-
1
-
-
0037136537
-
The effect of infections on susceptibility to autoimmune and allergic diseases
-
Bach J. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347: 911-920.
-
(2002)
N Engl J Med
, vol.347
, pp. 911-920
-
-
Bach, J.1
-
3
-
-
84949099597
-
Microbe-Associated immunomodulatory metabolites: Influence on T cell fate and function
-
Castro CN, Freitag J, Berod L, Lochner M, Sparwasser T. Microbe-Associated immunomodulatory metabolites: Influence on T cell fate and function. Mol Immunol 2015; 68: 575-584.
-
(2015)
Mol Immunol
, vol.68
, pp. 575-584
-
-
Castro, C.N.1
Freitag, J.2
Berod, L.3
Lochner, M.4
Sparwasser, T.5
-
4
-
-
84902657623
-
Finding the missing links among metabolites, microbes, and the host
-
Dorrestein PC, Mazmanian SK, Knight R. Finding the missing links among metabolites, microbes, and the host. Immunity 2014; 40: 824-832.
-
(2014)
Immunity
, vol.40
, pp. 824-832
-
-
Dorrestein, P.C.1
Mazmanian, S.K.2
Knight, R.3
-
5
-
-
84971201113
-
Gut microbiota, metabolites and host immunity
-
Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol 2016; 16: 341-352.
-
(2016)
Nat Rev Immunol
, vol.16
, pp. 341-352
-
-
Rooks, M.G.1
Garrett, W.S.2
-
7
-
-
33846423147
-
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
-
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J ExpMed 2007; 204: 57-63.
-
(2007)
J ExpMed
, vol.204
, pp. 57-63
-
-
Lahl, K.1
Loddenkemper, C.2
Drouin, C.3
Freyer, J.4
Arnason, J.5
Eberl, G.6
-
8
-
-
84904671611
-
Few Foxp3+regulatory T cells are sufficient to protect adult mice from lethal autoimmunity
-
Mayer CT, Ghorbani P, Kühl AA, Stüve P, Hegemann M, Berod L, et al. Few Foxp3+regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Eur J Immunol 2014; 44: 2990-3002.
-
(2014)
Eur J Immunol
, vol.44
, pp. 2990-3002
-
-
Mayer, C.T.1
Ghorbani, P.2
Kühl, A.A.3
Stüve, P.4
Hegemann, M.5
Berod, L.6
-
9
-
-
76249088097
-
Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
-
Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, deRoos P, et al. Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 2009; 183: 7631-7634.
-
(2009)
J Immunol
, vol.183
, pp. 7631-7634
-
-
Kim, J.1
Lahl, K.2
Hori, S.3
Loddenkemper, C.4
-
10
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007; 8: 191-197.
-
(2007)
Nat Immunol.
, vol.8
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
12
-
-
84964267895
-
Fatty acid metabolism in the regulation of T cell function
-
Lochner M, Berod L, Sparwasser T. Fatty acid metabolism in the regulation of T cell function. Trends Immunol 2015; 36: 81-91.
-
(2015)
Trends Immunol
, vol.36
, pp. 81-91
-
-
Lochner, M.1
Berod, L.2
Sparwasser, T.3
-
13
-
-
79953172571
-
Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol 2011; 186: 3299-3303.
-
(2011)
J Immunol
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
Gerriets, V.A.2
Jacobs, S.R.3
Macintyre, A.N.4
MacIver, N.J.5
Mason, E.F.6
-
14
-
-
84861157343
-
Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
-
Waickman AT, Powell JD. Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J Immunol 2012; 188: 4721-4729.
-
(2012)
J Immunol
, vol.188
, pp. 4721-4729
-
-
Waickman, A.T.1
Powell, J.D.2
-
15
-
-
84922080059
-
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
-
Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2014; 20: 1327-1333.
-
(2014)
Nat Med
, vol.20
, pp. 1327-1333
-
-
Berod, L.1
Friedrich, C.2
Nandan, A.3
Freitag, J.4
Hagemann, S.5
Harmrolfs, K.6
-
17
-
-
84938772588
-
Metabolic signatures linked to macrophage polarization: From glucose metabolism to oxidative phosphorylation
-
Boscá L, González-Ramos S, Prieto P, Fernández-Velasco M, Mojena M, Martín-Sanz P, et al. Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation. Biochem Soc Trans 2015; 43: 740-744.
