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Volumn 94, Issue 10, 2016, Pages 925-934

Immunometabolism and autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FATTY ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; NCF1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG;

EID: 84990990534     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2016.77     Document Type: Review
Times cited : (52)

References (100)
  • 1
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach J. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347: 911-920.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.1
  • 3
    • 84949099597 scopus 로고    scopus 로고
    • Microbe-Associated immunomodulatory metabolites: Influence on T cell fate and function
    • Castro CN, Freitag J, Berod L, Lochner M, Sparwasser T. Microbe-Associated immunomodulatory metabolites: Influence on T cell fate and function. Mol Immunol 2015; 68: 575-584.
    • (2015) Mol Immunol , vol.68 , pp. 575-584
    • Castro, C.N.1    Freitag, J.2    Berod, L.3    Lochner, M.4    Sparwasser, T.5
  • 4
    • 84902657623 scopus 로고    scopus 로고
    • Finding the missing links among metabolites, microbes, and the host
    • Dorrestein PC, Mazmanian SK, Knight R. Finding the missing links among metabolites, microbes, and the host. Immunity 2014; 40: 824-832.
    • (2014) Immunity , vol.40 , pp. 824-832
    • Dorrestein, P.C.1    Mazmanian, S.K.2    Knight, R.3
  • 5
    • 84971201113 scopus 로고    scopus 로고
    • Gut microbiota, metabolites and host immunity
    • Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol 2016; 16: 341-352.
    • (2016) Nat Rev Immunol , vol.16 , pp. 341-352
    • Rooks, M.G.1    Garrett, W.S.2
  • 6
    • 0035283175 scopus 로고    scopus 로고
    • Tolerance and autoimmunity
    • Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med 2001; 344: 655-664.
    • (2001) N Engl J Med , vol.344 , pp. 655-664
    • Kamradt, T.1    Mitchison, N.A.2
  • 7
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
    • Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J ExpMed 2007; 204: 57-63.
    • (2007) J ExpMed , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3    Freyer, J.4    Arnason, J.5    Eberl, G.6
  • 8
    • 84904671611 scopus 로고    scopus 로고
    • Few Foxp3+regulatory T cells are sufficient to protect adult mice from lethal autoimmunity
    • Mayer CT, Ghorbani P, Kühl AA, Stüve P, Hegemann M, Berod L, et al. Few Foxp3+regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Eur J Immunol 2014; 44: 2990-3002.
    • (2014) Eur J Immunol , vol.44 , pp. 2990-3002
    • Mayer, C.T.1    Ghorbani, P.2    Kühl, A.A.3    Stüve, P.4    Hegemann, M.5    Berod, L.6
  • 9
    • 76249088097 scopus 로고    scopus 로고
    • Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    • Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, deRoos P, et al. Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 2009; 183: 7631-7634.
    • (2009) J Immunol , vol.183 , pp. 7631-7634
    • Kim, J.1    Lahl, K.2    Hori, S.3    Loddenkemper, C.4
  • 10
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007; 8: 191-197.
    • (2007) Nat Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 11
  • 12
    • 84964267895 scopus 로고    scopus 로고
    • Fatty acid metabolism in the regulation of T cell function
    • Lochner M, Berod L, Sparwasser T. Fatty acid metabolism in the regulation of T cell function. Trends Immunol 2015; 36: 81-91.
    • (2015) Trends Immunol , vol.36 , pp. 81-91
    • Lochner, M.1    Berod, L.2    Sparwasser, T.3
  • 13
    • 79953172571 scopus 로고    scopus 로고
    • Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol 2011; 186: 3299-3303.
    • (2011) J Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1    Gerriets, V.A.2    Jacobs, S.R.3    Macintyre, A.N.4    MacIver, N.J.5    Mason, E.F.6
  • 14
    • 84861157343 scopus 로고    scopus 로고
    • Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
    • Waickman AT, Powell JD. Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J Immunol 2012; 188: 4721-4729.
    • (2012) J Immunol , vol.188 , pp. 4721-4729
    • Waickman, A.T.1    Powell, J.D.2
  • 15
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2014; 20: 1327-1333.
