Marcos, E.3
-
4
-
-
0042881129
-
Bleomycin induces cellular senescence in alveolar epithelial cells
-
COI: 1:CAS:528:DC%2BD3sXotVegtLs%3D, PID: 14516132
-
Aoshiba K, Tsuji T, Nagai A (2003) Bleomycin induces cellular senescence in alveolar epithelial cells. Eur Respir J 22:436–443
-
(2003)
Eur Respir J
, vol.22
, pp. 436-443
-
-
Aoshiba, K.1
Tsuji, T.2
Nagai, A.3
-
5
-
-
84954508690
-
Molecular and biological hallmarks of ageing
-
COI: 1:STN:280:DC%2BC28nhtlOjsw%3D%3D, PID: 26771470
-
Aunan JR, Watson MM, Hagland HR, Søreide K (2016) Molecular and biological hallmarks of ageing. Br J Surg 103:e29–e46
-
(2016)
Br J Surg
, vol.103
, pp. e29-e46
-
-
Aunan, J.R.1
Watson, M.M.2
Hagland, H.R.3
Søreide, K.4
-
6
-
-
84900034466
-
Aging causes a slowing in ciliary beat frequency, mediated by PKCε
-
COI: 1:CAS:528:DC%2BC2cXlvVCgsbc%3D, PID: 24487393
-
Bailey KL, Bonasera SJ, Wilderdyke M et al (2014) Aging causes a slowing in ciliary beat frequency, mediated by PKCε. Am J Physiol Lung Cell Mol Physiol 306:L584–9
-
(2014)
Am J Physiol Lung Cell Mol Physiol
, vol.306
, pp. L584-L589
-
-
Bailey, K.L.1
Bonasera, S.J.2
Wilderdyke, M.3
-
7
-
-
80053386591
-
Natural killer cell function is altered during the primary response of aged mice to influenza infection
-
COI: 1:CAS:528:DC%2BC3MXht1OisrjK, PID: 21893080
-
Beli E, Clinthorne JF, Duriancik DM et al (2011) Natural killer cell function is altered during the primary response of aged mice to influenza infection. Mech Ageing Dev 132:503–510. doi:10.1016/j.mad.2011.08.005
-
(2011)
Mech Ageing Dev
, vol.132
, pp. 503-510
-
-
Beli, E.1
Clinthorne, J.F.2
Duriancik, D.M.3
-
8
-
-
0036605657
-
Overview of the innervation of the lung
-
COI: 1:CAS:528:DC%2BD38XjvVKitbc%3D, PID: 12020459
-
Belvisi MG (2002) Overview of the innervation of the lung. Curr Opin Pharmacol 2:211–215
-
(2002)
Curr Opin Pharmacol
, vol.2
, pp. 211-215
-
-
Belvisi, M.G.1
-
9
-
-
84961566760
-
Senescence-induced oxidative stress causes endothelial dysfunction
-
Bhayadia R, Schmidt BMW, Melk A, Hömme M (2016) Senescence-induced oxidative stress causes endothelial dysfunction. J Gerontol A 71:161–9
-
(2016)
J Gerontol A
, vol.71
, pp. 161-169
-
-
Bhayadia, R.1
Schmidt, B.M.W.2
Melk, A.3
Hömme, M.4
-
10
-
-
84873705404
-
Ageing and gut microbes: perspectives for health maintenance and longevity
-
Biagi E, Candela M, Turroni S et al (2013) Ageing and gut microbes: perspectives for health maintenance and longevity. Pharm Res 69:11–20
-
(2013)
Pharm Res
, vol.69
, pp. 11-20
-
-
Biagi, E.1
Candela, M.2
Turroni, S.3
-
11
-
-
33749534161
-
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
-
COI: 1:CAS:528:DC%2BD28XhtVChsrvM, PID: 17024208
-
Blackburn EH, Greider CW, Szostak JW (2006) Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med 12:1133–1138
-
(2006)
Nat Med
, vol.12
, pp. 1133-1138
-
-
Blackburn, E.H.1
Greider, C.W.2
Szostak, J.W.3
-
12
-
-
84861727490
-
Dysregulated inflammation as a risk factor for pneumonia in the elderly
-
PID: 22288022
-
Boyd AR, Orihuela CJ (2011) Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis 2:487–500
-
(2011)
Aging Dis
, vol.2
, pp. 487-500
-
-
Boyd, A.R.1
Orihuela, C.J.2
-
13
-
-
84861744885
-
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia
-
COI: 1:CAS:528:DC%2BC38XntFanu7w%3D, PID: 22548913
-
Boyd AR, Shivshankar P, Jiang S et al (2012) Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia. Exp Gerontol 47:507–18
-
(2012)
Exp Gerontol
, vol.47
, pp. 507-518
-
-
Boyd, A.R.1
Shivshankar, P.2
Jiang, S.3
-
14
-
-
84927514142
-
Enhanced allergic airway disease in old mice is associated with a Th17 response
-
COI: 1:CAS:528:DC%2BC2cXhs1SqtrzP, PID: 25109604
-
Brandenberger C, Li N, Jackson-Humbles DN et al (2014) Enhanced allergic airway disease in old mice is associated with a Th17 response. Clin Exp Allergy 44:1282–1292
-
(2014)
Clin Exp Allergy
, vol.44
, pp. 1282-1292
-
-
Brandenberger, C.1
Li, N.2
Jackson-Humbles, D.N.3
-
15
-
-
34548267728
-
International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study
-
PID: 17765523
-
Buist AS, McBurnie MA, Vollmer WM et al (2007) International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study. Lancet 370:741–750
-
(2007)
Lancet
, vol.370
, pp. 741-750
-
-
Buist, A.S.1
McBurnie, M.A.2
Vollmer, W.M.3
-
16
-
-
77957823632
-
Age-related changes in immune function: effect on airway inflammation
-
COI: 1:CAS:528:DC%2BC3cXht1Cnsr%2FM, PID: 20920759
-
Busse PJ, Mathur SK (2010) Age-related changes in immune function: effect on airway inflammation. J Allergy Clin Immunol 126:690–9
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 690-699
-
-
Busse, P.J.1
Mathur, S.K.2
-
17
-
-
84957661836
-
Senescent cells contribute to the physiological remodeling of aged lungs
-
Calhoun C, Shivshankar P, Saker M et al (2015) Senescent cells contribute to the physiological remodeling of aged lungs. J Gerontol A 1:1–9
-
(2015)
J Gerontol A
, vol.1
, pp. 1-9
-
-
Calhoun, C.1
Shivshankar, P.2
Saker, M.3
-
18
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
COI: 1:CAS:528:DC%2BC3sXjvFOntL4%3D, PID: 23140366
-
Campisi J (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75:685–705
-
(2013)
Annu Rev Physiol
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
19
-
-
84914158785
-
Proinflammatory status influences NK cells subsets in the elderly
-
Campos C, Pera A, Lopez-Fernandez I et al (2014) Proinflammatory status influences NK cells subsets in the elderly. Immunol Lett 162:10–14. doi:10.1016/j.imlet.2014.06.015
-
(2014)
Immunol Lett
, vol.162
, pp. 10-14
-
-
Campos, C.1
Pera, A.2
Lopez-Fernandez, I.3
-
20
-
-
84907336936
-
Characterization of lung inflammation and its impact on macrophage function in aging
-
PID: 24935957
-
Canan CH, Gokhale NS, Carruthers B et al (2014) Characterization of lung inflammation and its impact on macrophage function in aging. J Leukoc Biol 96:473–80
-
(2014)
J Leukoc Biol
, vol.96
, pp. 473-480
-
-
Canan, C.H.1
Gokhale, N.S.2
Carruthers, B.3
-
21
-
-
79959753075
-
Commensal microflora contribute to host defense against Escherichia coli pneumonia through Toll-like receptors
-
PID: 21412185
-
Chen L-W, Chen P-H, Hsu C-M (2011) Commensal microflora contribute to host defense against Escherichia coli pneumonia through Toll-like receptors. Shock 36:67–75
