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Volumn 16, Issue 6, 2016, Pages 341-352

Gut microbiota, metabolites and host immunity

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; DEXTRO GLYCERO BETA DEXTRO MANNOHEPTOSE 1,7 BISPHOSPHATE; LIGAND; PEPTIDE; PHOSPHATE; POLYAMINE; POLYSACCHARIDE; POLYSACCHARIDE A; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; FATTY ACID; PATTERN RECOGNITION RECEPTOR;

EID: 84971201113     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.42     Document Type: Review
Times cited : (2345)

References (126)
  • 1
    • 84900535804 scopus 로고    scopus 로고
    • Dynamics and associations of microbial community types across the human body
    • Ding T, & Schloss P. D. Dynamics and associations of microbial community types across the human body. Nature. 509, 357-360 (2014).
    • (2014) Nature , vol.509 , pp. 357-360
    • Ding, T.1    Schloss, P.D.2
  • 2
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortiu.m.
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 486, 207-214 (2012).
    • (2012) Nature , vol.486 , pp. 207-214
  • 3
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg P. B, et al. Diversity of the human intestinal microbial flora. Science. 308, 1635-1638 (2005).
    • (2005) Science , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1
  • 5
    • 84961288867 scopus 로고    scopus 로고
    • Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans
    • Sender R, Fuchs S, & Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 164, 337-340 (2016).
    • (2016) Cell , vol.164 , pp. 337-340
    • Sender, R.1    Fuchs, S.2    Milo, R.3
  • 6
    • 84929512453 scopus 로고    scopus 로고
    • Sequencing and beyond: Integrating molecular 'omics' for microbial community profiling
    • Franzosa E. A, et al. Sequencing and beyond: integrating molecular 'omics' for microbial community profiling. Nat. Rev. Microbiol. 13, 360-372 (2015).
    • (2015) Nat. Rev. Microbiol , vol.13 , pp. 360-372
    • Franzosa, E.A.1
  • 7
    • 84941647822 scopus 로고    scopus 로고
    • Host genetic variation impacts microbiome composition across human body sites
    • Blekhman R, et al. Host genetic variation impacts microbiome composition across human body sites. Genome Biol. 16, 191 (2015).
    • (2015) Genome Biol , vol.16 , pp. 191
    • Blekhman, R.1
  • 8
    • 84898808700 scopus 로고    scopus 로고
    • Meta'omic analytic techniques for studying the intestinal microbiome
    • Morgan X. C, & Huttenhower C. Meta'omic analytic techniques for studying the intestinal microbiome. Gastroenterology. 146, 1437-1448 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1437-1448
    • Morgan, X.C.1    Huttenhower, C.2
  • 9
    • 0031012926 scopus 로고    scopus 로고
    • T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment
    • Dianda L, et al. T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 150, 91-97 (1997).
    • (1997) Am J. Pathol , vol.150 , pp. 91-97
    • Dianda, L.1
  • 10
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin 10 deficient mice
    • Sellon R. K, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin 10 deficient mice. Infect. Immun. 66, 5224-5231 (1998).
    • (1998) Infect. Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1
  • 11
    • 0342264383 scopus 로고    scopus 로고
    • Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease
    • Reháková Z, et al. Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease. Hum. Immunol. 61, 555-558 (2000).
    • (2000) Hum. Immunol , vol.61 , pp. 555-558
    • Reháková, Z.1
  • 12
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-Adrenal system for stress response in mice
    • Sudo N, et al. Postnatal microbial colonization programs the hypothalamic-pituitary-Adrenal system for stress response in mice. J. Physiol. 558, 263-275 (2004).
    • (2004) J. Physiol , vol.558 , pp. 263-275
    • Sudo, N.1
  • 13
    • 33748446941 scopus 로고    scopus 로고
    • Host gene expression in the colon of gnotobiotic interleukin 2 deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: Common patterns and bacteria strain specific signatures
    • Bohn E, et al. Host gene expression in the colon of gnotobiotic interleukin 2 deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: common patterns and bacteria strain specific signatures. Inflamm. Bowel Dis. 12, 853-862 (2006).
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 853-862
    • Bohn, E.1
  • 14
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of type 1 diabetes
    • Wen L, et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature. 455, 1109-1113 (2008).
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1
  • 15
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu H. J, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 32, 815-827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1
  • 16
    • 77956569409 scopus 로고    scopus 로고
    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    • Garrett W. S, et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe. 8, 292-300 (2010).
    • (2010) Cell Host Microbe , vol.8 , pp. 292-300
    • Garrett, W.S.1
  • 17
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer K, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 479, 538-541 (2011).
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1
  • 18
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • Lee Y. K, Menezes J. S, Umesaki Y, & Mazmanian S. K. Proinflammatory T cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4615-4622 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 19
    • 33750705617 scopus 로고    scopus 로고
    • Humanized mice mount specific adaptive and innate immune responses to EBV and TSST 1
    • Melkus M. W, et al. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST 1. Nat. Med. 12, 1316-1322 (2006).
