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Volumn 205, Issue , 2005, Pages 60-71

Immunosenescence and macrophage functional plasticity: Dysregulation of macrophage function by age-associated microenvironmental changes

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CATECHOLAMINE; CELL SURFACE RECEPTOR; COMPLEMENT; CYTOKINE; FATTY ACID BINDING PROTEIN; FC RECEPTOR; GAMMA INTERFERON; GLUCOCORTICOID; HISTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTEGRIN; INTERLEUKIN RECEPTOR; LEUKOTRIENE C4; LIGAND; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NUCLEOTIDE BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROSTAGLANDIN E2; SOMATOMEDIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

EID: 20344384993     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2005.00260.x     Document Type: Review
Times cited : (166)

References (192)
  • 2
    • 0029826636 scopus 로고    scopus 로고
    • Antigen-independent changes in naive CD4 T cells with aging
    • Linton PJ, Haynes L, Klinman NR, Swain SL. Antigen-independent changes in naive CD4 T cells with aging. J Exp Med 1996;184: 1891-1900.
    • (1996) J Exp Med , vol.184 , pp. 1891-1900
    • Linton, P.J.1    Haynes, L.2    Klinman, N.R.3    Swain, S.L.4
  • 3
    • 0027380352 scopus 로고
    • Effect of age on the expressed B cell repertoire: Role of B cell subsets
    • Hu A, et al. Effect of age on the expressed B cell repertoire: role of B cell subsets. Int Immunol 1993;5:1035-1039.
    • (1993) Int Immunol , vol.5 , pp. 1035-1039
    • Hu, A.1
  • 4
    • 4444320808 scopus 로고    scopus 로고
    • Ageing, autoimmunity and arthritis: Senescence of the B cell compartment - Implications for humoral immunity
    • Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther 2004;6:131-139.
    • (2004) Arthritis Res Ther , vol.6 , pp. 131-139
    • Johnson, S.A.1    Cambier, J.C.2
  • 6
    • 0033975581 scopus 로고    scopus 로고
    • Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    • Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000;18:1717-1720.
    • (2000) Vaccine , vol.18 , pp. 1717-1720
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 7
    • 2142644403 scopus 로고    scopus 로고
    • Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
    • Haynes L, Eaton SM, Burns EM, Rincon M, Swain SL. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J Immunol 2004;172:5194-5199.
    • (2004) J Immunol , vol.172 , pp. 5194-5199
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Rincon, M.4    Swain, S.L.5
  • 8
    • 0037198015 scopus 로고    scopus 로고
    • The frail elderly: Role of dendritic cells in the susceptibility of infection
    • Uyemura K, Castle SC, Makinodan T. The frail elderly: role of dendritic cells in the susceptibility of infection. Mech Ageing Dev 2002;123:955-962.
    • (2002) Mech Ageing Dev , vol.123 , pp. 955-962
    • Uyemura, K.1    Castle, S.C.2    Makinodan, T.3
  • 9
    • 0346121457 scopus 로고    scopus 로고
    • Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase
    • Garcia GG, Miller RA. Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. Eur J Immunol 2003;33:3464-3472.
    • (2003) Eur J Immunol , vol.33 , pp. 3464-3472
    • Garcia, G.G.1    Miller, R.A.2
  • 11
    • 0030758821 scopus 로고    scopus 로고
    • Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response
    • Unanue ER. Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response. Immunol Rev 1997;158:11-25.
    • (1997) Immunol Rev , vol.158 , pp. 11-25
    • Unanue, E.R.1
  • 14
    • 0036658739 scopus 로고    scopus 로고
    • A novel phenotype for an activated macrophage: The type 2 activated macrophage
    • Anderson CF, Mosser DM. A novel phenotype for an activated macrophage: the type 2 activated macrophage. J Leukoc Biol 2002;72:101-106.
    • (2002) J Leukoc Biol , vol.72 , pp. 101-106
    • Anderson, C.F.1    Mosser, D.M.2
  • 15
    • 0037090186 scopus 로고    scopus 로고
    • Cutting edge: Biasing immune responses by directing antigen to macrophage Fc gamma receptors
    • Anderson CF, Mosser DM. Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors. J Immunol 2002;168:3697-3701.
    • (2002) J Immunol , vol.168 , pp. 3697-3701
    • Anderson, C.F.1    Mosser, D.M.2
  • 16
    • 9244225219 scopus 로고    scopus 로고
    • Are dendritic cells end cells?
    • Shortman K, Wu L. Are dendritic cells end cells? Nat Immunol 2004;5:1105-1106.
    • (2004) Nat Immunol , vol.5 , pp. 1105-1106
    • Shortman, K.1    Wu, L.2
  • 17
    • 9244241059 scopus 로고    scopus 로고
    • Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells
    • Zhang M, et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 2004;5:1124-1133.
    • (2004) Nat Immunol , vol.5 , pp. 1124-1133
    • Zhang, M.1
  • 18
    • 4344595492 scopus 로고    scopus 로고
    • Mechanism of age-associated up-regulation in macrophage PGE2 synthesis
    • Wu D, Meydani SN. Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. Brain Behav Immun 2004;18:487-494.
    • (2004) Brain Behav Immun , vol.18 , pp. 487-494
    • Wu, D.1    Meydani, S.N.2
  • 19
    • 0034671610 scopus 로고    scopus 로고
    • Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes
    • Apolloni E, et al. Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes. J Immunol 2000;165:6723-6730.
    • (2000) J Immunol , vol.165 , pp. 6723-6730
    • Apolloni, E.1
  • 20
    • 0032476615 scopus 로고    scopus 로고
    • Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect
    • Koblish HK, Hunter CA, Wysocka M, Trinchieri G, Lee WM. Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect. J Exp Med 1998;188:1603-1610.
    • (1998) J Exp Med , vol.188 , pp. 1603-1610
    • Koblish, H.K.1    Hunter, C.A.2    Wysocka, M.3    Trinchieri, G.4    Lee, W.M.5
  • 21
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • Bingle L, Brown NJ, Lewis CE. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002;196:254-265.
    • (2002) J Pathol , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 22
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser DM. The many faces of macrophage activation. J Leukoc Biol 2003;73:209-212.
    • (2003) J Leukoc Biol , vol.73 , pp. 209-212
    • Mosser, D.M.1
  • 23
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003;3:23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 24
    • 4344706372 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: Reversible adaptation to changing microenvironments
    • Stout RD, Suttles J. Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J Leukoc Biol 2004;76:509-513.
    • (2004) J Leukoc Biol , vol.76 , pp. 509-513
    • Stout, R.D.1    Suttles, J.2
  • 25
    • 0028855894 scopus 로고
    • IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes
    • Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 1995;96:2304-2310.
    • (1995) J Clin Invest , vol.96 , pp. 2304-2310
    • Lacraz, S.1    Nicod, L.P.2    Chicheportiche, R.3    Welgus, H.G.4    Dayer, J.M.5
  • 27
    • 0035117347 scopus 로고    scopus 로고
    • Effects of interleukin-10 on monocyte/endothelial cell adhesion and MMP-9/TIMP-1 secretion
    • Mostafa ME, et al. Effects of interleukin-10 on monocyte/endothelial cell adhesion and MMP-9/TIMP-1 secretion. Cardiovasc Res 2001;49:882-890.
    • (2001) Cardiovasc Res , vol.49 , pp. 882-890
    • Mostafa, M.E.1
  • 28
    • 2542478053 scopus 로고    scopus 로고
    • Wound healing: An overview of acute, fibrotic and delayed healing
    • Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 2004;9:283-289.
    • (2004) Front Biosci , vol.9 , pp. 283-289
    • Diegelmann, R.F.1    Evans, M.C.2
  • 29
    • 0041427760 scopus 로고    scopus 로고
    • Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    • Lucas M, Stuart LM, Savill J, Lacy-Hulbert A. Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. J Immunol 2003;171:2610-2615.
    • (2003) J Immunol , vol.171 , pp. 2610-2615
    • Lucas, M.1    Stuart, L.M.2    Savill, J.3    Lacy-Hulbert, A.4
  • 30
    • 0035741908 scopus 로고    scopus 로고
    • Alternatively activated antigen-presenting cells: Molecular repertoire, immune regulation, and healing
    • Gratchev A, Schledzewski K, Guillot P, Goerdt S. Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing. Skin Pharmacol Appl Skin Physiol 2001;14:272-279.