-
(2015)
Biochem Soc Trans
, vol.43
, pp. 740-744
-
-
Boscá, L.1
González-Ramos, S.2
Prieto, P.3
Fernández-Velasco, M.4
Mojena, M.5
Martín-Sanz, P.6
-
18
-
-
84876931396
-
Beyond oxidative stress: An immunologist's guide to reactive oxygen species
-
Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol 2013; 13: 349-361.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 349-361
-
-
Nathan, C.1
Cunningham-Bussel, A.2
-
19
-
-
84873684726
-
Metabolic control of the Treg/Th17 axis
-
Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev 2013; 252: 52-77.
-
(2013)
Immunol Rev
, vol.252
, pp. 52-77
-
-
Barbi, J.1
Pardoll, D.2
Pan, F.3
-
21
-
-
84894288992
-
Genetics of rheumatoid arthritis contributes to biology and drug discovery
-
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014; 506: 376-381.
-
(2014)
Nature
, vol.506
, pp. 376-381
-
-
Okada, Y.1
Wu, D.2
Trynka, G.3
Raj, T.4
Terao, C.5
Ikari, K.6
-
23
-
-
84855172814
-
The pathogenesis of rheumatoid arthritis
-
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-2219.
-
(2011)
N Engl J Med
, vol.365
, pp. 2205-2219
-
-
McInnes, I.B.1
Schett, G.2
-
24
-
-
84929023302
-
Rheumatoid arthritis therapy reappraisal: Strategies, opportunities and challenges
-
Smolen JS, Aletaha D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 2015; 11: 276-289.
-
(2015)
Nat Rev Rheumatol
, vol.11
, pp. 276-289
-
-
Smolen, J.S.1
Aletaha, D.2
-
25
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007; 87: 245-313.
-
(2007)
Physiol Rev
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
26
-
-
84901316606
-
Cellular mechanisms and physiological consequences of redox-dependent signalling
-
Holmström KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 2014; 15: 411-421.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 411-421
-
-
Holmström, K.M.1
Finkel, T.2
-
27
-
-
79960286223
-
Signal transduction by reactive oxygen species
-
Finkel T. Signal transduction by reactive oxygen species. J Cell Biol 2011; 194: 7-15.
-
(2011)
J Cell Biol
, vol.194
, pp. 7-15
-
-
Finkel, T.1
-
28
-
-
84874222253
-
Mitochondrial ROS. Fire up T cell activation
-
Murphy MP, Siegel RM, Mitochondrial ROS. fire up T cell activation. Immunity 2013; 38: 201-202.
-
(2013)
Immunity
, vol.38
, pp. 201-202
-
-
Murphy, M.P.1
Siegel, R.M.2
-
29
-
-
84874242919
-
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
-
Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 2013; 38: 225-236.
-
(2013)
Immunity
, vol.38
, pp. 225-236
-
-
Sena, L.A.1
Li, S.2
Jairaman, A.3
Prakriya, M.4
Ezponda, T.5
Hildeman, D.A.6
-
30
-
-
84874266256
-
New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation
-
Pelletier M, Lepow TS, Billingham LK, Murphy MP, Siegel RM. New tricks from an old dog: mitochondrial redox signaling in cellular inflammation. Semin Immunol 2012; 24: 384-392.
-
(2012)
Semin Immunol
, vol.24
, pp. 384-392
-
-
Pelletier, M.1
Lepow, T.S.2
Billingham, L.K.3
Murphy, M.P.4
Siegel, R.M.5
-
32
-
-
0026571239
-
Neutrophil stimulation and priming by direct contact with activated human T lymphocytes
-
Zhang JH, Ferrante A, Arrigo AP, Dayer JM. Neutrophil stimulation and priming by direct contact with activated human T lymphocytes. J Immunol 1992; 148: 177-181.
-
(1992)
J Immunol
, vol.148
, pp. 177-181
-
-
Zhang, J.H.1
Ferrante, A.2
Arrigo, A.P.3
Dayer, J.M.4
-
33
-
-
84950147039
-
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation
-
Holmdahl R, Sareila O, Olsson LM, Bäckdahl L, Wing K. Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation. Immunol Rev 2016; 269: 228-247.
