Aging causes a slowing in ciliary beat frequency, mediated by PKCε

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 6, 2014, Pages

  Bailey, K L ^a,b   Bonasera, S J ^b   Wilderdyke, M ^b   Hanisch, B W ^b   Pavlik, J A ^b   DeVasure, J ^b   Robinson, J E ^b   Sisson, J H ^b   Wyatt, T A ^a,b,c  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

DCP LA; Elderly; Innate immunity; Lung; PKC epsilon; Sisson Ammons video analysis (SAVA)

Indexed keywords

8 [2 (2 PENTYLCYCLOPROPYLMETHYL)CYCLOPROPYL]OCTANOIC ACID; PROCATEROL; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG; 8 (2 (2 PENTYL CYCLOPROPYLMETHYL)CYCLOPROPYL)OCTANOIC ACID; 8-(2-(2-PENTYL-CYCLOPROPYLMETHYL)CYCLOPROPYL)OCTANOIC ACID; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; OCTANOIC ACID DERIVATIVE;

AGING; ANIMAL TISSUE; ARTICLE; CAUSE OF DEATH; CILIARY MOTILITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; HIGH RISK POPULATION; HOSPITALIZATION; MOUSE; MUCOCILIARY CLEARANCE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; TRACHEA; AGE; AGED; ANIMAL; ANIMAL MODEL; BAGG ALBINO MOUSE; C57BL MOUSE; DCP-LA; ENZYMOLOGY; EPITHELIUM CELL; EUKARYOTIC FLAGELLUM; INNATE IMMUNITY; LUNG; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PKC EPSILON; SISSON-AMMONS VIDEO ANALYSIS (SAVA), LUNG; Β2 AGONISTS;

DCP-LA; ELDERLY; INNATE IMMUNITY; PKC EPSILON; PNEUMONIA; SISSON-AMMONS VIDEO ANALYSIS (SAVA), LUNG; Β2 AGONISTS;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; AGE FACTORS; AGING; ANIMALS; CAPRYLATES; CILIA; EPITHELIAL CELLS; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, ANIMAL; MUCOCILIARY CLEARANCE; PNEUMONIA; PROCATEROL; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-EPSILON;

EID: 84900034466     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00175.2013     Document Type: Article

References (30)

