Pneumonia in the elderly

Current Opinion in Infectious Diseases

Volumn 17, Issue 2, 2004, Pages 127-130

  Loeb, Mark ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b HENDERSON GENERAL HOSPITAL   (Canada)

Author keywords

Aging; Community; Long term care; Pneumonia; Respiratory

Indexed keywords

INFLUENZA VACCINE; PNEUMOCOCCUS VACCINE;

AGED; AGING; CLINICAL FEATURE; CLINICAL TRIAL; COMMUNITY ACQUIRED PNEUMONIA; DEATH; DRUG SAFETY; HIGH RISK POPULATION; HUMAN; INFECTION PREVENTION; INFLUENZA VACCINATION; LONG TERM CARE; MUCOSAL IMMUNITY; NONHUMAN; OUTCOMES RESEARCH; REVIEW; SEVERE ACUTE RESPIRATORY SYNDROME; STREPTOCOCCUS PNEUMONIAE; SYMPTOMATOLOGY;

AGED; COMMUNITY-ACQUIRED INFECTIONS; HEALTH SERVICES FOR THE AGED; HUMANS; LONG-TERM CARE; NURSING HOMES; PNEUMOCOCCAL VACCINES; PNEUMONIA, PNEUMOCOCCAL;

EID: 1842453024     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001432-200404000-00010     Document Type: Review

References (27)

1. Pneumonia and Influenza death rates, United States, 1979-1994. MMWR Morb Mortal Wkly Rep 1995; 44:535-537.
2. Jokinen C, Heiskanen L, Juvonen H, et al. Incidence of community-acquired pneumonia in the population of four municipalities in eastern Finland. Am J Epidemiol 1993; 137:977-988.
3. Muder R. Pneumonia in residents of long-term care facilities: epidemiology, etiology, management, and prevention. Am J Med 1998; 105:319-330.
4. Fernandez-Sabe N, Carratala J, Roson B, et al. Community-acquired pneumonia in very elderly patients: causative organisms, cinical characteristics, and outcomes. Medicine 2003; 82:159-169. Describes a large cohort study of older individuals with CAP.
5. Jokinen C, Heiskanen L, Juvonen H, et al. Microbial etiology of community-acquired pneumonia in the adult population of 4 municipalities in eastern Finland. Clin Infect Dis 2001; 32:1141-1154.
6. Ruiz M, Ewig S, Marcos M, et al. Etiology of community-acquired pneumonia: Impact of age, comorbidity, and severity. Am J Resp Crit Care Med 1999; 160:397-105.
7. Kupronis BA, Richards CL, Whitney CG. Invasive pneumococcal disease in older adults residing in long-term care facilities and in the community. J Geriatr Soc 2003; 51:1520-1525. An important paper because it b a population-based report addressing invasive pneumococcal disease in residents of long-term care facilities.
8. Nuorti JP, Butler JC, Crutcher JM, et al. An outbreak of multidrug-resistant pneumococcal pneumonia and bacteremia among unvaccinated nursing home residents. N Engl J Med 1998; 338:1861-1868.
9. Metlay JP, Schulz R, Li YH, et al. Influence of age on symptoms at presentation in patients with community-acquired pneumonia. Arch Intem Med 1997; 157:1453-1459.
10. Marrie TJ, Fine M, Coley C. Ambulatory patients with community-acquired pneumonia: the frequency of atypical agents and clinical course. Am J Med 1996; 101:508-515.
11. Johnson JC, Jayadevappa R, Baccash PD, Taylor L. Nonspecific presentation of pneumonia in hospitalized older people: age effect or dementia? J Am Geriatr Soc 2000; 48:1316-1320.
12. Muszkat M, Greenbaum E, Ben-Yehuda AB, et al. Local and systemic immune response in nursing-home elderly following intranasal or intramuscular immunization with inactivated influenza vaccine. Vaccine 2003; 21:1180-1186. This study emphasizes the importance of mucosal immunity in protection against influenza and raises the question about intranasal influenza vaccination in elderly.
13. Zimmerman RK, Santibanez TA, Fine MJ, et al. Barriers and facilitators of pneumococcal vaccination among the elderly. Vaccine 2003; 21:1510-1517. The importance of physician recommendations for promoting uptake of pneumococcal vaccination is emphasized in this study.
14. Fine M, Smith MA, Carson CA, et al. Efficacy of pneumococcal vaccination in adults. A meta-analysis of randomized controlled trials. Arch Intern Med 1994; 154:2666-2677.
15. Hutchison BG, Oxman AD, Shannon HS, et al. Clinical effectiveness of pneumococcal vaccine. Can Fam Physician 1999; 45:2381-2393.
16. Moore RA, Wiffen PJ, Lipsky BA. Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials. BMC Family Practise 2000; 1(1):1. Epub 2000 Oct 04.
17. Cornu C. Efficacy of pneumococcal polysaccharide vaccine in immunocompetent adults: a meta-analysis of randomized trials. Vaccine 2001; 19:4780-4790.
18. Watson L, Wilson BJ, Waugh N. Pneumococcal polysaccharide vaccine: a systematic review of clinical effectiveness in adults. Vaccine 2003; 20:2166-2173. An excellent summary of the clinical trial evidence for the pneumococcal polysaccharide vaccine.
19. Sisk JE, Moskowitz AJ, Whang W, et al. Cost-effectiveness of vaccination against pneumococcal bacteremia among elderly people. JAMA 1997; 278:1333-1339.
20. Ament A, Baltussen R, Duru G, et al. Cost-effectiveness of pneumococcal vaccination of older people: a study in 5 western European countries. Clin Infect Dis 2000; 31:444-450.
21. Fry AM, Zell ER, Schuchat A, et al. Comparing potential benefits of new polysaccharide vaccine in the elderly. Vaccine 2002; 21:303-311. Interesting paper that compares various hypothetical pneumococcal strategies with the current polysaccharide pneumococcal vaccine in the elderly.
22. http://www.who.int/csr/sara/country/table2003_09_23/en/
23. Ksiazek TG, Erdman D, Goldsmith C, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348:1953-1966.
24. Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 15:1967-1976.
25. Donnelly CA, Ghani AC, Leung GM, et al. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet 2003; 361:1761-1766. Excellent paper summarizing basic epidemiology of SARS, including morbidity and mortality in the elderly.
26. Booth CM, Matukaa LM, Tomlinson GA, et al. Both clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA 2003; 289:2801-2809. Good overview of clinical features of SARS and outcomes in hospitalized patients.
27. Fowler RA, Lapinsky SE, Hallett D, et al. Critically ill patients with severe acute respiratory syndrome. JAMA 2003; 290:367-373. The findings highlight the poor outcome of SARS in the elderly.