-
(2016)
Immunol Rev
, vol.269
, pp. 228-247
-
-
Holmdahl, R.1
Sareila, O.2
Olsson, L.M.3
Bäckdahl, L.4
Wing, K.5
-
34
-
-
79961123240
-
Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
-
Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, Fearon U, et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheum 2011; 63: 2172-2182.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 2172-2182
-
-
Biniecka, M.1
Fox, E.2
Gao, W.3
Ng, C.T.4
Veale, D.J.5
Fearon, U.6
-
35
-
-
84857918542
-
Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis
-
Harty LC, Biniecka M, O'Sullivan J, Fox E, Mulhall K, Veale DJ, et al. Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis. Ann Rheum Dis 2012; 71: 582-588.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 582-588
-
-
Harty, L.C.1
Biniecka, M.2
O'Sullivan, J.3
Fox, E.4
Mulhall, K.5
Veale, D.J.6
-
36
-
-
84961841635
-
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis
-
331ra38
-
Yang Z, Shen Y, Oishi H, Matteson EL, Tian L, Goronzy JJ, et al. Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci Transl Med 2016; 8: 331ra38.
-
(2016)
Sci Transl Med
, vol.8
-
-
Yang, Z.1
Shen, Y.2
Oishi, H.3
Matteson, E.L.4
Tian, L.5
Goronzy, J.J.6
-
37
-
-
84885448124
-
Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
-
Yang Z, Fujii H, Mohan SV, Goronzy JJ, Weyand CM. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J Exp Med 2013; 210: 2119-2134.
-
(2013)
J Exp Med
, vol.210
, pp. 2119-2134
-
-
Yang, Z.1
Fujii, H.2
Mohan, S.V.3
Goronzy, J.J.4
Weyand, C.M.5
-
38
-
-
62849106939
-
IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
-
Shen L, Zhi L, Hu W, Wu MX. IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ 2009; 16: 603-612.
-
(2009)
Cell Death Differ
, vol.16
, pp. 603-612
-
-
Shen, L.1
Zhi, L.2
Hu, W.3
Wu, M.X.4
-
39
-
-
84864800622
-
Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
-
Zhi L, Ustyugova IV, Chen X, Zhang Q, Wu MX. Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling. J Immunol 2012; 189: 1639-1647.
-
(2012)
J Immunol
, vol.189
, pp. 1639-1647
-
-
Zhi, L.1
Ustyugova, I.V.2
Chen, X.3
Zhang, Q.4
Wu, M.X.5
-
40
-
-
77649260574
-
Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): Causes and consequences for immune function, cell survival, and therapeutic intervention
-
Phillips DC, Dias HK, Kitas GD, Griffiths HR. Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention. Antioxid Redox Signal 2010; 12: 743-785.
-
(2010)
Antioxid Redox Signal
, vol.12
, pp. 743-785
-
-
Phillips, D.C.1
Dias, H.K.2
Kitas, G.D.3
Griffiths, H.R.4
-
41
-
-
0037331142
-
The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species
-
Phillips DC, Woollard KJ, Griffiths HR. The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. Br J Pharmacol 2003; 138: 501-511.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 501-511
-
-
Phillips, D.C.1
Woollard, K.J.2
Griffiths, H.R.3
-
42
-
-
34648839997
-
Rheumatoid arthritis: The role of reactive oxygen species in disease development and therapeutic strategies
-
Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, et al. Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. Antioxid Redox Signal 2007; 9: 1541-1567.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 1541-1567
-
-
Gelderman, K.A.1
Hultqvist, M.2
Olsson, L.M.3
Bauer, K.4
Pizzolla, A.5
Olofsson, P.6
-
43
-
-
0028893203
-
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
-
Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, et al. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 1995; 9: 202-209.
-
(1995)
Nat Genet
, vol.9
, pp. 202-209
-
-
Pollock, J.D.1
Williams, D.A.2
Gifford, M.A.3
Li, L.L.4
Du, X.5
Fisherman, J.6
-
44
-
-
0037224772
-
Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
-
Olofsson P, Holmberg J, Tordsson J, Lu S, Akerström B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 2003; 33: 25-32.