    • (2014) Nat Med , vol.20 , pp. 1327-1333
    • Berod, L.1    Friedrich, C.2    Nandan, A.3    Freitag, J.4    Hagemann, S.5    Harmrolfs, K.6
  • 18
    • 84876931396 scopus 로고    scopus 로고
    • Beyond oxidative stress: An immunologist's guide to reactive oxygen species
    • Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol 2013; 13: 349-361.
    • (2013) Nat Rev Immunol , vol.13 , pp. 349-361
    • Nathan, C.1    Cunningham-Bussel, A.2
  • 19
    • 84873684726 scopus 로고    scopus 로고
    • Metabolic control of the Treg/Th17 axis
    • Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev 2013; 252: 52-77.
    • (2013) Immunol Rev , vol.252 , pp. 52-77
    • Barbi, J.1    Pardoll, D.2    Pan, F.3
  • 21
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014; 506: 376-381.
    • (2014) Nature , vol.506 , pp. 376-381
    • Okada, Y.1    Wu, D.2    Trynka, G.3    Raj, T.4    Terao, C.5    Ikari, K.6
  • 23
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-2219.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 24
    • 84929023302 scopus 로고    scopus 로고
    • Rheumatoid arthritis therapy reappraisal: Strategies, opportunities and challenges
    • Smolen JS, Aletaha D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 2015; 11: 276-289.
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 276-289
    • Smolen, J.S.1    Aletaha, D.2
  • 25
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007; 87: 245-313.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 26
    • 84901316606 scopus 로고    scopus 로고
    • Cellular mechanisms and physiological consequences of redox-dependent signalling
    • Holmström KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 2014; 15: 411-421.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 411-421
    • Holmström, K.M.1    Finkel, T.2
  • 27
    • 79960286223 scopus 로고    scopus 로고
    • Signal transduction by reactive oxygen species
    • Finkel T. Signal transduction by reactive oxygen species. J Cell Biol 2011; 194: 7-15.
    • (2011) J Cell Biol , vol.194 , pp. 7-15
    • Finkel, T.1
  • 28
    • 84874222253 scopus 로고    scopus 로고
    • Mitochondrial ROS. Fire up T cell activation
    • Murphy MP, Siegel RM, Mitochondrial ROS. fire up T cell activation. Immunity 2013; 38: 201-202.
    • (2013) Immunity , vol.38 , pp. 201-202
    • Murphy, M.P.1    Siegel, R.M.2
  • 29
    • 84874242919 scopus 로고    scopus 로고
    • Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
    • Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 2013; 38: 225-236.
    • (2013) Immunity , vol.38 , pp. 225-236
    • Sena, L.A.1    Li, S.2    Jairaman, A.3    Prakriya, M.4    Ezponda, T.5    Hildeman, D.A.6
  • 30
  • 32
    • 0026571239 scopus 로고
    • Neutrophil stimulation and priming by direct contact with activated human T lymphocytes
    • Zhang JH, Ferrante A, Arrigo AP, Dayer JM. Neutrophil stimulation and priming by direct contact with activated human T lymphocytes. J Immunol 1992; 148: 177-181.
    • (1992) J Immunol , vol.148 , pp. 177-181
    • Zhang, J.H.1    Ferrante, A.2    Arrigo, A.P.3    Dayer, J.M.4
  • 33
    • 84950147039 scopus 로고    scopus 로고
    • Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation
    • Holmdahl R, Sareila O, Olsson LM, Bäckdahl L, Wing K. Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation. Immunol Rev 2016; 269: 228-247.
    • (2016) Immunol Rev , vol.269 , pp. 228-247
    • Holmdahl, R.1    Sareila, O.2    Olsson, L.M.3    Bäckdahl, L.4    Wing, K.5
  • 34
    • 79961123240 scopus 로고    scopus 로고
    • Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
    • Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, Fearon U, et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheum 2011; 63: 2172-2182.