    • (2001) Skin Pharmacol Appl Skin Physiol , vol.14 , pp. 272-279
    • Gratchev, A.1    Schledzewski, K.2    Guillot, P.3    Goerdt, S.4
  • 33
    • 9444226987 scopus 로고    scopus 로고
    • Life after corpse engulfment: Phagocytosis of apoptotic cells leads to VEGF secretion and cell growth
    • Golpon HA, et al. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J 2004;18:1716-1718.
    • (2004) FASEB J , vol.18 , pp. 1716-1718
    • Golpon, H.A.1
  • 34
    • 1642536490 scopus 로고    scopus 로고
    • Innate immune discrimination of apoptotic cells: Repression of proinflammatory macrophage transcription is coupled directly to specific recognition
    • Cvetanovic M, Ucker DS. Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition. J Immunol 2004;172:880-889.
    • (2004) J Immunol , vol.172 , pp. 880-889
    • Cvetanovic, M.1    Ucker, D.S.2
  • 35
    • 0343340411 scopus 로고    scopus 로고
    • Balanced macrophage activation hypothesis: A biological model for development of drugs targeted at macrophage functional states
    • McGrath MS, Kodelja V. Balanced macrophage activation hypothesis: a biological model for development of drugs targeted at macrophage functional states. Pathobiology 1999;67:277-281.
    • (1999) Pathobiology , vol.67 , pp. 277-281
    • McGrath, M.S.1    Kodelja, V.2
  • 36
    • 0031974687 scopus 로고    scopus 로고
    • IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
    • Allavena P, et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol 1998;28:359-369.
    • (1998) Eur J Immunol , vol.28 , pp. 359-369
    • Allavena, P.1
  • 37
    • 0032102990 scopus 로고    scopus 로고
    • Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: Competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype
    • Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol 1998;160:5347-5354.
    • (1998) J Immunol , vol.160 , pp. 5347-5354
    • Munder, M.1    Eichmann, K.2    Modolell, M.3
  • 38
    • 0033214545 scopus 로고    scopus 로고
    • Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells
    • Munder M, Eichmann K, Moran JM, Centeno F, Soler G, Modolell M. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol 1999;163:3771-3777.
    • (1999) J Immunol , vol.163 , pp. 3771-3777
    • Munder, M.1    Eichmann, K.2    Moran, J.M.3    Centeno, F.4    Soler, G.5    Modolell, M.6
  • 39
    • 0030272352 scopus 로고    scopus 로고
    • The many roles of CD40 in cell-mediated inflammatory responses
    • Stout RD, Suttles J. The many roles of CD40 in cell-mediated inflammatory responses. Immunol Today 1996;17:487-492.
    • (1996) Immunol Today , vol.17 , pp. 487-492
    • Stout, R.D.1    Suttles, J.2
  • 40
    • 0028586815 scopus 로고
    • Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte IL-1 synthesis
    • Wagner DH, Stout RD, Suttles J. Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte IL-1 synthesis. Eur J Immunol 1994;24:3148-3154.
    • (1994) Eur J Immunol , vol.24 , pp. 3148-3154
    • Wagner, D.H.1    Stout, R.D.2    Suttles, J.3
  • 41
    • 0029848664 scopus 로고    scopus 로고
    • T cell rescue of monocytes from apoptosis: Role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity
    • Suttles J, Evans M, Miller RW, Poe JC, Stout RD, Wahl LM. T cell rescue of monocytes from apoptosis: role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity. J Leukoc Biol 1996;60:651-657.
    • (1996) J Leukoc Biol , vol.60 , pp. 651-657
    • Suttles, J.1    Evans, M.2    Miller, R.W.3    Poe, J.C.4    Stout, R.D.5    Wahl, L.M.6
  • 42
    • 0030028044 scopus 로고    scopus 로고
    • Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice
    • Stout RD, Suttles J, Xu J, Grewal IS, Flavell RA. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J Immunol 1996;156:8-12.
    • (1996) J Immunol , vol.156 , pp. 8-12
    • Stout, R.D.1    Suttles, J.2    Xu, J.3    Grewal, I.S.4    Flavell, R.A.5
  • 43
    • 0028898462 scopus 로고
    • Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1
    • Tian L, Noelle RJ, Lawrence DA. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1. Eur J Immunol 1995;25:306-309.
    • (1995) Eur J Immunol , vol.25 , pp. 306-309
    • Tian, L.1    Noelle, R.J.2    Lawrence, D.A.3
  • 44
    • 0026471895 scopus 로고
    • Tumor necrosis factor alpha stimulates mycobactericidal/ mycobacteriostatic activity in human macrophages by a protein kinase C-independent pathway
    • Bermudez LE, Young LS. Tumor necrosis factor alpha stimulates mycobactericidal/mycobacteriostatic activity in human macrophages by a protein kinase C-independent pathway. Cell Immunol 1992;144:258-268.
    • (1992) Cell Immunol , vol.144 , pp. 258-268
    • Bermudez, L.E.1    Young, L.S.2
  • 45
    • 0028986629 scopus 로고
    • Tumor necrosis factor α rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages
    • Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, Riches DWH. Tumor necrosis factor α rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc Natl Acad Sci USA 1995;92:1614-1618.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1614-1618
    • Winston, B.W.1    Lange-Carter, C.A.2    Gardner, A.M.3    Johnson, G.L.4    Riches, D.W.H.5
  • 46
    • 0029827153 scopus 로고    scopus 로고
    • TNF-alpha-induced regulation and signalling in macrophages
    • Riches DW, Chan ED, Winston BW. TNF-alpha-induced regulation and signalling in macrophages. Immunobiology 1996;195:477-490.
    • (1996) Immunobiology , vol.195 , pp. 477-490
    • Riches, D.W.1    Chan, E.D.2    Winston, B.W.3
  • 47
    • 0031114648 scopus 로고    scopus 로고
    • Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: Role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis
    • Rose DM, et al. Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis. J Immunol 1997;158:3433-3438.
    • (1997) J Immunol , vol.158 , pp. 3433-3438
    • Rose, D.M.1
  • 48
    • 2142762520 scopus 로고    scopus 로고
    • TLRs: Differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression
    • Vogel SN, Fitzgerald KA, Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv 2003;3:466-477.
    • (2003) Mol Interv , vol.3 , pp. 466-477
    • Vogel, S.N.1    Fitzgerald, K.A.2    Fenton, M.J.3
  • 50
    • 0021564388 scopus 로고
    • The cell biology of macrophage activation
    • Adams DO, Hamilton TA. The cell biology of macrophage activation. Ann Rev Immunol 1984;2:283-318.
    • (1984) Ann Rev Immunol , vol.2 , pp. 283-318
    • Adams, D.O.1    Hamilton, T.A.2
  • 51
    • 0023907091 scopus 로고
    • Macrophage mediated tumoricidal activity: Mechanisms of activation and cytotoxicity
    • Drysdale BE, Agaarwal S, Shin HS. Macrophage mediated tumoricidal activity: mechanisms of activation and cytotoxicity. Prog Allergy 1988;40:111-161.
    • (1988) Prog Allergy , vol.40 , pp. 111-161
    • Drysdale, B.E.1    Agaarwal, S.2    Shin, H.S.3
  • 52
    • 0022982147 scopus 로고
    • Gamma-interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressers
    • Collart MA, Belin D, Vassalli J-D, de Kossodo S, Vassalli P. Gamma-interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressers. J Exp Med 1986;164:2113-2118.
    • (1986) J Exp Med , vol.164 , pp. 2113-2118
    • Collart, M.A.1    Belin, D.2    Vassalli, J.-D.3    De Kossodo, S.4    Vassalli, P.5
  • 53
    • 0026805989 scopus 로고
    • The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an 1-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta
    • Gazzinelli RT, Oswald IP, Hieny S, James SL, Sher A. The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an 1-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta. Eur J Immunol 1992;22:2501-2506.