    • (2006) Nat. Med , vol.12 , pp. 1316-1322
    • Melkus, M.W.1
  • 20
    • 84879799136 scopus 로고    scopus 로고
    • Cryptopatches are essential for the development of human GALT
    • Nochi T, Denton P. W, Wahl A, & Garcia J. V. Cryptopatches are essential for the development of human GALT. Cell Rep. 3, 1874-1884 (2013).
    • (2013) Cell Rep , vol.3 , pp. 1874-1884
    • Nochi, T.1    Denton, P.W.2    Wahl, A.3    Garcia, J.V.4
  • 21
    • 84961999746 scopus 로고    scopus 로고
    • Heterogeneity of the gut microbiome in mice: Guidelines for optimizing experimental design
    • Laukens D, Brinkman B. M, Raes J, De Vos M, & Vandenabeele P. Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design. FEMS Microbiol. Rev. 40, 117-132 (2016).
    • (2016) FEMS Microbiol. Rev , vol.40 , pp. 117-132
    • Laukens, D.1    Brinkman, B.M.2    Raes, J.3    De Vos, M.4    Vandenabeele, P.5
  • 22
    • 84887096280 scopus 로고    scopus 로고
    • Host-centric proteomics of stool: A novel strategy focused on intestinal responses to the gut microbiota
    • Lichtman J. S, Marcobal A, Sonnenburg J. L, & Elias J. E. Host-centric proteomics of stool: a novel strategy focused on intestinal responses to the gut microbiota. Mol. Cell Proteom. 12, 3310-3318 (2013).
    • (2013) Mol. Cell Proteom , vol.12 , pp. 3310-3318
    • Lichtman, J.S.1    Marcobal, A.2    Sonnenburg, J.L.3    Elias, J.E.4
  • 23
    • 84884671077 scopus 로고    scopus 로고
    • A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice
    • Marcobal A, et al. A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice. ISME J 7 1933-1943 (2013).
    • (2013) ISME J , vol.7 , pp. 1933-1943
    • Marcobal, A.1
  • 24
    • 84923359335 scopus 로고    scopus 로고
    • Prediction and quantification of bioactive microbiota metabolites in the mouse gut
    • Sridharan G. V, et al. Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Nat. Commun. 5, 5492 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 5492
    • Sridharan, G.V.1
  • 25
    • 84892848164 scopus 로고    scopus 로고
    • Metaproteomics of our microbiome - Developing insight in function and activity in man and model systems
    • Kolmeder C. A, & de Vos W. M. Metaproteomics of our microbiome - developing insight in function and activity in man and model systems. J. Proteomics. 97, 3-16 (2014).
    • (2014) J. Proteomics , vol.97 , pp. 3-16
    • Kolmeder, C.A.1    De Vos, W.M.2
  • 26
    • 84944152234 scopus 로고    scopus 로고
    • Microbial metaproteomics for characterizing the range of metabolic functions and activities of human gut microbiota
    • Xiong W, Abraham P. E, Li Z, Pan C, & Hettich R. L. Microbial metaproteomics for characterizing the range of metabolic functions and activities of human gut microbiota. Proteomics. 15, 3424-3438 (2015).
    • (2015) Proteomics , vol.15 , pp. 3424-3438
    • Xiong, W.1    Abraham, P.E.2    Li, Z.3    Pan, C.4    Hettich, R.L.5
  • 27
    • 84906317195 scopus 로고    scopus 로고
    • Recent advances in genomic DNA sequencing of microbial species from single cells
    • Lasken R. S, & McLean J. S. Recent advances in genomic DNA sequencing of microbial species from single cells. Nat. Rev. Genet. 15, 577-584 (2014).
    • (2014) Nat. Rev. Genet , vol.15 , pp. 577-584
    • Lasken, R.S.1    McLean, J.S.2
  • 28
    • 84943595976 scopus 로고    scopus 로고
    • Detection of low-Abundance bacterial strains in metagenomic datasets by eigengenome partitioning
    • Cleary B, et al. Detection of low-Abundance bacterial strains in metagenomic datasets by eigengenome partitioning. Nat. Biotechnol. 33, 1053-1060 (2015).
    • (2015) Nat. Biotechnol , vol.33 , pp. 1053-1060
    • Cleary, B.1
  • 29
    • 84943606160 scopus 로고    scopus 로고
    • ConStrains identifies microbial strains in metagenomic datasets
    • Luo C, et al. ConStrains identifies microbial strains in metagenomic datasets. Nat. Biotechnol. 33, 1045-1052 (2015).
    • (2015) Nat. Biotechnol , vol.33 , pp. 1045-1052
    • Luo, C.1
  • 30
    • 84936992706 scopus 로고    scopus 로고
    • Discovery of new protein families and functions: New challenges in functional metagenomics for biotechnologies and microbial ecology
    • Ufarté L, Potocki-Veronese G, & Laville É. Discovery of new protein families and functions: new challenges in functional metagenomics for biotechnologies and microbial ecology. Front. Microbiol. 6, 563 (2015).