-
(2011)
Shock
, vol.36
, pp. 67-75
-
-
Chen, L.-W.1
Chen, P.-H.2
Hsu, C.-M.3
-
22
-
-
84898804496
-
Age-related differences in the neutrophil response to pulmonary pseudomonas infection
-
PID: 24398045
-
Chen MM, Palmer JL, Plackett TP et al (2014) Age-related differences in the neutrophil response to pulmonary pseudomonas infection. Exp Gerontol 54:42–46
-
(2014)
Exp Gerontol
, vol.54
, pp. 42-46
-
-
Chen, M.M.1
Palmer, J.L.2
Plackett, T.P.3
-
23
-
-
84951797366
-
Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs
-
COI: 1:CAS:528:DC%2BC2MXitV2is7vF, PID: 26518879
-
Chen R, Zhang K, Chen H et al (2015) Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs. J Biol Chem 290:30813–30829
-
(2015)
J Biol Chem
, vol.290
, pp. 30813-30829
-
-
Chen, R.1
Zhang, K.2
Chen, H.3
-
24
-
-
84882925367
-
Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
-
COI: 1:CAS:528:DC%2BC3sXhtFWjtLnJ, PID: 23831269
-
Chilosi M, Carloni A, Rossi A, Poletti V (2013) Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema. Transl Res 162:156–173
-
(2013)
Transl Res
, vol.162
, pp. 156-173
-
-
Chilosi, M.1
Carloni, A.2
Rossi, A.3
Poletti, V.4
-
25
-
-
84941799579
-
Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction
-
COI: 1:CAS:528:DC%2BC2MXhsVygsL7K, PID: 26246142
-
Chougnet CA, Thacker RI, Shehata HM et al (2015) Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction. J Immunol 195:2624–32
-
(2015)
J Immunol
, vol.195
, pp. 2624-2632
-
-
Chougnet, C.A.1
Thacker, R.I.2
Shehata, H.M.3
-
26
-
-
79952757721
-
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
-
COI: 1:CAS:528:DC%2BC3MXjvVCkurg%3D, PID: 20571116
-
Claesson MJ, Cusack S, O’Sullivan O et al (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 108:4586–91
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4586-4591
-
-
Claesson, M.J.1
Cusack, S.2
O’Sullivan, O.3
-
27
-
-
84864722033
-
Gut microbiota composition correlates with diet and health in the elderly
-
COI: 1:CAS:528:DC%2BC38XhtFKiur%2FP, PID: 22797518
-
Claesson MJ, Jeffery IB, Conde S et al (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488:178–84
-
(2012)
Nature
, vol.488
, pp. 178-184
-
-
Claesson, M.J.1
Jeffery, I.B.2
Conde, S.3
-
28
-
-
61849115705
-
Lung disease caused by exposure to coal mine and silica dust
-
PID: 19221963
-
Cohen RAC, Patel A, Green FHY (2008) Lung disease caused by exposure to coal mine and silica dust. Semin Respir Crit Care Med 29:651–661
-
(2008)
Semin Respir Crit Care Med
, vol.29
, pp. 651-661
-
-
Cohen, R.A.C.1
Patel, A.2
Green, F.H.Y.3
-
29
-
-
0029089162
-
Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells
-
COI: 1:CAS:528:DyaK2MXntlSltb0%3D, PID: 7628547
-
Comi P, Chiaramonte R, Maier JAM (1995) Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells. Exp Cell Res 219:304–308
-
(1995)
Exp Cell Res
, vol.219
, pp. 304-308
-
-
Comi, P.1
Chiaramonte, R.2
Maier, J.A.M.3
-
30
-
-
84876010682
-
Aging, diabetes, and hypertension are associated with decreased nasal mucociliary clearance
-
PID: 23100111
-
De Oliveira-Maul JP, De Carvalho HB, Goto DM et al (2013) Aging, diabetes, and hypertension are associated with decreased nasal mucociliary clearance. Chest 143:1091–1097
-
(2013)
Chest
, vol.143
, pp. 1091-1097
-
-
De Oliveira-Maul, J.P.1
De Carvalho, H.B.2
Goto, D.M.3
-
32
-
-
84978698951
-
Balancing inflammation: The link between Th17 and regulatory T cells
-
Diller ML, Kudchadkar RR, Delman KA et al (2016) Balancing inflammation: The link between Th17 and regulatory T cells. Mediat Inflamm. doi:10.1017/CBO9781107415324.004
-
(2016)
Mediat Inflamm
-
-
Diller, M.L.1
Kudchadkar, R.R.2
Delman, K.A.3
-
33
-
-
78349269946
-
Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
-
COI: 1:CAS:528:DC%2BC3cXhs1ans7fL, PID: 20538817
-
Doe C, Bafadhel M, Siddiqui S et al (2010) Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 138:1140–1147
-
(2010)
Chest
, vol.138
, pp. 1140-1147
-
-
Doe, C.1
Bafadhel, M.2
Siddiqui, S.3
-
34
-
-
33747046745
-
Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia
-
COI: 1:CAS:528:DC%2BD28XhtVGms7jO, PID: 16934054
-
Ebihara T, Ebihara S, Watando A et al (2006) Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia. Br J Clin Pharmacol 62:369–371
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 369-371
-
-
Ebihara, T.1
Ebihara, S.2
Watando, A.3
-
35
-
-
79959580196
-
Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers
-
PID: 21711545
-
Ebihara S, Ebihara T, Kanezaki M et al (2011) Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers. Cough. doi:10.1186/1745-9974-7-3
-
(2011)
Cough
-
-
Ebihara, S.1
Ebihara, T.2
Kanezaki, M.3
-
36
-
-
84857641829
-
Effect of aging on cough and swallowing reflexes: Implications for preventing aspiration pneumonia
-
PID: 22033612
-
Ebihara S, Ebihara T, Kohzuki M (2012) Effect of aging on cough and swallowing reflexes: Implications for preventing aspiration pneumonia. Lung 190:29–33
-
(2012)
Lung
, vol.190
, pp. 29-33
-
-
Ebihara, S.1
Ebihara, T.2
Kohzuki, M.3
-
38
-
-
84881187196
-
Oxidative stress and vascular inflammation in aging
-
PID: 23851032
-
El Assar M, Angulo J, Rodriguez-Manas L (2013) Oxidative stress and vascular inflammation in aging. Free Radic Biol Med 65:380–401. doi:10.1016/j.freeradbiomed.2013.07.003
-
(2013)
Free Radic Biol Med
, vol.65
, pp. 380-401
-
-
El Assar, M.1
Angulo, J.2
Rodriguez-Manas, L.3
-
39
-
-
0036138688
-
Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome
-
PID: 11777361
-
Ely EW, Wheeler AP, Thompson BT et al (2002) Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med 136:25–36
-
(2002)
Ann Intern Med
, vol.136
, pp. 25-36
-
-
Ely, E.W.1
Wheeler, A.P.2
Thompson, B.T.3
-
40
-
-
58849155179
-
Vascular endothelial senescence: from mechanisms to pathophysiology
-
COI: 1:CAS:528:DC%2BD1MXitVyrt70%3D, PID: 19036896
-
Erusalimsky JD (2009) Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 106:326–32
-
(2009)
J Appl Physiol
, vol.106
, pp. 326-332
-
-
Erusalimsky, J.D.1
-
41
-
-
39649094505
-
Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts
-
COI: 1:CAS:528:DC%2BD1cXit1yhs7w%3D, PID: 18027853
-
Falchetti ML, Mongiardi MP, Fiorenzo P et al (2008) Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts. Int J Cancer 122:1236–1242
