메뉴 건너뛰기




Volumn 252, Issue 1, 2013, Pages 139-145

Transcriptional regulation of follicular T-helper (Tfh) cells

Author keywords

Dendritic cells; T cell lineages and subsets; Tfh cells

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; INTERFERON REGULATORY FACTOR; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR;

EID: 84873640954     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12040     Document Type: Article
Times cited : (133)

References (75)
  • 1
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 2
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 3
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1
  • 4
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: an updated view of their molecular identity and genetic programming
    • Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 2008;8:337-348.
    • (2008) Nat Rev Immunol , vol.8 , pp. 337-348
    • Dong, C.1
  • 5
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000;192:1545-1552.
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1
  • 6
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000;192:1553-1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 7
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011;29:621-663.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 8
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu D, Vinuesa CG. The elusive identity of T follicular helper cells. Trends Immunol 2010;31:377-383.
    • (2010) Trends Immunol , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 9
    • 0035908122 scopus 로고    scopus 로고
    • Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
    • Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med 2001;193:1373-1381.
    • (2001) J Exp Med , vol.193 , pp. 1373-1381
    • Kim, C.H.1    Rott, L.S.2    Clark-Lewis, I.3    Campbell, D.J.4    Wu, L.5    Butcher, E.C.6
  • 10
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva RI, et al. Bcl6 mediates the development of T follicular helper cells. Science 2009;325:1001-1005.
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 11
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009;325:1006-1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 12
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009;31:457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 13
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva RI, et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008;29:138-149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1
  • 14
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007;448:480-483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1
  • 15
    • 84859711557 scopus 로고    scopus 로고
    • Functional STAT3 deficiency compromises the generation of human T follicular helper cells
    • Ma CS, et al. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood 2012;119:3997-4008.
    • (2012) Blood , vol.119 , pp. 3997-4008
    • Ma, C.S.1
  • 16
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007;26:371-381.
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1
  • 18
    • 84859487740 scopus 로고    scopus 로고
    • STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function
    • Nurieva RI, et al. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem 2012;287:11234-11239.
    • (2012) J Biol Chem , vol.287 , pp. 11234-11239
    • Nurieva, R.I.1
  • 19
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato A, et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 2012;36:847-856.
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1
  • 20
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • Fazilleau N, McHeyzer-Williams LJ, Rosen H, McHeyzer-Williams MG. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol 2009;10:375-384.
    • (2009) Nat Immunol , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 21
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 2008;26:741-766.
    • (2008) Annu Rev Immunol , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 22
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997;276:589-592.
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 23
    • 0032827421 scopus 로고    scopus 로고
    • Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching
    • Harris MB, et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 1999;19:7264-7275.
    • (1999) Mol Cell Biol , vol.19 , pp. 7264-7275
    • Harris, M.B.1
  • 24
    • 17144439800 scopus 로고    scopus 로고
    • The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    • Ye BH, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 1997;16:161-170.
    • (1997) Nat Genet , vol.16 , pp. 161-170
    • Ye, B.H.1
  • 25
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: role in B-cell physiology and malignancy
    • Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 2008;8:22-33.
    • (2008) Nat Rev Immunol , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 26
    • 67651001561 scopus 로고    scopus 로고
    • The AP-1 transcription factor Batf controls T(H)17 differentiation
    • Schraml BU, et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 2009;460:405-409.
    • (2009) Nature , vol.460 , pp. 405-409
    • Schraml, B.U.1
  • 27
    • 79956106132 scopus 로고    scopus 로고
    • A BATF-ling connection between B cells and follicular helper T cells
    • Ellyard JI, Vinuesa CG. A BATF-ling connection between B cells and follicular helper T cells. Nat Immunol 2011;12:519-520.
    • (2011) Nat Immunol , vol.12 , pp. 519-520
    • Ellyard, J.I.1    Vinuesa, C.G.2
  • 28
    • 77952304784 scopus 로고    scopus 로고
    • Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
    • Betz BC, et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med 2010;207:933-942.
    • (2010) J Exp Med , vol.207 , pp. 933-942
    • Betz, B.C.1
  • 29
    • 79956081339 scopus 로고    scopus 로고
    • The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
    • Ise W, et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol 2011;12:536-543.