    • (1992) Eur J Immunol , vol.22 , pp. 2501-2506
    • Gazzinelli, R.T.1    Oswald, I.P.2    Hieny, S.3    James, S.L.4    Sher, A.5
  • 54
    • 0001137345 scopus 로고    scopus 로고
    • T cell signaling of macrophage function in inflammatory disease
    • Stout RD, Suttles J. T cell signaling of macrophage function in inflammatory disease. Front Biosci 1997;2:d197-d206.
    • (1997) Front Biosci , vol.2
    • Stout, R.D.1    Suttles, J.2
  • 55
    • 0020502358 scopus 로고
    • Identification of gamma interferon as the lymphokine that activates human macrophage oxidative metabolism and antibacterial activity
    • Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of gamma interferon as the lymphokine that activates human macrophage oxidative metabolism and antibacterial activity. J Exp Med 1983;158:670.
    • (1983) J Exp Med , vol.158 , pp. 670
    • Nathan, C.F.1    Murray, H.W.2    Wiebe, M.E.3    Rubin, B.Y.4
  • 56
    • 0029022703 scopus 로고
    • Superoxide generation by alveolar macrophages from aged rats: Improvement by in vitro treatment with IFN-gamma
    • Hayakawa H, Sato A, Yagi T, Uchiyama H, Ide K, Nakano M. Superoxide generation by alveolar macrophages from aged rats: improvement by in vitro treatment with IFN-gamma. Mech Ageing Dev 1995;80:199-211.
    • (1995) Mech Ageing Dev , vol.80 , pp. 199-211
    • Hayakawa, H.1    Sato, A.2    Yagi, T.3    Uchiyama, H.4    Ide, K.5    Nakano, M.6
  • 57
    • 0342470977 scopus 로고    scopus 로고
    • Alternative versus classical activation of macrophages
    • Goerdt S, et al. Alternative versus classical activation of macrophages. Pathobiology 1999;67:222-226.
    • (1999) Pathobiology , vol.67 , pp. 222-226
    • Goerdt, S.1
  • 58
    • 0025889036 scopus 로고
    • Macrophage deactivation by interleukin 10
    • Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. J Exp Med 1991;174:1549-1555.
    • (1991) J Exp Med , vol.174 , pp. 1549-1555
    • Bogdan, C.1    Vodovotz, Y.2    Nathan, C.3
  • 60
    • 0026700173 scopus 로고
    • Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation
    • Oswald IP, Wynn TA, Sher A, James SL. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Proc Natl Acad Sci USA 1992;89:8676-8680.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8676-8680
    • Oswald, I.P.1    Wynn, T.A.2    Sher, A.3    James, S.L.4
  • 61
    • 0026559756 scopus 로고
    • IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity
    • Oswald IP, Gazzinelli RT, Sher A, James SL. IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol 1992;148:3578-3582.
    • (1992) J Immunol , vol.148 , pp. 3578-3582
    • Oswald, I.P.1    Gazzinelli, R.T.2    Sher, A.3    James, S.L.4
  • 62
    • 0025099266 scopus 로고
    • IL-4 inhibits superoxide production by human mononuclear phagocytes
    • Abramson SL, Gallin JI. IL-4 inhibits superoxide production by human mononuclear phagocytes. J Immunol 1990;144:625-630.
    • (1990) J Immunol , vol.144 , pp. 625-630
    • Abramson, S.L.1    Gallin, J.I.2
  • 63
    • 0026781705 scopus 로고
    • In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation
    • Appelberg R, Orme IM, Pinto de Sousa MI, Silva MT. In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation. Immunology 1992;76:553-559.
    • (1992) Immunology , vol.76 , pp. 553-559
    • Appelberg, R.1    Orme, I.M.2    Pinto De Sousa, M.I.3    Silva, M.T.4
  • 64
    • 0025041133 scopus 로고
    • Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes
    • Cheung DL, Hart PH, Vitti GF, Whitty GA, Hamilton JA. Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes. Immunology 1990;71:70-75.
    • (1990) Immunology , vol.71 , pp. 70-75
    • Cheung, D.L.1    Hart, P.H.2    Vitti, G.F.3    Whitty, G.A.4    Hamilton, J.A.5
  • 65
    • 0000999931 scopus 로고
    • Potential antiinflammatory effects of interleukin 4: Suppression of human monocyte tumor necrosis factor α, interleukin 1 and prostaglandin E2
    • Hart PH, Vitti GF, Burgess DR, Whitty GA, Piccoli DS, Hamilton JA. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor α, interleukin 1 and prostaglandin E2. Proc Natl Acad Sci USA 1989;86:3803-3807.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3803-3807
    • Hart, P.H.1    Vitti, G.F.2    Burgess, D.R.3    Whitty, G.A.4    Piccoli, D.S.5    Hamilton, J.A.6
  • 66
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production
    • D'Andrea A, Ma X, Aste Amezaga M, Paganin C, Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 1995;181:537-546.
    • (1995) J Exp Med , vol.181 , pp. 537-546
    • D'Andrea, A.1    Ma, X.2    Aste Amezaga, M.3    Paganin, C.4    Trinchieri, G.5
  • 67
    • 0033082935 scopus 로고    scopus 로고
    • Other functions, other genes: Alternative activation of antigen-presenting cells
    • Goerdt S, Orfanos CE. Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 1999;10:137-142.
    • (1999) Immunity , vol.10 , pp. 137-142
    • Goerdt, S.1    Orfanos, C.E.2
  • 68
    • 0026762988 scopus 로고
    • Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
    • Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992;176:287-292.
    • (1992) J Exp Med , vol.176 , pp. 287-292
    • Stein, M.1    Keshav, S.2    Harris, N.3    Gordon, S.4
  • 69
    • 0036953476 scopus 로고    scopus 로고
    • Modulating macrophage function with IgG immune complexes
    • Anderson CF, Gerber JS, Mosser DM. Modulating macrophage function with IgG immune complexes. J Endotoxin Res 2002;8:477-481.
    • (2002) J Endotoxin Res , vol.8 , pp. 477-481
    • Anderson, C.F.1    Gerber, J.S.2    Mosser, D.M.3
  • 71
    • 0037218547 scopus 로고    scopus 로고
    • Induction of in vitro reprogramming by Toll-like receptor (TLR) 2 and TLR4 agonists in murine macrophages: Effects of TLR 'homotolerance' versus 'heterotolerance' on NF-kappa B signaling pathway components
    • Dobrovolskaia MA, et al. Induction of in vitro reprogramming by Toll-like receptor (TLR) 2 and TLR4 agonists in murine macrophages: effects of TLR 'homotolerance' versus 'heterotolerance' on NF-kappa B signaling pathway components. J Immunol 2003;170:508-519.
    • (2003) J Immunol , vol.170 , pp. 508-519
    • Dobrovolskaia, M.A.1
  • 72
    • 0036721716 scopus 로고    scopus 로고
    • Shaping gene expression in activated and resting primary macrophages by IL-10
    • Lang R, Patel D, Morris JJ, Rutschman RL, Murray PJ. Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol 2002;169:2253-2263.
    • (2002) J Immunol , vol.169 , pp. 2253-2263
    • Lang, R.1    Patel, D.2    Morris, J.J.3    Rutschman, R.L.4    Murray, P.J.5
  • 73
  • 74
    • 0642367583 scopus 로고    scopus 로고
    • Genetic control of the innate immune response
    • Wells CA, et al. Genetic control of the innate immune response. BMC Immunol 2003;4:5-23.
    • (2003) BMC Immunol , vol.4 , pp. 5-23
    • Wells, C.A.1
  • 75
    • 0036307544 scopus 로고    scopus 로고
    • Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity
    • Elenkov IJ, Chrousos GP. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann NY Acad Sci 2002;966:290-303.
    • (2002) Ann NY Acad Sci , vol.966 , pp. 290-303
    • Elenkov, I.J.1    Chrousos, G.P.2
  • 76
    • 0037107345 scopus 로고    scopus 로고
    • Existence of functional beta1- and beta2-adrenergic receptors on microglia
    • Tanaka KF, Kashima H, Suzuki H, Ono K, Sawada M. Existence of functional beta1- and beta2-adrenergic receptors on microglia. J Neurosci Res 2002;70:232-237.