    • (2015) Front. Microbiol , vol.6 , pp. 563
    • Ufarté, L.1    Potocki-Veronese, G.2    Laville, É.3
  • 31
    • 84944234155 scopus 로고    scopus 로고
    • Quantitative imaging of gut microbiota spatial organization
    • Earle K. A, et al. Quantitative imaging of gut microbiota spatial organization. Cell Host Microbe. 18, 478-488 (2015).
    • (2015) Cell Host Microbe , vol.18 , pp. 478-488
    • Earle, K.A.1
  • 32
    • 84940984328 scopus 로고    scopus 로고
    • In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria
    • Geva-Zatorsky N, et al. In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria. Nat. Med. 21, 1091-1100 (2015).
    • (2015) Nat. Med , vol.21 , pp. 1091-1100
    • Geva-Zatorsky, N.1
  • 33
    • 0036399823 scopus 로고    scopus 로고
    • How host-microbial interactions shape the nutrient environment of the mammalian intestine
    • Hooper L. V, Midtvedt T, & Gordon J. I. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu. Rev. Nutr. 22, 283-307 (2002).
    • (2002) Annu. Rev. Nutr , vol.22 , pp. 283-307
    • Hooper, L.V.1    Midtvedt, T.2    Gordon, J.I.3
  • 34
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings J. H, Pomare E. W, Branch W. J, Naylor C. P, & Macfarlane G. T. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 28, 1221-1227 (1987).
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    MacFarlane, G.T.5
  • 35
    • 42949171444 scopus 로고    scopus 로고
    • Butyrate and trichostatin A attenuate nuclear factor ?B activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells
    • Usami M, et al. Butyrate and trichostatin A attenuate nuclear factor ?B activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. Nutr. Res. 28, 321-328 (2008).
    • (2008) Nutr. Res , vol.28 , pp. 321-328
    • Usami, M.1
  • 36
    • 80051471073 scopus 로고    scopus 로고
    • Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils
    • Vinolo M. A. R, et al. Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. J. Nutr. Biochem. 22, 849-855 (2011).
    • (2011) J. Nutr. Biochem , vol.22 , pp. 849-855
    • Vinolo, M.A.R.1
  • 37
    • 77952695807 scopus 로고    scopus 로고
    • Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis
    • Kendrick S. F. W, et al. Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology. 51, 1988-1997 (2010).
    • (2010) Hepatology , vol.51 , pp. 1988-1997
    • Kendrick, S.F.W.1
  • 38
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang P. V, Hao L, Offermanns S, & Medzhitov R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl Acad. Sci. USA. 111, 2247-2252 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 39
    • 77956237892 scopus 로고    scopus 로고
    • Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
    • Singh N, et al. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J. Biol. Chem. 285, 27601-27608 (2010).
    • (2010) J. Biol. Chem , vol.285 , pp. 27601-27608
    • Singh, N.1
  • 40
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette A, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat. Med. 20, 159-166 (2014).
    • (2014) Nat. Med , vol.20 , pp. 159-166
    • Trompette, A.1
  • 41
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • Tao R, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307 (2007).
    • (2007) Nat. Med , vol.13 , pp. 1299-1307
    • Tao, R.1
  • 42
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 504, 446-450 (2013).
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1
  • 43
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
    • Arpaia N, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation. Nature. 504, 451-455 (2013).
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 44
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith P. M, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 341, 569-573 (2013).
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 45
    • 84934987107 scopus 로고    scopus 로고
    • Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
    • Thorburn A. N, et al. Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat. Commun. 6, 7320 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 7320
    • Thorburn, A.N.1
  • 46
    • 78650408264 scopus 로고    scopus 로고
    • Diet, gut microbiota and immune responses
    • Maslowski K. M, & Mackay C. R. Diet, gut microbiota and immune responses. Nat. Immunol. 12, 5-9 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 5-9
    • Maslowski, K.M.1    MacKay, C.R.2
  • 47
    • 73449117582 scopus 로고    scopus 로고
    • Immunomodulatory effects of deacetylase inhibitors: Therapeutic targeting of FOXP3+ regulatory T cells
    • Wang L, de Zoeten E. F, Greene M. I, & Hancock W. W. Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat. Rev. Drug Discov. 8, 969-981 (2009).
    • (2009) Nat. Rev. Drug Discov , vol.8 , pp. 969-981
    • Wang, L.1    De Zoeten, E.F.2    Greene, M.I.3    Hancock, W.W.4
  • 48
    • 84902657771 scopus 로고    scopus 로고
    • Diet, metabolites, and 'western-lifestyle' inflammatory diseases
    • Thorburn A. N, Macia L, & Mackay C. R. Diet, metabolites, and 'western-lifestyle' inflammatory diseases. Immunity. 40, 833-842 (2014).
