Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts

International Journal of Cancer

Volumn 122, Issue 6, 2008, Pages 1236-1242

  Falchetti, Maria Laura ^a   Mongiardi, Maria Patrizia ^a   Fiorenzo, Paolo ^a   Petrucci, Giovanna ^b   Pierconti, Francesco ^b   D'Agnano, Igea ^a   D'Alessandris, Giorgio ^b   Alessandri, Giulio ^c   Gelati, Maurizio ^c   Ricci Vitiani, Lucia ^d   Maira, Giulio ^b   Larocca, Luigi Maria ^b   Levi, Andrea ^a   Pallini, Roberto ^b  

^a CNR   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Glioblastoma multiforme; HUVEC; Telomerase; Tumor xenograft

Indexed keywords

MATRIGEL; TELOMERASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME REGULATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNE ADHERENCE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; UPREGULATION; VASCULAR ENDOTHELIUM;

BRAIN NEOPLASMS; CELL LINE, TUMOR; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE;

EID: 39649094505     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23193     Document Type: Article

References (25)

1. Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992;359:845-8.
2. Pallini R, Pierconti F, Falchetti ML, D'Arcangelo D, Fernandez E, Maira G, D'Ambrosio E, Larocca LM. Evidence for telomerase involvement in the angiogenesis of astrocytic tumors: expression of human telomerase reverse transcriptase messenger RNA by vascular endothelial cells. J Neurosurg 2001;94:961-71.
3. Falchetti ML, Pierconti F, Casalbore P, Maggiano N, Levi A, Larocca LM, Pallini R. Glioblastoma induces vascular endothelial cells to express telomerase in vitro. Cancer Res 2003;63:3750-4.
4. Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A, Bronstein A, Chiu CP, Herron GS. Human endothelial cell life extension by telomerase expression. J Biol Chem 1999;274:26141-8.
5. De Stasio G, Casalbore P, Pallini R, Gilbert B, Sanita F, Ciotti MT, Rosi G, Festinesi A, Larocca LM, Rinelli A, Perret D, Mogk DW, et al. Gadolinium in human glioblastoma cells for gadolinium neutron capture therapy. Cancer Res 2001;61:4272-7.
6. Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 1998;95:14723-8.
7. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999;5:1164-70.
8. Pallini R, Sorrentino A, Pierconti F, Maggiano N, Faggi R, Montano N, Maira G, Larocca LM, Levi A, Falchetti ML. Telomerase inhibition by stable RNA interference impairs tumor growth and angiogenesis in glioblastoma xenografts. Im J Cancer 2006;118:2158-67.
9. Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L. A third-generation lentivirus vector with a conditional packaging system. J Virol 1998;72:8463-71.
10. Salton SR, Ferri GL, Hahm S, Snyder SE, Wilson AJ, Possenti R, Levi A. VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance. Front Neuroendocrinol 2000;21:199-219.
11. Freedman DA, Folkman J. Maintenance of G1 checkpoint controls in telomerase-immortalized endothelial cells. Cell Cycle 2004;3:811-16.
12. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002;296:550-3.
13. Halliwell B, Aruoma OI. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 1991;281:9-19.
14. Yang J, Nagavarapu U, Relloma K, Sjaastad MD, Moss WC, Passaniti A, Herron GS. Telomerized human microvasculature is functional in vivo. Nat Biotechnol 2001;19:219-24.
15. Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Myc activates telomerase. Genes Dev 1998;12:1769-74.
16. Falchetti ML, Falcone G, D'Ambrosio E, Verna R, Alema S, Levi A. Induction of telomerase activity in v-myc-transformed avian cells. Oncogene 1999;18:1515-19.
17. Franco S, Segura I, Riese HH, Blasco MA. Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res 2002;62:552-9.
18. Murasawa S, Llevadot J, Silver M, Isner JM, Losordo DW, Asahara T. Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation 2002;106:1133-9.
19. Folini M, Brambilla C, Villa R, Gandellini P, Vignati S, Paduano F, Daidone MG, Zaffaroni N. Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells. Eur J Cancer 2005;41:624-34.
20. Fu W, Killen M, Culmsee C, Dhar S, Pandita TK, Mattson MP. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J Mol Neurosci 2000;14:3-15.
21. Li S, Rosenberg JE, Donjacour AA, Botchkina IL, Hom YK, Cunha GR, Blackburn EH. Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res 2004;64:4833-40.
22. Zhu H, Fu W, Mattson MP. The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis. J Neurochem 2000;75:117-24.
23. Oh H, Taffet GE, Youker KA, Entman ML, Overbeek PA, Michael LH, Schneider MD. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc Natl Acad Sci USA 2001;98:10308-13.
24. Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci USA 2005;102:8222-7.
25. Beliveau A, Bassett E, Lo AT, Garbe J, Rubio MA, Bissell MJ, Campisi J, Yaswen P. p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci USA 2007;104:4431-6.