    • (2002) J Neurosci Res , vol.70 , pp. 232-237
    • Tanaka, K.F.1    Kashima, H.2    Suzuki, H.3    Ono, K.4    Sawada, M.5
  • 77
    • 0035678649 scopus 로고    scopus 로고
    • Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumour necrosis factor-alpha and interleukin-10
    • Zinyama RB, Bancroft GJ, Sigola LB. Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumour necrosis factor-alpha and interleukin-10. Immunology 2001;104:439-446.
    • (2001) Immunology , vol.104 , pp. 439-446
    • Zinyama, R.B.1    Bancroft, G.J.2    Sigola, L.B.3
  • 78
    • 2542487411 scopus 로고    scopus 로고
    • Potential use of drugs that target neural-immune pathways in the treatment of rheumatoid arthritis and other autoimmune diseases
    • Lorton D, Lubahn C, Bellinger DL. Potential use of drugs that target neural-immune pathways in the treatment of rheumatoid arthritis and other autoimmune diseases. Curr Drug Targets Inflamm Allergy 2003;2:1-30.
    • (2003) Curr Drug Targets Inflamm Allergy , vol.2 , pp. 1-30
    • Lorton, D.1    Lubahn, C.2    Bellinger, D.L.3
  • 79
    • 0025017619 scopus 로고
    • Induction of IL-1 release through stimulation of the C3b/C4b complement receptor type one (CR1,CD35) on human monocytes
    • Bacle F, Haeffner-Cavaillon N, Laude M, Couturier C, Kazatchkine MD. Induction of IL-1 release through stimulation of the C3b/C4b complement receptor type one (CR1,CD35) on human monocytes. J Immunol 1990;144:147-152.
    • (1990) J Immunol , vol.144 , pp. 147-152
    • Bacle, F.1    Haeffner-Cavaillon, N.2    Laude, M.3    Couturier, C.4    Kazatchkine, M.D.5
  • 80
    • 0032080865 scopus 로고    scopus 로고
    • Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls
    • Medvedev AE, et al. Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol 1998;160:4535-4542.
    • (1998) J Immunol , vol.160 , pp. 4535-4542
    • Medvedev, A.E.1
  • 81
    • 0028912580 scopus 로고
    • Age-related declines in hematopoietic reserve capacity
    • Lipschitz DA. Age-related declines in hematopoietic reserve capacity. Semin Oncol 1995;22:3-5.
    • (1995) Semin Oncol , vol.22 , pp. 3-5
    • Lipschitz, D.A.1
  • 82
    • 0033521239 scopus 로고    scopus 로고
    • Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis
    • Yuasa T, et al. Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med 1999;189:187-194.
    • (1999) J Exp Med , vol.189 , pp. 187-194
    • Yuasa, T.1
  • 84
    • 0032490575 scopus 로고    scopus 로고
    • Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I
    • Sutterwala FS, Noel GJ, Salgame P, Mosser DM. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med 1998;188:217-222.
    • (1998) J Exp Med , vol.188 , pp. 217-222
    • Sutterwala, F.S.1    Noel, G.J.2    Salgame, P.3    Mosser, D.M.4
  • 85
    • 0029066664 scopus 로고
    • Nitric oxide synthesis in rat peritoneal macrophages is induced by IgE/DNP complexes and cyclic AMP analogues
    • Alonso A, Carvalho J, Alonso-Torre SR, Nunez L, Bosca L, Crespo MS. Nitric oxide synthesis in rat peritoneal macrophages is induced by IgE/DNP complexes and cyclic AMP analogues. J Immunol 1995;154:6475-6483.
    • (1995) J Immunol , vol.154 , pp. 6475-6483
    • Alonso, A.1    Carvalho, J.2    Alonso-Torre, S.R.3    Nunez, L.4    Bosca, L.5    Crespo, M.S.6
  • 86
    • 0028807614 scopus 로고
    • Soluble CD23 directly activates monocytes to contribute to the antigen-independent stimulation of resting T cells
    • Armant M, Rubio M, Delespesse G, Sarfati M. Soluble CD23 directly activates monocytes to contribute to the antigen-independent stimulation of resting T cells. J Immunol 1995;155:4868-4875.
    • (1995) J Immunol , vol.155 , pp. 4868-4875
    • Armant, M.1    Rubio, M.2    Delespesse, G.3    Sarfati, M.4
  • 87
    • 0028030872 scopus 로고
    • Regulation of cytokine production by soluble CD23: Costimulation of interferon-γ secretion and triggering of tumor necrosis factor-α release
    • Armant M, Ishihara H, Rubio M, Delespesse G, Sarfati M. Regulation of cytokine production by soluble CD23: costimulation of interferon-γ secretion and triggering of tumor necrosis factor-α release. J Exp Med 1994;180:1005-1011.
    • (1994) J Exp Med , vol.180 , pp. 1005-1011
    • Armant, M.1    Ishihara, H.2    Rubio, M.3    Delespesse, G.4    Sarfati, M.5
  • 88
    • 3442893287 scopus 로고    scopus 로고
    • Mini-review: The role of peptidoglycan recognition in innate immunity
    • Girardin SE, Philpott DJ. Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol 2004;34: 1777-1782.
    • (2004) Eur J Immunol , vol.34 , pp. 1777-1782
    • Girardin, S.E.1    Philpott, D.J.2
  • 89
    • 5144228220 scopus 로고    scopus 로고
    • The role of Toll-like receptors and Nod proteins in bacterial infection
    • Philpott DJ, Girardin SE. The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol 2004;41: 1099-1108.
    • (2004) Mol Immunol , vol.41 , pp. 1099-1108
    • Philpott, D.J.1    Girardin, S.E.2
  • 90
    • 0242643726 scopus 로고    scopus 로고
    • Detection of peptidoglycans by NOD proteins
    • Royet J, Reichhart JM. Detection of peptidoglycans by NOD proteins. Trends Cell Biol 2003;13:610-614.
    • (2003) Trends Cell Biol , vol.13 , pp. 610-614
    • Royet, J.1    Reichhart, J.M.2
  • 91
    • 0033793133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
    • Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 2000;49:497-505.
    • (2000) Inflamm Res , vol.49 , pp. 497-505
    • Chinetti, G.1    Fruchart, J.C.2    Staels, B.3
  • 92
    • 1042286477 scopus 로고    scopus 로고
    • Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: Effects on lipid homeostasis, inflammation, and atherosclerosis
    • Ricote M, Valledor AF, Glass CK. Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arterioscler Thromb Vasc Biol 2004;24:230-239.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 230-239
    • Ricote, M.1    Valledor, A.F.2    Glass, C.K.3
  • 93
    • 0032737858 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function
    • Ricote M, Huang JT, Welch JS, Glass CK. The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/ macrophage function. J Leukoc Biol 1999;66:733-739.
    • (1999) J Leukoc Biol , vol.66 , pp. 733-739
    • Ricote, M.1    Huang, J.T.2    Welch, J.S.3    Glass, C.K.4
  • 94
    • 0034959752 scopus 로고    scopus 로고
    • Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
    • Makowski L, et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 2001;7:699-705.
    • (2001) Nat Med , vol.7 , pp. 699-705
    • Makowski, L.1
  • 95
    • 4444296764 scopus 로고    scopus 로고
    • Fatty acid binding proteins - The evolutionary crossroads of inflammatory and metabolic responses
    • Makowski L, Hotamisligil GS. Fatty acid binding proteins - the evolutionary crossroads of inflammatory and metabolic responses. J Nutr 2004;134:2464S-2468S.
    • (2004) J Nutr , vol.134
    • Makowski, L.1    Hotamisligil, G.S.2
  • 96
    • 0037011067 scopus 로고    scopus 로고
    • Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation
    • Bellingan GJ, et al. Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med 2002;196:1515-1521.
    • (2002) J Exp Med , vol.196 , pp. 1515-1521
    • Bellingan, G.J.1
  • 97
    • 0030823951 scopus 로고    scopus 로고
    • Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18
    • Lecoanet-Henchoz S, et al. Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18. Eur J Immunol 1997;27:2290-2294.