    • (2014) Immunity , vol.40 , pp. 833-842
    • Thorburn, A.N.1    Macia, L.2    MacKay, C.R.3
  • 49
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski K. M, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 461, 1282-1286 (2009).
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1
  • 50
    • 84455188294 scopus 로고    scopus 로고
    • A novel antiinflammatory role for the short-chain fatty acids in human labor
    • Voltolini C, et al. A novel antiinflammatory role for the short-chain fatty acids in human labor. Endocrinology 153 395-403 (2012).
    • (2012) Endocrinology , vol.153 , pp. 395-403
    • Voltolini, C.1
  • 51
    • 84929855038 scopus 로고    scopus 로고
    • A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout
    • Vieira A. T, et al. A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout. Arthritis Rheumatol 67 1646-1656 (2015).
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1646-1656
    • Vieira, A.T.1
  • 52
    • 84933043202 scopus 로고    scopus 로고
    • Host microbiota constantly control maturation and function of microglia in the CNS
    • Erny D, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci. 18, 965-977 (2015).
    • (2015) Nat. Neurosci , vol.18 , pp. 965-977
    • Erny, D.1
  • 53
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • Singh N, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 40, 128-139 (2014).
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1
  • 54
    • 84943275888 scopus 로고    scopus 로고
    • Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth
    • Ghorbani P, et al. Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth. Eur. Respir. J. 46, 1033-1045 (2015).
    • (2015) Eur. Respir. J , vol.46 , pp. 1033-1045
    • Ghorbani, P.1
  • 55
    • 0141645569 scopus 로고    scopus 로고
    • Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts
    • Willemsen L. E. M, Koetsier M. A, van Deventer S. J. H, & van Tol E. A. F. Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts. Gut. 52, 1442-1447 (2003).
    • (2003) Gut , vol.52 , pp. 1442-1447
    • Willemsen, L.E.M.1    Koetsier, M.A.2    Van Deventer, S.J.H.3    Van Tol, E.A.F.4
  • 56
    • 9244245819 scopus 로고    scopus 로고
    • Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose
    • Gaudier E, et al. Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. Am. J. Physiol. Gastrointest. Liver Physiol. 287, G1168-G1174 (2004).
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol , vol.287 , pp. G1168-G1174
    • Gaudier, E.1
  • 57
    • 84877913270 scopus 로고    scopus 로고
    • Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
    • Wrzosek L, et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol. 11, 61 (2013).
    • (2013) BMC Biol , vol.11 , pp. 61
    • Wrzosek, L.1
  • 58
    • 79251584066 scopus 로고    scopus 로고
    • Bifidobacteria can protect from enteropathogenic infection through production of acetate
    • Fukuda S, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature. 469, 543-547 (2011).
    • (2011) Nature , vol.469 , pp. 543-547
    • Fukuda, S.1
  • 59
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia L, et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 6734
    • Macia, L.1
  • 60
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 145, 745-757 (2011).
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1
  • 61
    • 84883717655 scopus 로고    scopus 로고
    • Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis
    • Schilderink R, Verseijden C, & de Jonge W. J. Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis. Front. Immunol. 4, 226 (2013).
    • (2013) Front. Immunol , vol.4 , pp. 226
    • Schilderink, R.1    Verseijden, C.2    De Jonge, W.J.3
  • 62
    • 84865012300 scopus 로고    scopus 로고
    • Butyrate-induced GPR41 activation inhibits histone acetylation and cell growth
    • Wu J, Zhou Z, Hu Y, & Dong S. Butyrate-induced GPR41 activation inhibits histone acetylation and cell growth. J. Genet. Genom. 39, 375-384 (2012).
    • (2012) J. Genet. Genom , vol.39 , pp. 375-384
    • Wu, J.1    Zhou, Z.2    Hu, Y.3    Dong, S.4
  • 63
    • 80155164160 scopus 로고    scopus 로고
    • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    • Li Y, et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell. 147, 629-640 (2011).
    • (2011) Cell , vol.147 , pp. 629-640
    • Li, Y.1
  • 64
    • 83855160821 scopus 로고    scopus 로고
    • Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    • Kiss E. A, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 334, 1561-1565 (2011).
    • (2011) Science , vol.334 , pp. 1561-1565
    • Kiss, E.A.1
  • 65
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin 22
    • Zelante T, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin 22. Immunity. 39, 372-385 (2013).
    • (2013) Immunity , vol.39 , pp. 372-385
    • Zelante, T.1
  • 66
    • 84938675563 scopus 로고    scopus 로고
    • Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
    • Hubbard T. D, et al. Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles. Sci. Rep. 5, 12689 (2015).
    • (2015) Sci. Rep , vol.5 , pp. 12689
    • Hubbard, T.D.1
  • 67
    • 84887615895 scopus 로고    scopus 로고
    • Polyamines: Emerging players in bacteria-host interactions
    • Di Martino M. L, et al. Polyamines: emerging players in bacteria-host interactions. Int. J. Med. Microbiol. 303, 484-491 (2013).