    • (2011) Arthritis Rheum , vol.63 , pp. 2172-2182
    • Biniecka, M.1    Fox, E.2    Gao, W.3    Ng, C.T.4    Veale, D.J.5    Fearon, U.6
  • 35
    • 84857918542 scopus 로고    scopus 로고
    • Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis
    • Harty LC, Biniecka M, O'Sullivan J, Fox E, Mulhall K, Veale DJ, et al. Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis. Ann Rheum Dis 2012; 71: 582-588.
    • (2012) Ann Rheum Dis , vol.71 , pp. 582-588
    • Harty, L.C.1    Biniecka, M.2    O'Sullivan, J.3    Fox, E.4    Mulhall, K.5    Veale, D.J.6
  • 36
    • 84961841635 scopus 로고    scopus 로고
    • Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis
    • 331ra38
    • Yang Z, Shen Y, Oishi H, Matteson EL, Tian L, Goronzy JJ, et al. Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci Transl Med 2016; 8: 331ra38.
    • (2016) Sci Transl Med , vol.8
    • Yang, Z.1    Shen, Y.2    Oishi, H.3    Matteson, E.L.4    Tian, L.5    Goronzy, J.J.6
  • 37
    • 84885448124 scopus 로고    scopus 로고
    • Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
    • Yang Z, Fujii H, Mohan SV, Goronzy JJ, Weyand CM. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J Exp Med 2013; 210: 2119-2134.
    • (2013) J Exp Med , vol.210 , pp. 2119-2134
    • Yang, Z.1    Fujii, H.2    Mohan, S.V.3    Goronzy, J.J.4    Weyand, C.M.5
  • 38
    • 62849106939 scopus 로고    scopus 로고
    • IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
    • Shen L, Zhi L, Hu W, Wu MX. IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ 2009; 16: 603-612.
    • (2009) Cell Death Differ , vol.16 , pp. 603-612
    • Shen, L.1    Zhi, L.2    Hu, W.3    Wu, M.X.4
  • 39
    • 84864800622 scopus 로고    scopus 로고
    • Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
    • Zhi L, Ustyugova IV, Chen X, Zhang Q, Wu MX. Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling. J Immunol 2012; 189: 1639-1647.
    • (2012) J Immunol , vol.189 , pp. 1639-1647
    • Zhi, L.1    Ustyugova, I.V.2    Chen, X.3    Zhang, Q.4    Wu, M.X.5
  • 40
    • 77649260574 scopus 로고    scopus 로고
    • Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): Causes and consequences for immune function, cell survival, and therapeutic intervention
    • Phillips DC, Dias HK, Kitas GD, Griffiths HR. Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention. Antioxid Redox Signal 2010; 12: 743-785.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 743-785
    • Phillips, D.C.1    Dias, H.K.2    Kitas, G.D.3    Griffiths, H.R.4
  • 41
    • 0037331142 scopus 로고    scopus 로고
    • The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species
    • Phillips DC, Woollard KJ, Griffiths HR. The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. Br J Pharmacol 2003; 138: 501-511.
    • (2003) Br J Pharmacol , vol.138 , pp. 501-511
    • Phillips, D.C.1    Woollard, K.J.2    Griffiths, H.R.3
  • 42
    • 34648839997 scopus 로고    scopus 로고
    • Rheumatoid arthritis: The role of reactive oxygen species in disease development and therapeutic strategies
    • Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, et al. Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. Antioxid Redox Signal 2007; 9: 1541-1567.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1541-1567
    • Gelderman, K.A.1    Hultqvist, M.2    Olsson, L.M.3    Bauer, K.4    Pizzolla, A.5    Olofsson, P.6
  • 43
    • 0028893203 scopus 로고
    • Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    • Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, et al. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 1995; 9: 202-209.
    • (1995) Nat Genet , vol.9 , pp. 202-209
    • Pollock, J.D.1    Williams, D.A.2    Gifford, M.A.3    Li, L.L.4    Du, X.5    Fisherman, J.6
  • 44
    • 0037224772 scopus 로고    scopus 로고
    • Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
    • Olofsson P, Holmberg J, Tordsson J, Lu S, Akerström B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 2003; 33: 25-32.
