-
1
-
-
27144511241
-
Engineering novel binding proteins from nonimmunoglobulin domains
-
Binz, H.K., Amstutz, P. & Pluckthun, A. Engineering novel binding proteins from nonimmunoglobulin domains. Nat. Biotechnol. 23, 1257-1268 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1257-1268
-
-
Binz, H.K.1
Amstutz, P.2
Pluckthun, A.3
-
2
-
-
34548522063
-
Alternative non-antibody scaffolds for molecular recognition
-
Skerra, A. Alternative non-antibody scaffolds for molecular recognition. Curr. Opin. Biotechnol. 18, 295-304 (2007).
-
(2007)
Curr. Opin. Biotechnol.
, vol.18
, pp. 295-304
-
-
Skerra, A.1
-
3
-
-
67649872364
-
Engineered protein scaffolds as next-generation antibody therapeutics
-
Gebauer, M. & Skerra, A. Engineered protein scaffolds as next-generation antibody therapeutics. Curr. Opin. Chem. Biol. 13, 245-255 (2009).
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 245-255
-
-
Gebauer, M.1
Skerra, A.2
-
4
-
-
84881115632
-
Tandem-repeat proteins: Regularity plus modularity equals design-ability
-
Javadi, Y. & Itzhaki, L.S. Tandem-repeat proteins: regularity plus modularity equals design-ability. Curr. Opin. Struct. Biol. 23, 622-631 (2013).
-
(2013)
Curr. Opin. Struct. Biol.
, vol.23
, pp. 622-631
-
-
Javadi, Y.1
Itzhaki, L.S.2
-
5
-
-
84877274659
-
Nanostructured functional films from engineered repeat proteins
-
Grove, T.Z., Regan, L. & Cortajarena, A.L. Nanostructured functional films from engineered repeat proteins. J. R. Soc. Interface 10, 20130051 (2013).
-
(2013)
J. R. Soc. Interface
, vol.10
, pp. 20130051
-
-
Grove, T.Z.1
Regan, L.2
Cortajarena, A.L.3
-
6
-
-
84871955080
-
Fibrous nanostructures from the self-assembly of designed repeat protein modules
-
Phillips, J.J., Millership, C. & Main, E.R. Fibrous nanostructures from the self-assembly of designed repeat protein modules. Angew. Chem. Int. Edn Engl. 51, 13132-13135 (2012).
-
(2012)
Angew. Chem. Int. Edn Engl.
, vol.51
, pp. 13132-13135
-
-
Phillips, J.J.1
Millership, C.2
Main, E.R.3
-
7
-
-
84877736928
-
Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices
-
Han, S.H., Lee, M.K. & Lim, Y.B. Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices. Biomacromolecules 14, 1594-1599 (2013).
-
(2013)
Biomacromolecules
, vol.14
, pp. 1594-1599
-
-
Han, S.H.1
Lee, M.K.2
Lim, Y.B.3
-
8
-
-
0035692811
-
The leucine-rich repeat as a protein recognition motif
-
Kobe, B. & Kajava, A.V. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11, 725-732 (2001).
-
(2001)
Curr. Opin. Struct. Biol.
, vol.11
, pp. 725-732
-
-
Kobe, B.1
Kajava, A.V.2
-
9
-
-
1042291215
-
Structural principles of leucine-rich repeat (LRR) proteins
-
Enkhbayar, P., Kamiya, M., Osaki, M., Matsumoto, T. & Matsushima, N. Structural principles of leucine-rich repeat (LRR) proteins. Proteins 54, 394-403 (2004).
-
(2004)
Proteins
, vol.54
, pp. 394-403
-
-
Enkhbayar, P.1
Kamiya, M.2
Osaki, M.3
Matsumoto, T.4
Matsushima, N.5
-
10
-
-
34548222514
-
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
-
Kim, H.M. et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130, 906-917 (2007).
-
(2007)
Cell
, vol.130
, pp. 906-917
-
-
Kim, H.M.1
-
11
-
-
84904169024
-
Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment
-
Parker, R., Mercedes-Camacho, A. & Grove, T.Z. Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment. Protein Sci. 23, 790-800 (2014).
-
(2014)
Protein Sci.
, vol.23
, pp. 790-800
-
-
Parker, R.1
Mercedes-Camacho, A.2
Grove, T.Z.3
-
12
-
-
84863229636
-
Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering
-
Lee, S.C. et al. Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering. Proc. Natl. Acad. Sci. USA 109, 3299-3304 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 3299-3304
-
-
Lee, S.C.1
-
13
-
-
2342624119
-
High-affinity binders selected from designed ankyrin repeat protein libraries
-
Binz, H.K. et al. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat. Biotechnol. 22, 575-582 (2004).
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 575-582
-
-
Binz, H.K.1
-
14
-
-
0037468685
-
A novel strategy to design binding molecules harnessing the modular nature of repeat proteins
-
Forrer, P., Stumpp, M.T., Binz, H.K. & Pluckthun, A. A novel strategy to design binding molecules harnessing the modular nature of repeat proteins. FEBS Lett. 539, 2-6 (2003).
