A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Clark, Carolyn E ^a,b   Hasan, Milena ^a   Bousso, Philippe ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C FOS; ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; FEMALE; IMMEDIATE EARLY GENE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR IMPRINTING; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION; ANIMAL; CELL NUCLEUS; CYTOLOGY; DENDRITIC CELL; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; TIME;

ANIMALS; ANTIGENS; CELL NUCLEUS; DENDRITIC CELLS; FEMALE; GENES, IMMEDIATE-EARLY; MICE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS;

EID: 79955738613     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018916     Document Type: Article

References (27)

1. Iezzi G, Karjalainen K, Lanzavecchia A, (1998) The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8: 89-95.
2. Huppa JB, Gleimer M, Sumen C, Davis MM, (2003) Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol 4: 749-755.
3. Celli S, Lemaitre F, Bousso P, (2007) Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 27: 625-634.
4. Gunzer M, Schafer A, Borgmann S, Grabbe S, Zanker KS, et al. (2000) Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13: 323-332.
5. Munitic I, Ryan PE, Ashwell JD, (2005) T cells in G1 provide a memory-like response to secondary stimulation. J Immunol 174: 4010-4018.
6. Faroudi M, Zaru R, Paulet P, Muller S, Valitutti S, (2003) Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J Immunol 171: 1128-1132.
7. Locasale JW, (2007) Computational investigations into the origins of short-term biochemical memory in T cell activation. PLoS One 2: e627.
8. Bousso P, (2008) T-cell activation by dendritic cells in the lymph node: lessons from the movies. Nat Rev Immunol 8: 675-684.
9. Mempel TR, Henrickson SE, Von Andrian UH, (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159.
10. Miller MJ, Safrina O, Parker I, Cahalan MD, (2004) Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med 200: 847-856.
11. Celli S, Garcia Z, Bousso P, (2005) CD4 T cells integrate signals delivered during successive DC encounters in vivo. J Exp Med 202: 1271-1278.
12. Iezzi G, Scheidegger D, Lanzavecchia A, (2001) Migration and function of antigen-primed nonpolarized T lymphocytes in vivo. J Exp Med 193: 987-993.
13. Das J, Ho M, Zikherman J, Govern C, Yang M, et al. (2009) Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136: 337-351.
14. Cuddapah S, Barski A, Zhao K, (2010) Epigenomics of T cell activation, differentiation, and memory. Curr Opin Immunol 22: 341-347.
15. Jain J, Loh C, Rao A, (1995) Transcriptional regulation of the IL-2 gene. Curr Opin Immunol 7: 333-342.
16. Jain J, Valge-Archer VE, Rao A, (1992) Analysis of the AP-1 sites in the IL-2 promoter. J Immunol 148: 1240-1250.
17. Karin M, Liu Z, Zandi E, (1997) AP-1 function and regulation. Curr Opin Cell Biol 9: 240-246.
18. Reed JC, Alpers JD, Nowell PC, Hoover RG, (1986) Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes. Proc Natl Acad Sci U S A 83: 3982-3986.
19. Ullman KS, Northrop JP, Verweij CL, Crabtree GR, (1990) Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol 8: 421-452.
20. Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, et al. (2008) Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 9: 513-521.
21. Galkina E, Tanousis K, Preece G, Tolaini M, Kioussis D, et al. (2003) L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. The Journal of experimental medicine 198: 1323-1335.
22. Miethke T, Wahl C, Holzmann B, Heeg K, Wagner H, (1993) Bacterial superantigens induce rapid and T cell receptor V beta-selective down-regulation of L-selectin (gp90Mel-14) in vivo. Journal of immunology 151: 6777-6782.
23. Azar GA, Lemaitre F, Robey EA, Bousso P, (2010) Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci U S A.
24. Okazaki K, Sagata N, (1995) The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. Embo J 14: 5048-5059.
25. Chen RH, Abate C, Blenis J, (1993) Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc Natl Acad Sci U S A 90: 10952-10956.
26. Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J, (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol 4: 556-564.
27. Schade AE, Levine AD, (2004) Cutting edge: extracellular signal-regulated kinases 1/2 function as integrators of TCR signal strength. J Immunol 172: 5828-5832.