-
(2003)
Nat Genet
, vol.33
, pp. 25-32
-
-
Olofsson, P.1
Holmberg, J.2
Tordsson, J.3
Lu, S.4
Akerström, B.5
Holmdahl, R.6
-
45
-
-
0034141543
-
Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis
-
Bergsteinsdottir K, Yang HT, Pettersson U, Holmdahl R. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. J Immunol 2000; 164: 1564-1568.
-
(2000)
J Immunol
, vol.164
, pp. 1564-1568
-
-
Bergsteinsdottir, K.1
Yang, H.T.2
Pettersson, U.3
Holmdahl, R.4
-
46
-
-
79957475372
-
Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats
-
Hultqvist M, Sareila O, Vilhardt F, Norin U, Olsson LM, Olofsson P, et al. Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats. Antioxid Redox Signal 2011; 14: 2373-2383.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 2373-2383
-
-
Hultqvist, M.1
Sareila, O.2
Vilhardt, F.3
Norin, U.4
Olsson, L.M.5
Olofsson, P.6
-
47
-
-
33748062329
-
T cell surface redox levels determine T cell reactivity and arthritis susceptibility
-
Gelderman KA, Hultqvist M, Holmberg J, Olofsson P, Holmdahl R. T cell surface redox levels determine T cell reactivity and arthritis susceptibility. Proc Natl Acad Sci USA 2006; 103: 12831-12836.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12831-12836
-
-
Gelderman, K.A.1
Hultqvist, M.2
Holmberg, J.3
Olofsson, P.4
Holmdahl, R.5
-
48
-
-
4344591766
-
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
-
Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci USA 2004; 101: 12646-12651.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12646-12651
-
-
Hultqvist, M.1
Olofsson, P.2
Holmberg, J.3
Bäckström, B.T.4
Tordsson, J.5
Holmdahl, R.6
-
49
-
-
0141648399
-
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models
-
van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts E, Joosten LA, et al. Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am J Pathol 2003; 163: 1525-1537.
-
(2003)
Am J Pathol
, vol.163
, pp. 1525-1537
-
-
Van De Loo, F.A.1
Bennink, M.B.2
Arntz, O.J.3
Smeets, R.L.4
Lubberts, E.5
Joosten, L.A.6
-
50
-
-
0028984840
-
The p47phox mouse knock-out model of chronic granulomatous disease
-
Jackson SH, Gallin JI, Holland SM. The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med 1995; 182: 751-758.
-
(1995)
J Exp Med
, vol.182
, pp. 751-758
-
-
Jackson, S.H.1
Gallin, J.I.2
Holland, S.M.3
-
51
-
-
0033795342
-
P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+
-
Huang CK, Zhan L, Hannigan MO, Ai Y, Leto TL. P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J Leukoc Biol 2000; 67: 210-215.
-
(2000)
J Leukoc Biol
, vol.67
, pp. 210-215
-
-
Huang, C.K.1
Zhan, L.2
Hannigan, M.O.3
Ai, Y.4
Leto, T.L.5
-
52
-
-
84874542636
-
Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation
-
Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation. J Leukoc Biol 2013; 93: 427-435.
-
(2013)
J Leukoc Biol
, vol.93
, pp. 427-435
-
-
Sareila, O.1
Jaakkola, N.2
Olofsson, P.3
Kelkka, T.4
Holmdahl, R.5
-
53
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity 2013; 38: 633-643.
-
(2013)
Immunity
, vol.38
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
54
-
-
84961290082
-
Targeting T cell metabolism for therapy
-
O'Sullivan D, Pearce EL. Targeting T cell metabolism for therapy. Trends Immunol 2015; 36: 71-80.
-
(2015)
Trends Immunol
, vol.36
, pp. 71-80
-
-
O'Sullivan, D.1
Pearce, E.L.2
-
55
-
-
84962885862
-
Dysregulated bioenergetics: A key regulator of joint inflammation
-
24 March
-
Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, et al. Dysregulated bioenergetics: a key regulator of joint inflammation. Ann Rheum Dis, e-pub ahead of print 24 March 2016; doi:10.1136/annrheumdis-2015-208476.
-
(2016)
Ann Rheum Dis, E-pub Ahead of Print
-
-
Biniecka, M.1
Canavan, M.2
McGarry, T.3
Gao, W.4
McCormick, J.5
Cregan, S.6
-
57
-
-
84926336855
-
Role of the innate and adaptive immune responses in the course of multiple sclerosis
-
Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol 2015; 14: 406-419.