-
(2003)
FEBS Lett.
, vol.539
, pp. 2-6
-
-
Forrer, P.1
Stumpp, M.T.2
Binz, H.K.3
Pluckthun, A.4
-
15
-
-
49549084586
-
Ligand binding by repeat proteins: Natural and designed
-
Grove, T.Z., Cortajarena, A.L. & Regan, L. Ligand binding by repeat proteins: natural and designed. Curr. Opin. Struct. Biol. 18, 507-515 (2008).
-
(2008)
Curr. Opin. Struct. Biol.
, vol.18
, pp. 507-515
-
-
Grove, T.Z.1
Cortajarena, A.L.2
Regan, L.3
-
16
-
-
0037648552
-
Design of stable alpha-helical arrays from an idealized TPR motif
-
Main, E.R., Xiong, Y., Cocco, M.J., D'Andrea, L. & Regan, L. Design of stable alpha-helical arrays from an idealized TPR motif. Structure 11, 497-508 (2003).
-
(2003)
Structure
, vol.11
, pp. 497-508
-
-
Main, E.R.1
Xiong, Y.2
Cocco, M.J.3
D'Andrea, L.4
Regan, L.5
-
17
-
-
84857198283
-
Modular recognition of nucleic acids by PUF, TALE and PPR proteins
-
Filipovska, A. & Rackham, O. Modular recognition of nucleic acids by PUF, TALE and PPR proteins. Mol. Biosyst. 8, 699-708 (2012).
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 699-708
-
-
Filipovska, A.1
Rackham, O.2
-
18
-
-
84895035916
-
Modular peptide binding: From a comparison of natural binders to designed armadillo repeat proteins
-
Reichen, C., Hansen, S. & Pluckthun, A. Modular peptide binding: from a comparison of natural binders to designed armadillo repeat proteins. J. Struct. Biol. 185, 147-162 (2014).
-
(2014)
J. Struct. Biol.
, vol.185
, pp. 147-162
-
-
Reichen, C.1
Hansen, S.2
Pluckthun, A.3
-
19
-
-
84857029597
-
The crystal structure of TAL effector PthXo1 bound to its DNA target
-
Mak, A.N., Bradley, P., Cernadas, R.A., Bogdanove, A.J. & Stoddard, B.L. The crystal structure of TAL effector PthXo1 bound to its DNA target. Science 335, 716-719 (2012).
-
(2012)
Science
, vol.335
, pp. 716-719
-
-
Mak, A.N.1
Bradley, P.2
Cernadas, R.A.3
Bogdanove, A.J.4
Stoddard, B.L.5
-
20
-
-
84903163054
-
Soluble expression of human glycoprotein Ibα in Escherichia coli through replacement of the N-terminal capping domain
-
Ryou, J.H., Park, K., Lee, J.J., Kim, D. & Kim, H.S. Soluble expression of human glycoprotein Ibα in Escherichia coli through replacement of the N-terminal capping domain. Protein Expr. Purif. 101, 21-27 (2014).
-
(2014)
Protein Expr. Purif.
, vol.101
, pp. 21-27
-
-
Ryou, J.H.1
Park, K.2
Lee, J.J.3
Kim, D.4
Kim, H.S.5
-
21
-
-
70350540674
-
Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis
-
Jung, K. et al. Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis. PLoS ONE 4, e7403 (2009).
-
(2009)
PLoS One
, vol.4
, pp. e7403
-
-
Jung, K.1
-
22
-
-
84920768290
-
A general computational approach for repeat protein design
-
Parmeggiani, F. et al. A general computational approach for repeat protein design. J. Mol. Biol. doi:10.1016/j.jmb.2014.11.005.
-
J. Mol. Biol.
-
-
Parmeggiani, F.1
-
23
-
-
80052334922
-
RosettaRemodel: A generalized framework for flexible backbone protein design
-
Huang, P.S. et al. RosettaRemodel: a generalized framework for flexible backbone protein design. PLoS ONE 6, e24109 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e24109
-
-
Huang, P.S.1
-
24
-
-
84885431817
-
High-resolution comparative modeling with RosettaCM
-
Song, Y. et al. High-resolution comparative modeling with RosettaCM. Structure 21, 1735-1742 (2013).
-
(2013)
Structure
, vol.21
, pp. 1735-1742
-
-
Song, Y.1
-
25
-
-
78650905964
-
ROSETTA3: An object-oriented software suite for the simulation and design of macromolecules
-
Leaver-Fay, A. et al. ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol. 487, 545-574 (2011).
-
(2011)
Methods Enzymol.
, vol.487
, pp. 545-574
-
-
Leaver-Fay, A.1
-
26
-
-
58149463441
-
RosettaHoles: Rapid assessment of protein core packing for structure prediction, refinement, design, and validation
-
Sheffler, W. & Baker, D. RosettaHoles: rapid assessment of protein core packing for structure prediction, refinement, design, and validation. Protein Sci. 18, 229-239 (2009).
-
(2009)
Protein Sci.