-
(2008)
Int J Cancer
, vol.122
, pp. 1236-1242
-
-
Falchetti, M.L.1
Mongiardi, M.P.2
Fiorenzo, P.3
-
42
-
-
84865121012
-
Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
-
COI: 1:CAS:528:DC%2BC38XhsFChs7zF, PID: 22582162
-
Faner R, Rojas M, Macnee W, Agustí A (2012) Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 186:306–13
-
(2012)
Am J Respir Crit Care Med
, vol.186
, pp. 306-313
-
-
Faner, R.1
Rojas, M.2
Macnee, W.3
Agustí, A.4
-
43
-
-
54249156556
-
Aging and neutrophils: there is still much to do
-
COI: 1:CAS:528:DC%2BD1cXht1yntrfO, PID: 18847379
-
Fortin CF, McDonald PP, Lesur O, Fülöp T (2008) Aging and neutrophils: there is still much to do. Rejuvenation Res 11:873–882
-
(2008)
Rejuvenation Res
, vol.11
, pp. 873-882
-
-
Fortin, C.F.1
McDonald, P.P.2
Lesur, O.3
Fülöp, T.4
-
44
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
COI: 1:STN:280:DC%2BD3czpvF2qsw%3D%3D, PID: 10911963
-
Franceschi C, Bonafè M, Valensin S et al (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254
-
(2000)
Ann N Y Acad Sci
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafè, M.2
Valensin, S.3
-
45
-
-
84955342527
-
Inflammaging decreases adaptive and innate immune responses in mice and humans
-
PID: 25921609
-
Frasca D, Blomberg BB (2015) Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology. doi:10.1007/s10522-015-9578-8
-
(2015)
Biogerontology
-
-
Frasca, D.1
Blomberg, B.B.2
-
46
-
-
73149095385
-
The aging lung and chronic obstructive pulmonary disease: similarity and difference
-
COI: 1:CAS:528:DC%2BD1MXhsFKku7%2FJ, PID: 19934351
-
Fukuchi Y (2009) The aging lung and chronic obstructive pulmonary disease: similarity and difference. Proc Am Thorac Soc 6:570–572
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 570-572
-
-
Fukuchi, Y.1
-
47
-
-
84863930878
-
The innate immune system and ageing: what is the contribution to immunosenescence
-
COI: 1:CAS:528:DC%2BC38XhtVyis73P
-
Fulop T, Fortin C, Lesur O (2012) The innate immune system and ageing: what is the contribution to immunosenescence. Bentham Open 6:121–131. doi:10.2174/1876326X01206010121
-
(2012)
Bentham Open
, vol.6
, pp. 121-131
-
-
Fulop, T.1
Fortin, C.2
Lesur, O.3
-
48
-
-
84910115459
-
Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease
-
PID: 25253795
-
Garcia-Nunez M, Millares L, Pomares X et al (2014) Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease. J Clin Microbiol 52:4217–4223
-
(2014)
J Clin Microbiol
, vol.52
, pp. 4217-4223
-
-
Garcia-Nunez, M.1
Millares, L.2
Pomares, X.3
-
49
-
-
79959669679
-
Immunosenescence of human natural killer cells
-
COI: 1:CAS:528:DC%2BC3MXnvF2jtr4%3D, PID: 21576928
-
Gayoso I, Sanchez-Correa B, Campos C et al (2011) Immunosenescence of human natural killer cells. J Innate Immun 3:337–343
-
(2011)
J Innate Immun
, vol.3
, pp. 337-343
-
-
Gayoso, I.1
Sanchez-Correa, B.2
Campos, C.3
-
50
-
-
0023766704
-
Age-related changes in vasoactive intestinal polypeptide levels and distribution in the rat
-
COI: 1:STN:280:DyaL1M%2FhtVOntg%3D%3D, PID: 3171570
-
Geppetti P, De Rossi M, Mione MC et al (1988) Age-related changes in vasoactive intestinal polypeptide levels and distribution in the rat. J Neural Transm 74:1–10
-
(1988)
J Neural Transm
, vol.74
, pp. 1-10
-
-
Geppetti, P.1
De Rossi, M.2
Mione, M.C.3
-
51
-
-
84961159953
-
Decreased laminin expression by human lung epithelial cells and fibroblasts cultured in acellular lung scaffolds from aged mice
-
Godin LM, Sandri BJ, Wagner DE et al (2016) Decreased laminin expression by human lung epithelial cells and fibroblasts cultured in acellular lung scaffolds from aged mice. PLoS ONE. doi:10.1371/journal.pone.0150966
-
(2016)
PLoS ONE
-
-
Godin, L.M.1
Sandri, B.J.2
Wagner, D.E.3
-
52
-
-
84925465211
-
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
-
PID: 25470051
-
Gomez Perdiguero E, Klapproth K, Schulz C et al (2014) Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518:547–551
-
(2014)
Nature
, vol.518
, pp. 547-551
-
-
Gomez Perdiguero, E.1
Klapproth, K.2
Schulz, C.3
-
53
-
-
33845920088
-
Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure
-
COI: 1:CAS:528:DC%2BD2sXjtVej, PID: 17133178
-
Gomez CR, Hirano S, Cutro BT et al (2007) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Crit Care Med 35:246–51
-
(2007)
Crit Care Med
, vol.35
, pp. 246-251
-
-
Gomez, C.R.1
Hirano, S.2
Cutro, B.T.3
-
54
-
-
84872414169
-
Environmental determinants of lung aging
-
Harding R, Pinkerton KE, Plopper CG, (eds), Elsevier, San Diego
-
Green FHY, Pinkerton KE (2004) Environmental determinants of lung aging. In: Harding R, Pinkerton KE, Plopper CG (eds) The lung: development, aging and the environment. Elsevier, San Diego, pp 377–395
-
(2004)
The lung: development, aging and the environment
, pp. 377-395
-
-
Green, F.H.Y.1
Pinkerton, K.E.2
-
55
-
-
0029128905
-
The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature
-
COI: 1:STN:280:DyaK2MzptVGruw%3D%3D, PID: 7661497
-
Gross P, Hermogenes A, Sacks H et al (1995) The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature. Ann Intern Med 123:518–527
-
(1995)
Ann Intern Med
, vol.123
, pp. 518-527
-
-
Gross, P.1
Hermogenes, A.2
Sacks, H.3
-
56
-
-
33744478401
-
Free radical theory of aging: An update - Increasing the functional life span
-
COI: 1:CAS:528:DC%2BD28Xms1Oksrk%3D, PID: 16803965
-
Harman D (2006) Free radical theory of aging: An update - Increasing the functional life span. Ann N Y Acad Sci 1067:10–21
-
(2006)
Ann N Y Acad Sci
, vol.1067
, pp. 10-21
-
-
Harman, D.1
-
57
-
-
84984623453
-
27-Hydroxycholesterol Accelerates Cellular Senescence in Human Lung Resident Cells
-
PID: 27036870
-
Hashimoto Y, Sugiura H (2016) 27-Hydroxycholesterol Accelerates Cellular Senescence in Human Lung Resident Cells. Am J Physiol Lung Cell Mol Physiol 310:L1028–1041
-
(2016)
Am J Physiol Lung Cell Mol Physiol
, vol.310
, pp. L1028-L1041
-
-
Hashimoto, Y.1
Sugiura, H.2
-
58
-
-
77953914911
-
Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset
-
COI: 1:CAS:528:DC%2BC3cXnvVeltL4%3D, PID: 20394788
-
Hayhoe RPG, Henson SM, Akbar AN, Palmer DB (2010) Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset. Hum Immunol 71:676–681
-
(2010)
Hum Immunol
, vol.71
, pp. 676-681
-
-
Hayhoe, R.P.G.1
Henson, S.M.2
