-
1
-
-
0035855833
-
How the olfactory system makes sense of scents
-
Firestein, S. How the olfactory system makes sense of scents. Nature 413, 211-218 (2001).
-
(2001)
Nature
, vol.413
, pp. 211-218
-
-
Firestein, S.1
-
2
-
-
66249144426
-
The structure and function of G-protein-coupled receptors
-
Rosenbaum, D. M., Rasmussen, S. G. F. & Kobilka, B. K. The structure and function of G-protein-coupled receptors. Nature 459, 356-363 (2009).
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.F.2
Kobilka, B.K.3
-
3
-
-
0035461311
-
ATP synthase - A marvellous rotary engine of the cell
-
Yoshida, M., Muneyuki, E. & Hisabori, T. ATP synthase - a marvellous rotary engine of the cell. Nature Rev. Mol. Cell Biol. 2, 669-677 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol.
, vol.2
, pp. 669-677
-
-
Yoshida, M.1
Muneyuki, E.2
Hisabori, T.3
-
4
-
-
0035344213
-
The myosin swinging cross-bridge model
-
Spudich, J. A. The myosin swinging cross-bridge model. Nature Rev. Mol. Cell Biol. 2, 387-392 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol.
, vol.2
, pp. 387-392
-
-
Spudich, J.A.1
-
5
-
-
70349774561
-
Directed evolution: New parts and optimized function
-
Dougherty, M. J. & Arnold, F. H. Directed evolution: new parts and optimized function. Curr. Opin. Biotechnol. 20, 486-491 (2009).
-
(2009)
Curr. Opin. Biotechnol.
, vol.20
, pp. 486-491
-
-
Dougherty, M.J.1
Arnold, F.H.2
-
6
-
-
84949190783
-
The nature of chemical innovation: New enzymes by evolution
-
Arnold, F. H. The nature of chemical innovation: new enzymes by evolution. Q. Rev. Biophys. 48, 404-410 (2015).
-
(2015)
Q. Rev. Biophys.
, vol.48
, pp. 404-410
-
-
Arnold, F.H.1
-
7
-
-
84865306330
-
Directed enzyme evolution: Beyond the low-hanging fruit
-
Goldsmith, M. & Tawfik, D. S. Directed enzyme evolution: beyond the low-hanging fruit. Curr. Opin. Struct. Biol. 22, 406-412 (2012).
-
(2012)
Curr. Opin. Struct. Biol.
, vol.22
, pp. 406-412
-
-
Goldsmith, M.1
Tawfik, D.S.2
-
8
-
-
84892898809
-
Protein folding and de novo protein design for biotechnological applications
-
Khoury, G. A., Smadbeck, J., Kieslich, C. A. & Floudas, C. A. Protein folding and de novo protein design for biotechnological applications. Trends Biotechnol. 32, 99-109 (2014).
-
(2014)
Trends Biotechnol.
, vol.32
, pp. 99-109
-
-
Khoury, G.A.1
Smadbeck, J.2
Kieslich, C.A.3
Floudas, C.A.4
-
9
-
-
85010841410
-
Protein design: Past, present, and future
-
Regan, L. et al. Protein design: past, present, and future. Biopolymers 104, 334-350 (2015).
-
(2015)
Biopolymers
, vol.104
, pp. 334-350
-
-
Regan, L.1
-
10
-
-
0035810165
-
Functional proteins from a random-sequence library
-
Keefe, A. D. & Szostak, J. W. Functional proteins from a random-sequence library. Nature 410, 715-718 (2001).