-
(2015)
Lancet Neurol
, vol.14
, pp. 406-419
-
-
Hemmer, B.1
Kerschensteiner, M.2
Korn, T.3
-
58
-
-
17644396349
-
Immunology of multiple sclerosis
-
Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 683-747
-
-
Sospedra, M.1
Martin, R.2
-
59
-
-
68049084584
-
Oxygen radical production in leukocytes and disease severity in multiple sclerosis
-
Mossberg N, Movitz C, Hellstrand K, Bergström T, Nilsson S, Andersen O. Oxygen radical production in leukocytes and disease severity in multiple sclerosis. J Neuroimmunol 2009; 213: 131-134.
-
(2009)
J Neuroimmunol
, vol.213
, pp. 131-134
-
-
Mossberg, N.1
Movitz, C.2
Hellstrand, K.3
Bergström, T.4
Nilsson, S.5
Andersen, O.6
-
60
-
-
84857538385
-
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
-
Fischer MT, Sharma R, Lim JL, Haider L, Frischer JM, Drexhage J, et al. NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012; 135: 886-899.
-
(2012)
Brain
, vol.135
, pp. 886-899
-
-
Fischer, M.T.1
Sharma, R.2
Lim, J.L.3
Haider, L.4
Frischer, J.M.5
Drexhage, J.6
-
61
-
-
33646493351
-
Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis
-
Becanovic K, Jagodic M, Sheng JR, Dahlman I, Aboul-Enein F, Wallstrom E, et al. Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis. J Immunol 2006; 176: 6055-6064.
-
(2006)
J Immunol
, vol.176
, pp. 6055-6064
-
-
Becanovic, K.1
Jagodic, M.2
Sheng, J.R.3
Dahlman, I.4
Aboul-Enein, F.5
Wallstrom, E.6
-
62
-
-
41649106850
-
Catechin gallates are NADP +-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme
-
Shin ES, Park J, Shin J-M, Cho D, Cho SY, Shin DW, et al. Catechin gallates are NADP +-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorganic & Medicinal Chemistry 2008; 16: 3580-3586.
-
(2008)
Bioorganic & Medicinal Chemistry
, vol.16
, pp. 3580-3586
-
-
Shin, E.S.1
Park, J.2
Shin, J.-M.3
Cho, D.4
Cho, S.Y.5
Shin, D.W.6
-
63
-
-
80054087636
-
Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation
-
Herges K, Millward JM, Hentschel N, Infante-Duarte C, Aktas O, Zipp F. Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation. PLoS ONE 2011; 6: e25456.
-
(2011)
PLoS ONE
, vol.6
, pp. e25456
-
-
Herges, K.1
Millward, J.M.2
Hentschel, N.3
Infante-Duarte, C.4
Aktas, O.5
Zipp, F.6
-
64
-
-
83455258147
-
Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets
-
Wang J, Ren Z, Xu Y, Xiao S, Meydani SN, Wu D. Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets. The American Journal of Pathology 2012; 180: 221-234.
-
(2012)
The American Journal of Pathology
, vol.180
, pp. 221-234
-
-
Wang, J.1
Ren, Z.2
Xu, Y.3
Xiao, S.4
Meydani, S.N.5
Wu, D.6
-
65
-
-
0030977992
-
Crystal structure of the obese protein leptin-E100
-
Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, et al. Crystal structure of the obese protein leptin-E100. Nature 1997; 387: 206-209.
-
(1997)
Nature
, vol.387
, pp. 206-209
-
-
Zhang, F.1
Basinski, M.B.2
Beals, J.M.3
Briggs, S.L.4
Churgay, L.M.5
Clawson, D.K.6
-
66
-
-
0842308729
-
Unraveling the multiple roles of leptin in inflammation and autoimmunity
-
La Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 2004; 82: 4-11.
-
(2004)
J Mol Med
, vol.82
, pp. 4-11
-
-
La Cava, A.1
Alviggi, C.2
Matarese, G.3
-
67
-
-
84891887896
-
Regulatory T cell proliferative potential is impaired in human autoimmune disease
-
Carbone F, De Rosa V, Carrieri PB, Montella S, Bruzzese D, Porcellini A, et al. Regulatory T cell proliferative potential is impaired in human autoimmune disease. Nat Med 2014; 20: 69-74.