    • (2003) Nat Genet , vol.33 , pp. 25-32
    • Olofsson, P.1    Holmberg, J.2    Tordsson, J.3    Lu, S.4    Akerström, B.5    Holmdahl, R.6
  • 45
    • 0034141543 scopus 로고    scopus 로고
    • Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis
    • Bergsteinsdottir K, Yang HT, Pettersson U, Holmdahl R. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. J Immunol 2000; 164: 1564-1568.
    • (2000) J Immunol , vol.164 , pp. 1564-1568
    • Bergsteinsdottir, K.1    Yang, H.T.2    Pettersson, U.3    Holmdahl, R.4
  • 46
    • 79957475372 scopus 로고    scopus 로고
    • Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats
    • Hultqvist M, Sareila O, Vilhardt F, Norin U, Olsson LM, Olofsson P, et al. Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats. Antioxid Redox Signal 2011; 14: 2373-2383.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2373-2383
    • Hultqvist, M.1    Sareila, O.2    Vilhardt, F.3    Norin, U.4    Olsson, L.M.5    Olofsson, P.6
  • 48
    • 4344591766 scopus 로고    scopus 로고
    • Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
    • Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci USA 2004; 101: 12646-12651.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12646-12651
    • Hultqvist, M.1    Olofsson, P.2    Holmberg, J.3    Bäckström, B.T.4    Tordsson, J.5    Holmdahl, R.6
  • 49
    • 0141648399 scopus 로고    scopus 로고
    • Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models
    • van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts E, Joosten LA, et al. Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am J Pathol 2003; 163: 1525-1537.
    • (2003) Am J Pathol , vol.163 , pp. 1525-1537
    • Van De Loo, F.A.1    Bennink, M.B.2    Arntz, O.J.3    Smeets, R.L.4    Lubberts, E.5    Joosten, L.A.6
  • 50
    • 0028984840 scopus 로고
    • The p47phox mouse knock-out model of chronic granulomatous disease
    • Jackson SH, Gallin JI, Holland SM. The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med 1995; 182: 751-758.
    • (1995) J Exp Med , vol.182 , pp. 751-758
    • Jackson, S.H.1    Gallin, J.I.2    Holland, S.M.3
  • 51
    • 0033795342 scopus 로고    scopus 로고
    • P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+
    • Huang CK, Zhan L, Hannigan MO, Ai Y, Leto TL. P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J Leukoc Biol 2000; 67: 210-215.
    • (2000) J Leukoc Biol , vol.67 , pp. 210-215
    • Huang, C.K.1    Zhan, L.2    Hannigan, M.O.3    Ai, Y.4    Leto, T.L.5
  • 52
    • 84874542636 scopus 로고    scopus 로고
    • Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation
    • Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation. J Leukoc Biol 2013; 93: 427-435.
    • (2013) J Leukoc Biol , vol.93 , pp. 427-435
    • Sareila, O.1    Jaakkola, N.2    Olofsson, P.3    Kelkka, T.4    Holmdahl, R.5
  • 53
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity 2013; 38: 633-643.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 54
    • 84961290082 scopus 로고    scopus 로고
    • Targeting T cell metabolism for therapy
    • O'Sullivan D, Pearce EL. Targeting T cell metabolism for therapy. Trends Immunol 2015; 36: 71-80.
    • (2015) Trends Immunol , vol.36 , pp. 71-80
    • O'Sullivan, D.1    Pearce, E.L.2
  • 57
    • 84926336855 scopus 로고    scopus 로고
    • Role of the innate and adaptive immune responses in the course of multiple sclerosis
    • Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol 2015; 14: 406-419.
    • (2015) Lancet Neurol , vol.14 , pp. 406-419
    • Hemmer, B.1    Kerschensteiner, M.2    Korn, T.3
  • 58
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 60
    • 84857538385 scopus 로고    scopus 로고
    • NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
    • Fischer MT, Sharma R, Lim JL, Haider L, Frischer JM, Drexhage J, et al. NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012; 135: 886-899.