Akbar, A.N.3
Palmer, D.B.4
-
59
-
-
33744996006
-
Why aging T cells fail: implications for vaccination
-
COI: 1:CAS:528:DC%2BD28Xms1Crt74%3D, PID: 16782020
-
Haynes L, Swain SL (2006) Why aging T cells fail: implications for vaccination. Immunity 24:663–6
-
(2006)
Immunity
, vol.24
, pp. 663-666
-
-
Haynes, L.1
Swain, S.L.2
-
60
-
-
84888206218
-
The impact of ageing on natural killer cell function and potential consequences for health in older adults
-
COI: 1:CAS:528:DC%2BC3sXpt1Cmtr8%3D, PID: 23660515
-
Hazeldine J, Lord JM (2013) The impact of ageing on natural killer cell function and potential consequences for health in older adults. Ageing Res Rev 12:1069–1078
-
(2013)
Ageing Res Rev
, vol.12
, pp. 1069-1078
-
-
Hazeldine, J.1
Lord, J.M.2
-
61
-
-
84866449395
-
Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function
-
COI: 1:CAS:528:DC%2BC38XhsFCls7zE, PID: 22708967
-
Hearps AC, Martin GE, Angelovich TA et al (2012) Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell 11:867–875
-
(2012)
Aging Cell
, vol.11
, pp. 867-875
-
-
Hearps, A.C.1
Martin, G.E.2
Angelovich, T.A.3
-
62
-
-
80051570891
-
Dysregulation of allergic airway inflammation in the absence of microbial colonization
-
COI: 1:CAS:528:DC%2BC3MXhtFWjsbvF, PID: 21471101
-
Herbst T, Sichelstiel A, Schär C et al (2011) Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med 184:198–205
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 198-205
-
-
Herbst, T.1
Sichelstiel, A.2
Schär, C.3
-
63
-
-
0027297089
-
The effects of aging on the function of alveolar macrophages in mice
-
COI: 1:CAS:528:DyaK3sXmt1Cjsro%3D, PID: 8412370
-
Higashimoto Y, Fukuchi Y, Shimada Y et al (1993) The effects of aging on the function of alveolar macrophages in mice. Mech Ageing Dev 69:207–217
-
(1993)
Mech Ageing Dev
, vol.69
, pp. 207-217
-
-
Higashimoto, Y.1
Fukuchi, Y.2
Shimada, Y.3
-
64
-
-
84964669956
-
CD4+ T-cell subsets in inflammatory diseases: Beyond the Th1/Th2 paradigm
-
COI: 1:CAS:528:DC%2BC28Xht12rsbnK, PID: 26874355
-
Hirahara K, Nakayama T (2016) CD4+ T-cell subsets in inflammatory diseases: Beyond the Th1/Th2 paradigm. Int Immunol 28:163–171
-
(2016)
Int Immunol
, vol.28
, pp. 163-171
-
-
Hirahara, K.1
Nakayama, T.2
-
65
-
-
84908181343
-
Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-γ by infiltrating lung tissue T cells, natural killer (NK) T-like and NK cells
-
COI: 1:CAS:528:DC%2BC2cXhsFSqtbnJ, PID: 24894428
-
Hodge G, Barnawi J, Jurisevic C et al (2014) Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-γ by infiltrating lung tissue T cells, natural killer (NK) T-like and NK cells. Clin Exp Immunol 178:79–85
-
(2014)
Clin Exp Immunol
, vol.178
, pp. 79-85
-
-
Hodge, G.1
Barnawi, J.2
Jurisevic, C.3
-
66
-
-
84933679533
-
Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts
-
COI: 1:CAS:528:DC%2BC2MXjsF2hu7s%3D, PID: 25700689
-
Holly AC, Grellscheid S, van de Walle P et al (2015) Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology 16:423–434
-
(2015)
Biogerontology
, vol.16
, pp. 423-434
-
-
Holly, A.C.1
Grellscheid, S.2
van de Walle, P.3
-
67
-
-
84861980130
-
Interactions between the microbiota and the immune system
-
COI: 1:CAS:528:DC%2BC38XnvFektL8%3D, PID: 22674334
-
Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science 336:1268–73
-
(2012)
Science
, vol.336
, pp. 1268-1273
-
-
Hooper, L.V.1
Littman, D.R.2
Macpherson, A.J.3
-
68
-
-
84860472372
-
Gut matters: microbe-host interactions in allergic diseases
-
PID: 22322009
-
Hörmannsperger G, Clavel T, Haller D (2012) Gut matters: microbe-host interactions in allergic diseases. J Allergy Clin Immunol 129:1452–9
-
(2012)
J Allergy Clin Immunol
, vol.129
, pp. 1452-1459
-
-
Hörmannsperger, G.1
Clavel, T.2
Haller, D.3
-
69
-
-
33846147683
-
Age-dependent changes of airway and lung parenchyma in C57BL/6J mice
-
PID: 16946023
-
Huang K, Rabold R, Schofield B et al (2007) Age-dependent changes of airway and lung parenchyma in C57BL/6J mice. J Appl Physiol 102:200–206
-
(2007)
J Appl Physiol
, vol.102
, pp. 200-206
-
-
Huang, K.1
Rabold, R.2
Schofield, B.3
-
70
-
-
84913530827
-
Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis
-
COI: 1:CAS:528:DC%2BC2cXitVSiur3P, PID: 25451236
-
Huang WT, Akhter H, Jiang C et al (2015) Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Exp Gerontol 61:62–75
-
(2015)
Exp Gerontol
, vol.61
, pp. 62-75
-
-
Huang, W.T.1
Akhter, H.2
Jiang, C.3
-
71
-
-
0034928191
-
Decreased surfactant protein-B expression and surfactant dysfunction in a murine model of acute lung injury
-
COI: 1:CAS:528:DC%2BD3MXlvFSnt7w%3D, PID: 11472973
-
Ingenito EP, Mora R, Cullivan M et al (2001) Decreased surfactant protein-B expression and surfactant dysfunction in a murine model of acute lung injury. Am J Respir Cell Mol Biol 25:35–44
-
(2001)
Am J Respir Cell Mol Biol
, vol.25
, pp. 35-44
-
-
Ingenito, E.P.1
Mora, R.2
Cullivan, M.3
-
72
-
-
84905040757
-
Persistent inflammation and T cell exhaustion in severe sepsis in the elderly
-
PID: 24962182
-
Inoue S, Suzuki K, Komori Y et al (2014) Persistent inflammation and T cell exhaustion in severe sepsis in the elderly. Crit Care. doi:10.1186/cc13941
-
(2014)
Crit Care
-
-
Inoue, S.1
Suzuki, K.2
Komori, Y.3
-
73
-
-
61849126736
-
Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages
-
COI: 1:CAS:528:DC%2BD1MXisFagtL8%3D, PID: 18690550
-
Ito Y, Betsuyaku T, Moriyama C et al (2009) Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages. Biogerontology 10:173–80
-
(2009)
Biogerontology
, vol.10
, pp. 173-180
-
-
Ito, Y.1
Betsuyaku, T.2
Moriyama, C.3
-
74
-
-
84858027120
-
Mechanisms of dysfunction in senescent pulmonary endothelium
-
Jane-Wit D, Chun HJ (2012) Mechanisms of dysfunction in senescent pulmonary endothelium. J Gerontol A 67:236–241
-
(2012)
J Gerontol A
, vol.67
, pp. 236-241
-
-
Jane-Wit, D.1
Chun, H.J.2
-
75
-
-
0033035039
-
Physiological changes in respiratory function associated with ageing
-
COI: 1:STN:280:DC%2BD3czos1Gltw%3D%3D, PID: 10836348
-
Janssens JP, Pache JC, Nicod LP (1999) Physiological changes in respiratory function associated with ageing. Eur Respir J 13:197–205
-
(1999)
Eur Respir J
, vol.13
, pp. 197-205
-
-
Janssens, J.P.1
Pache, J.C.2
Nicod, L.P.3
-
76
-
-
84866976062
-
