Age-related increases in PGD 2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

Journal of Clinical Investigation

Volumn 121, Issue 12, 2011, Pages 4921-4930

  Zhao, Jincun ^a   Zhao, Jingxian ^a,b   Legge, Kevin ^c   Perlman, Stanley ^a  

^a UNIVERSITY OF IOWA   (United States)

^b JINAN UNIVERSITY   (China)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; PROSTAGLANDIN D2; PROSTAGLANDIN D2 DERIVATIVE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CELLULAR IMMUNITY; CHEMOTAXIS; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; DISEASE SEVERITY; IN VITRO STUDY; IN VIVO STUDY; LUNG; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; RESPIRATORY DENDRITIC CELL; RESPIRATORY SYSTEM; RESPIRATORY VIRUS; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; T LYMPHOCYTE; VIRAL RESPIRATORY TRACT INFECTION; VIRUS STRAIN;

AGING; ANIMALS; CELL MOVEMENT; CELLULAR MICROENVIRONMENT; CORONAVIRUS INFECTIONS; DENDRITIC CELLS; DISEASE SUSCEPTIBILITY; IMMUNOCOMPROMISED HOST; INFLUENZA A VIRUS; LUNG; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MURINE HEPATITIS VIRUS; ORTHOMYXOVIRIDAE INFECTIONS; PROSTAGLANDIN ANTAGONISTS; PROSTAGLANDIN D2; RECEPTORS, CCR7; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS;

EID: 84055190787     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59777     Document Type: Article

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