-
(2001)
Nature
, vol.410
, pp. 715-718
-
-
Keefe, A.D.1
Szostak, J.W.2
-
11
-
-
79251539227
-
De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth
-
Fisher, M. A., McKinley, K. L., Bradley, L. H., Viola, S. R. & Hecht, M. H. De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth. PLoS ONE 6, e15364 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e15364
-
-
Fisher, M.A.1
McKinley, K.L.2
Bradley, L.H.3
Viola, S.R.4
Hecht, M.H.5
-
12
-
-
84957541025
-
De novo proteins with life-sustaining functions are structurally dynamic
-
Murphy, G. S., Greisman, J. B. & Hecht, M. H. De novo proteins with life-sustaining functions are structurally dynamic. J. Mol. Biol. 428, 399-411 (2016).
-
(2016)
J. Mol. Biol.
, vol.428
, pp. 399-411
-
-
Murphy, G.S.1
Greisman, J.B.2
Hecht, M.H.3
-
13
-
-
0000379806
-
The genetic control of tertiary protein structure: Studies with model systems
-
Epstein, C. J., Goldberger, R. F. & Anfinsen, C. B. The genetic control of tertiary protein structure: studies with model systems. Cold Spring Harb. Simp. Quant. Biol. 28, 439-449 (1963).
-
(1963)
Cold Spring Harb. Simp. Quant. Biol.
, vol.28
, pp. 439-449
-
-
Epstein, C.J.1
Goldberger, R.F.2
Anfinsen, C.B.3
-
14
-
-
78650905964
-
ROSETTA3: An object-oriented software suite for the simulation and design of macromolecules
-
Leaver-Fay, A. et al. ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol. 487, 545-574 (2011).
-
(2011)
Methods Enzymol.
, vol.487
, pp. 545-574
-
-
Leaver-Fay, A.1
-
15
-
-
84911394089
-
CCBuilder: An interactive web-based tool for building, designing and assessing coiled-coil protein assemblies
-
Wood, C. W. et al. CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies. Bioinformatics 30, 3029-3035 (2014).
-
(2014)
Bioinformatics
, vol.30
, pp. 3029-3035
-
-
Wood, C.W.1
-
16
-
-
84874061083
-
Multistate protein design using CLEVER and CLASSY
-
Negron, C. & Keating, A. E. Multistate protein design using CLEVER and CLASSY. Methods Enzymol. 523, 171-190 (2013).
-
(2013)
Methods Enzymol.
, vol.523
, pp. 171-190
-
-
Negron, C.1
Keating, A.E.2
-
17
-
-
84880843785
-
Protein WISDOM: A workbench for in silico de novo design of biomolecules
-
Smadbeck, J., Peterson, M. B., Khoury, G. A., Taylor, M. S. & Floudas, C. A. Protein WISDOM: a workbench for in silico de novo design of biomolecules. J. Vis. Exp. 77, e50476 (2013).
-
(2013)
J. Vis. Exp.
, vol.77
, pp. e50476
-
-
Smadbeck, J.1
Peterson, M.B.2
Khoury, G.A.3
Taylor, M.S.4
Floudas, C.A.5
-
18
-
-
22244449669
-
Do all backbone polar groups in proteins form hydrogen bonds?
-
Fleming, P. J. & Rose, G. D. Do all backbone polar groups in proteins form hydrogen bonds? Protein Sci. 14, 1911-1917 (2005).
-
(2005)
Protein Sci.
, vol.14
, pp. 1911-1917
-
-
Fleming, P.J.1
Rose, G.D.2
-
19
-
-
0023155210
-
Tertiary templates for proteins: Use of packing criteria in the enumeration of allowed sequences for different structural classes
-
Ponder, J. W. & Richards, F. M. Tertiary templates for proteins: use of packing criteria in the enumeration of allowed sequences for different structural classes. J. Mol. Biol. 193, 775-791 (1987).
-
(1987)
J. Mol. Biol.
, vol.193
, pp. 775-791
-
-
Ponder, J.W.1
Richards, F.M.2
-
20
-
-
0029920337
-
Protein design automation
-
Dahiyat, B. I. & Mayo, S. L. Protein design automation. Protein Sci. 5, 895-903 (1996).
-
(1996)
Protein Sci.