    • (2011) Nat Immunol , vol.12 , pp. 536-543
    • Ise, W.1
  • 30
    • 84867861268 scopus 로고    scopus 로고
    • BATF-JUN is critical for IRF4-mediated transcription in T cells
    • Li P, et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 2012;490:543-546.
    • (2012) Nature , vol.490 , pp. 543-546
    • Li, P.1
  • 31
    • 84869116884 scopus 로고    scopus 로고
    • A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes
    • Glasmacher E, et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science 2012;338:975-980.
    • (2012) Science , vol.338 , pp. 975-980
    • Glasmacher, E.1
  • 32
    • 84867884822 scopus 로고    scopus 로고
    • Compensatory dendritic cell development mediated by BATF-IRF interactions
    • Tussiwand R, et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature 2012;490:502-507.
    • (2012) Nature , vol.490 , pp. 502-507
    • Tussiwand, R.1
  • 33
    • 13444283466 scopus 로고    scopus 로고
    • Roles of interferon-regulatory factors in T-helper-cell differentiation
    • Lohoff M, Mak TW. Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat Rev Immunol 2005;5:125-135.
    • (2005) Nat Rev Immunol , vol.5 , pp. 125-135
    • Lohoff, M.1    Mak, T.W.2
  • 34
    • 0035061538 scopus 로고    scopus 로고
    • IRF family of transcription factors as regulators of host defense
    • Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 2001;19:623-655.
    • (2001) Annu Rev Immunol , vol.19 , pp. 623-655
    • Taniguchi, T.1    Ogasawara, K.2    Takaoka, A.3    Tanaka, N.4
  • 35
    • 0029763203 scopus 로고    scopus 로고
    • Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1
    • Brass AL, Kehrli E, Eisenbeis CF, Storb U, Singh H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev 1996;10:2335-2347.
    • (1996) Genes Dev , vol.10 , pp. 2335-2347
    • Brass, A.L.1    Kehrli, E.2    Eisenbeis, C.F.3    Storb, U.4    Singh, H.5
  • 36
    • 18744377964 scopus 로고    scopus 로고
    • Crystal structure of PU.1/IRF-4/DNA ternary complex
    • Escalante CR, et al. Crystal structure of PU.1/IRF-4/DNA ternary complex. Mol Cell 2002;10:1097-1105.
    • (2002) Mol Cell , vol.10 , pp. 1097-1105
    • Escalante, C.R.1
  • 37
    • 71749089605 scopus 로고    scopus 로고
    • Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
    • Kwon H, et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 2009;31:941-952.
    • (2009) Immunity , vol.31 , pp. 941-952
    • Kwon, H.1
  • 38
    • 84861872906 scopus 로고    scopus 로고
    • Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
    • Bollig N, et al. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci USA 2012;109:8664-8669.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8664-8669
    • Bollig, N.1
  • 39
    • 0037015052 scopus 로고    scopus 로고
    • Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
    • Lohoff M, et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci USA 2002;99:11808-11812.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11808-11812
    • Lohoff, M.1
  • 40
    • 0037253846 scopus 로고    scopus 로고
    • Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4
    • Tominaga N, Ohkusu-Tsukada K, Udono H, Abe R, Matsuyama T, Yui K. Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4. Int Immunol 2003;15:1-10.
    • (2003) Int Immunol , vol.15 , pp. 1-10
    • Tominaga, N.1    Ohkusu-Tsukada, K.2    Udono, H.3    Abe, R.4    Matsuyama, T.5    Yui, K.6
  • 41
    • 0037089575 scopus 로고    scopus 로고
    • Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
    • Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 2002;195:1003-1012.
    • (2002) J Exp Med , vol.195 , pp. 1003-1012
    • Rengarajan, J.1    Mowen, K.A.2    McBride, K.D.3    Smith, E.D.4    Singh, H.5    Glimcher, L.H.6
  • 42
    • 0037147204 scopus 로고    scopus 로고
    • Modulation of T cell cytokine production by interferon regulatory factor-4
    • Hu CM, Jang SY, Fanzo JC, Pernis AB. Modulation of T cell cytokine production by interferon regulatory factor-4. J Biol Chem 2002;277:49238-49246.
    • (2002) J Biol Chem , vol.277 , pp. 49238-49246
    • Hu, C.M.1    Jang, S.Y.2    Fanzo, J.C.3    Pernis, A.B.4
  • 43
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt V, et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 2010;33:192-202.
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1
  • 44
    • 58549094107 scopus 로고    scopus 로고
    • IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    • Huber M, et al. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci USA 2008;105:20846-20851.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20846-20851
    • Huber, M.1
  • 45
    • 34548128307 scopus 로고    scopus 로고
    • The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    • Brustle A, et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 2007;8:958-966.
    • (2007) Nat Immunol , vol.8 , pp. 958-966
    • Brustle, A.1
  • 46
    • 15444346834 scopus 로고    scopus 로고
    • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
    • Mittrucker HW, et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997;275:540-543.
    • (1997) Science , vol.275 , pp. 540-543
    • Mittrucker, H.W.1
  • 47
    • 0033152267 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
    • Kim JI, Ho IC, Grusby MJ, Glimcher LH. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 1999;10:745-751.
    • (1999) Immunity , vol.10 , pp. 745-751
    • Kim, J.I.1    Ho, I.C.2    Grusby, M.J.3    Glimcher, L.H.4
  • 48
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations. Annu Rev Immunol 2010;28:445-489.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 49
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009;10:167-175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1
  • 50
    • 84859897308 scopus 로고    scopus 로고
    • The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    • Luthje K, et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 2012;13:491-498.
