Unraveling the multiple roles of leptin in inflammation and autoimmunity

Journal of Molecular Medicine

Volumn 82, Issue 1, 2004, Pages 4-11

  La Cava, Antonio ^a,b   Alviggi, Carlo ^b   Matarese, Giuseppe ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CNR   (Italy)

Author keywords

Autoimmunity; Inflammation; Leptin; T cells

Indexed keywords

LEPTIN;

AUTOIMMUNITY; CHRONIC INFLAMMATION; DELAYED HYPERSENSITIVITY; DRUG TARGETING; ENDOMETRIOSIS; HORMONE DEFICIENCY; HUMAN; IMMUNOTHERAPY; INFLAMMATION; NEUROENDOCRINE SYSTEM; NONHUMAN; OBESITY; PROTEIN FUNCTION; REVIEW; STARVATION;

ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; ENDOMETRIOSIS; FEMALE; HUMANS; IMMUNE SYSTEM; IMMUNOTHERAPY; INFLAMMATION; LEPTIN; NEUROSECRETORY SYSTEMS;

EID: 0842308729     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-003-0492-1     Document Type: Review

References (46)

1. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395:763-770
2. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW (1997) Crystal structure of the obese protein leptin-E100. Nature 387:206-208
3. Tartaglia LA (1997) The leptin receptor. J Biol Chem 272:6093-6070
4. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS (1998) Leptin regulates proinflammatory immune responses. FASEB J 12:57-63
5. Matarese G (2000) Leptin and the immune system: how nutritional status influences the immune response. Eur Cytokine Netw 11:7-14
6. Flier JS (1998) Lowered leptin slims immune response. Nat Med 10:1124-1125
7. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252
8. Chan JL, Heist C, DePaoli A, Veldhuis JD, Mantzoros CS (2003) The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 111:1409-1421
9. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ (1998) The stomach is a source of leptin. Nature 395:790-792
10. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897-901
11. Chandra RK (1980) Cell-mediated immunity in genetically obese (C57BL/6\J ob/ob) mice. Am J Clin Nutr 33:13-20
12. Mandel MA, Mahmoud AA (1978) Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol 120:1375-1380
13. Fernandes G, Handwerger BS, Yunis EJ, Brown DM (1978) Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays. J Clin Invest 61:243-249
14. Ozata M, Ozdemir IC, Licinio J (1998) Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicates new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 84:3686-3690
15. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398-400
16. Lichtman AH, Abbas AK (1997) T-cell subsets: recruiting the right kind of help. Curr Biol 7:R242-44
17. Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR (1999) Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104:1051-1059
18. Moret Y, Schmid-Hempel P (2000) Survival for immunity: the price of immune system activation for bumblebee workers. Science 290:1166-1168
19. Lord GM, Matarese G, Howard JK, Lechler RI (2001) The bioenergetics of the immune system. Science 292:855-856
20. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB (2002) Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 168:4018-4024
21. Gualillo O, Eiras S, Lago F, Dieguez C, Casanueva FF (2000) Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci 67:2433-2441
22. Barbier M, Attoub S, Joubert M, Bado A, Laboisse C, Cherbut C, Galmiche JP (2001) Proinflammatory role of leptin in experimental colitis in rats benefit of cholecystokinin-B antagonist and beta3-agonist. Life Sci 69:567-580
23. Sanna V, Di Giacomo A, La Cava A, Lechler RI, Fontana S, Zappacosta S, Matarese G (2003) Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 111:241-250
24. Landman RE, Puder JJ, Xiao E, Freda PU, Ferin M, Wardlaw SL (2003) Endotoxin stimulates leptin in the human and nonhuman primate. J Clin Endocrinol Metab 88:1285-1291
25. Matarese G, Alviggi C, Sanna V, Howard JK, Lord GM, Carravetta C, Fontana S, Lechler RI, Bloom SR, De Placido G (2000) Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab 85:2483-2487
26. Schols AM, Creutzberg EC, Buurman WA, Campfield LA, Saris WH, Wouters EF (1999) Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160:1220-1226
27. Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, Grunfeld C, Fantuzzi G (2000) Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci USA 97:2367-2372
28. Oral, E, Arici A (1997) Pathogenesis of endometriosis. Obstet Gynecol Clin North Am 24:219-233
29. Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang Y, Cho SY, Kim HS (2001) Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33:95-102
30. Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH (1998) Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci U S A 95:9558-9561
31. Vinatier D, Dufour P (1997) Is endometriosis an immunological disease? Contracept Fertil Sex 25:179-191
32. Gonzalez RR, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Pellicer A, Simon C (2000) Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst. J Clin Endocrinol Metab 85:4883-4888
33. Steinman L (1999) Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron 24:511-514
34. Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, Bloom SR, Lechler RI, Zappacosta S, Fontana S (2001) Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 166:5909-5916
35. Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A (2002) Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 51:1356-1361
36. Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D, Gabay C (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168:875-882
37. Siegmund B, Lehr HA, Fantuzzi G (2002) Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology 122:2011-2025
38. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110:1093-1103
39. Tolle V, Kadem M, Bluet-Pajot MT, Frere D, Foulon C, Bossu C, Dardennes R, Mounier C, Zizzari P, Lang F, Epelbaum J, Estour B (2003) Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J Clin Endocrinol Metab 88:109-116
40. Allende LM, Corell A, Manzanares J, Madruga D, Marcos A, Madrono A, Lopez-Goyanes A, Garcia-Perez MA, Moreno JM, Rodrigo M, Sanz F, Arnaiz-Villena A (1998) Immunodeficiency associated with anorexia nervosa is secondary and improves after refeeding. Immunology 94:543-551
41. Ballinger A, Kelly P, Hallyburton E, Besser R, Farthing M (1998) Plasma leptin in chronic inflammatory bowel disease and HIV: implications for the pathogenesis of anorexia and weight loss. Clin Sci (Colch) 94:479-483
42. Grunfeld C, Pang M, Shigenaga JK, Jensen P, Lallone R, Friedman J, Feingold KR (1996) Serum leptin levels in the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 81:4342-4346
43. Matarese G, Castelli-Gattinara G, Cancrini C, Bernardi S, Romiti ML, Savarese C, Di Giacomo A, Rossi P, Racioppi L (2002) Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy. Clin Endocrinol (Oxf) 57:643-646
44. Reseland JE, Haugen F, Hollung K, Solvoll K, Halvorsen B, Brude IR, Nenseter MS, Christiansen EN, Drevon CA (2001) Reduction of leptin gene expression by dietary polyunsaturated fatty acids. J Lipid Res 42:743-750
45. Mantzoros CS, Prasad AS, Beck FW, Grabowski S, Kaplan J, Adair C, Brewer GJ (1998) Zinc may regulate serum leptin concentrations in humans. J Am Coll Nutr 17:270-275
46. Fraser DA, Thoen J, Reseland JE, Forre O, Kjeldsen-Kragh J (1999) Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin Rheumatol 18:394-401