Pulmonary macrophage subpopulations in the induction and resolution of acute lung injury
-
COI: 1:CAS:528:DC%2BC38XhsFSmsLfF, PID: 22721830
-
Johnston LK, Rims CR, Gill SE et al (2012) Pulmonary macrophage subpopulations in the induction and resolution of acute lung injury. Am J Respir Cell Mol Biol 47:417–426
-
(2012)
Am J Respir Cell Mol Biol
, vol.47
, pp. 417-426
-
-
Johnston, L.K.1
Rims, C.R.2
Gill, S.E.3
-
77
-
-
84954419818
-
Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice
-
Kim K-A, Jeong J-J, Yoo S-Y, Kim D-H (2016) Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice. BMC Microbiol. doi:10.1186/s12866-016-0625-7
-
(2016)
BMC Microbiol
-
-
Kim, K.-A.1
Jeong, J.-J.2
Yoo, S.-Y.3
Kim, D.-H.4
-
78
-
-
0023137626
-
Pulmonary fibrosis in asbestos insulation workers with lung cancer: a radiological and histopathological evaluation
-
COI: 1:CAS:528:DyaL2sXhvVWqs7s%3D, PID: 3814551
-
Kipen HM, Lilis R, Suzuki Y et al (1987) Pulmonary fibrosis in asbestos insulation workers with lung cancer: a radiological and histopathological evaluation. Br J Ind Med 44:96–100
-
(1987)
Br J Ind Med
, vol.44
, pp. 96-100
-
-
Kipen, H.M.1
Lilis, R.2
Suzuki, Y.3
-
79
-
-
33746865596
-
Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages
-
Lakshman CR, Liu Y, Popa D et al (2006) Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages. J Leucoc Biol 79:1314–1327
-
(2006)
J Leucoc Biol
, vol.79
, pp. 1314-1327
-
-
Lakshman, C.R.1
Liu, Y.2
Popa, D.3
-
80
-
-
42049114444
-
Aging of the immune system as a prognostic factor for human longevity
-
COI: 1:CAS:528:DC%2BD1cXmtFKls70%3D, PID: 18400689
-
Larbi A, Franceschi C, Mazzatti D et al (2008) Aging of the immune system as a prognostic factor for human longevity. Physiology 23:64–74
-
(2008)
Physiology
, vol.23
, pp. 64-74
-
-
Larbi, A.1
Franceschi, C.2
Mazzatti, D.3
-
81
-
-
84877064608
-
Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
-
COI: 1:CAS:528:DC%2BC3sXotFyl
-
Lech M, Anders HJ (2013) Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair. Biochim Biophys Acta Mol Basis Dis 1832:989–997
-
(2013)
Biochim Biophys Acta Mol Basis Dis
, vol.1832
, pp. 989-997
-
-
Lech, M.1
Anders, H.J.2
-
82
-
-
84858019892
-
T-cell biology in aging, with a focus on lung disease
-
Lee N, Shin MS, Kang I (2012) T-cell biology in aging, with a focus on lung disease. J Gerontol A 67:254–63
-
(2012)
J Gerontol A
, vol.67
, pp. 254-263
-
-
Lee, N.1
Shin, M.S.2
Kang, I.3
-
83
-
-
84910089881
-
Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells
-
PID: 25139266
-
Lee Y, Kim SY, Bae Y (2014) Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells. Mol Cells 37:620–627
-
(2014)
Mol Cells
, vol.37
, pp. 620-627
-
-
Lee, Y.1
Kim, S.Y.2
Bae, Y.3
-
84
-
-
84947491951
-
Age-dependent alterations in the inflammatory response to pulmonary challenge
-
COI: 1:CAS:528:DC%2BC2MXhsVaru77E, PID: 26318747
-
Linge HM, Ochani K, Lin K et al (2015) Age-dependent alterations in the inflammatory response to pulmonary challenge. Immunol Res 63:209–215
-
(2015)
Immunol Res
, vol.63
, pp. 209-215
-
-
Linge, H.M.1
Ochani, K.2
Lin, K.3
-
85
-
-
1842453024
-
Pneumonia in the elderly
-
PID: 15021052
-
Loeb M (2004) Pneumonia in the elderly. Curr Opin Infect Dis 17:127–130
-
(2004)
Curr Opin Infect Dis
, vol.17
, pp. 127-130
-
-
Loeb, M.1
-
87
-
-
84857899576
-
Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats
-
COI: 1:CAS:528:DC%2BC38XivFKqtLg%3D, PID: 22139303
-
Lu H, Yuan H, Chen S et al (2012) Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. Mol Cell Biochem 363:217–224
-
(2012)
Mol Cell Biochem
, vol.363
, pp. 217-224
-
-
Lu, H.1
Yuan, H.2
Chen, S.3
-
88
-
-
84958041334
-
Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli
-
PID: 26867806
-
Maciel-Barón LA, Morales-Rosales SL, Aquino-Cruz AA et al (2016) Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli. Age. doi:10.1007/s11357-016-9886-1
-
(2016)
Age
-
-
Maciel-Barón, L.A.1
Morales-Rosales, S.L.2
Aquino-Cruz, A.A.3
-
90
-
-
0027194495
-
Senescence stimulates U937-endothelial cell interactions
-
COI: 1:CAS:528:DyaK3sXmsVKmsLo%3D, PID: 8359220
-
Maier JA, Statuto M, Ragnotti G (1993) Senescence stimulates U937-endothelial cell interactions. Exp Cell Res 208:270–274
-
(1993)
Exp Cell Res
, vol.208
, pp. 270-274
-
-
Maier, J.A.1
Statuto, M.2
Ragnotti, G.3
-
92
-
-
0029060706
-
Longitudinal effects of aging on lung function at rest and exercise in healthy active fit elderly adults
-
COI: 1:STN:280:DyaK2MznvVWltg%3D%3D, PID: 7649935
-
McClaran SR, Babcock MA, Pegelow DF et al (1995) Longitudinal effects of aging on lung function at rest and exercise in healthy active fit elderly adults. J Appl Physiol 78:1957–1968
-
(1995)
J Appl Physiol
, vol.78
, pp. 1957-1968
-
-
McClaran, S.R.1
Babcock, M.A.2
Pegelow, D.F.3
-
93
-
-
84923993482
-
Hallmarks of the ageing lung
-
COI: 1:CAS:528:DC%2BC2MXmsV2qs78%3D, PID: 25657021
-
Meiners S, Eickelberg O, Königshoff M (2015) Hallmarks of the ageing lung. Eur Respir J 45:807–827
-
(2015)
Eur Respir J
, vol.45
, pp. 807-827
-
-
Meiners, S.1
Eickelberg, O.2
Königshoff, M.3
-
95
-
-
77958148045
-
The role of immunity and inflammation in lung senescence and susceptibility to infection in the elderly
-
Meyer K (2010) The role of immunity and inflammation in lung senescence and susceptibility to infection in the elderly. Sem Respir Crit Care Med 31:561–574
-
(2010)
Sem Respir Crit Care Med
, vol.31
, pp. 561-574
-
-
Meyer, K.1
-
96
-
-
84864867277
-
Management of interstitial lung disease in elderly patients
-
PID: 22617808
-
Meyer KC (2012) Management of interstitial lung disease in elderly patients. Curr Opin Pulm Med 18:483–92
-
(2012)
Curr Opin Pulm Med
, vol.18
, pp. 483-492
-
-
Meyer, K.C.1
-
97
-
-
0029880176
-
Immune dysregulation in the aging human lung
-
COI: 1:STN:280:DyaK287osFCitg%3D%3D, PID: 8630547
-
Meyer KC, Ershler W, Rosenthal NS et al (1996) Immune dysregulation in the aging human lung. Am J Respir Crit Care Med 153:1072–1079
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 1072-1079
-
-
Meyer, K.C.1
Ershler, W.2
Rosenthal, N.S.3
-
98
-
-
77958125585
-
Structural and physiological age-associated changes in aging lungs
-
PID: 20941653
-
Miller MR (2010) Structural and physiological age-associated changes in aging lungs. Semin Respir Crit Care Med 31:521–527
