Computational design of a leucine-rich repeat protein with a predefined geometry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 50, 2014, Pages 17875-17880

  Rämisch, Sebastian ^a   Weininger, Ulrich ^a   Martinsson, Jonas ^a   Akke, Mikael ^a   André, Ingemar ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Binding scaffold; Buried cysteines; Computational protein design; Geometrical design; Rosetta

Indexed keywords

ANKYRIN; LEUCIN RICH REPEAT PROTEIN; LEUCINE; PROTEIN; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG; LEUCINE-RICH REPEAT PROTEINS; PROTEIN BINDING;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; DIMERIZATION; ENERGY TRANSFER; ESCHERICHIA COLI; GEOMETRY; HYDROGEN BOND; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; GENETICS; INFRARED SPECTROSCOPY; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PROCEDURES; PROTEIN ENGINEERING; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, AFFINITY; CIRCULAR DICHROISM; COMPUTATIONAL BIOLOGY; DIMERIZATION; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; ULTRACENTRIFUGATION;

EID: 84918555133     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1413638111     Document Type: Article

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