    • (2013) Int. J. Med. Microbiol , vol.303 , pp. 484-491
    • Di Martino, M.L.1
  • 68
    • 34548812106 scopus 로고    scopus 로고
    • Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity
    • Chen J, et al. Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G568-G576 (2007).
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol , vol.293 , pp. G568-G576
    • Chen, J.1
  • 69
    • 65649100183 scopus 로고    scopus 로고
    • Polyamines regulate e cadherin transcription through c Myc modulating intestinal epithelial barrier function
    • Liu L, et al. Polyamines regulate E cadherin transcription through c Myc modulating intestinal epithelial barrier function. Am. J. Physiol. Cell Physiol. 296, C801-C810 (2009).
    • (2009) Am. J. Physiol. Cell Physiol , vol.296 , pp. C801-C810
    • Liu, L.1
  • 70
    • 0023883576 scopus 로고
    • Spermine and spermidine induce intestinal maturation in the rat
    • Dufour C, et al. Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology. 95, 112-116 (1988).
    • (1988) Gastroenterology , vol.95 , pp. 112-116
    • Dufour, C.1
  • 72
    • 0032998218 scopus 로고    scopus 로고
    • Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development
    • Löser C, Eisel A, Harms D, & Fölsch U. R. Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development. Gut. 44, 12-16 (1999).
    • (1999) Gut , vol.44 , pp. 12-16
    • Löser, C.1    Eisel, A.2    Harms, D.3    Fölsch, U.R.4
  • 73
    • 0034097797 scopus 로고    scopus 로고
    • Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story
    • Zhang M, Wang H, & Tracey K. J. Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story. Crit. Care Med. 28, N60-N66 (2000).
    • (2000) Crit. Care Med , vol.28 , pp. N60-N66
    • Zhang, M.1    Wang, H.2    Tracey, K.J.3
  • 74
    • 84897424557 scopus 로고    scopus 로고
    • Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
    • Kibe R, et al. Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Sci. Rep. 4, 4548 (2014).
    • (2014) Sci. Rep , vol.4 , pp. 4548
    • Kibe, R.1
  • 77
    • 80051699548 scopus 로고    scopus 로고
    • Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production
    • Matsumoto M, Kurihara S, Kibe R, Ashida H, & Benno Y. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production. PLoS ONE 6, e23652 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e23652
    • Matsumoto, M.1    Kurihara, S.2    Kibe, R.3    Ashida, H.4    Benno, Y.5
  • 78
    • 84944278561 scopus 로고    scopus 로고
    • Remaining mysteries of molecular biology: The role of polyamines in the cell
    • Miller-Fleming L, Olin-Sandoval V, Campbell K, & Ralser M. Remaining mysteries of molecular biology: the role of polyamines in the cell. J. Mol. Biol. 427, 3389-3406 (2015).
    • (2015) J. Mol. Biol , vol.427 , pp. 3389-3406
    • Miller-Fleming, L.1    Olin-Sandoval, V.2    Campbell, K.3    Ralser, M.4
  • 79
    • 4944242891 scopus 로고    scopus 로고
    • Polyamines and cancer: Old molecules, new understanding
    • Gerner E. W, & Meyskens F. L. Polyamines and cancer: old molecules, new understanding. Nat. Rev. Cancer. 4, 781-792 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 781-792
    • Gerner, E.W.1    Meyskens, F.L.2
  • 80
    • 84930575721 scopus 로고    scopus 로고
    • Metabolism links bacterial biofilms and colon carcinogenesis
    • Johnson C. H, et al. Metabolism links bacterial biofilms and colon carcinogenesis. Cell. Metab. 21, 891-897 (2015).
    • (2015) Cell. Metab , vol.21 , pp. 891-897
    • Johnson, C.H.1
  • 81
    • 84921434962 scopus 로고    scopus 로고
    • Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment
    • Hayes C. S, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol. Res. 2, 274-285 (2014).
    • (2014) Cancer Immunol. Res , vol.2 , pp. 274-285
    • Hayes, C.S.1
  • 82
    • 33845864460 scopus 로고    scopus 로고
    • A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
    • Wang Q, et al. A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J. Exp. Med. 203, 2853-2863 (2006).
    • (2006) J. Exp Med , vol.203 , pp. 2853-2863
    • Wang, Q.1
  • 83
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian S. K, Liu C. H, Tzianabos A. O, & Kasper D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 122, 107-118 (2005).
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 84
    • 84898647980 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
    • Dasgupta S, Erturk-Hasdemir D, Ochoa-Repáraz J, Reinecker H. C, & Kasper D. L. Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe. 15, 413-423 (2014).
    • (2014) Cell Host Microbe , vol.15 , pp. 413-423
    • Dasgupta, S.1    Erturk-Hasdemir, D.2    Ochoa-Repáraz, J.3    Reinecker, H.C.4    Kasper, D.L.5
  • 85
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian S. K, Round J. L, & Kasper D. L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453 620-625 (2008).