-
(2010)
Semin Respir Crit Care Med
, vol.31
, pp. 521-527
-
-
Miller, M.R.1
-
99
-
-
84881238056
-
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung
-
COI: 1:CAS:528:DC%2BC3sXhs1KjsbvK, PID: 23672262
-
Misharin AV, Morales-Nebreda L, Mutlu GM et al (2013) Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol 49:503–10
-
(2013)
Am J Respir Cell Mol Biol
, vol.49
, pp. 503-510
-
-
Misharin, A.V.1
Morales-Nebreda, L.2
Mutlu, G.M.3
-
100
-
-
84905387043
-
Molecular composition of the alveolar lining fluid in the aging lung
-
COI: 1:CAS:528:DC%2BC2cXhtFWit7jO
-
Moliva JI, Rajaram MVS, Sidiki S et al (2014) Molecular composition of the alveolar lining fluid in the aging lung. Age 36:1187–1199
-
(2014)
Age
, vol.36
, pp. 1187-1199
-
-
Moliva, J.I.1
Rajaram, M.V.S.2
Sidiki, S.3
-
101
-
-
45149089630
-
Influence of aging on murine neutrophil and macrophage function against Candida albicans
-
COI: 1:CAS:528:DC%2BD1cXot1aqt7w%3D, PID: 18445021
-
Murciano C, Yáñez A, O’Connor JE et al (2008) Influence of aging on murine neutrophil and macrophage function against Candida albicans. FEMS Immunol Med Microbiol 53:214–221
-
(2008)
FEMS Immunol Med Microbiol
, vol.53
, pp. 214-221
-
-
Murciano, C.1
Yáñez, A.2
O’Connor, J.E.3
-
102
-
-
84904394690
-
Macrophage activation and polarization: Nomenclature and experimental guidelines
-
COI: 1:CAS:528:DC%2BC2cXhtFOrsLjM, PID: 25035950
-
Murray PJ, Allen JE, Biswas SK et al (2014) Macrophage activation and polarization: Nomenclature and experimental guidelines. Immunity 41:14–20
-
(2014)
Immunity
, vol.41
, pp. 14-20
-
-
Murray, P.J.1
Allen, J.E.2
Biswas, S.K.3
-
104
-
-
84971373023
-
Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study
-
PID: 27220822
-
Odamaki T, Kato K, Sugahara H et al (2016) Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol. doi:10.1186/s12866-016-0708-5
-
(2016)
BMC Microbiol
-
-
Odamaki, T.1
Kato, K.2
Sugahara, H.3
-
105
-
-
56349156642
-
The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly
-
PID: 18950479
-
Ogawa K, Suzuki K, Okutsu M et al (2008) The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly. Immun Ageing. doi:10.1186/1742-4933-5-13
-
(2008)
Immun Ageing
-
-
Ogawa, K.1
Suzuki, K.2
Okutsu, M.3
-
106
-
-
27744600560
-
The immunopathogenesis of sepsis in elderly patients
-
COI: 1:CAS:528:DC%2BD2MXht1emu7fM, PID: 16237654
-
Opal SM, Girard TD, Ely EW (2005) The immunopathogenesis of sepsis in elderly patients. Clin Infect Dis 41:S504–12
-
(2005)
Clin Infect Dis
, vol.41
, pp. S504-S512
-
-
Opal, S.M.1
Girard, T.D.2
Ely, E.W.3
-
107
-
-
85013494327
-
Effects of aging, disease and the environment on the surfactant system
-
Harding R, Pinkerton KE, Plopper CG, (eds), Elsevier, San Diego
-
Orgeig S, Daniels CB (2004) Effects of aging, disease and the environment on the surfactant system. In: Harding R, Pinkerton KE, Plopper CG (eds) The lung: development, aging and the environment. Elsevier, San Diego, pp 363–375
-
(2004)
The lung: development, aging and the environment
, pp. 363-375
-
-
Orgeig, S.1
Daniels, C.B.2
-
108
-
-
84966644175
-
Analysis of cell turnover in the bronchiolar epithelium through the normal aging process
-
PID: 27164984
-
Ortega-Martínez M, Rodríguez-Flores LE, Ancer-Arellano A et al (2016) Analysis of cell turnover in the bronchiolar epithelium through the normal aging process. Lung. doi:10.1007/s00408-016-9890-3
-
(2016)
Lung
-
-
Ortega-Martínez, M.1
Rodríguez-Flores, L.E.2
Ancer-Arellano, A.3
-
109
-
-
33847624197
-
Aspiration pneumonia Pathophysiological aspects, prevention and management: A review
-
COI: 1:STN:280:DC%2BD2s%2FitVWluw%3D%3D, PID: 17215795
-
Petroianni A, Ceccarelli D, Conti V, Terzano C (2006) Aspiration pneumonia Pathophysiological aspects, prevention and management: A review. Panminerva Med 48:231–239
-
(2006)
Panminerva Med
, vol.48
, pp. 231-239
-
-
Petroianni, A.1
Ceccarelli, D.2
Conti, V.3
Terzano, C.4
-
110
-
-
74949091915
-
Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats
-
COI: 1:CAS:528:DC%2BC3cXhvVylt7Y%3D
-
Podlutsky A, Ballabh P, Csiszar A (2010) Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats. AJP Heart Circ Physiol 298:H346–51
-
(2010)
AJP Heart Circ Physiol
, vol.298
, pp. H346-H351
-
-
Podlutsky, A.1
Ballabh, P.2
Csiszar, A.3
-
111
-
-
84867427320
-
The lung microbiome in moderate and severe chronic obstructive pulmonary disease
-
PID: 23071781
-
Pragman AA, Kim HB, Reilly CS et al (2012) The lung microbiome in moderate and severe chronic obstructive pulmonary disease. PLoS ONE. doi:10.1371/journal.pone.0047305
-
(2012)
PLoS ONE
-
-
Pragman, A.A.1
Kim, H.B.2
Reilly, C.S.3
-
112
-
-
84969398992
-
Experimental evidence of age-related adaptive changes in human acinar airways
-
COI: 1:CAS:528:DC%2BC28XitFKqtb%2FO, PID: 26542518
-
Quirk JD, Sukstanskii AL, Woods JC et al (2016) Experimental evidence of age-related adaptive changes in human acinar airways. J Appl Physiol 120:159–165
-
(2016)
J Appl Physiol
, vol.120
, pp. 159-165
-
-
Quirk, J.D.1
Sukstanskii, A.L.2
Woods, J.C.3
-
113
-
-
33749444308
-
Incidence and prevalence of idiopathic pulmonary fibrosis
-
PID: 16809633
-
Raghu G, Weycker D, Edelsberg J et al (2006) Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 174:810–816
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 810-816
-
-
Raghu, G.1
Weycker, D.2
Edelsberg, J.3
-
114
-
-
57349098186
-
Aging increases upper airway collapsibility in Fischer 344 rats
-
PID: 18756010
-
Ray AD, Ogasa T, Magalang UJ et al (2008) Aging increases upper airway collapsibility in Fischer 344 rats. J Appl Physiol 105:1471–1476
-
(2008)
J Appl Physiol
, vol.105
, pp. 1471-1476
-
-
Ray, A.D.1
Ogasa, T.2
Magalang, U.J.3
-
115
-
-
84995753800
-
Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases
-
PID: 27155208
-
Regina C, Panatta E, Candi E et al (2016) Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases. Mech Ageing Dev. doi:10.1016/j.mad.2016.05.003
-
(2016)
Mech Ageing Dev
-
-
Regina, C.1
Panatta, E.2
Candi, E.3
-
116
-
-
0031592366
-
Age-related changes of the noradrenergic innervation of rat tracheo-bronchial tree and pulmonary vasculature
-
COI: 1:STN:280:DyaK1c7ksVCqsg%3D%3D, PID: 9483496
-