, vol.5
, pp. 895-903
-
-
Dahiyat, B.I.1
Mayo, S.L.2
-
21
-
-
0030793767
-
De novo protein design: Fully automated sequence selection
-
Dahiyat, B. I. & Mayo, S. L. De novo protein design: fully automated sequence selection. Science 278, 82-87 (1997).
-
(1997)
Science
, vol.278
, pp. 82-87
-
-
Dahiyat, B.I.1
Mayo, S.L.2
-
22
-
-
0034641749
-
Native protein sequences are close to optimal for their structures
-
Kuhlman, B. & Baker, D. Native protein sequences are close to optimal for their structures. Proc. Natl Acad. Sci. USA 97, 10383-10388 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 10383-10388
-
-
Kuhlman, B.1
Baker, D.2
-
23
-
-
0031585984
-
Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions
-
Simons, K. T., Kooperberg, C., Huang, E. & Baker, D. Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions. J. Mol. Biol. 268, 209-225 (1997).
-
(1997)
J. Mol. Biol.
, vol.268
, pp. 209-225
-
-
Simons, K.T.1
Kooperberg, C.2
Huang, E.3
Baker, D.4
-
24
-
-
79952488320
-
Learning generative models for protein fold families
-
Balakrishnan, S., Kamisetty, H., Carbonell, J. G., Lee, S.-I. & Langmead, C. J. Learning generative models for protein fold families. Proteins 79, 1061-1078 (2011).
-
(2011)
Proteins
, vol.79
, pp. 1061-1078
-
-
Balakrishnan, S.1
Kamisetty, H.2
Carbonell, J.G.3
Lee, S.-I.4
Langmead, C.J.5
-
25
-
-
84884603324
-
Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era
-
Kamisetty, H., Ovchinnikov, S. & Baker, D. Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era. Proc. Natl Acad. Sci. USA 110, 15674-15679 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 15674-15679
-
-
Kamisetty, H.1
Ovchinnikov, S.2
Baker, D.3
-
26
-
-
84899847547
-
Robust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information
-
Ovchinnikov, S., Kamisetty, H. & Baker, D. Robust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information. eLife 3, e02030 (2014).
-
(2014)
ELife
, vol.3
, pp. e02030
-
-
Ovchinnikov, S.1
Kamisetty, H.2
Baker, D.3
-
27
-
-
84945928515
-
Large-scale determination of previously unsolved protein structures using evolutionary information
-
Ovchinnikov, S. et al. Large-scale determination of previously unsolved protein structures using evolutionary information. eLife 4, e09248 (2015).
-
(2015)
ELife
, vol.4
, pp. e09248
-
-
Ovchinnikov, S.1
-
28
-
-
0345306764
-
Design of a novel globular protein fold with atomic-level accuracy
-
Kuhlman, B. Design of a novel globular protein fold with atomic-level accuracy. Science 302, 1364-1368 (2003).
-
(2003)
Science
, vol.302
, pp. 1364-1368
-
-
Kuhlman, B.1
-
29
-
-
80052334922
-
Rosetta remodel: A generalized framework for flexible backbone protein design
-
Huang, P.-S. et al. Rosetta Remodel: a generalized framework for flexible backbone protein design. PLoS ONE 6, e24109 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e24109
-
-
Huang, P.-S.1
-
30
-
-
0032553587
-
High-resolution protein design with backbone freedom
-
Harbury, P. B., Plecs, J. J., Tidor, B., Alber, T. & Kim, P. S. High-resolution protein design with backbone freedom. Science 282, 1462-1467 (1998).
-
(1998)
Science
, vol.282
, pp. 1462-1467
-
-
Harbury, P.B.1
Plecs, J.J.2
Tidor, B.3
Alber, T.4
Kim, P.S.5
-
31
-
-
84908244550
-
Computational design of water-soluble α-helical barrels
-
Thomson, A. R. et al. Computational design of water-soluble α-helical barrels. Science 346, 485-488 (2014).