    • (1997) Eur J Immunol , vol.27 , pp. 2290-2294
    • Lecoanet-Henchoz, S.1
  • 98
    • 0032194101 scopus 로고    scopus 로고
    • Soluble ICAM-1 activates lung macrophages and enhances lung injury
    • Schmal H, et al. Soluble ICAM-1 activates lung macrophages and enhances lung injury. J Immunol 1998;161:3685-3693.
    • (1998) J Immunol , vol.161 , pp. 3685-3693
    • Schmal, H.1
  • 99
    • 0027144465 scopus 로고
    • Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes
    • Geng Y, Zhang B, Lotz M. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J Immunol 1993;151:6692-6700.
    • (1993) J Immunol , vol.151 , pp. 6692-6700
    • Geng, Y.1    Zhang, B.2    Lotz, M.3
  • 100
    • 0033595261 scopus 로고    scopus 로고
    • Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase
    • Huang JT, et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999;400:378-382.
    • (1999) Nature , vol.400 , pp. 378-382
    • Huang, J.T.1
  • 101
    • 2942722569 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP
    • Aronoff DM, Canetti C, Peters-Golden M. Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J Immunol 2004;173:559-565.
    • (2004) J Immunol , vol.173 , pp. 559-565
    • Aronoff, D.M.1    Canetti, C.2    Peters-Golden, M.3
  • 102
    • 4544231848 scopus 로고    scopus 로고
    • Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages
    • Rouzer CA, et al. Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages. J Biol Chem 2004;279:34256-34268.
    • (2004) J Biol Chem , vol.279 , pp. 34256-34268
    • Rouzer, C.A.1
  • 105
    • 85047690709 scopus 로고    scopus 로고
    • Increased CD36 protein as a response to defective insulin signaling in macrophages
    • Liang CP, et al. Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest 2004;113: 764-773.
    • (2004) J Clin Invest , vol.113 , pp. 764-773
    • Liang, C.P.1
  • 106
    • 3142583168 scopus 로고    scopus 로고
    • Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus
    • Hartman ME, O'Connor JC, Godbout JP, Minor KD, Mazzocco VR, Freund GG. Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus. J Biol Chem 2004;279:28045-28050.
    • (2004) J Biol Chem , vol.279 , pp. 28045-28050
    • Hartman, M.E.1    O'Connor, J.C.2    Godbout, J.P.3    Minor, K.D.4    Mazzocco, V.R.5    Freund, G.G.6
  • 107
    • 0034892257 scopus 로고    scopus 로고
    • Functional heterogeneity in liver and lung macrophages
    • Laskin DL, Weinberger B, Laskin JD. Functional heterogeneity in liver and lung macrophages. J Leukoc Biol 2001;70:163-170.
    • (2001) J Leukoc Biol , vol.70 , pp. 163-170
    • Laskin, D.L.1    Weinberger, B.2    Laskin, J.D.3
  • 108
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: A review of function and identification
    • Guillemin GJ, Brew BJ. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 2004;75:388-397.
    • (2004) J Leukoc Biol , vol.75 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 109
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch UK. Microglia as a source and target of cytokines. Glia 2002;40:140-155.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 110
    • 0035576207 scopus 로고    scopus 로고
    • Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: Granulomatous pathology is shaped by the pattern of 1-arginine metabolism
    • Hesse M, et al. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of 1-arginine metabolism. J Immunol 2001;167:6533-6544.
    • (2001) J Immunol , vol.167 , pp. 6533-6544
    • Hesse, M.1
  • 111
    • 0242421851 scopus 로고    scopus 로고
    • IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype
    • Loke P, Nair MG, Parkinson J, Guiliano D, Blaxter M, Allen JE. IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunol 2002;3:7.
    • (2002) BMC Immunol , vol.3 , pp. 7
    • Loke, P.1    Nair, M.G.2    Parkinson, J.3    Guiliano, D.4    Blaxter, M.5    Allen, J.E.6
  • 112
    • 0033825617 scopus 로고    scopus 로고
    • Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact
    • Loke P, MacDonald AS, Robb A, Maizels RM, Allen JE. Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact. Eur J Immunol 2000;30:2669-2678.
    • (2000) Eur J Immunol , vol.30 , pp. 2669-2678
    • Loke, P.1    MacDonald, A.S.2    Robb, A.3    Maizels, R.M.4    Allen, J.E.5
  • 113
  • 114
    • 0035881861 scopus 로고    scopus 로고
    • Functional transitions in macrophages during in vivo infection with Mycobacterium bovis bacillus Calmette-Guerin
    • Hamerman JA, Aderem A. Functional transitions in macrophages during in vivo infection with Mycobacterium bovis bacillus Calmette-Guerin. J Immunol 2001;167:2227-2233.
    • (2001) J Immunol , vol.167 , pp. 2227-2233
    • Hamerman, J.A.1    Aderem, A.2
  • 115
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002;23:549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 116
    • 0027241426 scopus 로고
    • Mechanisms generating functionally heterogeneous macrophages: Chaos revisited
    • Rutherford MS, Witsell A, Schook LB. Mechanisms generating functionally heterogeneous macrophages: chaos revisited. J Leukoc Biol 1993;53:602-618.
    • (1993) J Leukoc Biol , vol.53 , pp. 602-618
    • Rutherford, M.S.1    Witsell, A.2    Schook, L.B.3
  • 117
    • 0026026034 scopus 로고
    • Macrophage heterogeneity occurs through a developmental mechanism
    • Witsell AL, Schook LB. Macrophage heterogeneity occurs through a developmental mechanism. Proc Natl Acad Sci USA 1991;88:1963-1967.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1963-1967
    • Witsell, A.L.1    Schook, L.B.2
  • 118
    • 0029781035 scopus 로고    scopus 로고
    • Development and heterogeneity of macrophages and their related cells through their differentiation pathways
    • Takahashi K, Naito M, Takeya M. Development and heterogeneity of macrophages and their related cells through their differentiation pathways. Pathol Int 1996;46:473-485.
    • (1996) Pathol Int , vol.46 , pp. 473-485
    • Takahashi, K.1    Naito, M.2    Takeya, M.3
  • 119
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003;19:71-82.
    • (2003) Immunity , vol.19 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 120
    • 0030578447 scopus 로고    scopus 로고
    • IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes
    • Kambayashi T, Jacob CO, Strassmann G. IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes. Cell Immunol 1996;171:153-158.
    • (1996) Cell Immunol , vol.171 , pp. 153-158
    • Kambayashi, T.1    Jacob, C.O.2    Strassmann, G.3
  • 121
    • 0345168228 scopus 로고    scopus 로고
    • Neuroscience. Microglia: The enemy within?
    • Kempermann G, Neumann H. Neuroscience. Microglia: the enemy within? Science 2003;302:1689-1690.
    • (2003) Science , vol.302 , pp. 1689-1690
    • Kempermann, G.1    Neumann, H.2
  • 122
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
    • Liu B, Hong JS. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 2003;304:1-7.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 123
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging. An evolutionary perspective on immunosenescence
    • Franceschi C, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000;908:244-254.
    • (2000) Ann NY Acad Sci , vol.908 , pp. 244-254
    • Franceschi, C.1
  • 124
    • 5444244870 scopus 로고    scopus 로고
    • Inflammatory arthropathy: A review of rheumatoid arthritis in older patients
    • Kerr LD. Inflammatory arthropathy: a review of rheumatoid arthritis in older patients. Geriatrics 2004;59:32-35.
    • (2004) Geriatrics , vol.59 , pp. 32-35
    • Kerr, L.D.1
  • 125
    • 4544267426 scopus 로고    scopus 로고
    • Crystal arthritis. Gout and pseudogout in the geriatric patient
    • Cassetta M, Gorevic PD. Crystal arthritis. Gout and pseudogout in the geriatric patient. Geriatrics 2004;59:25-30.
    • (2004) Geriatrics , vol.59 , pp. 25-30
    • Cassetta, M.1    Gorevic, P.D.2
  • 127
    • 1842528400 scopus 로고    scopus 로고
    • Convergence of atherosclerosis and Alzheimer's disease: Inflammation, cholesterol, and misfolded proteins
    • Casserly I, Topol E. Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 2004;363:1139-1146.