Ricci A, Mariotta S, Greco S et al (1997) Age-related changes of the noradrenergic innervation of rat tracheo-bronchial tree and pulmonary vasculature. Mech Ageing Dev 99:245–255
-
(1997)
Mech Ageing Dev
, vol.99
, pp. 245-255
-
-
Ricci, A.1
Mariotta, S.2
Greco, S.3
-
117
-
-
77950265945
-
Linking functional decline of telomeres, mitochondria and stem cells during ageing
-
COI: 1:CAS:528:DC%2BC3cXjvVGlsbo%3D, PID: 20336134
-
Sahin E, DePinho RA (2010) Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 464:520–8
-
(2010)
Nature
, vol.464
, pp. 520-528
-
-
Sahin, E.1
DePinho, R.A.2
-
118
-
-
40949123149
-
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
-
COI: 1:CAS:528:DC%2BD1cXmsVyksr0%3D, PID: 17964225
-
Salminen A, Huuskonen J, Ojala J et al (2008) Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 7:83–105
-
(2008)
Ageing Res Rev
, vol.7
, pp. 83-105
-
-
Salminen, A.1
Huuskonen, J.2
Ojala, J.3
-
119
-
-
84884964160
-
The Th17/Treg balance is disturbed during aging
-
COI: 1:CAS:528:DC%2BC3sXhvVahu7fM, PID: 24055797
-
Schmitt V, Rink L, Uciechowski P (2013) The Th17/Treg balance is disturbed during aging. Exp Gerontol 48:1379–1386
-
(2013)
Exp Gerontol
, vol.48
, pp. 1379-1386
-
-
Schmitt, V.1
Rink, L.2
Uciechowski, P.3
-
120
-
-
34250633656
-
Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats
-
COI: 1:CAS:528:DC%2BD2sXmvVOjs78%3D, PID: 17374516
-
Seebart BR, Stoffel RT, Behan M (2007) Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats. Respir Physiol Neurobiol 158:14–21
-
(2007)
Respir Physiol Neurobiol
, vol.158
, pp. 14-21
-
-
Seebart, B.R.1
Stoffel, R.T.2
Behan, M.3
-
121
-
-
38449106142
-
Effect of aging on respiratory system physiology and immunology
-
COI: 1:CAS:528:DC%2BD28Xhtlars7nO, PID: 18046878
-
Sharma G, Goodwin J (2006) Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 1:253–260
-
(2006)
Clin Interv Aging
, vol.1
, pp. 253-260
-
-
Sharma, G.1
Goodwin, J.2
-
122
-
-
79955947701
-
Dysregulation of human Toll-like receptor function in aging
-
COI: 1:CAS:528:DC%2BC3MXmtlyrsbo%3D, PID: 21074638
-
Shaw AC, Panda A, Joshi SR et al (2011) Dysregulation of human Toll-like receptor function in aging. Ageing Res Rev 10:346–53
-
(2011)
Ageing Res Rev
, vol.10
, pp. 346-353
-
-
Shaw, A.C.1
Panda, A.2
Joshi, S.R.3
-
123
-
-
45949103778
-
NK cells play a critical protective role in host defense against acute extracellular
-
COI: 1:CAS:528:DC%2BD1cXkt1art7k%3D, PID: 18390740
-
Small C-L, Mccormick S, Gill N et al (2008) NK cells play a critical protective role in host defense against acute extracellular. J Immunol 180:5558–68
-
(2008)
J Immunol
, vol.180
, pp. 5558-5568
-
-
Small, C.-L.1
Mccormick, S.2
Gill, N.3
-
124
-
-
78651239219
-
The effects of aging on pulmonary oxidative damage, protein nitration and extracellular dismutase down-regulation during systemic inflammation
-
Starr ME, Ueda J, Yamamoto S et al (2012) The effects of aging on pulmonary oxidative damage, protein nitration and extracellular dismutase down-regulation during systemic inflammation. Free Radic Biol Med 50:371–380. doi:10.1016/j.freeradbiomed.2010.11.013.The
-
(2012)
Free Radic Biol Med
, vol.50
, pp. 371-380
-
-
Starr, M.E.1
Ueda, J.2
Yamamoto, S.3
-
125
-
-
20344384993
-
Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
-
COI: 1:CAS:528:DC%2BD2MXmtl2ju7Y%3D, PID: 15882345
-
Stout RD, Suttles J (2005) Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes. Immunol Rev 205:60–71
-
(2005)
Immunol Rev
, vol.205
, pp. 60-71
-
-
Stout, R.D.1
Suttles, J.2
-
126
-
-
84857866008
-
Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin
-
COI: 1:CAS:528:DC%2BC38Xjt1GntLs%3D, PID: 22327078
-
Stout-Delgado HW, Vaughan SE, Shirali AC et al (2012) Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. J Immunol 188:2815–24
-
(2012)
J Immunol
, vol.188
, pp. 2815-2824
-
-
Stout-Delgado, H.W.1
Vaughan, S.E.2
Shirali, A.C.3
-
127
-
-
0030949617
-
Increased mortality of older patients with acute respiratory distress syndrome
-
COI: 1:STN:280:DyaK2s3ptlKqtQ%3D%3D, PID: 9149591
-
Suchyta MR, Clemmer TP, Elliott CG et al (1997) Increased mortality of older patients with acute respiratory distress syndrome. Chest 111:1334–1339
-
(1997)
Chest
, vol.111
, pp. 1334-1339
-
-
Suchyta, M.R.1
Clemmer, T.P.2
Elliott, C.G.3
-
128
-
-
57349151482
-
Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease
-
COI: 1:CAS:528:DC%2BD1cXhsVKitrfO, PID: 18566336
-
Suzuki M, Betsuyaku T, Ito Y et al (2008) Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 39:673–82
-
(2008)
Am J Respir Cell Mol Biol
, vol.39
, pp. 673-682
-
-
Suzuki, M.1
Betsuyaku, T.2
Ito, Y.3
-
129
-
-
26844496437
-
Long-term clearance from small airways decreases with age
-
COI: 1:STN:280:DC%2BD2MrivFWqtg%3D%3D, PID: 16204590
-
Svartengren M, Falk R, Philipson K (2005) Long-term clearance from small airways decreases with age. Eur Respir J 26:609–615
-
(2005)
Eur Respir J
, vol.26
, pp. 609-615
-
-
Svartengren, M.1
Falk, R.2
Philipson, K.3
-
130
-
-
84938612864
-
The host response to the lung microbiome in chronic obstructive pulmonary disease
-
COI: 1:CAS:528:DC%2BC28XkvVCnuw%3D%3D, PID: 25945594
-
Sze MA, Dimitriu PA, Suzuki M et al (2015) The host response to the lung microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 192:438–445
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 438-445
-
-
Sze, M.A.1
Dimitriu, P.A.2
Suzuki, M.3
-
131
-
-
84880328546
-
Senescent cells spread the word: non-cell autonomous propagation of cellular senescence
-
COI: 1:CAS:528:DC%2BC3sXpsFKqtrw%3D, PID: 23778965
-
Tasdemir N, Lowe SW (2013) Senescent cells spread the word: non-cell autonomous propagation of cellular senescence. EMBO J 32:1975–6
-
(2013)
EMBO J
, vol.32
, pp. 1975-1976
-
-
Tasdemir, N.1
Lowe, S.W.2
-
132
-
-
84898862913
-
The hallmarks of fibroblast ageing
-
COI: 1:CAS:528:DC%2BC2cXosFalsLw%3D, PID: 24686308
-
Tigges J, Krutmann J, Fritsche E et al (2014) The hallmarks of fibroblast ageing. Mech Ageing Dev 138:26–44
-
(2014)
Mech Ageing Dev
, vol.138
, pp. 26-44
-
-
Tigges, J.1
Krutmann, J.2
Fritsche, E.3
-
133
-
-
73949091048
-
Impaired immune responses in the lungs of aged mice following influenza infection
-
PID: 19922665
-
Toapanta FR, Ross TM (2009) Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res. doi:10.1186/1465-9921-10-112
