De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic

Journal of Molecular Biology

Volumn 428, Issue 2, 2016, Pages 399-411

  Murphy, Grant S ^a   Greisman, Jack B ^a   Hecht, Michael H ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

artificial proteomes; de novo protein design; helix bundle; synthetic biology

Indexed keywords

PROTEIN; SYNRESCUE PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; AUXOTROPHY; CONTROLLED STUDY; ESCHERICHIA COLI; LETHAL MUTANT; MOLECULAR EVOLUTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY; THERMOSTABILITY; AMINO ACID SEQUENCE; BIOPHYSICS; CHEMISTRY; CIRCULAR DICHROISM; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL VIABILITY; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

AMINO ACID SEQUENCE; BIOPHYSICAL PHENOMENA; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; ESCHERICHIA COLI; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEINS;

EID: 84957541025     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.12.008     Document Type: Article

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