    • (2012) Brain , vol.135 , pp. 886-899
    • Fischer, M.T.1    Sharma, R.2    Lim, J.L.3    Haider, L.4    Frischer, J.M.5    Drexhage, J.6
  • 61
    • 33646493351 scopus 로고    scopus 로고
    • Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis
    • Becanovic K, Jagodic M, Sheng JR, Dahlman I, Aboul-Enein F, Wallstrom E, et al. Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis. J Immunol 2006; 176: 6055-6064.
    • (2006) J Immunol , vol.176 , pp. 6055-6064
    • Becanovic, K.1    Jagodic, M.2    Sheng, J.R.3    Dahlman, I.4    Aboul-Enein, F.5    Wallstrom, E.6
  • 62
    • 41649106850 scopus 로고    scopus 로고
    • Catechin gallates are NADP +-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme
    • Shin ES, Park J, Shin J-M, Cho D, Cho SY, Shin DW, et al. Catechin gallates are NADP +-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorganic & Medicinal Chemistry 2008; 16: 3580-3586.
    • (2008) Bioorganic & Medicinal Chemistry , vol.16 , pp. 3580-3586
    • Shin, E.S.1    Park, J.2    Shin, J.-M.3    Cho, D.4    Cho, S.Y.5    Shin, D.W.6
  • 63
    • 80054087636 scopus 로고    scopus 로고
    • Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation
    • Herges K, Millward JM, Hentschel N, Infante-Duarte C, Aktas O, Zipp F. Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation. PLoS ONE 2011; 6: e25456.
    • (2011) PLoS ONE , vol.6 , pp. e25456
    • Herges, K.1    Millward, J.M.2    Hentschel, N.3    Infante-Duarte, C.4    Aktas, O.5    Zipp, F.6
  • 64
    • 83455258147 scopus 로고    scopus 로고
    • Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets
    • Wang J, Ren Z, Xu Y, Xiao S, Meydani SN, Wu D. Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets. The American Journal of Pathology 2012; 180: 221-234.
    • (2012) The American Journal of Pathology , vol.180 , pp. 221-234
    • Wang, J.1    Ren, Z.2    Xu, Y.3    Xiao, S.4    Meydani, S.N.5    Wu, D.6
  • 66
    • 0842308729 scopus 로고    scopus 로고
    • Unraveling the multiple roles of leptin in inflammation and autoimmunity
    • La Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 2004; 82: 4-11.
    • (2004) J Mol Med , vol.82 , pp. 4-11
    • La Cava, A.1    Alviggi, C.2    Matarese, G.3
  • 68
    • 17044381726 scopus 로고    scopus 로고
    • Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells
    • Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci USA 2005; 102: 5150-5155.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5150-5155
    • Matarese, G.1    Carrieri, P.B.2    La Cava, A.3    Perna, F.4    Sanna, V.5    De Rosa, V.6
  • 70
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010; 33: 929-941.
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1    De Rosa, V.2    Galgani, M.3    Abanni, L.4    Calì, G.5    Porcellini, A.6
  • 71
    • 0034843181 scopus 로고    scopus 로고
    • Why is L-glutamine metabolism important to cells of the immune system in health, postinjury surgery or infection?
    • Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr 2001; 131: 2515S-2522S.
    • (2001) J Nutr , vol.131 , pp. 2515S-2522S
    • Newsholme, P.1
  • 72
    • 0043025561 scopus 로고    scopus 로고
    • Excitatory amino acids and multiple sclerosis: Evidence from cerebrospinal fluid
    • Sarchielli P, Greco L, Floridi A, Floridi A, Gallai V. Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid. Arch Neurol 2003; 60: 1082-1088.
    • (2003) Arch Neurol , vol.60 , pp. 1082-1088
    • Sarchielli, P.1    Greco, L.2    Floridi, A.3    Floridi, A.4    Gallai, V.5
  • 73
    • 84876271669 scopus 로고    scopus 로고
    • Increased concentrations of glutamate and glutamine in normal-Appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans
    • Tisell A, Leinhard OD, Warntjes JB, Aalto A, Smedby O, Landtblom AM, et al. Increased concentrations of glutamate and glutamine in normal-Appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans. PLoS One 2013; 8: e61817.
