GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity

Biochemical and Biophysical Research Communications

Volumn 452, Issue 3, 2014, Pages 649-654

  Prud'Homme, Gérald J ^a,b,c   Glinka, Yelena ^a   Udovyk, Oleksandr ^a   Hasilo, Craig ^d,e   Paraskevas, Steven ^d,e   Wang, Qinghua ^a,c,f  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^f FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Diabetes; GABA; NAD; NF kappaB; Sirtuin 1

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; HYDROLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; MUSCIMOL; NICOTINAMIDE ADENINE DINUCLEOTIDE; PANOBINOSTAT; SIRTINOL; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 6; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; PICROTOXIN; RELA PROTEIN, RAT; SACLOFEN; SIRT1 PROTEIN, RAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CLONE; CELL CULTURE; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; INS 1 CELL LINE; INSULIN RELEASE; INSULIN SYNTHESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BACLOFEN; CELL LINE, TUMOR; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; HUMANS; INSULIN-SECRETING CELLS; MUSCIMOL; NAD; PICROTOXIN; PRIMARY CELL CULTURE; RATS; RECEPTORS, GABA-A; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTOR RELA;

EID: 84907482559     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.08.135     Document Type: Article

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