, vol.18
, pp. 229-239
-
-
Sheffler, W.1
Baker, D.2
-
27
-
-
84896575295
-
Recognition of lipopolysaccharide pattern by TLR4 complexes
-
Park, B.S. & Lee, J.O. Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp. Mol. Med. 45, e66 (2013).
-
(2013)
Exp. Mol. Med.
, vol.45
, pp. e66
-
-
Park, B.S.1
Lee, J.O.2
-
28
-
-
85016370378
-
Leucine-rich repeat (LRR) domains containing intervening motifs in plants
-
Matsushima, N. & Miyashita, H. Leucine-rich repeat (LRR) domains containing intervening motifs in plants. Biomolecules 2, 288-311 (2012).
-
(2012)
Biomolecules
, vol.2
, pp. 288-311
-
-
Matsushima, N.1
Miyashita, H.2
-
29
-
-
60849092269
-
LRRML: A conformational database and an XML description of leucine-rich repeats (LRRs)
-
Wei, T. et al. LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs). BMC Struct. Biol. 8, 47 (2008).
-
(2008)
BMC Struct. Biol.
, vol.8
, pp. 47
-
-
Wei, T.1
-
30
-
-
23344431978
-
The molecular structure of the Toll-like receptor 3 ligand-binding domain
-
Bell, J.K. et al. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc. Natl. Acad. Sci. USA 102, 10976-10980 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10976-10980
-
-
Bell, J.K.1
-
31
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park, B.S. et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458, 1191-1195 (2009).
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
-
32
-
-
79959563138
-
Structural basis of steroid hormone perception by the receptor kinase BRI1
-
Hothorn, M. et al. Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature 474, 467-471 (2011).
-
(2011)
Nature
, vol.474
, pp. 467-471
-
-
Hothorn, M.1
-
33
-
-
0038185277
-
A novel shape complementarity scoring function for protein-protein docking
-
Chen, R. & Weng, Z. A novel shape complementarity scoring function for protein-protein docking. Proteins 51, 397-408 (2003).
-
(2003)
Proteins
, vol.51
, pp. 397-408
-
-
Chen, R.1
Weng, Z.2
-
34
-
-
0031565730
-
Modelling protein docking using shape complementarity, electrostatics and biochemical information
-
Gabb, H.A., Jackson, R.M. & Sternberg, M.J. Modelling protein docking using shape complementarity, electrostatics and biochemical information. J. Mol. Biol. 272, 106-120 (1997).
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 106-120
-
-
Gabb, H.A.1
Jackson, R.M.2
Sternberg, M.J.3
-
35
-
-
0027772959
-
Shape complementarity at protein/protein interfaces
-
Lawrence, M.C. & Colman, P.M. Shape complementarity at protein/protein interfaces. J. Mol. Biol. 234, 946-950 (1993).
-
(1993)
J. Mol. Biol.
, vol.234
, pp. 946-950
-
-
Lawrence, M.C.1
Colman, P.M.2
-
37
-
-
79956017135
-
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
-
Fleishman, S.J. et al. Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science 332, 816-821 (2011).
-
(2011)
Science
, vol.332
, pp. 816-821
-
-
Fleishman, S.J.1
-
38
-
-
84883277095
-
Computational design of a protein-based enzyme inhibitor
-
Procko, E. et al. Computational design of a protein-based enzyme inhibitor. J. Mol. Biol. 425, 3563-3575 (2013).
-
(2013)
J. Mol. Biol.
, vol.425
, pp. 3563-3575
-
-
Procko, E.1
-
39
-
-
84875098026
-
Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2
-
Epa, V.C. et al. Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2. PLoS ONE 8, e59163 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e59163
-
-
Epa, V.C.1
-
40
-
-
84903763186
-
A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer
-
Lee, J.J. et al. A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol. Ther. 22, 1254-1265 (2014).
-
(2014)
Mol. Ther.
, vol.22
, pp. 1254-1265
-
-
Lee, J.J.1
-
41
-
-
84875671926
-
Pareto-optimal refinement method for protein design scaffolds
-
Nivón, L.G., Moretti, R. & Baker, D. A Pareto-optimal refinement method for protein design scaffolds. PLoS ONE 8, e59004 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e59004
-
-
Nivón, L.G.1
Moretti, R.2
Baker, D.A.3
-
42
-
-
67349270900
-
Enzymatic assembly of DNA molecules up to several hundred kilobases
-
Gibson, D.G. et al. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 6, 343-345 (2009).
-
(2009)
Nat. Methods
, vol.6
, pp. 343-345
-
-
Gibson, D.G.1
-
43
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
44
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A.J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674 (2007).
-
(2007)
J. Appl. Crystallogr.
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
-
46
-
-
0013461295
-
Macromolecular TLS refinement in REFMAC at moderate resolutions
-
Winn, M.D., Murshudov, G.N. & Papiz, M.Z. Macromolecular TLS refinement in REFMAC at moderate resolutions. Methods Enzymol. 374, 300-321 (2003).
-
(2003)
Methods Enzymol.
, vol.374
, pp. 300-321
-
-
Winn, M.D.1
Murshudov, G.N.2
Papiz, M.Z.3
|