    • (2013) PLoS One , vol.8 , pp. e61817
    • Tisell, A.1    Leinhard, O.D.2    Warntjes, J.B.3    Aalto, A.4    Smedby, O.5    Landtblom, A.M.6
  • 74
    • 0033958462 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in a model of multiple sclerosis
    • Pitt D, Werner P, Raine CS. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 2000; 6: 67-70.
    • (2000) Nat Med , vol.6 , pp. 67-70
    • Pitt, D.1    Werner, P.2    Raine, C.S.3
  • 75
    • 84900440370 scopus 로고    scopus 로고
    • Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
    • Nakaya M, Xiao Y, Zhou X, Chang J-H, Chang M, Cheng X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity 2014; 40: 692-705.
    • (2014) Immunity , vol.40 , pp. 692-705
    • Nakaya, M.1    Xiao, Y.2    Zhou, X.3    Chang, J.-H.4    Chang, M.5    Cheng, X.6
  • 76
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, DA C. Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 2013; 14: 500-508.
    • (2013) Nat Immunol , vol.14 , pp. 500-508
    • Sinclair, L.V.1    Rolf, J.2    Emslie, E.3    Shi, Y.B.4    Taylor, P.M.5
  • 79
    • 0029072626 scopus 로고
    • Short-Term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders
    • De Stefano N, Matthews PM, Phil D, Ford B, Genge A, Karpati G, et al. Short-Term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders. Neurology 1995; 45: 1193-1198.
    • (1995) Neurology , vol.45 , pp. 1193-1198
    • De Stefano, N.1    Matthews, P.M.2    Phil, D.3    Ford, B.4    Genge, A.5    Karpati, G.6
  • 80
    • 33646830260 scopus 로고    scopus 로고
    • Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
    • Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell EM, et al. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 2006; 117: 1519-1531.
    • (2006) Pediatrics , vol.117 , pp. 1519-1531
    • Stacpoole, P.W.1    Kerr, D.S.2    Barnes, C.3    Bunch, S.T.4    Carney, P.R.5    Fennell, E.M.6
  • 81
    • 0037038402 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef S, Stüve O, Patarroyo JC, Ruiz PJ, Radosevich JL, Hur EM, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002; 420: 78-84.
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.1    Stüve, O.2    Patarroyo, J.C.3    Ruiz, P.J.4    Radosevich, J.L.5    Hur, E.M.6
  • 82
    • 84886547277 scopus 로고    scopus 로고
    • Statins as modulators of regulatory T-cell biology
    • Forero-Peña DA, Gutierrez FR. Statins as modulators of regulatory T-cell biology. Mediators Inflamm 2013; 2013: 167086.
    • (2013) Mediators Inflamm , vol.2013 , pp. 167086
    • Forero-Peña, D.A.1    Gutierrez, F.R.2
  • 83
    • 84860723016 scopus 로고    scopus 로고
    • Randomized controlled trial of atorvastatin in clinically isolated syndrome: The STAyCIS study
    • Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, et al. Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study. Neurology 2012; 78: 1171-1178.
    • (2012) Neurology , vol.78 , pp. 1171-1178
    • Waubant, E.1    Pelletier, D.2    Mass, M.3    Cohen, J.A.4    Kita, M.5    Cross, A.6
  • 84
    • 84875432419 scopus 로고    scopus 로고
    • Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
    • Herold KC, Vignali DAA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 2013; 13: 243-256.
    • (2013) Nat Rev Immunol , vol.13 , pp. 243-256
    • Herold, K.C.1    Vignali, D.A.A.2    Cooke, A.3    Bluestone, J.A.4
  • 86
    • 75949129400 scopus 로고    scopus 로고
    • Protein and energy metabolism in type 1 diabetes
    • Hebert SL, Nair KS. Protein and energy metabolism in type 1 diabetes. Clin Nutr 2010; 29: 13-17.
    • (2010) Clin Nutr , vol.29 , pp. 13-17
    • Hebert, S.L.1    Nair, K.S.2
  • 89
    • 84908670728 scopus 로고    scopus 로고
    • Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice
    • Malaguti C, La Guardia PG, Leite AC, Oliveira DN, de Lima Zollner RL, Catharino RR, et al. Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice. Free Radic Res 2014; 48: 1494-1504.