-
(2014)
Nat Med
, vol.20
, pp. 69-74
-
-
Carbone, F.1
De Rosa, V.2
Carrieri, P.B.3
Montella, S.4
Bruzzese, D.5
Porcellini, A.6
-
68
-
-
17044381726
-
Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells
-
Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci USA 2005; 102: 5150-5155.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 5150-5155
-
-
Matarese, G.1
Carrieri, P.B.2
La Cava, A.3
Perna, F.4
Sanna, V.5
De Rosa, V.6
-
69
-
-
33847312289
-
A key role of leptin in the control of regulatory T cell proliferation
-
De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007; 26: 241-255.
-
(2007)
Immunity
, vol.26
, pp. 241-255
-
-
De Rosa, V.1
Procaccini, C.2
Calì, G.3
Pirozzi, G.4
Fontana, S.5
Zappacosta, S.6
-
70
-
-
78650188983
-
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
-
Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010; 33: 929-941.
-
(2010)
Immunity
, vol.33
, pp. 929-941
-
-
Procaccini, C.1
De Rosa, V.2
Galgani, M.3
Abanni, L.4
Calì, G.5
Porcellini, A.6
-
71
-
-
0034843181
-
Why is L-glutamine metabolism important to cells of the immune system in health, postinjury surgery or infection?
-
Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr 2001; 131: 2515S-2522S.
-
(2001)
J Nutr
, vol.131
, pp. 2515S-2522S
-
-
Newsholme, P.1
-
72
-
-
0043025561
-
Excitatory amino acids and multiple sclerosis: Evidence from cerebrospinal fluid
-
Sarchielli P, Greco L, Floridi A, Floridi A, Gallai V. Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid. Arch Neurol 2003; 60: 1082-1088.
-
(2003)
Arch Neurol
, vol.60
, pp. 1082-1088
-
-
Sarchielli, P.1
Greco, L.2
Floridi, A.3
Floridi, A.4
Gallai, V.5
-
73
-
-
84876271669
-
Increased concentrations of glutamate and glutamine in normal-Appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans
-
Tisell A, Leinhard OD, Warntjes JB, Aalto A, Smedby O, Landtblom AM, et al. Increased concentrations of glutamate and glutamine in normal-Appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans. PLoS One 2013; 8: e61817.
-
(2013)
PLoS One
, vol.8
, pp. e61817
-
-
Tisell, A.1
Leinhard, O.D.2
Warntjes, J.B.3
Aalto, A.4
Smedby, O.5
Landtblom, A.M.6
-
74
-
-
0033958462
-
Glutamate excitotoxicity in a model of multiple sclerosis
-
Pitt D, Werner P, Raine CS. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 2000; 6: 67-70.
-
(2000)
Nat Med
, vol.6
, pp. 67-70
-
-
Pitt, D.1
Werner, P.2
Raine, C.S.3
-
75
-
-
84900440370
-
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
-
Nakaya M, Xiao Y, Zhou X, Chang J-H, Chang M, Cheng X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity 2014; 40: 692-705.
-
(2014)
Immunity
, vol.40
, pp. 692-705
-
-
Nakaya, M.1
Xiao, Y.2
Zhou, X.3
Chang, J.-H.4
Chang, M.5
Cheng, X.6
-
76
-
-
84876514626
-
Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, DA C. Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 2013; 14: 500-508.
-
(2013)
Nat Immunol
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
Rolf, J.2
Emslie, E.3
Shi, Y.B.4
Taylor, P.M.5
-
77
-
-
84920481006
-
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
-
Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest 2015; 125: 194-207.
-
(2015)
J Clin Invest
, vol.125
, pp. 194-207
-
-
Gerriets, V.A.1
Kishton, R.J.2
Nichols, A.G.3
Macintyre, A.N.4
Inoue, M.5
Ilkayeva, O.6
-
78
-
-
75649122284
-
Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice
-
Bian L, Josefsson E, Jonsson IM, Verdrengh M, Ohlsson C, Bokarewa M, et al. Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice. Arthritis Res Ther 2009; 11: R132.