    • (2004) Lancet , vol.363 , pp. 1139-1146
    • Casserly, I.1    Topol, E.2
  • 129
    • 0347511004 scopus 로고    scopus 로고
    • Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging
    • Tracy RP. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging. Int J Obes Relat Metab Disord 2003;27:S29-S34.
    • (2003) Int J Obes Relat Metab Disord , vol.27
    • Tracy, R.P.1
  • 130
    • 0031931635 scopus 로고    scopus 로고
    • Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing
    • Ashcroft GS, Horan MA, Ferguson MW. Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest 1998;78:47-58.
    • (1998) Lab Invest , vol.78 , pp. 47-58
    • Ashcroft, G.S.1    Horan, M.A.2    Ferguson, M.W.3
  • 131
    • 0035725929 scopus 로고    scopus 로고
    • Age-related alterations in the inflammatory response to dermal injury
    • Swift ME, Burns AL, Gray KL, DiPietro LA. Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol 2001;117:1027-1035.
    • (2001) J Invest Dermatol , vol.117 , pp. 1027-1035
    • Swift, M.E.1    Burns, A.L.2    Gray, K.L.3    DiPietro, L.A.4
  • 132
    • 0033398390 scopus 로고    scopus 로고
    • Impaired wound repair and delayed angiogenesis in aged mice
    • Swift ME, Kleinman HK, DiPietro LA. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 1999;79:1479-1487.
    • (1999) Lab Invest , vol.79 , pp. 1479-1487
    • Swift, M.E.1    Kleinman, H.K.2    DiPietro, L.A.3
  • 133
    • 0033995803 scopus 로고    scopus 로고
    • Modulation of adherence and chemotaxis of macrophages by norepinephrine. Influence of ageing
    • Ortega E, Garcia JJ, De la FM. Modulation of adherence and chemotaxis of macrophages by norepinephrine. Influence of ageing. Mol Cell Biochem 2000;203:113-117.
    • (2000) Mol Cell Biochem , vol.203 , pp. 113-117
    • Ortega, E.1    Garcia, J.J.2    De La, F.M.3
  • 134
    • 0034880889 scopus 로고    scopus 로고
    • Effect of age on respiratory defense mechanisms: Pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenes
    • Antonini JM, et al. Effect of age on respiratory defense mechanisms: pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenes. Chest 2001;120:240-249.
    • (2001) Chest , vol.120 , pp. 240-249
    • Antonini, J.M.1
  • 135
    • 0027990354 scopus 로고
    • Ageing alters the competence of the immune system to control parasitic infection
    • Albright JW, Albright JF. Ageing alters the competence of the immune system to control parasitic infection. Immunol Lett 1994;40:279-285.
    • (1994) Immunol Lett , vol.40 , pp. 279-285
    • Albright, J.W.1    Albright, J.F.2
  • 136
    • 0025174802 scopus 로고
    • Aging and the response to Salmonella infection
    • Bradley SF, Kauffman CA. Aging and the response to Salmonella infection. Exp Gerontol 1990;25:75-80.
    • (1990) Exp Gerontol , vol.25 , pp. 75-80
    • Bradley, S.F.1    Kauffman, C.A.2
  • 137
    • 0034855409 scopus 로고    scopus 로고
    • Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages
    • Mancuso P, McNish RW, Peters-Golden M, Brock TG. Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages. Mech Ageing Dev 2001;122:1899-1913.
    • (2001) Mech Ageing Dev , vol.122 , pp. 1899-1913
    • Mancuso, P.1    McNish, R.W.2    Peters-Golden, M.3    Brock, T.G.4
  • 138
    • 0025355495 scopus 로고
    • Macrophages but not B cells from aged mice are defective in stimulating autoreactive T cells in vitro
    • Seth A, Nagarkatti M, Nagarkatti PS, Subbarao B, Udhayakumar V. Macrophages but not B cells from aged mice are defective in stimulating autoreactive T cells in vitro. Mech Ageing Dev 1990;52:107-124.
    • (1990) Mech Ageing Dev , vol.52 , pp. 107-124
    • Seth, A.1    Nagarkatti, M.2    Nagarkatti, P.S.3    Subbarao, B.4    Udhayakumar, V.5
  • 139
    • 0029909142 scopus 로고    scopus 로고
    • Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice
    • Garg M, Luo W, Kaplan AM, Bondada S. Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice. Infect Immun 1996;64:4456-4462.
    • (1996) Infect Immun , vol.64 , pp. 4456-4462
    • Garg, M.1    Luo, W.2    Kaplan, A.M.3    Bondada, S.4
  • 140
    • 0021680290 scopus 로고
    • The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis
    • Effros RB, Walford RL. The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis. Cell Immunol 1984;88:531-539.
    • (1984) Cell Immunol , vol.88 , pp. 531-539
    • Effros, R.B.1    Walford, R.L.2
  • 141
    • 0029066952 scopus 로고
    • Abnormalities of B cells and dendritic cells in SAMP1 mice
    • Haruna H, et al. Abnormalities of B cells and dendritic cells in SAMP1 mice. Eur J Immunol 1995;25:1319-1325.
    • (1995) Eur J Immunol , vol.25 , pp. 1319-1325
    • Haruna, H.1
  • 142
    • 0032617861 scopus 로고    scopus 로고
    • Age-related decrease in accessory cell function of human alveolar macrophages
    • Zissel G, Schlaak M, Muller-Quernheim J. Age-related decrease in accessory cell function of human alveolar macrophages. J Invest Med 1999;47:51-56.
    • (1999) J Invest Med , vol.47 , pp. 51-56
    • Zissel, G.1    Schlaak, M.2    Muller-Quernheim, J.3
  • 143
    • 0030890046 scopus 로고    scopus 로고
    • The effects of ageing on wound healing: Immunolocalisation of growth factors and their receptors in a murine incisional model
    • Ashcroft GS, Horan MA, Ferguson MW. The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model. J Anat 1997;190:351-365.
    • (1997) J Anat , vol.190 , pp. 351-365
    • Ashcroft, G.S.1    Horan, M.A.2    Ferguson, M.W.3
  • 144
    • 0033562121 scopus 로고    scopus 로고
    • Macrophage TNF secretion in endotoxin tolerance: Role of SAPK, p38, and MAPK
    • Kraatz J, Clair L, Rodriguez JL, West MA. Macrophage TNF secretion in endotoxin tolerance: role of SAPK, p38, and MAPK. J Surg Res 1999;83:158-164.
    • (1999) J Surg Res , vol.83 , pp. 158-164
    • Kraatz, J.1    Clair, L.2    Rodriguez, J.L.3    West, M.A.4
  • 146
    • 0021843808 scopus 로고
    • Influence of age on the production and regulation of interleukin-1 in mice
    • Inamizu T, Chang MP, Makinodan T. Influence of age on the production and regulation of interleukin-1 in mice. Immunology 1985;55:447-455.
    • (1985) Immunology , vol.55 , pp. 447-455
    • Inamizu, T.1    Chang, M.P.2    Makinodan, T.3
  • 148
    • 0842309938 scopus 로고    scopus 로고
    • Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
    • Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 2004;75:342-349.
    • (2004) J Leukoc Biol , vol.75 , pp. 342-349
    • Boehmer, E.D.1    Goral, J.2    Faunce, D.E.3    Kovacs, E.J.4
  • 149
    • 0033567932 scopus 로고    scopus 로고
    • A defective protein kinase C anchoring system underlying age-associated impairment in TNF-alpha production in rat macrophages
    • Corsini E, et al. A defective protein kinase C anchoring system underlying age-associated impairment in TNF-alpha production in rat macrophages. J Immunol 1999;163:3468-3473.
    • (1999) J Immunol , vol.163 , pp. 3468-3473
    • Corsini, E.1
  • 150
    • 0029022703 scopus 로고
    • Superoxide generation by alveolar macrophages from aged rats: Improvement by in vitro treatment with IFN-gamma
    • Hayakawa H, Sato A, Yagi T, Uchiyama H, Ide K, Nakano M. Superoxide generation by alveolar macrophages from aged rats: improvement by in vitro treatment with IFN-gamma. Mech Ageing Dev 1995;80:199-211.