-
(2009)
Respir Res
-
-
Toapanta, F.R.1
Ross, T.M.2
-
134
-
-
84859757583
-
Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis
-
PID: 22227563
-
Torres-González E, Bueno M, Tanaka A et al (2012) Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. Am J Respir Cell Mol Biol 46:748–56
-
(2012)
Am J Respir Cell Mol Biol
, vol.46
, pp. 748-756
-
-
Torres-González, E.1
Bueno, M.2
Tanaka, A.3
-
135
-
-
80052577423
-
Gut flora enhance bacterial clearance in lung through toll-like receptors 4
-
PID: 21906393
-
Tsay T-B, Yang M-C, Chen P-H et al (2011) Gut flora enhance bacterial clearance in lung through toll-like receptors 4. J Biomed Sci. doi:10.1186/1423-0127-18-68
-
(2011)
J Biomed Sci
-
-
Tsay, T.-B.1
Yang, M.-C.2
Chen, P.-H.3
-
136
-
-
0029810053
-
Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery
-
COI: 1:CAS:528:DyaK28XlsFOgsbY%3D, PID: 8770860
-
Tschudi MR, Barton M, Bersinger NA et al (1996) Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. J Clin Invest 98:899–905
-
(1996)
J Clin Invest
, vol.98
, pp. 899-905
-
-
Tschudi, M.R.1
Barton, M.2
Bersinger, N.A.3
-
137
-
-
33749841717
-
Alveolar cell senescence in patients with pulmonary emphysema
-
COI: 1:CAS:528:DC%2BD28Xht1SgtLjO, PID: 16888288
-
Tsuji T, Aoshiba K, Nagai A (2006) Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med 174:886–893
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 886-893
-
-
Tsuji, T.1
Aoshiba, K.2
Nagai, A.3
-
138
-
-
0034684652
-
Enhanced peroxynitrite formation is associated with vascular aging
-
PID: 11120770
-
Van der Loo B, Labugger R, Skepper JN et al (2000) Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 192:1731–44
-
(2000)
J Exp Med
, vol.192
, pp. 1731-1744
-
-
Van der Loo, B.1
Labugger, R.2
Skepper, J.N.3
-
139
-
-
79954606842
-
Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders
-
COI: 1:CAS:528:DC%2BC3MXntVCls74%3D, PID: 21097694
-
Vanaudenaerde BM, Verleden SE, Vos R et al (2011) Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders. Am J Respir Crit Care Med 183:977–86
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 977-986
-
-
Vanaudenaerde, B.M.1
Verleden, S.E.2
Vos, R.3
-
140
-
-
84930958871
-
Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease
-
PID: 26090504
-
Vital M, Harkema JR, Rizzo M et al (2015) Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease. J Immunol Res. doi:10.1155/2015/892568
-
(2015)
J Immunol Res
-
-
Vital, M.1
Harkema, J.R.2
Rizzo, M.3
-
141
-
-
84905969043
-
The exposome: a new paradigm to study the impact of environment on health
-
PID: 24906490
-
Vrijheid M (2014) The exposome: a new paradigm to study the impact of environment on health. Thorax 69:876–8
-
(2014)
Thorax
, vol.69
, pp. 876-878
-
-
Vrijheid, M.1
-
142
-
-
77956664068
-
Pulmonary surfactant: ultrastructural features and putative mechanisms of aging
-
PID: 20134052
-
Walski M, Pokorski M, Antosiewicz J et al (2009) Pulmonary surfactant: ultrastructural features and putative mechanisms of aging. J Physiol Pharmacol 60:121–125
-
(2009)
J Physiol Pharmacol
, vol.60
, pp. 121-125
-
-
Walski, M.1
Pokorski, M.2
Antosiewicz, J.3
-
144
-
-
67649651896
-
Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice
-
Xu J, Gonzalez ET, Iyer SS et al (2009) Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice. J Gerontol A 64:731–739
-
(2009)
J Gerontol A
, vol.64
, pp. 731-739
-
-
Xu, J.1
Gonzalez, E.T.2
Iyer, S.S.3
-
145
-
-
84943413120
-
Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients
-
Yanai H, Shteinberg A, Porat Z et al (2015) Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients. Aging (iIpact) 7:664–672
-
(2015)
Aging (iIpact)
, vol.7
, pp. 664-672
-
-
Yanai, H.1
Shteinberg, A.2
Porat, Z.3
-
146
-
-
84939153632
-
Reactive oxygen species in mesenchymal stem cell aging: implication to lung diseases
-
Yang S-R, Park J-R, Kang K-S (2015) Reactive oxygen species in mesenchymal stem cell aging: implication to lung diseases. Oxidative Med Cell Longev. doi:10.1155/2015/486263
-
(2015)
Oxidative Med Cell Longev
-
-
Yang, S.-R.1
Park, J.-R.2
Kang, K.-S.3
-
147
-
-
30344445361
-
Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia
-
PID: 16166617
-
Yende S, Tuomanen EI, Wunderink R et al (2005) Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. Am J Respir Crit Care Med 172:1440–6
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 1440-1446
-
-
Yende, S.1
Tuomanen, E.I.2
Wunderink, R.3
-
148
-
-
34447556991
-
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
-
COI: 1:CAS:528:DC%2BD2sXptFGlsLs%3D, PID: 17615396
-
Yoshida T, Tuder R (2007) Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev 87:1047–1082
-
(2007)
Physiol Rev
, vol.87
, pp. 1047-1082
-
-
Yoshida, T.1
Tuder, R.2
-
149
-
-
84949495879
-
Aging Impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 Ligand
-
PID: 26474053
-
Zacca ER, Crespo MI, Acland RP et al (2015) Aging Impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 Ligand. PLoS ONE. doi:10.1371/journal.pone.0140672
-
(2015)
PLoS ONE
-
-
Zacca, E.R.1
Crespo, M.I.2
Acland, R.P.3
-
150
-
-
20244373955
-
Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia
-
COI: 1:CAS:528:DC%2BD2MXjtFSlsr8%3D, PID: 15687494
-
Zaccagnini G, Gaetano C, Della Pietra L et al (2005) Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia. J Biol Chem 280:14790–14798
-
(2005)
J Biol Chem
, vol.280
, pp. 14790-14798
-
-
Zaccagnini, G.1
Gaetano, C.2
Della Pietra, L.3
-
151
-
-
65349157884
-
Transepithelial migration of neutrophils: Mechanisms and implications for acute lung injury
-
COI: 1:CAS:528:DC%2BD1MXlsF2isbg%3D, PID: 18978300
-
Zemans RL, Colgan SP, Downey GP (2009) Transepithelial migration of neutrophils: Mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol 40:519–535
-
(2009)
Am J Respir Cell Mol Biol
, vol.40
, pp. 519-535
-
-
Zemans, R.L.1
Colgan, S.P.2
Downey, G.P.3
-
152
-
-
84055190787
-
Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
-
COI: 1:CAS:528:DC%2BC3MXhs1ShsLnI, PID: 22105170
-
Zhao J, Zhao J, Legge K, Perlman S (2011) Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest 121:4921–30
-
(2011)
J Clin Invest
, vol.121
, pp. 4921-4930
-
-
Zhao, J.1
Zhao, J.2
Legge, K.3
Perlman, S.4
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