1. Agius AM, Smallman LA, Pahor AL. Age, smoking and nasal ciliary beat frequency. Clin Otolaryngol Allied Sci 23: 227-230, 1998.
2. Bailey KL, LeVan TD, Yanov DA, Pavlik JA, DeVasure JM, Sisson JH, Wyatt TA. Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase C epsilon. Respir Res 13: 49, 2012.
3. Bailey KL, Poole JA, Mathisen TL, Wyatt TA, Von Essen SG, Romberger DJ. Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium. Am J Physiol Lung Cell Mol Physiol 294: L1049-L1054, 2008.
4. Battaini F, Pascale A. Protein kinase C signal transduction regulation in physiological and pathological aging. Ann NY Acad Sci 1057: 177-192, 2005.
5. Colombo PJ, Wetsel WC, Gallagher M. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Proc Natl Acad Sci USA 94: 14195-14199, 1997.
6. Heron M, Hoyert DL, Murphy SL, Xu J, Kochanek KD, Tejada-Vera B. Deaths: final data for 2006. Natl Vital Stat Rep 57: 1-134, 2009.
7. Ho JC, Chan KN, Hu WH, Lam WK, Zheng L, Tipoe GL, Sun J, Leung R, Tsang KW. The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia. Am J Respir Crit Care Med 163: 983-988, 2001.
8. Jackson ML, Neuzil KM, Thompson WW, Shay DK, Yu O, Hanson CA, Jackson LA. The burden of community-acquired pneumonia in seniors: results of a population-based study. Clin Infect Dis 39: 1642-1650, 2004.
9. Janssens J, Krause K. Pneumonia in the very old. Lancet Infect Dis 4: 112-124, 2004.
10. Joki S, Saano V. Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. Clin Exp Pharmacol Physiol 24: 166-169, 1997.
11. Kelsen SG, Aksoy MO, Brennan K, Ciccolella D, Borbely B. Chronic effects of inhaled albuterol on beta-adrenoceptor system function in human respiratory cells. J Asthma 37: 361-370, 2000.
12. Kochanek KD, Xu J, Murphy SL, Miniño AM, Kung H-C. Deaths: preliminary data for 2009. Natl Vital Stat Rep 59: 1-51, 2011.
13. Kobayashi K, Salathe M, Pratt MM, Cartagena NJ, Soloni F, Seybold ZV, Wanner A. Mechanism of hydrogen peroxide-induced inhibition of sheep airway cilia. Am J Respir Cell Mol Biol 6: 667-673, 1992.
14. Korzick DH, Holiman DA, Boluyt MO, Laughlin MH, Lakatta EG. Diminished β1-adrenergic-mediated contraction and translocation of PKC in senescent rat heart. Am J Physiol Heart Circ Physiol 281: H581-H589, 2001.
15. Kothe H, Bauer T, Marre R, Suttorp N, Welte T, Dalhoff K; Competence Network for Community-Acquired Pneumonia study group. Outcome of community-acquired pneumonia: influence of age, residence status and antimicrobial treatment. Eur Respir J 32: 139-146, 2008.
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T) method. Methods 25: 402-408, 2001.
17. Marston BJ, Plouffe JF, File TM Jr, Hackman BA, Salstrom SJ, Lipman HB, Kolczak MS, Breiman RF. Incidence of communityacquired pneumonia requiring hospitalization. Results of a populationbased active surveillance study in Ohio. The Community-Based Pneumonia Incidence Study Group. Arch Intern Med 157: 1709-1718, 1997.
18. May DS, Kelly JJ, Mendlein JM, Garbe PL. Surveillance of major causes of hospitalization among the elderly, 1988. MMWR CDC Surveill Summ 40: 7-21, 1991.
19. Patterson AJ, Chen M, Xue Q, Xiao D, Zhang L. Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts. Circ Res 107: 365-373, 2010.
20. Puchelle E, Zahm JM, Bertrand A. Influence of age on bronchial mucociliary transport. Scand J Respir Dis 60: 307-313, 1979.
21. Salathe M. Regulation of mammalian ciliary beating. Annu Rev Physiol 69: 401-422, 2007.
22. Sisson JH, Stoner JA, Ammons BA, Wyatt TA. All-digital image capture and whole-field analysis of ciliary beat frequency. J Microsc 211: 103-111, 2003.
23. Slager RE, Sisson JH, Pavlik JA, Johnson JK, Nicolarsen JR, Jerrells TR, Wyatt TA. Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment. Exp Lung Res 32: 349-362, 2006.
24. Svartengren M, Falk R, Philipson K. Long-term clearance from small airways decreases with age. Eur Respir J 26: 609-615, 2005.
25. Whaley SL, Muggenburg BA, Seiler FA, Wolff RK. Effect of aging on tracheal mucociliary clearance in beagle dogs. J Appl Physiol 62: 1331-1334, 1987.
26. Whisler RL, Grants IS. Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells. Mech Ageing Dev 71: 31-46, 1993.
27. Wong LB, Miller IF, Yeates DB. Regulation of ciliary beat frequency by autonomic mechanisms: in vitro. J Appl Physiol 65: 1895-1901, 1988.
28. Wyatt TA, Sisson JH, Allen-Gipson DS, McCaskill ML, Boten JA, Devasure JM, Bailey KL, Poole JA. Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase C epsilon-dependent manner. Am J Pathol 181: 431-440, 2012.
29. Wyatt TA, Slager RE, Devasure J, Auvermann BW, Mulhern ML, Von Essen S, Mathisen T, Floreani AA, Romberger DJ. Feedlot dust stimulation of interleukin-6 and-8 requires protein kinase Ciiin human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 293: L1163-L1170, 2007.
30. Zhang H, Meyer KD, Zhang L. Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring. Biol Reprod 80: 440-448, 2009.