    • (1995) Mech Ageing Dev , vol.80 , pp. 199-211
    • Hayakawa, H.1    Sato, A.2    Yagi, T.3    Uchiyama, H.4    Ide, K.5    Nakano, M.6
  • 151
    • 0029995022 scopus 로고    scopus 로고
    • Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages
    • Alvarez E, Machado A, Sobrino F, Santa MC. Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages. Cell Immunol 1996;169:152-155.
    • (1996) Cell Immunol , vol.169 , pp. 152-155
    • Alvarez, E.1    Machado, A.2    Sobrino, F.3    Santa, M.C.4
  • 152
    • 0034860328 scopus 로고    scopus 로고
    • Panning T cells on vascular endothelial cell monolayers: A rapid method for enriching naive T cells
    • Hoellman JR, Suttles J, Stout RD. Panning T cells on vascular endothelial cell monolayers: a rapid method for enriching naive T cells. Immunobiology 2001;203:769-777.
    • (2001) Immunobiology , vol.203 , pp. 769-777
    • Hoellman, J.R.1    Suttles, J.2    Stout, R.D.3
  • 153
    • 0030319530 scopus 로고    scopus 로고
    • Effect of aging on the tumoricidal functions of murine peritoneal macrophages
    • Khare V, Sodhi A, Singh SM. Effect of aging on the tumoricidal functions of murine peritoneal macrophages. Nat Immun 1996;15:285-294.
    • (1996) Nat Immun , vol.15 , pp. 285-294
    • Khare, V.1    Sodhi, A.2    Singh, S.M.3
  • 155
    • 0029995022 scopus 로고    scopus 로고
    • Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages
    • Alvarez E, Machado A, Sobrino F, Santa Maria C. Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages. Cell Immunol 1996;169:152-155.
    • (1996) Cell Immunol , vol.169 , pp. 152-155
    • Alvarez, E.1    Machado, A.2    Sobrino, F.3    Santa Maria, C.4
  • 156
    • 0028145440 scopus 로고
    • Effect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolism
    • Ding A, Hwang S, Schwab R. Effect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolism. J Immunol 1994;153:2146-2152.
    • (1994) J Immunol , vol.153 , pp. 2146-2152
    • Ding, A.1    Hwang, S.2    Schwab, R.3
  • 157
    • 0027379466 scopus 로고
    • Respiratory burst reaction changes with age in rat peritoneal macrophages
    • Alvarez E, Santa MC, Machado A. Respiratory burst reaction changes with age in rat peritoneal macrophages. Biochim Biophys Acta 1993;1179:247-252.
    • (1993) Biochim Biophys Acta , vol.1179 , pp. 247-252
    • Alvarez, E.1    Santa, M.C.2    Machado, A.3
  • 158
    • 0029560296 scopus 로고
    • Decrease in free-radical production with age in rat peritoneal macrophages
    • Alvarez E, Conde M, Machado A, Sobrino F, Santa Maria C. Decrease in free-radical production with age in rat peritoneal macrophages. Biochem J 1995;312:555-560.
    • (1995) Biochem J , vol.312 , pp. 555-560
    • Alvarez, E.1    Conde, M.2    Machado, A.3    Sobrino, F.4    Santa Maria, C.5
  • 159
  • 160
    • 0031227764 scopus 로고    scopus 로고
    • Enhanced expression of inducible cyclooxygenase with age in murine macrophages
    • Hayek MG, et al. Enhanced expression of inducible cyclooxygenase with age in murine macrophages. J Immunol 1997;159:2445-2451.
    • (1997) J Immunol , vol.159 , pp. 2445-2451
    • Hayek, M.G.1
  • 161
    • 0031669304 scopus 로고    scopus 로고
    • Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E
    • Wu D, et al. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. Am J Physiol 1998;275:C661-C668.
    • (1998) Am J Physiol , vol.275
    • Wu, D.1
  • 162
    • 0029998281 scopus 로고    scopus 로고
    • Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative
    • Spencer NF, Norton SD, Harrison LL, Li GZ, Daynes RA. Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative. Exp Gerontol 1996;31:393-408.
    • (1996) Exp Gerontol , vol.31 , pp. 393-408
    • Spencer, N.F.1    Norton, S.D.2    Harrison, L.L.3    Li, G.Z.4    Daynes, R.A.5
  • 163
    • 0032722001 scopus 로고    scopus 로고
    • Phenotypic and functional characteristics of circulating monocytes of elderly persons
    • Sadeghi HM, Schnelle JF, Thoma JK, Nishanian P, Fahey JL. Phenotypic and functional characteristics of circulating monocytes of elderly persons. Exp Gerontol 1999;34:959-970.
    • (1999) Exp Gerontol , vol.34 , pp. 959-970
    • Sadeghi, H.M.1    Schnelle, J.F.2    Thoma, J.K.3    Nishanian, P.4    Fahey, J.L.5
  • 164
    • 0842302961 scopus 로고    scopus 로고
    • Macrophage hyporesponsiveness to interferon-gamma in aged mice is associated with impaired signaling through Jak-STAT
    • Yoon P, Keylock KT, Hartman ME, Freund GG, Woods JA. Macrophage hyporesponsiveness to interferon-gamma in aged mice is associated with impaired signaling through Jak-STAT. Mech Ageing Dev 2004;125:137-143.
    • (2004) Mech Ageing Dev , vol.125 , pp. 137-143
    • Yoon, P.1    Keylock, K.T.2    Hartman, M.E.3    Freund, G.G.4    Woods, J.A.5
  • 165
    • 5444232420 scopus 로고    scopus 로고
    • Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior
    • Kohut ML, Senchina DS, Madden KS, Martin AE, Felten DL, Moynihan JA. Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior. Exp Gerontol 2004;39:1347-1360.
    • (2004) Exp Gerontol , vol.39 , pp. 1347-1360
    • Kohut, M.L.1    Senchina, D.S.2    Madden, K.S.3    Martin, A.E.4    Felten, D.L.5    Moynihan, J.A.6
  • 166
    • 0029890517 scopus 로고    scopus 로고
    • Heterogeneous aging of macrophage-lineage cells in the capacity for TNF production and self renewal in C57BL/6 mice
    • Shimada Y, Ito H. Heterogeneous aging of macrophage-lineage cells in the capacity for TNF production and self renewal in C57BL/6 mice. Mech Ageing Dev 1996;87:183-195.
    • (1996) Mech Ageing Dev , vol.87 , pp. 183-195
    • Shimada, Y.1    Ito, H.2
  • 167
    • 0032878394 scopus 로고    scopus 로고
    • Role of the endogenous prostaglandin E2 in human lung fibroblast interleukin-11 production
    • Matsui S, et al. Role of the endogenous prostaglandin E2 in human lung fibroblast interleukin-11 production. Respir Med 1999;93:637-642.
    • (1999) Respir Med , vol.93 , pp. 637-642
    • Matsui, S.1
  • 169
    • 0343052725 scopus 로고    scopus 로고
    • Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras
    • Doria G, Mancini C, Utsuyama M, Frasca D, Hirokawa K. Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras. Mech Ageing Dev 1997;95: 131-142.
    • (1997) Mech Ageing Dev , vol.95 , pp. 131-142
    • Doria, G.1    Mancini, C.2    Utsuyama, M.3    Frasca, D.4    Hirokawa, K.5
  • 170
    • 0033555960 scopus 로고    scopus 로고
    • Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population
    • Timm JA, Thoman ML. Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population. J Immunol 1999;162:711-717.
    • (1999) J Immunol , vol.162 , pp. 711-717
    • Timm, J.A.1    Thoman, M.L.2
  • 171
    • 0031568406 scopus 로고    scopus 로고
    • Development of B cells in aged mice: Decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
    • Stephan RP, Lill-Elghanian DA, Witte PL. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J Immunol 1997;158:1598-1609.
    • (1997) J Immunol , vol.158 , pp. 1598-1609
    • Stephan, R.P.1    Lill-Elghanian, D.A.2    Witte, P.L.3
  • 172
    • 0033991121 scopus 로고    scopus 로고
    • Aging affects the regeneration of the CD8+ T cell compartment in bone marrow transplanted mice
    • Mu XY, Thoman ML. Aging affects the regeneration of the CD8+ T cell compartment in bone marrow transplanted mice. Mech Ageing Dev 2000;112: 113-124.