-
(2014)
Science
, vol.346
, pp. 485-488
-
-
Thomson, A.R.1
-
32
-
-
79251600167
-
Probing designability via a generalized model of helical bundle geometry
-
Grigoryan, G. & DeGrado, W. F. Probing designability via a generalized model of helical bundle geometry. J. Mol. Biol. 405, 1079-1100 (2011).
-
(2011)
J. Mol. Biol.
, vol.405
, pp. 1079-1100
-
-
Grigoryan, G.1
DeGrado, W.F.2
-
33
-
-
84908235298
-
High thermodynamic stability of parametrically designed helical bundles
-
Huang, P.-S. et al. High thermodynamic stability of parametrically designed helical bundles. Science 346, 481-485 (2014).
-
(2014)
Science
, vol.346
, pp. 481-485
-
-
Huang, P.-S.1
-
34
-
-
84919486520
-
2+-transporting four-helix bundle
-
2+-transporting four-helix bundle. Science 346, 1520-1524 (2014).
-
(2014)
Science
, vol.346
, pp. 1520-1524
-
-
Joh, N.H.1
-
35
-
-
0023812695
-
Characterization of a helical protein designed from first principles
-
Regan, L. & DeGrado, W. F. Characterization of a helical protein designed from first principles. Science 241, 976-978 (1988).
-
(1988)
Science
, vol.241
, pp. 976-978
-
-
Regan, L.1
DeGrado, W.F.2
-
36
-
-
84943415110
-
Control over overall shape and size in de novo designed proteins
-
Lin, Y.-R. et al. Control over overall shape and size in de novo designed proteins. Proc. Natl Acad. Sci. USA 112, E5478-E5485 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E5478-E5485
-
-
Lin, Y.-R.1
-
37
-
-
84868611622
-
Principles for designing ideal protein structures
-
Koga, N. et al. Principles for designing ideal protein structures. Nature 491, 222-227 (2012).
-
(2012)
Nature
, vol.491
, pp. 222-227
-
-
Koga, N.1
-
38
-
-
84955289568
-
Precise assembly of complex beta sheet topologies from de novo designed building blocks
-
King, I. C. et al. Precise assembly of complex beta sheet topologies from de novo designed building blocks. eLife 4, e11012 (2015).
-
(2015)
ELife
, vol.4
, pp. e11012
-
-
King, I.C.1
-
39
-
-
84918555133
-
Computational design of a leucine-rich repeat protein with a predefined geometry
-
Rämisch, S., Weininger, U., Martinsson, J., Akke, M. & André, I. Computational design of a leucine-rich repeat protein with a predefined geometry. Proc. Natl Acad. Sci. USA 111, 17875-17880 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 17875-17880
-
-
Rämisch, S.1
Weininger, U.2
Martinsson, J.3
Akke, M.4
André, I.5
-
40
-
-
84926289262
-
Control of repeat-protein curvature by computational protein design
-
Park, K. et al. Control of repeat-protein curvature by computational protein design. Nature Struct. Mol. Biol. 22, 167-174 (2015).
-
(2015)
Nature Struct. Mol. Biol.
, vol.22
, pp. 167-174
-
-
Park, K.1
-
41
-
-
84951325903
-
Rational design of α-helical tandem repeat proteins with closed architectures
-
Doyle, L. et al. Rational design of α-helical tandem repeat proteins with closed architectures. Nature 528, 585-588 (2015).
-
(2015)
Nature
, vol.528
, pp. 585-588
-
-
Doyle, L.1
-
42
-
-
84950276750
-
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
-
Huang, P.-S. et al. De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy. Nature Chem. Biol. 12, 29-34 (2016).
-
(2016)
Nature Chem. Biol.
, vol.12
, pp. 29-34
-
-
Huang, P.-S.1
-
43
-
-
84951320596
-
Exploring the repeat protein universe through computational protein design
-
Brunette, T. J. et al. Exploring the repeat protein universe through computational protein design. Nature 528, 580-584 (2015).
