27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 11, 2016, Pages L1028-L1041

  Hashimoto, Yuichiro ^a   Sugiura, Hisatoshi ^a   Togo, Shinsaku ^b   Koarai, Akira ^a   Abe, Kyoko ^a   Yamada, Mitsuhiro ^a   Ichikawa, Tomohiro ^c   Kikuchi, Takashi ^c   Numakura, Tadahisa ^a   Onodera, Katsuhiro ^a   Tanaka, Rie ^a   Sato, Kei ^a   Yanagisawa, Satoru ^a   Okazaki, Tatsuma ^a   Tamada, Tsutomu ^a   Kikuchi, Toshiaki ^d   Hoshikawa, Yasushi ^e   Okada, Yoshinori ^e   Ichinose, Masakazu ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

Chronic obstructive pulmonary disease; Oxysterols; Senescence

Indexed keywords

26 HYDROXYCHOLESTEROL; BETA GALACTOSIDASE; CD68 ANTIGEN; CHOLESTANETRIOL 26 MONOOXYGENASE; FIBRONECTIN; NITRIC OXIDE; PROSTAGLANDIN E2; PROSTAGLANDIN G2; PROTEIN P16; PROTEIN P53; REACTIVE NITROGEN SPECIES; VIMENTIN; 27-HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; P16 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

AGED; AIRWAY EPITHELIAL CELL; ARTICLE; CELL AGING; CELL CONTRACTION ASSAY; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LONG TERM EXPOSURE; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROBLAST; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TISSUE REPAIR; WESTERN BLOTTING; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; FIBROBLAST; LUNG; METABOLISM; PATHOLOGY; PHYSIOLOGY;

CELL AGING; CELL LINE; CELL PROLIFERATION; CHOLESTANETRIOL 26-MONOOXYGENASE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; HYDROXYCHOLESTEROLS; LUNG; MACROPHAGES, ALVEOLAR; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE NITROGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84984623453     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00351.2015     Document Type: Article

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