    • (2000) Mech Ageing Dev , vol.112 , pp. 113-124
    • Mu, X.Y.1    Thoman, M.L.2
  • 173
    • 0031732988 scopus 로고    scopus 로고
    • In vitro secretion of cytokines by human bone marrow: Effects of age and estrogen status
    • Cheleuitte D, Mizuno S, Glowacki J. In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status. J Clin Endocrinol Metab 1998;83: 2043-2051.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2043-2051
    • Cheleuitte, D.1    Mizuno, S.2    Glowacki, J.3
  • 174
    • 0031985281 scopus 로고    scopus 로고
    • Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
    • Stephan RP, Reilly CR, Witte PL. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 1998;91:75-88.
    • (1998) Blood , vol.91 , pp. 75-88
    • Stephan, R.P.1    Reilly, C.R.2    Witte, P.L.3
  • 175
    • 0842303113 scopus 로고    scopus 로고
    • Follicular dendritic cells in aging, a 'bottle-neck' in the humoral immune response
    • Aydar Y, Balogh P, Tew JG, Szakal AK. Follicular dendritic cells in aging, a 'bottle-neck' in the humoral immune response. Ageing Res Rev 2004;3:15-29.
    • (2004) Ageing Res Rev , vol.3 , pp. 15-29
    • Aydar, Y.1    Balogh, P.2    Tew, J.G.3    Szakal, A.K.4
  • 176
    • 0345016411 scopus 로고    scopus 로고
    • Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation
    • Aydar Y, Balogh P, Tew JG, Szakal AK. Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation. J Immunol 2003;171:5975-5987.
    • (2003) J Immunol , vol.171 , pp. 5975-5987
    • Aydar, Y.1    Balogh, P.2    Tew, J.G.3    Szakal, A.K.4
  • 177
    • 0033951305 scopus 로고    scopus 로고
    • Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells
    • Lung TL, Saurwein-Teissl M, Parson W, Schonitzer D, Grubeck-Loebenstein B. Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells. Vaccine 2000;18:1606-1612.
    • (2000) Vaccine , vol.18 , pp. 1606-1612
    • Lung, T.L.1    Saurwein-Teissl, M.2    Parson, W.3    Schonitzer, D.4    Grubeck-Loebenstein, B.5
  • 178
    • 0029793898 scopus 로고    scopus 로고
    • Altered regulation of inducible nitric oxide synthase expression in macrophages from senescent mice
    • Chen LC, Pace JL, Russell SW, Morrison DC. Altered regulation of inducible nitric oxide synthase expression in macrophages from senescent mice. Infect Immun 1996;64:4288-4298.
    • (1996) Infect Immun , vol.64 , pp. 4288-4298
    • Chen, L.C.1    Pace, J.L.2    Russell, S.W.3    Morrison, D.C.4
  • 179
    • 0032968287 scopus 로고    scopus 로고
    • The immune-endocrine loop during aging: Role of growth hormone and insulin-like growth factor-I
    • Burgess W, et al. The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I. Neuroimmunomodulation 1999;6:56-68.
    • (1999) Neuroimmunomodulation , vol.6 , pp. 56-68
    • Burgess, W.1
  • 180
    • 0034253463 scopus 로고    scopus 로고
    • Role of redox-regulated transcription factors in inflammation, aging and age-related diseases
    • Lavrovsky Y, Chatterjee B, Clark RA, Roy AK. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 2000;35:521-532.
    • (2000) Exp Gerontol , vol.35 , pp. 521-532
    • Lavrovsky, Y.1    Chatterjee, B.2    Clark, R.A.3    Roy, A.K.4
  • 181
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    • Poynter ME, Daynes RA. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 1998;273:32833-32841.
    • (1998) J Biol Chem , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 182
    • 0030828307 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappa B in an animal model of aging
    • Spencer NF, Poynter ME, Im SY, Daynes RA. Constitutive activation of NF-kappa B in an animal model of aging. Int Immunol 1997;9:1581-1588.
    • (1997) Int Immunol , vol.9 , pp. 1581-1588
    • Spencer, N.F.1    Poynter, M.E.2    Im, S.Y.3    Daynes, R.A.4
  • 183
    • 0030429462 scopus 로고    scopus 로고
    • Aging, immunity and neuroendocrine hormones
    • Mosley RL. Aging, immunity and neuroendocrine hormones. Adv Neuroimmunol 1996;6:419-432.
    • (1996) Adv Neuroimmunol , vol.6 , pp. 419-432
    • Mosley, R.L.1
  • 184
    • 0001137345 scopus 로고    scopus 로고
    • T cell signaling of macrophage function in inflammatory disease
    • Stout RD, Suttles J. T cell signaling of macrophage function in inflammatory disease. Front Biosci 1997;2:d197-d206.
    • (1997) Front Biosci , vol.2
    • Stout, R.D.1    Suttles, J.2
  • 185
    • 0030064804 scopus 로고    scopus 로고
    • CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages
    • Kennedy MK, et al. CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages. Eur J Immunol 1996;26:370-378.
    • (1996) Eur J Immunol , vol.26 , pp. 370-378
    • Kennedy, M.K.1
  • 186
    • 0026442689 scopus 로고
    • Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity
    • Cox GW, Melillo G, Chattopadhyay U, Mullet D, Fertel RH, Varesio L. Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity. J Immunol 1992;149:3290-3296.
    • (1992) J Immunol , vol.149 , pp. 3290-3296
    • Cox, G.W.1    Melillo, G.2    Chattopadhyay, U.3    Mullet, D.4    Fertel, R.H.5    Varesio, L.6
  • 187
    • 0028172004 scopus 로고
    • TNP-α IFN-γ stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner
    • Leenen PJM, Canono BP, Drevets DA, Voerman JSA, Campbell PA. TNP-α and IFN-γ stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner. J Immunol 1994;153:5141-5147.
    • (1994) J Immunol , vol.153 , pp. 5141-5147
    • Leenen, P.J.M.1    Canono, B.P.2    Drevets, D.A.3    Voerman, J.S.A.4    Campbell, P.A.5
  • 188
    • 0028986629 scopus 로고
    • Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages
    • Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, Riches DW. Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1614-1618
    • Winston, B.W.1    Lange-Carter, C.A.2    Gardner, A.M.3    Johnson, G.L.4    Riches, D.W.5
  • 189
    • 17344368340 scopus 로고    scopus 로고
    • Divergent roles for Fc receptors and complement in vivo
    • Ravetch JV, Clynes RA. Divergent roles for Fc receptors and complement in vivo. Annu Rev Immunol 1998;16:421-432.
    • (1998) Annu Rev Immunol , vol.16 , pp. 421-432
    • Ravetch, J.V.1    Clynes, R.A.2
  • 190
    • 0028036854 scopus 로고
    • Modulation of signaling via the B cell antigen receptor by CD21, the receptor for C3dg and EBV
    • Luxembourg AT, Cooper NR. Modulation of signaling via the B cell antigen receptor by CD21, the receptor for C3dg and EBV. J Immunol 1994;153:4448-4457.
    • (1994) J Immunol , vol.153 , pp. 4448-4457
    • Luxembourg, A.T.1    Cooper, N.R.2
  • 191
    • 0031570942 scopus 로고    scopus 로고
    • The 25-kDa soluble CD23 activates type III constitutive nitric oxide synthase activity via CD11b and CD11c expressed by human monocytes
    • Aubry JP, et al. The 25-kDa soluble CD23 activates type III constitutive nitric oxide synthase activity via CD11b and CD11c expressed by human monocytes. J Immunol 1997;159:614-622.
    • (1997) J Immunol , vol.159 , pp. 614-622
    • Aubry, J.P.1
  • 192
    • 0029806068 scopus 로고    scopus 로고
    • Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production
    • Renier G, Clement I, Desfaits AC, Lambert A. Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production. Endocrinology 1996;137:4611-4618.
    • (1996) Endocrinology , vol.137 , pp. 4611-4618
    • Renier, G.1    Clement, I.2    Desfaits, A.C.3    Lambert, A.4


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