-
(2015)
Nature
, vol.528
, pp. 580-584
-
-
Brunette, T.J.1
-
44
-
-
84966372824
-
Design of structurally distinct proteins using strategies inspired by evolution
-
Jacobs, T. M. et al. Design of structurally distinct proteins using strategies inspired by evolution. Science 352, 687-690 (2016).
-
(2016)
Science
, vol.352
, pp. 687-690
-
-
Jacobs, T.M.1
-
45
-
-
84861966405
-
Increasing sequence diversity with flexible backbone protein design: The complete redesign of a protein hydrophobic core
-
Murphy, G. S. et al. Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core. Structure 20, 1086-1096 (2012).
-
(2012)
Structure
, vol.20
, pp. 1086-1096
-
-
Murphy, G.S.1
-
46
-
-
84896315237
-
Proof of principle for epitope-focused vaccine design
-
Correia, B. E. et al. Proof of principle for epitope-focused vaccine design. Nature 507, 201-206 (2014).
-
(2014)
Nature
, vol.507
, pp. 201-206
-
-
Correia, B.E.1
-
47
-
-
0000920828
-
The packing of α-helices: Simple coiled-coils
-
Crick, F. H. C. The packing of α-helices: simple coiled-coils. Acta Cryst. 6, 689-697 (1953).
-
(1953)
Acta Cryst.
, vol.6
, pp. 689-697
-
-
Crick, F.H.C.1
-
48
-
-
0033545937
-
Solution structure and dynamics of a de novo designed three-helix bundle protein
-
Walsh, S. T., Cheng, H., Bryson, J. W., Roder, H. & DeGrado, W. F. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc. Natl Acad. Sci. USA 96, 5486-5491 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 5486-5491
-
-
Walsh, S.T.1
Cheng, H.2
Bryson, J.W.3
Roder, H.4
DeGrado, W.F.5
-
49
-
-
84866511067
-
A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology
-
Fletcher, J. M. et al. A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology. ACS Synth. Biol. 1, 240-250 (2012).
-
(2012)
ACS Synth. Biol.
, vol.1
, pp. 240-250
-
-
Fletcher, J.M.1
-
50
-
-
81355127213
-
A de novo peptide hexamer with a mutable channel
-
Zaccai, N. R. et al. A de novo peptide hexamer with a mutable channel. Nature Chem. Biol. 7, 935-941 (2011).
-
(2011)
Nature Chem. Biol.
, vol.7
, pp. 935-941
-
-
Zaccai, N.R.1
-
51
-
-
0022964503
-
The design, synthesis, and crystallization of an alpha-helical peptide
-
Eisenberg, D. et al. The design, synthesis, and crystallization of an alpha-helical peptide. Proteins 1, 16-22 (1986).
-
(1986)
Proteins
, vol.1
, pp. 16-22
-
-
Eisenberg, D.1
-
52
-
-
0035909890
-
Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils
-
Keating, A. E., Malashkevich, V. N., Tidor, B. & Kim, P. S. Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils. Proc. Natl Acad. Sci. USA 98, 14825-14830 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 14825-14830
-
-
Keating, A.E.1
Malashkevich, V.N.2
Tidor, B.3
Kim, P.S.4
-
53
-
-
79957589641
-
Computational design of virus-like protein assemblies on carbon nanotube surfaces
-
Grigoryan, G. et al. Computational design of virus-like protein assemblies on carbon nanotube surfaces. Science 332, 1071-1076 (2011).
-
(2011)
Science
, vol.332
, pp. 1071-1076
-
-
Grigoryan, G.1
-
54
-
-
84877588832
-
Self-assembling cages from coiled-coil peptide modules
-
Fletcher, J. M. et al. Self-assembling cages from coiled-coil peptide modules. Science 340, 595-599 (2013).
