GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone

Transplantation

Volumn 96, Issue 7, 2013, Pages 616-623

  Prud'Homme, Gérald J ^a,b,c   Glinka, Yelena ^a   Hasilo, Craig ^d   Paraskevas, Steven ^d   Li, Xiaoming ^a   Wang, Qinghua ^a,b,e  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Apoptosis; GABA; Immunosuppression; Islet; NF JB; Rapamycin

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM; CD3 ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INSULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; INSULIN RELEASE; PANCREAS ISLET CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CELL PROLIFERATION; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GAMMA-AMINOBUTYRIC ACID; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MICE; MYCOPHENOLIC ACID; NF-KAPPA B; RECEPTORS, GABA-A; SIROLIMUS; T-LYMPHOCYTES; TACROLIMUS; TIME FACTORS; TISSUE CULTURE TECHNIQUES;

EID: 84885419055     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31829c24be     Document Type: Article

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