    • (2012) Nat Immunol , vol.13 , pp. 491-498
    • Luthje, K.1
  • 51
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008;29:127-137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 52
    • 65549114338 scopus 로고    scopus 로고
    • IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • King IL, Mohrs M. IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 2009;206:1001-1007.
    • (2009) J Exp Med , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 54
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007;448:484-487.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1
  • 55
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    • Yusuf I, et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol 2010;185:190-202.
    • (2010) J Immunol , vol.185 , pp. 190-202
    • Yusuf, I.1
  • 56
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot SM, et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 2011;34:947-960.
    • (2011) Immunity , vol.34 , pp. 947-960
    • Kerfoot, S.M.1
  • 57
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano M, et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 2011;34:961-972.
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1
  • 58
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011;34:932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1
  • 59
    • 80052649061 scopus 로고    scopus 로고
    • Cutting edge: distinct waves of BCL6 expression during T follicular helper cell development
    • Baumjohann D, Okada T, Ansel KM. Cutting edge: distinct waves of BCL6 expression during T follicular helper cell development. J Immunol 2011;187:2089-2092.
    • (2011) J Immunol , vol.187 , pp. 2089-2092
    • Baumjohann, D.1    Okada, T.2    Ansel, K.M.3
  • 60
    • 82055177182 scopus 로고    scopus 로고
    • How T cells earn the follicular rite of passage
    • Vinuesa CG, Cyster JG. How T cells earn the follicular rite of passage. Immunity 2011;35:671-680.
    • (2011) Immunity , vol.35 , pp. 671-680
    • Vinuesa, C.G.1    Cyster, J.G.2
  • 61
    • 79960544931 scopus 로고    scopus 로고
    • Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
    • Lahoud MH, et al. Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. J Immunol 2011;187:842-850.
    • (2011) J Immunol , vol.187 , pp. 842-850
    • Lahoud, M.H.1
  • 62
    • 34250765587 scopus 로고    scopus 로고
    • Lymphoid reservoirs of antigen-specific memory T helper cells
    • Fazilleau N, et al. Lymphoid reservoirs of antigen-specific memory T helper cells. Nat Immunol 2007;8:753-761.
    • (2007) Nat Immunol , vol.8 , pp. 753-761
    • Fazilleau, N.1
  • 63
    • 33645984847 scopus 로고    scopus 로고
    • Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice
    • Han X, et al. Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice. J Immunol 2006;176:5232-5239.
    • (2006) J Immunol , vol.176 , pp. 5232-5239
    • Han, X.1
  • 64
    • 73949090666 scopus 로고    scopus 로고
    • Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
    • Gigoux M, et al. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci USA 2009;106:20371-20376.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20371-20376
    • Gigoux, M.1
  • 65
    • 70450265288 scopus 로고    scopus 로고
    • Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12
    • Ma CS, et al. Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol 2009;87:590-600.
    • (2009) Immunol Cell Biol , vol.87 , pp. 590-600
    • Ma, C.S.1
  • 66
    • 68249158536 scopus 로고    scopus 로고
    • Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12
    • Schmitt N, et al. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 2009;31:158-169.
    • (2009) Immunity , vol.31 , pp. 158-169
    • Schmitt, N.1
  • 67
    • 84870285173 scopus 로고    scopus 로고
    • Bcl6 expression specifies the T follicular helper cell program in vivo
    • Liu X, et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 2012;209:1841-1852.
    • (2012) J Exp Med , vol.209 , pp. 1841-1852
    • Liu, X.1
  • 68
    • 84859711533 scopus 로고    scopus 로고
    • Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation
    • Kroenke MA, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol 2012;188:3734-3744.
    • (2012) J Immunol , vol.188 , pp. 3734-3744
    • Kroenke, M.A.1
  • 69
    • 3242792378 scopus 로고    scopus 로고
    • In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses
    • Smith KM, Brewer JM, Rush CM, Riley J, Garside P. In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses. J Immunol 2004;173:1640-1646.
    • (2004) J Immunol , vol.173 , pp. 1640-1646
    • Smith, K.M.1    Brewer, J.M.2    Rush, C.M.3    Riley, J.4    Garside, P.5
  • 70
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol 2009;10:385-393.
    • (2009) Nat Immunol , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 71
    • 0034665088 scopus 로고    scopus 로고
    • Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo
    • Smith KM, et al. Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo. J Immunol 2000;165:3136-3144.
    • (2000) J Immunol , vol.165 , pp. 3136-3144
    • Smith, K.M.1
  • 72
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004;173:68-78.
    • (2004) J Immunol , vol.173 , pp. 68-78
    • Chtanova, T.1
  • 73
    • 80755163540 scopus 로고    scopus 로고
    • Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection
    • Marshall HD, et al. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity 2011;35:633-646.
    • (2011) Immunity , vol.35 , pp. 633-646
    • Marshall, H.D.1
  • 75
    • 84864742274 scopus 로고    scopus 로고
    • T-follicular helper cells survive as long-term memory cells
    • Weber JP, Fuhrmann F, Hutloff A. T-follicular helper cells survive as long-term memory cells. Eur J Immunol 2012;42:1981-1988.
    • (2012) Eur J Immunol , vol.42 , pp. 1981-1988
    • Weber, J.P.1    Fuhrmann, F.2    Hutloff, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.