-
(2013)
Science
, vol.340
, pp. 595-599
-
-
Fletcher, J.M.1
-
55
-
-
84983605294
-
Installing hydrolytic activity into a completely de novo protein framework
-
Burton, A. J., Thomson, A. R., Dawson, W. M., Brady, R. L. & Woolfson, D. N. Installing hydrolytic activity into a completely de novo protein framework. Nature Chem. http://dx.doi.org/10.1038/nchem.2555 (2016).
-
(2016)
Nature Chem.
-
-
Burton, A.J.1
Thomson, A.R.2
Dawson, W.M.3
Brady, R.L.4
Woolfson, D.N.5
-
56
-
-
65249171530
-
Design of protein-interaction specificity gives selective bZIP-binding peptides
-
Grigoryan, G., Reinke, A. W. & Keating, A. E. Design of protein-interaction specificity gives selective bZIP-binding peptides. Nature 458, 859-864 (2009).
-
(2009)
Nature
, vol.458
, pp. 859-864
-
-
Grigoryan, G.1
Reinke, A.W.2
Keating, A.E.3
-
57
-
-
77951685234
-
A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering
-
Reinke, A. W., Grant, R. A. & Keating, A. E. A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering. J. Am. Chem. Soc. 132, 6025-6031 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 6025-6031
-
-
Reinke, A.W.1
Grant, R.A.2
Keating, A.E.3
-
58
-
-
84894942090
-
An accurate binding interaction model in de novo computational protein design of interactions: If you build it, they will bind
-
London, N. & Ambroggio, X. An accurate binding interaction model in de novo computational protein design of interactions: if you build it, they will bind. J. Struct. Biol. 185, 136-146 (2014).
-
(2014)
J. Struct. Biol.
, vol.185
, pp. 136-146
-
-
London, N.1
Ambroggio, X.2
-
59
-
-
84879093742
-
Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments
-
Gradišar, H. et al. Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments. Nature Chem. Biol. 9, 362-366 (2013).
-
(2013)
Nature Chem. Biol.
, vol.9
, pp. 362-366
-
-
Gradišar, H.1
-
60
-
-
78651463425
-
De novo design of orthogonal peptide pairs forming parallel coiled-coil heterodimers
-
Gradišar, H. & Jerala, R. De novo design of orthogonal peptide pairs forming parallel coiled-coil heterodimers. J. Pept. Sci. 17, 100-106 (2011).
-
(2011)
J. Pept. Sci.
, vol.17
, pp. 100-106
-
-
Gradišar, H.1
Jerala, R.2
-
61
-
-
79551681222
-
Protein binding specificity versus promiscuity
-
Schreiber, G. & Keating, A. E. Protein binding specificity versus promiscuity. Curr. Opin. Struct. Biol. 21, 50-61 (2011).
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 50-61
-
-
Schreiber, G.1
Keating, A.E.2
-
62
-
-
84873024403
-
A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds
-
Stranges, P. B. & Kuhlman, B. A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds. Protein Sci. 22, 74-82 (2013).
-
(2013)
Protein Sci.
, vol.22
, pp. 74-82
-
-
Stranges, P.B.1
Kuhlman, B.2
-
63
-
-
84966333727
-
De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity
-
Boyken, S. E. et al. De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science 352, 680-687 (2016).
-
(2016)
Science
, vol.352
, pp. 680-687
-
-
Boyken, S.E.1
-
64
-
-
85015106657
-
DNA in a material world
-
Seeman, N. C. DNA in a material world. Nature 421, 427-431 (2003).
-
(2003)
Nature
, vol.421
, pp. 427-431
-
-
Seeman, N.C.1
-
65
-
-
84880941909
-
The enabled state of DNA nanotechnology
-
Linko, V. & Dietz, H. The enabled state of DNA nanotechnology. Curr. Opin. Biotechnol. 24, 555-561 (2013).
-
(2013)
Curr. Opin. Biotechnol.