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 86
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round J. L, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 332, 974-977 (2011).
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1
  • 87
    • 84908340275 scopus 로고    scopus 로고
    • A commensal bacterial product elicits and modulates migratory capacity of CD39+ CD4 T regulatory subsets in the suppression of neuroinflammation
    • Wang Y, et al. A commensal bacterial product elicits and modulates migratory capacity of CD39+ CD4 T regulatory subsets in the suppression of neuroinflammation. Gut Microbes 5 552-561 (2014).
    • (2014) Gut Microbes , vol.5 , pp. 552-561
    • Wang, Y.1
  • 88
    • 33947647317 scopus 로고    scopus 로고
    • CD39 and control of cellular immune responses
    • Dwyer K. M, et al. CD39 and control of cellular immune responses. Purinerg. Signal. 3, 171-180 (2007).
    • (2007) Purinerg. Signal , vol.3 , pp. 171-180
    • Dwyer, K.M.1
  • 89
    • 84944445669 scopus 로고    scopus 로고
    • A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39+Foxp3+ T cells and Treg function
    • Telesford K. M, et al. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39+Foxp3+ T cells and Treg function. Gut Microbes 6 234-242 (2015).
    • (2015) Gut Microbes , vol.6 , pp. 234-242
    • Telesford, K.M.1
  • 90
    • 84948144960 scopus 로고    scopus 로고
    • Heightened expression of CD39 by regulatory T lymphocytes is associated with therapeutic remission in inflammatory bowel disease
    • Gibson D. J, et al. Heightened expression of CD39 by regulatory T lymphocytes is associated with therapeutic remission in inflammatory bowel disease. Inflamm. Bowel Dis. 21, 2806-2814 (2015).
    • (2015) Inflamm. Bowel Dis , vol.21 , pp. 2806-2814
    • Gibson, D.J.1
  • 91
    • 84897423338 scopus 로고    scopus 로고
    • Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing
    • Liu M, et al. Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing. PLoS ONE 9, e90613 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e90613
    • Liu, M.1
  • 92
    • 84929165302 scopus 로고    scopus 로고
    • Peptide length and folding state govern the capacity of staphylococcal β type phenol-soluble modulins to activate human formyl-peptide receptors 1 or 2
    • Kretschmer D, Rautenberg M, Linke D, & Peschel A. Peptide length and folding state govern the capacity of staphylococcal β type phenol-soluble modulins to activate human formyl-peptide receptors 1 or 2. J. Leukoc. Biol. 97, 689-697 (2015).
    • (2015) J. Leukoc. Biol , vol.97 , pp. 689-697
    • Kretschmer, D.1    Rautenberg, M.2    Linke, D.3    Peschel, A.4
  • 93
    • 84923071799 scopus 로고    scopus 로고
    • Enemy attraction: Bacterial agonists for leukocyte chemotaxis receptors
    • Bloes D. A, Kretschmer D, & Peschel A. Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors. Nat. Rev. Microbiol. 13, 95-104 (2015).
    • (2015) Nat. Rev. Microbiol , vol.13 , pp. 95-104
    • Bloes, D.A.1    Kretschmer, D.2    Peschel, A.3
  • 94
    • 84883739860 scopus 로고    scopus 로고
    • Bacteria activate sensory neurons that modulate pain and inflammation
    • Chiu I. M, et al. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 501, 52-57 (2013).
    • (2013) Nature , vol.501 , pp. 52-57
    • Chiu, I.M.1
  • 95
    • 6344272749 scopus 로고    scopus 로고
    • N terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor
    • Haas P. J, et al. N terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor. J. Immunol 173 5704-5711 (2004).
    • (2004) J. Immunol , vol.173 , pp. 5704-5711
    • Haas, P.J.1
  • 96
    • 77952814319 scopus 로고    scopus 로고
    • A homolog of formyl peptide receptor-like 1 (FPRL1) inhibitor from Staphylococcus aureus (FPRL1 inhibitory protein) that inhibits FPRL1 and FPR
    • Prat C, et al. A homolog of formyl peptide receptor-like 1 (FPRL1) inhibitor from Staphylococcus aureus (FPRL1 inhibitory protein) that inhibits FPRL1 and FPR. J. Immunol 183 6569-6578 (2009).
    • (2009) J. Immunol , vol.183 , pp. 6569-6578
    • Prat, C.1
  • 97
    • 84906502930 scopus 로고    scopus 로고
    • Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria
    • Yang S, et al. Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. Eur. J. Med. Chem. 86, 133-152 (2014).
    • (2014) Eur. J. Med. Chem , vol.86 , pp. 133-152
    • Yang, S.1
  • 98
    • 84879009116 scopus 로고    scopus 로고
    • Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity
    • Lewandowski T, et al. Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity. Antimicrob. Agents Chemother. 57, 2929-2936 (2013).
