Structural and physiological age-associated changes in aging lungs

Seminars in Respiratory and Critical Care Medicine

Volumn 31, Issue 5, 2010, Pages 521-527

  Miller, Martin R ^a  

^a UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

age; elastic recoil; Lung function; total lung capacity

Indexed keywords

CARBON DIOXIDE; COLLAGEN; ELASTIN;

AGING; BLOOD CARBON DIOXIDE TENSION; BREATHING MUSCLE; EXPIRATORY FLOW; FORCED VITAL CAPACITY; HUMAN; KYPHOSIS; LUNG ALVEOLUS; LUNG ALVEOLUS OXYGEN TENSION; LUNG ALVEOLUS SURFACE TENSION; LUNG CLOSING VOLUME; LUNG FUNCTION; LUNG GAS EXCHANGE; LUNG PARENCHYMA; LUNG PERFUSION; LUNG STRUCTURE; LUNG VENTILATION; MUSCLE FUNCTION; PRIORITY JOURNAL; REVIEW; SCOLIOSIS; THORAX WALL; TOTAL LUNG CAPACITY;

AGED; AGING; ELASTICITY; HUMANS; LUNG; RESPIRATION; RESPIRATORY FUNCTION TESTS; TOTAL LUNG CAPACITY;

EID: 77958125585     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0030-1265893     Document Type: Review

References (53)