, vol.24
, pp. 555-561
-
-
Linko, V.1
Dietz, H.2
-
66
-
-
84906079714
-
Structural DNA nanotechnology: State of the art and future perspective
-
Zhang, F., Nangreave, J., Liu, Y. & Yan, H. Structural DNA nanotechnology: state of the art and future perspective. J. Am. Chem. Soc. 136, 11198-11211 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 11198-11211
-
-
Zhang, F.1
Nangreave, J.2
Liu, Y.3
Yan, H.4
-
67
-
-
84878935468
-
Design of protein catalysts
-
Hilvert, D. Design of protein catalysts. Annu. Rev. Biochem. 82, 447-470 (2013).
-
(2013)
Annu. Rev. Biochem.
, vol.82
, pp. 447-470
-
-
Hilvert, D.1
-
68
-
-
84876720680
-
De novo enzymes by computational design
-
Kries, H., Blomberg, R. & Hilvert, D. De novo enzymes by computational design. Curr. Opin. Chem. Biol. 17, 221-228 (2013).
-
(2013)
Curr. Opin. Chem. Biol.
, vol.17
, pp. 221-228
-
-
Kries, H.1
Blomberg, R.2
Hilvert, D.3
-
69
-
-
84878025107
-
Computational enzyme design
-
Kiss, G., Çelebi-Ölçüm, N., Moretti, R., Baker, D. & Houk, K. N. Computational enzyme design. Angew. Chem. Int. Edn Engl. 52, 5700-5725 (2013).
-
(2013)
Angew. Chem. Int. Edn Engl.
, vol.52
, pp. 5700-5725
-
-
Kiss, G.1
Çelebi-Ölçüm, N.2
Moretti, R.3
Baker, D.4
Houk, K.N.5
-
70
-
-
79956088540
-
De novo enzyme design using rosetta3
-
Richter, F., Leaver-Fay, A., Khare, S. D., Bjelic, S. & Baker, D. De novo enzyme design using Rosetta3. PLoS ONE 6, e19230 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e19230
-
-
Richter, F.1
Leaver-Fay, A.2
Khare, S.D.3
Bjelic, S.4
Baker, D.5
-
71
-
-
77957316716
-
An exciting but challenging road ahead for computational enzyme design
-
Baker, D. An exciting but challenging road ahead for computational enzyme design. Protein Sci. 19, 1817-1819 (2010).
-
(2010)
Protein Sci.
, vol.19
, pp. 1817-1819
-
-
Baker, D.1
-
72
-
-
77956357583
-
Evaluation and ranking of enzyme designs
-
Kiss, G., Röthlisberger, D., Baker, D. & Houk, K. N. Evaluation and ranking of enzyme designs. Protein Sci. 19, 1760-1773 (2010).
-
(2010)
Protein Sci.
, vol.19
, pp. 1760-1773
-
-
Kiss, G.1
Röthlisberger, D.2
Baker, D.3
Houk, K.N.4
-
73
-
-
84974589189
-
Fast knoevenagel condensations catalyzed by an artificial schiff-base-forming enzyme
-
Garrabou, X., Wicky, B. I. & Hilvert, D. Fast Knoevenagel condensations catalyzed by an artificial Schiff-base-forming enzyme. J. Am. Chem. Soc. 138, 6972-6974. (2016).
-
(2016)
J. Am. Chem. Soc.
, vol.138
, pp. 6972-6974
-
-
Garrabou, X.1
Wicky, B.I.2
Hilvert, D.3
-
74
-
-
84959485747
-
A computationally designed hemagglutinin stem-binding protein provides in vivo protection from influenza independent of a host immune response
-
Koday, M. T. et al. A computationally designed hemagglutinin stem-binding protein provides in vivo protection from influenza independent of a host immune response. PLoS Pathog. 12, e1005409 (2016).
-
(2016)
PLoS Pathog.
