De novo design of a transmembrane zn2+-transporting four-helix bundle

Science

Volumn 346, Issue 6216, 2014, Pages 1520-1524

  Joh, Nathan H ^a   Wang, Tuo ^b   Bhate, Manasi P ^a   Acharya, Rudresh ^c   Wu, Yibing ^a   Grabe, Michael ^a   Hong, Mei ^b   Grigoryan, Gevorg ^d   DeGrado, William F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c NATIONAL INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

^d Dartmouth Department of Computer Science_Dartmouth College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COBALT; DIMER; DODECYLPHOSPHORYLCHOLINE; MEMBRANE PROTEIN; PROTON; TRANSITION ELEMENT; ZINC; CARRIER PROTEIN; LIPID BILAYER; MICELLE; ZINC-BINDING PROTEIN;

DYNAMIC ANALYSIS; EXPERIMENTAL STUDY; ION EXCHANGE; NUCLEAR MAGNETIC RESONANCE; PROTEIN; TRANSITION ELEMENT;

ALGORITHM; ARTICLE; BINDING AFFINITY; BINDING SITE; ENTROPY; GEOMETRY; ION TRANSPORT; METAL BINDING; MICELLE; MICHAELIS MENTEN KINETICS; MOLECULAR DYNAMICS; PHOSPHOLIPID BILAYER; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SOLID STATE; STOICHIOMETRY; ULTRACENTRIFUGATION; X RAY CRYSTALLOGRAPHY; CHEMISTRY; LIPID BILAYER; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE;

CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; ION TRANSPORT; LIPID BILAYERS; MEMBRANE PROTEINS; MICELLES; MOLECULAR DYNAMICS SIMULATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; ZINC;

EID: 84919486520     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1261172     Document Type: Article

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