-
(2009)
Arthritis Res Ther
, vol.11
, pp. R132
-
-
Bian, L.1
Josefsson, E.2
Jonsson, I.M.3
Verdrengh, M.4
Ohlsson, C.5
Bokarewa, M.6
-
79
-
-
0029072626
-
Short-Term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders
-
De Stefano N, Matthews PM, Phil D, Ford B, Genge A, Karpati G, et al. Short-Term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders. Neurology 1995; 45: 1193-1198.
-
(1995)
Neurology
, vol.45
, pp. 1193-1198
-
-
De Stefano, N.1
Matthews, P.M.2
Phil, D.3
Ford, B.4
Genge, A.5
Karpati, G.6
-
80
-
-
33646830260
-
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
-
Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell EM, et al. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 2006; 117: 1519-1531.
-
(2006)
Pediatrics
, vol.117
, pp. 1519-1531
-
-
Stacpoole, P.W.1
Kerr, D.S.2
Barnes, C.3
Bunch, S.T.4
Carney, P.R.5
Fennell, E.M.6
-
81
-
-
0037038402
-
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
-
Youssef S, Stüve O, Patarroyo JC, Ruiz PJ, Radosevich JL, Hur EM, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002; 420: 78-84.
-
(2002)
Nature
, vol.420
, pp. 78-84
-
-
Youssef, S.1
Stüve, O.2
Patarroyo, J.C.3
Ruiz, P.J.4
Radosevich, J.L.5
Hur, E.M.6
-
82
-
-
84886547277
-
Statins as modulators of regulatory T-cell biology
-
Forero-Peña DA, Gutierrez FR. Statins as modulators of regulatory T-cell biology. Mediators Inflamm 2013; 2013: 167086.
-
(2013)
Mediators Inflamm
, vol.2013
, pp. 167086
-
-
Forero-Peña, D.A.1
Gutierrez, F.R.2
-
83
-
-
84860723016
-
Randomized controlled trial of atorvastatin in clinically isolated syndrome: The STAyCIS study
-
Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, et al. Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study. Neurology 2012; 78: 1171-1178.
-
(2012)
Neurology
, vol.78
, pp. 1171-1178
-
-
Waubant, E.1
Pelletier, D.2
Mass, M.3
Cohen, J.A.4
Kita, M.5
Cross, A.6
-
84
-
-
84875432419
-
Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
-
Herold KC, Vignali DAA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 2013; 13: 243-256.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 243-256
-
-
Herold, K.C.1
Vignali, D.A.A.2
Cooke, A.3
Bluestone, J.A.4
-
85
-
-
84954443667
-
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
-
315ra189
-
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, et al. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med 2015; 7: 315ra189.
-
(2015)
Sci Transl Med
, vol.7
-
-
Bluestone, J.A.1
Buckner, J.H.2
Fitch, M.3
Gitelman, S.E.4
Gupta, S.5
Hellerstein, M.K.6
-
86
-
-
75949129400
-
Protein and energy metabolism in type 1 diabetes
-
Hebert SL, Nair KS. Protein and energy metabolism in type 1 diabetes. Clin Nutr 2010; 29: 13-17.
-
(2010)
Clin Nutr
, vol.29
, pp. 13-17
-
-
Hebert, S.L.1
Nair, K.S.2
-
88
-
-
53849124696
-
-
Guichard C, Moreau R, Pessayre D, Epperson TK, Krause KH. NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans 2008; 36: 920-929.
-
(2008)
NOX Family NADPH Oxidases in Liver and in Pancreatic Islets: A Role in the Metabolic Syndrome and Diabetes? Biochem Soc Trans
, vol.36
, pp. 920-929
-
-
Guichard, C.1
Moreau, R.2
Pessayre, D.3
Epperson, T.K.4
Krause, K.H.5
-
89
-
-
84908670728
-
Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice
-
Malaguti C, La Guardia PG, Leite AC, Oliveira DN, de Lima Zollner RL, Catharino RR, et al. Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice. Free Radic Res 2014; 48: 1494-1504.
-
(2014)
Free Radic Res
, vol.48
, pp. 1494-1504
-
-
Malaguti, C.1
La Guardia, P.G.2
Leite, A.C.3
Oliveira, D.N.4
De Lima Zollner, R.L.5
Catharino, R.R.6
-
90
-
-
78149485627
-
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity
-
Tse HM, Thayer TC, Steele C, Cuda CM, Morel L, Piganelli JD, et al. NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. J Immunol 2010; 185: 5247-5258.