, vol.12
, pp. e1005409
-
-
Koday, M.T.1
-
75
-
-
84884166196
-
Computational design of ligand-binding proteins with high affinity and selectivity
-
Tinberg, C. E. et al. Computational design of ligand-binding proteins with high affinity and selectivity. Nature 501, 212-216 (2013).
-
(2013)
Nature
, vol.501
, pp. 212-216
-
-
Tinberg, C.E.1
-
76
-
-
84902839007
-
Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring
-
Griss, R. et al. Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring. Nature Chem. Biol. 10, 598-603 (2014).
-
(2014)
Nature Chem. Biol.
, vol.10
, pp. 598-603
-
-
Griss, R.1
-
77
-
-
84956906488
-
A general strategy to construct small molecule biosensors in eukaryotes
-
Feng, J. et al. A general strategy to construct small molecule biosensors in eukaryotes. eLife 4, e10606 (2015).
-
(2015)
ELife
, vol.4
, pp. e10606
-
-
Feng, J.1
-
78
-
-
84940548990
-
Computational design and experimental verification of a symmetric protein homodimer
-
Mou, Y., Huang, P.-S., Hsu, F.-C., Huang, S.-J. & Mayo, S. L. Computational design and experimental verification of a symmetric protein homodimer. Proc. Natl Acad. Sci. USA 112, 10714-10719 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 10714-10719
-
-
Mou, Y.1
Huang, P.-S.2
Hsu, F.-C.3
Huang, S.-J.4
Mayo, S.L.5
-
79
-
-
84861676223
-
Computational design of self-assembling protein nanomaterials with atomic level accuracy
-
King, N. P. et al. Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science 336, 1171-1174 (2012).
-
(2012)
Science
, vol.336
, pp. 1171-1174
-
-
King, N.P.1
-
80
-
-
84902006780
-
Accurate design of co-assembling multi-component protein nanomaterials
-
King, N. P. et al. Accurate design of co-assembling multi-component protein nanomaterials. Nature 510, 103-108 (2014).
-
(2014)
Nature
, vol.510
, pp. 103-108
-
-
King, N.P.1
-
81
-
-
84933556352
-
Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces
-
Gonen, S., Dimaio, F., Gonen, T. & Baker, D. Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces. Science 348, 1365-1368 (2015).
-
(2015)
Science
, vol.348
, pp. 1365-1368
-
-
Gonen, S.1
Dimaio, F.2
Gonen, T.3
Baker, D.4
-
82
-
-
84977663424
-
Design of a hyperstable 60-subunit protein icosahedron
-
Hsia, Y. et al. Design of a hyperstable 60-subunit protein icosahedron. Nature 535, 136-139 (2016).
-
(2016)
Nature
, vol.535
, pp. 136-139
-
-
Hsia, Y.1
-
83
-
-
84979578745
-
Accurate design of megadalton-scale two-component icosahedral protein complexes
-
Bale, J. B. et al. Accurate design of megadalton-scale two-component icosahedral protein complexes. Science 353, 389-394 (2016).
-
(2016)
Science
, vol.353
, pp. 389-394
-
-
Bale, J.B.1
-
84
-
-
84988352784
-
Accurate de novo design of hyperstable constrained peptides
-
Bhardwaj, G., Mulligan, V. K., Bahl, C. D. & Baker, D. Accurate de novo design of hyperstable constrained peptides. Nature http://dx.doi.org/10.1038/nature19791 (2016).
-
(2016)
Nature
-
-
Bhardwaj, G.1
Mulligan, V.K.2
Bahl, C.D.3
Baker, D.4
-
85
-
-
84880920662
-
Evolution of a designed retro-aldolase leads to complete active site remodeling
-
Giger, L. et al. Evolution of a designed retro-aldolase leads to complete active site remodeling. Nature Chem. Biol. 9, 494-498 (2013).
-
(2013)
Nature Chem. Biol.
, vol.9
, pp. 494-498
-
-
Giger, L.1
|