Age-related differences in the neutrophil response to pulmonary pseudomonas infection

Experimental Gerontology

Volumn 54, Issue , 2014, Pages 42-46

  Chen, Michael M ^a   Palmer, Jessica L ^a,b   Plackett, Timothy P ^b   Deburghgraeve, Cory R ^a,b   Kovacs, Elizabeth J ^a,b,c  

^a Burn and Shock Trauma Institute   (United States)

^b Department of Surgery Loyola University Chicago Health Sciences Campus ^*  (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Aging; Infection; Inflamm aging; Inflammation; Neutrophil; Pneumonia; Pseudomonas aeruginosa

Indexed keywords

CXCL1 CHEMOKINE;

AGE; ANALYSIS OF VARIANCE; ANIMAL; BACTERIAL PNEUMONIA; BAGG ALBINO MOUSE; FEMALE; IMMUNOLOGY; IMMUNOPATHOLOGY; LEUKOCYTE DISORDER; METABOLISM; NEUTROPHIL; PATHOPHYSIOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SURVIVAL;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; CHEMOKINE CXCL1; FEMALE; IMMUNE SYSTEM DISEASES; LEUKOCYTE DISORDERS; MICE, INBRED BALB C; NEUTROPHILS; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SURVIVAL ANALYSIS;

EID: 84898804496     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.12.010     Document Type: Article

References (15)

1. Brubaker A.L., Rendon J.L., Ramirez L., Choudhry M.A., Kovacs E.J. Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J. Immunol. 2013, 190:1746-1757.
2. Davis K.A., Santaniello J.M., He L.K., Muthu K., Sen S., Jones S.B., Gamelli R.L., Shankar R. Burn injury and pulmonary sepsis: development of a clinically relevant model. J. Trauma 2004, 56:272-278.
3. Gomez C.R., Hirano S., Cutro B.T., Birjandi S., Baila H., Nomellini V., Kovacs E.J. Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Crit. Care Med. 2007, 35:246-251.
4. Gomez C.R., Nomellini V., Baila H., Oshima K., Kovacs E.J. Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus I.P. LPS administration. Shock 2009, 31:178-184.
5. Jones R.N. Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin. Infect. Dis. 2010, 51(Suppl. 1):S81-S87.
6. Klesney-Tait J., Keck K., Li X., Gilfillan S., Otero K., Baruah S., Meyerholz D.K., Varga S.M., Knudson C.J., Moninger T.O., Moreland J., Zabner J., Colonna M. Transepithelial migration of neutrophils into the lung requires TREM-1. J. Clin. Invest. 2013, 123:138-149.
7. McConnell K.W., McDunn J.E., Clark A.T., Dunne W.M., Dixon D.J., Turnbull I.R., Dipasco P.J., Osberghaus W.F., Sherman B., Martin J.R., Walter M.J., Cobb J.P., Buchman T.G., Hotchkiss R.S., Coopersmith C.M. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit. Care Med. 2010, 38:223-241.
8. Murdoch E.L., Brown H.G., Gamelli R.L., Kovacs E.J. Effects of ethanol on pulmonary inflammation in postburn intratracheal infection. J. Burn Care Res. 2008, 29:323-330.
9. Nomellini V., Faunce D.E., Gomez C.R., Kovacs E.J. An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J. Leukoc. Biol. 2008, 83:1493-1501.
10. Nomellini V., Brubaker A.L., Mahbub S., Palmer J.L., Gomez C.R., Kovacs E.J. Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis. 2012, 3:234-247.
11. Patel P.J., Faunce D.E., Gregory M.S., Duffner L.A., Kovacs E.J. Elevation in pulmonary neutrophils and prolonged production of pulmonary macrophage inflammatory protein-2 after burn injury with prior alcohol exposure. Am. J. Respir. Cell Mol. Biol. 1999, 20:1229-1237.
12. Plackett T.P., Boehmer E.D., Faunce D.E., Kovacs E.J. Aging and innate immune cells. J. Leukoc. Biol. 2004, 76:291-299.
13. Sapey E., Greenwood H., Walton G., Mann E., Love A., Aaronson N., Insall R.H., Stockley R.A., Lord J.M. Phosphoinositide 3 kinase inhibition restores neutrophil accuracy in the elderly: towards targeted treatments for immunesenescence. Blood 2013, (in press). 10.1182/blood-2013-08-519520.
14. Tumbarello M., De Pascale G., Trecarichi E.M., Spanu T., Antonicelli F., Maviglia R., Pennisi M.A., Bello G., Antonelli M. Clinical outcomes of Pseudomonas aeruginosa pneumonia in intensive care unit patients. Intensive Care Med. 2013, 39:682-692.
15. Venier A.G., Gruson D., Lavigne T., Jarno P., L'Heriteau F., Coignard B., Savey A., Rogues A.M. Group, R.-R. Identifying new risk factors for Pseudomonas aeruginosa pneumonia in intensive care units: experience of the French national surveillance, REA-RAISIN. J. Hosp. Infect. 2011, 79:44-48.