-
(2010)
J Immunol
, vol.185
, pp. 5247-5258
-
-
Tse, H.M.1
Thayer, T.C.2
Steele, C.3
Cuda, C.M.4
Morel, L.5
Piganelli, J.D.6
-
91
-
-
0033992422
-
Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide
-
Ichikawa M, Koh CS, Inoue A, Tsuyusaki J, Yamazaki M, Inaba Y, et al. Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide. J Neuroimmunol 2000; 102: 56-66.
-
(2000)
J Neuroimmunol
, vol.102
, pp. 56-66
-
-
Ichikawa, M.1
Koh, C.S.2
Inoue, A.3
Tsuyusaki, J.4
Yamazaki, M.5
Inaba, Y.6
-
92
-
-
0027378612
-
Following a diabetogenic T cell from genesis through pathogenesis
-
Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74: 1089-1100.
-
(1993)
Cell
, vol.74
, pp. 1089-1100
-
-
Katz, J.D.1
Wang, B.2
Haskins, K.3
Benoist, C.4
Mathis, D.5
-
93
-
-
84962144532
-
Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in Type 1 Diabetes
-
Padgett LE, Anderson B, Liu C, Ganini D, Mason RP, Piganelli JD, et al. Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in Type 1 Diabetes. Diabetes 2015; 64: 4171-4183.
-
(2015)
Diabetes
, vol.64
, pp. 4171-4183
-
-
Padgett, L.E.1
Anderson, B.2
Liu, C.3
Ganini, D.4
Mason, R.P.5
Piganelli, J.D.6
-
94
-
-
59649105735
-
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
-
Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008; 205: 2975-2984.
-
(2008)
J Exp Med
, vol.205
, pp. 2975-2984
-
-
Oresic, M.1
Simell, S.2
Sysi-Aho, M.3
Näntö-Salonen, K.4
Seppänen-Laakso, T.5
Parikka, V.6
-
95
-
-
6344285328
-
Gamma-Aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model
-
Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. Gamma-Aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol 2004; 173: 5298-5304.
-
(2004)
J Immunol
, vol.173
, pp. 5298-5304
-
-
Tian, J.1
Lu, Y.2
Zhang, H.3
Chau, C.H.4
Dang, H.N.5
Kaufman, D.L.6
-
97
-
-
84885419055
-
GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone
-
Prud'homme GJ, Glinka Y, Hasilo C, Paraskevas S, Li X, Wang Q. GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. Transplantation 2013; 96: 616-623.
-
(2013)
Transplantation
, vol.96
, pp. 616-623
-
-
Prud'Homme, G.J.1
Glinka, Y.2
Hasilo, C.3
Paraskevas, S.4
Li, X.5
Wang, Q.6
-
98
-
-
84907482559
-
GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity
-
Prud'homme GJ, Glinka Y, Udovyk O, Hasilo C, Paraskevas S, Wang Q. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochem Biophys Res Commun 2014; 452: 649-654.
-
(2014)
Biochem Biophys Res Commun
, vol.452
, pp. 649-654
-
-
Prud'Homme, G.J.1
Glinka, Y.2
Udovyk, O.3
Hasilo, C.4
Paraskevas, S.5
Wang, Q.6
-
99
-
-
84941260909
-
Immunological GABAergic interactions and therapeutic applications in autoimmune diseases
-
Prud'homme GJ, Glinka Y, Qinghua Wang. Immunological GABAergic interactions and therapeutic applications in autoimmune diseases. Autoimmunity Reviews 2015; 14: 1048-1056.
-
(2015)
Autoimmunity Reviews
, vol.14
, pp. 1048-1056
-
-
Prud'Homme, G.J.1
Glinka, Y.2
Qinghua, W.3
-
100
-
-
84866545697
-
P40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation
-
Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, Terhorst C, et al. p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol 2012; 89: 3631-3640.
-
(2012)
J Immunol
, vol.89
, pp. 3631-3640
-
-
Conway, K.L.1
Goel, G.2
Sokol, H.3
Manocha, M.4
Mizoguchi, E.5
Terhorst, C.6
|