    • (2014) Free Radic Res , vol.48 , pp. 1494-1504
    • Malaguti, C.1    La Guardia, P.G.2    Leite, A.C.3    Oliveira, D.N.4    De Lima Zollner, R.L.5    Catharino, R.R.6
  • 90
    • 78149485627 scopus 로고    scopus 로고
    • NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity
    • Tse HM, Thayer TC, Steele C, Cuda CM, Morel L, Piganelli JD, et al. NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. J Immunol 2010; 185: 5247-5258.
    • (2010) J Immunol , vol.185 , pp. 5247-5258
    • Tse, H.M.1    Thayer, T.C.2    Steele, C.3    Cuda, C.M.4    Morel, L.5    Piganelli, J.D.6
  • 91
    • 0033992422 scopus 로고    scopus 로고
    • Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide
    • Ichikawa M, Koh CS, Inoue A, Tsuyusaki J, Yamazaki M, Inaba Y, et al. Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide. J Neuroimmunol 2000; 102: 56-66.
    • (2000) J Neuroimmunol , vol.102 , pp. 56-66
    • Ichikawa, M.1    Koh, C.S.2    Inoue, A.3    Tsuyusaki, J.4    Yamazaki, M.5    Inaba, Y.6
  • 92
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74: 1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 93
    • 84962144532 scopus 로고    scopus 로고
    • Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in Type 1 Diabetes
    • Padgett LE, Anderson B, Liu C, Ganini D, Mason RP, Piganelli JD, et al. Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in Type 1 Diabetes. Diabetes 2015; 64: 4171-4183.
    • (2015) Diabetes , vol.64 , pp. 4171-4183
    • Padgett, L.E.1    Anderson, B.2    Liu, C.3    Ganini, D.4    Mason, R.P.5    Piganelli, J.D.6
  • 94
    • 59649105735 scopus 로고    scopus 로고
    • Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
    • Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008; 205: 2975-2984.
    • (2008) J Exp Med , vol.205 , pp. 2975-2984
    • Oresic, M.1    Simell, S.2    Sysi-Aho, M.3    Näntö-Salonen, K.4    Seppänen-Laakso, T.5    Parikka, V.6
  • 95
    • 6344285328 scopus 로고    scopus 로고
    • Gamma-Aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model
    • Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. Gamma-Aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol 2004; 173: 5298-5304.
    • (2004) J Immunol , vol.173 , pp. 5298-5304
    • Tian, J.1    Lu, Y.2    Zhang, H.3    Chau, C.H.4    Dang, H.N.5    Kaufman, D.L.6
  • 97
    • 84885419055 scopus 로고    scopus 로고
    • GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone
    • Prud'homme GJ, Glinka Y, Hasilo C, Paraskevas S, Li X, Wang Q. GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. Transplantation 2013; 96: 616-623.
    • (2013) Transplantation , vol.96 , pp. 616-623
    • Prud'Homme, G.J.1    Glinka, Y.2    Hasilo, C.3    Paraskevas, S.4    Li, X.5    Wang, Q.6
  • 99
    • 84941260909 scopus 로고    scopus 로고
    • Immunological GABAergic interactions and therapeutic applications in autoimmune diseases
    • Prud'homme GJ, Glinka Y, Qinghua Wang. Immunological GABAergic interactions and therapeutic applications in autoimmune diseases. Autoimmunity Reviews 2015; 14: 1048-1056.
    • (2015) Autoimmunity Reviews , vol.14 , pp. 1048-1056
    • Prud'Homme, G.J.1    Glinka, Y.2    Qinghua, W.3
  • 100
    • 84866545697 scopus 로고    scopus 로고
    • P40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation
    • Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, Terhorst C, et al. p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol 2012; 89: 3631-3640.
    • (2012) J Immunol , vol.89 , pp. 3631-3640
    • Conway, K.L.1    Goel, G.2    Sokol, H.3    Manocha, M.4    Mizoguchi, E.5    Terhorst, C.6


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