    • (2013) Antimicrob. Agents Chemother , vol.57 , pp. 2929-2936
    • Lewandowski, T.1
  • 99
    • 84940193658 scopus 로고    scopus 로고
    • Frequency of spontaneous resistance to peptide deformylase inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
    • Min S, et al. Frequency of spontaneous resistance to peptide deformylase inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 59, 4644-4652 (2015).
    • (2015) Antimicrob. Agents Chemother , vol.59 , pp. 4644-4652
    • Min, S.1
  • 100
    • 84931023881 scopus 로고    scopus 로고
    • Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
    • Gaudet R. G, et al. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Science. 348, 1251-1255 (2015).
    • (2015) Science , vol.348 , pp. 1251-1255
    • Gaudet, R.G.1
  • 101
    • 78649512174 scopus 로고    scopus 로고
    • Multiplexed DNA sequence capture of mitochondrial genomes using PCR products
    • Maricic T, Whitten M, & Pääbo S. Multiplexed DNA sequence capture of mitochondrial genomes using PCR products. PLoS ONE 5, e14004 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e14004
    • Maricic, T.1    Whitten, M.2    Pääbo, S.3
  • 102
    • 77952206860 scopus 로고    scopus 로고
    • Targeted investigation of the Neandertal genome by array-based sequence capture
    • Burbano H. A, et al. Targeted investigation of the Neandertal genome by array-based sequence capture. Science. 328, 723-725 (2010).
    • (2010) Science , vol.328 , pp. 723-725
    • Burbano, H.A.1
  • 103
    • 79954604151 scopus 로고    scopus 로고
    • Hybrid capture and next-generation sequencing identify viral integration sites from formalin-fixed, paraffin-embedded tissue
    • Duncavage E. J, et al. Hybrid capture and next-generation sequencing identify viral integration sites from formalin-fixed, paraffin-embedded tissue. J. Mol. Diagn. 13, 325-333 (2011).
    • (2011) J. Mol. Diagn , vol.13 , pp. 325-333
    • Duncavage, E.J.1
  • 104
    • 84902967827 scopus 로고    scopus 로고
    • CDNA hybrid capture improves transcriptome analysis on low-input and archived samples
    • Cabanski C. R, et al. cDNA hybrid capture improves transcriptome analysis on low-input and archived samples. J. Mol. Diagn. 16, 440-451 (2014).
    • (2014) J. Mol. Diagn , vol.16 , pp. 440-451
    • Cabanski, C.R.1
  • 105
    • 84922422638 scopus 로고    scopus 로고
    • PCR-Activated cell sorting for cultivation-free enrichment and sequencing of rare microbes
    • Lim S. W, Tran T. M, & Abate A. R. PCR-Activated cell sorting for cultivation-free enrichment and sequencing of rare microbes. PLoS ONE 10, e0113549 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0113549
    • Lim, S.W.1    Tran, T.M.2    Abate, A.R.3
  • 106
    • 84881248157 scopus 로고    scopus 로고
    • Quantifying the metabolic activities of human-Associated microbial communities across multiple ecological scales
    • Maurice C. F, & Turnbaugh P. J. Quantifying the metabolic activities of human-Associated microbial communities across multiple ecological scales. FEMS Microbiol. Rev. 37, 830-848 (2013).
    • (2013) FEMS Microbiol. Rev , vol.37 , pp. 830-848
    • Maurice, C.F.1    Turnbaugh, P.J.2
  • 107
    • 84881548286 scopus 로고    scopus 로고
    • Computational meta'omics for microbial community studies
    • Segata N, et al. Computational meta'omics for microbial community studies. Mol. Syst. Biol. 9, 666 (2013).
    • (2013) Mol. Syst. Biol , vol.9 , pp. 666
    • Segata, N.1
  • 108
    • 77956094318 scopus 로고    scopus 로고
    • Creating and characterizing communities of human gut microbes in gnotobiotic mice
    • Faith J. J, et al. Creating and characterizing communities of human gut microbes in gnotobiotic mice. ISME J. 4, 1094-1098 (2010).
    • (2010) ISME J , vol.4 , pp. 1094-1098
    • Faith, J.J.1
  • 109
    • 0020710588 scopus 로고
    • Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats
    • Wostmann B. S, Larkin C, Moriarty A, & Bruckner-Kardoss E. Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. Lab. Anim. Sci. 33, 46-50 (1983).
    • (1983) Lab. Anim. Sci , vol.33 , pp. 46-50
    • Wostmann, B.S.1    Larkin, C.2    Moriarty, A.3    Bruckner-Kardoss, E.4
  • 110
    • 84940447812 scopus 로고    scopus 로고
    • The gut microbiota in human energy homeostasis and obesity
    • Rosenbaum M, Knight R, & Leibel R. L. The gut microbiota in human energy homeostasis and obesity. Trends Endocrinol. Metab. 26, 493-501 (2015).
