Mechanisms of dysfunction in senescent pulmonary endothelium

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67 A, Issue 3, 2012, Pages 236-241

  Jane Wit, Daniel ^a   Chun, Hyung J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Endothelium

Indexed keywords

NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL; ENDOTHELIUM; HUMAN; LUNG; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY HYPERTENSION; RAT; RESPIRATORY TRACT MUCOSA; REVIEW; SIGNAL TRANSDUCTION; VASCULARIZATION;

AGING; ANIMALS; ENDOTHELIUM; HUMANS; HYPERTENSION, PULMONARY; LUNG; MICE; NITRIC OXIDE; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 84858027120     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr248     Document Type: Article

References (47)

1. Palinski W, Rosenfeld ME, Yla-Herttuala S, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA. 1989;86:1372-1376. (Pubitemid 19061548)
2. Tsimikas S, Brilakis ES, Miller ER, et al. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med. 2005;353:46-57. (Pubitemid 41007806)
3. Sun J, Sukhova GK, Wolters PJ, et al. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007;13:719-724. (Pubitemid 46889760)
4. Ley K, Miller YI, Hedrick CC. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol. 2011;31:1506-1516.
5. Smith E, Prasad KM, Butcher M, et al. Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2010;121:1746-1755.
6. Schulte S, Sukhova GK, Libby P. Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am J Pathol. 2008;172:1500-1508. (Pubitemid 351793344)
7. Folz RJ, Abushamaa AM, Suliman HB. Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. J Clin Invest. 1999;103:1055-1066. (Pubitemid 29169614)
8. Auten RL, O'Reilly MA, Oury TD, Nozik-Grayck E, Whorton MH. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006;290:L32-L40.
9. Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006;34:15-21. (Pubitemid 43032375)
10. Gorina Y, Hoyert D, Lentzner H, Goulding M. Trends in causes of death among older persons in the United States. Aging Trends. 2005;6:1-12.
11. Starr ME, Ueda J, Yamamoto S, Evers BM, Saito H. The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation. Free Radic Biol Med. 2011;50:371-380.
12. Starr ME, Ueda J, Takahashi H, et al. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. Blood. 2010;115:4886-4893.
13. Podlutsky A, Ballabh P, Csiszar A. Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats. Am J Physiol Heart Circ Physiol. 2010;298:H346-H351.
14. Zhang YW, Bi LT, Hou SP, et al. Reduced lung water transport rate associated with downregulation of aquaporin-1 and aquaporin-5 in aged mice. Clin Exp Pharmacol Physiol. 2009;36:734-738.
15. Minneci PC, Deans KJ, Natanson C. Corticosteroid therapy for severe sepsis and septic shock. JAMA. 2009;302:1643; author reply 1644-1645.
16. Rapoport RM, Draznin MB, Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature. 1983;306:174-176. (Pubitemid 14228339)
17. Toporsian M, Gros R, Kabir MG, et al. A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res. 2005;96:684-692. (Pubitemid 40478336)
18. Barbara NP, Wrana JL, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem. 1999;274:584-594.
19. Lastres P, Letamendia A, Zhang H, et al. Endoglin modulates cellular responses to TGF-beta 1. J Cell Biol. 1996;133:1109-1121. (Pubitemid 26172515)
20. Li DY, Sorenson LK, Brooke BS, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-1537.
21. Bourdeau A, Dumont DJ, Letarte M. A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest. 1999;104:1343-1351.
22. Toporsian M, Jerkic M, Zhou YQ, et al. Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia. Arterioscler Thromb Vasc Biol. 2010;30:509-517.
23. Belik J, Jerkic M, McIntyre BA, et al. Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1170-L1178.
24. Hayashi T, Yano K, Matsui-Hirai H, Yokoo H, Hattori Y, Iguchi A. Nitric oxide and endothelial cellular senescence. Pharmacol Ther. 2008;120:333-339.
25. Jakob S, Haendeler J. Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase. Z Gerontol Geriatr. 2007;40:334-338.
26. Rochette PJ, Brash DE. Human telomeres are hypersensitive to UV-induced DNA damage and refractory to repair. PLoS Genet. 2010;6:e1000926.
27. Ramirez R, Carracedo J, Jimenez R, et al. Massive telomere loss is an early event of DNA damage-induced apoptosis. J Biol Chem. 2003;278:836-842. (Pubitemid 36790757)
28. Verdun RE, Karlseder J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell. 2006;127:709-720. (Pubitemid 44716251)
29. Sfeir A, Kosiyatrakul ST, Hockemeyer D, et al. Mammalian telomeres resemble fragile sites and require TRF-1 for efficient replication. Cell. 2009;138:90-103.
30. Martinez P, Thanasoula M, Munoz P, et al. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 2009;23:2060-2075.
31. Gonzalez-Suarez E, Geserick C, Flores JM, Blasco MA. Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. Oncogene. 2005;24:2256-2270. (Pubitemid 40516592)
32. Tomas-Loba A, Flores I, Fernandez-Marcos PJ, et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008;135:609-622.
33. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation. 2002;105:1541-1544. (Pubitemid 34297628)
34. Bode-Boger SM, Martens-Lobenhoffer J, Tager M, Schroder H, Scalera F. Aspirin reduces endothelial cell senescence. Biochem Biophys Res Commun. 2005;334:1226-1232. (Pubitemid 41074705)
35. Misiti S, Nanni S, Fontemaggi G, et al. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol. 2000;20:3764-3771. (Pubitemid 30314476)
36. Ogawa D, Nomiyama T, Nakamachi T, et al. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Circ Res. 2006;98:e50-e59.
37. Haendeler J, Hoffman J, Diehl JF, et al. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res. 94:768-775.
38. Muller AM, Nesslinger M, Skipka G, Muller KM. Expression of CD34 in pulmonary endothelial cells in vivo. Pathobiology. 2002;70:11-17. (Pubitemid 36151548)
39. Kajstura J, Rota M, Hall SR, et al. Evidence for human lung stem cells. N Engl J Med. 364:1795-1806.
40. Mahalingam D, Mita A, Sankhala K, et al. Targeting sarcomas: novel biological agents and future perspectives. Curr Drug Targets. 2009;10:937-949.
41. Toffalini F, Demoulin JB. New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases. Blood. 2010;116:2429-2437.
42. Xia L, Zhu JH, Qiu FY, et al. Senescent endothelial progenitor cells from dogs with pulmonary arterial hypertension: a before-after self-controlled study. J Physiol Sci. 2009;59:429-437.
43. Farkas L, Farkas D, Ask K, et al. VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. J Clin Invest. 2009;119:1298-1311.
44. Yeager ME, Halley GR, Golpon HA, Voelkel NF, Tuder RM. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circ Res. 2001;88:E2-E11.
45. McVerry BJ, Garcia JG. Endothelial cell barrier regulation by sphingosine 1-phosphate. J Cell Biochem. 2004;92:1075-1085. (Pubitemid 44264219)
46. Chandra SM, Razavi H, Kim J, et al. Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2011;31:814-820.
47. Cen Y, Youn DY, Sauve AA. Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications. Curr Med Chem. 2011;18:1919-1935.