1. Kirkwood T B. Understanding the odd science of aging. Cell 2005 120 437-447
2. Ito K, Barnes P J. COPD as a disease of accelerated lung aging. Chest 2009 135 173-180
3. Hogg J C., Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004 350 2645-2653
4. The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis 1985 132 182-185
5. Saetta M, Shiner R J., Angus G E. et al. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis 1985 131 764-769
6. Verbeken E K., Cauberghs M, Mertens I, Clement J, Lauweryns J M., Van de Woestijne K P. The senile lung: comparison with normal and emphysematous lungs, I: Structural aspects. Chest 1992 101 793-799
7. Verbeken E K., Cauberghs M, Mertens I, Clement J, Lauweryns J M., Van de Woestijne K P. The senile lung: comparison with normal and emphysematous lungs, II: Functional aspects. Chest 1992 101 800-809
8. Gillooly M, Lamb D. Airspace size in lungs of lifelong non-smokers: effect of age and sex. Thorax 1993 48 39-43
9. Turner J M., Mead J, Wohl M E. Elasticity of human lungs in relation to age. J Appl Physiol 1968 25 664-671
10. Babb T G., Rodarte J R. Mechanism of reduced maximal expiratory flow with aging. J Appl Physiol 2000 89 505-511
11. Pierce J A., Ebert R V. Fibrous network of the lung and its change with age. Thorax 1965 20 469-476
12. Tenney S DM. A tangled web: Young, Laplace and the surface tension laws. News Physiol Sci 1993 8 179-183
13. Bachofen H, Hildebrandt J, Bachofen M. Pressure-volume curves of air- and liquid-filled excised lungs-surface tension in situ. J Appl Physiol 1970 29 422-431
14. Rebello C M., Jobe A H., Eisele J W., Ikegami M. Alveolar and tissue surfactant pool sizes in humans. Am J Respir Crit Care Med 1996 154 (3 Pt 1) 625-628
15. Gillooly M, Lamb D. Airspace size in lungs of lifelong non-smokers: effect of age and sex. Thorax 1993 48 39-43
16. Verbeken E K., Cauberghs M, Mertens I, Clement J, Lauweryns J M., Van de Woestijne K P. The senile lung: comparison with normal and emphysematous lungs, II: Functional aspects. Chest 1992 101 800-809
17. Forrest J B. The effect of changes in lung volume on the size and shape of alveoli. J Physiol 1970 210 533-547
18. Janssens J P., Pache J C., Nicod L P. Physiological changes in respiratory function associated with ageing. Eur Respir J 1999 13 197-205
19. Bouhuys A, Jonson B. Alveolar pressure, airflow rate, and lung inflation in man. J Appl Physiol 1967 22 1086-1100
20. Babb T G., Rodarte J R. Mechanism of reduced maximal expiratory flow with aging. J Appl Physiol 2000 89 505-511
21. Dawson S V., Elliott E A. Wave-speed limitation on expiratory flow-a unifying concept. J Appl Physiol 1977 43 498-515
22. Leblanc P, Ruff F, Milic-Emili J. Effects of age and body position on airway closure in man. J Appl Physiol 1970 28 448-451
23. McCarthy D S., Spencer R, Greene R, Milic-Emili J. Measurement of closing volume as a simple and sensitive test for early detection of small airway disease. Am J Med 1972 52 747-753
24. Murray P M., Weinstein S L., Spratt K F. The natural history and long-term follow-up of Scheuermann kyphosis. J Bone Joint Surg Am 1993 75 236-248
25. Mittman C, Edelman N H., Norris A H., Shock M W. Relationship between chest wall and pulmonary compliance and age. J Appl Physiol 1965 20 1211-1216
26. Hankinson J L., Odencrantz J R., Fedan K B. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999 159 179-187
27. Crapo R O., Morris A H., Clayton P D., Nixon C R. Lung volumes in healthy nonsmoking adults. Bull Eur Physiopathol Respir 1982 18 419-425
28. Miller A, Thornton J C., Warshaw R, Anderson H, Teirstein A S., Selikoff I J. Single breath diffusing capacity in a representative sample of the population of Michigan, a large industrial state: predicted values, lower limits of normal, and frequencies of abnormality by smoking history. Am Rev Respir Dis 1983 127 270-277
29. Rantanen T, Guralnik J M., Foley D et al. Midlife hand grip strength as a predictor of old age disability. JAMA 1999 281 558-560
30. Enright P L., Kronmal R A., Manolio T A., Schenker M B., Hyatt R E., Cardiovascular Health Study Research Group. Respiratory muscle strength in the elderly: correlates and reference values. Am J Respir Crit Care Med 1994 149 (2 Pt 1) 430-438
31. Enright P L., Adams A B., Boyle P J., Sherrill D L. Spirometry and maximal respiratory pressure references from healthy Minnesota 65- to 85-year-old women and men. Chest 1995 108 663-669 erratum 1776
32. Polkey M I., Harris M L., Hughes P D. et al. The contractile properties of the elderly human diaphragm. Am J Respir Crit Care Med 1997 155 1560-1564
33. Tolep K, Higgins N, Muza S, Criner G, Kelsen S G. Comparison of diaphragm strength between healthy adult elderly and young men. Am J Respir Crit Care Med 1995 152 677-682
34. Cerveri I, Zoia M C., Fanfulla F et al. Reference values of arterial oxygen tension in the middle-aged and elderly. Am J Respir Crit Care Med 1995 152 934-941
35. Hardie J A., Vollmer W M., Buist A S., Ellingsen I, Mørkve O. Reference values for arterial blood gases in the elderly. Chest 2004 125 2053-2060
36. Wagner P D., Laravuso R B., Uhl R R., West J B. Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100 per cent O2. J Clin Invest 1974 54 54-68
37. Cardús J, Burgos F, Diaz O et al. Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals. Am J Respir Crit Care Med 1997 156 (2 Pt 1) 648-653
38. Derion T, Guy H J., Tsukimoto K et al. Ventilation-perfusion relationships in the lung during head-out water immersion. J Appl Physiol 1992 72 64-72
39. McConnell A K., Davies C T. A comparison of the ventilatory responses to exercise of elderly and younger humans. J Gerontol 1992 47 B137-B141
40. McConnell A K., Semple E S., Davies C T. Ventilatory responses to exercise and carbon dioxide in elderly and younger humans. Eur J Appl Physiol Occup Physiol 1993 66 332-337
41. Brischetto M J., Millman R P., Peterson D D., Silage D A., Pack A I. Effect of aging on ventilatory response to exercise and CO2. J Appl Physiol 1984 56 1143-1150
42. Poulin M J., Cunningham D A., Paterson D H., Rechnitzer P A., Ecclestone N A., Koval J J. Ventilatory response to exercise in men and women 55 to 86 years of age. Am J Respir Crit Care Med 1994 149 (2 Pt 1) 408-415
43. McClaran S R., Babcock M A., Pegelow D F., Reddan W G., Dempsey J A. Longitudinal effects of aging on lung function at rest and exercise in healthy active fit elderly adults. J Appl Physiol 1995 78 1957-1968
44. Douglas N J., White D P., Weil J V., Pickett C K., Zwillich C W. Hypercapnic ventilatory response in sleeping adults. Am Rev Respir Dis 1982 126 758-762
45. Bixler E O., Vgontzas A N., Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men, I: Prevalence and severity. Am J Respir Crit Care Med 1998 157 144-148
46. Browne H AK, Adams L, Simonds A K., Morrell M J. Aging does not influence the sleep-related decrease in the hypercapnic ventilatory response. Eur Respir J 2003 21 523-529
47. Hankinson J L., Odencrantz J R., Fedan K B. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999 159 179-187
48. van Pelt W, Borsboom G JJM, Rijcken B, Schouten J P., van Zomeren B C., Quanjer P H. Discrepancies between longitudinal and cross-sectional change in ventilatory function in 12 years of follow-up. Am J Respir Crit Care Med 1994 149 1218-1226
49. Quanjer P H., Tammeling G J., Cotes J E. et al. Lung volumes and forced ventilatory flows. Report Working Party Standardisation of Lung Function Tests, European Community for Steel and Coal. Eur Respir J 1993 6 (Suppl 16) 5-40
50. Miller M R., Pedersen O F. New concepts for expressing forced expiratory volume in lungs arising from survival analysis. Eur Respir J 2010 35 873-882
51. Miller M R., Pedersen O F., Dirksen A. A new staging strategy for chronic obstructive lung disease. Int J Chron Obstruct Pulmon Dis 2007 2 657-663
52. Chinn S, Gislason T, Aspelund T, Gudnason V. Optimum expression of adult lung function based on all-cause mortality: results from the Reykjavik study. Respir Med 2007 101 601-609
53. Miller M R., Pedersen O F., Lange P, Vestbo J. Improved survival prediction from lung function data in a large population sample. Respir Med 2009 103 442-448