    • (2015) Trends Endocrinol. Metab , vol.26 , pp. 493-501
    • Rosenbaum, M.1    Knight, R.2    Leibel, R.L.3
  • 111
    • 0034994474 scopus 로고    scopus 로고
    • Microbial modulation of innate defense: Goblet cells and the intestinal mucus layer
    • Deplancke B, & Gaskins H. R. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am. J. Clin. Nutr. 73, 1131S-1141S (2001).
    • (2001) Am. J. Clin. Nutr , vol.73 , pp. 1131S-1141S
    • Deplancke, B.1    Gaskins, H.R.2
  • 112
    • 34249284197 scopus 로고    scopus 로고
    • Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    • Smith K, McCoy K. D, & Macpherson A. J. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin. Immunol. 19, 59-69 (2007).
    • (2007) Semin. Immunol , vol.19 , pp. 59-69
    • Smith, K.1    McCoy, K.D.2    MacPherson, A.J.3
  • 113
    • 84870252354 scopus 로고    scopus 로고
    • New concepts in the generation and functions of IgA
    • Pabst O. New concepts in the generation and functions of IgA. Nat. Rev. Immunol. 12, 821-832 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 821-832
    • Pabst, O.1
  • 114
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL 17 producing T helper cells in the mucosa of the small intestine
    • Ivanov I. I, et al. Specific microbiota direct the differentiation of IL 17 producing T helper cells in the mucosa of the small intestine. Cell Host Microbe. 4, 337-349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 115
    • 27444440273 scopus 로고    scopus 로고
    • Influence of intestinal bacteria on induction of regulatory T cells: Lessons from a transfer model of colitis
    • Strauch U. G, et al. Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut. 54, 1546-1552 (2005).
    • (2005) Gut , vol.54 , pp. 1546-1552
    • Strauch, U.G.1
  • 116
    • 84879338344 scopus 로고    scopus 로고
    • Compartmentalized and systemic control of tissue immunity by commensals
    • Belkaid Y, & Naik S. Compartmentalized and systemic control of tissue immunity by commensals. Nat. Immunol. 14, 646-653 (2013).
    • (2013) Nat. Immunol , vol.14 , pp. 646-653
    • Belkaid, Y.1    Naik, S.2
  • 117
    • 85027945471 scopus 로고    scopus 로고
    • Microbiota and neurodevelopmental windows: Implications for brain disorders
    • Borre Y. E, et al. Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol. Med. 20, 509-518 (2014).
    • (2014) Trends Mol. Med , vol.20 , pp. 509-518
    • Borre, Y.E.1
  • 118
    • 84904543667 scopus 로고    scopus 로고
    • Gut microbial metabolism drives transformation of MSH2 deficient colon epithelial cells
    • Belcheva A, et al. Gut microbial metabolism drives transformation of MSH2 deficient colon epithelial cells. Cell. 158, 288-299 (2014).
    • (2014) Cell , vol.158 , pp. 288-299
    • Belcheva, A.1
  • 119
    • 84911993839 scopus 로고    scopus 로고
    • A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner
    • Donohoe D. R, et al. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- And butyrate-dependent manner. Cancer Discov 4 1387-1397 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 1387-1397
    • Donohoe, D.R.1
  • 120
    • 84928806486 scopus 로고    scopus 로고
    • Metabolic signatures of bacterial vaginosis
    • Srinivasan S, et al. Metabolic signatures of bacterial vaginosis. MBio 6, e00204-00215 (2015).
    • (2015) MBio , vol.6 , pp. e00204-00215
    • Srinivasan, S.1
  • 121
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L carnitine a nutrient in red meat promotes atherosclerosis
    • Koeth R. A, et al. Intestinal microbiota metabolism of L carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19, 576-585 (2013).
    • (2013) Nat. Med , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 122
    • 84875047650 scopus 로고    scopus 로고
    • Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    • Pluznick J. L, et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc. Natl Acad. Sci. USA. 110, 4410-4415 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4410-4415
    • Pluznick, J.L.1
  • 123
    • 77954793132 scopus 로고    scopus 로고
    • P Cresol and cardiovascular risk in mild to moderate kidney disease
    • Meijers B. K. I, et al. p Cresol and cardiovascular risk in mild to moderate kidney disease. Clin. J. Am. Soc. Nephrol. 5, 1182-1189 (2010).
    • (2010) Clin J. Am. Soc. Nephrol , vol.5 , pp. 1182-1189
    • Meijers, B.K.I.1
  • 124
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao E. Y, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 155, 1451-1463 (2013).
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 125
    • 84911884131 scopus 로고    scopus 로고
    • The gut microbiota influences blood-brain barrier permeability in mice
    • 263ra158
    • Braniste V, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci. Transl Med. 6, 263ra158 (2014).
    • (2014) Sci. Transl Med , vol.6
    • Braniste, V.1
  • 126
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie C. G, et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature. 517, 205-208 (2015).
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.