Active caspase-1 induces plasma membrane pores that precede pyroptotic lysis and are blocked by lanthanides

Journal of Immunology

Volumn 197, Issue 4, 2016, Pages 1353-1367

  Russo, Hana M ^a   Rathkey, Joseph ^a   Boyd Tressler, Andrea ^a   Katsnelson, Michael A ^a   Abbott, Derek W ^a   Dubyak, George R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CLOSTRIDIUM DIFFICILE TOXIN B; CRYOPYRIN; GASDERMIN D; GLYCINE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; LANTHANIDE; NIGERICIN; PROPIDIUM IODIDE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; GSDMD PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL MEMBRANE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY ASSAY; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; KINETICS; MOUSE; NONHUMAN; PLASMA MEMBRANE PORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYROPTOSIS; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; CELL MEMBRANE; INFLAMMASOMES; INTERLEUKIN-1BETA; LANTHANOID SERIES ELEMENTS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PYROPTOSIS;

EID: 84983776563     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1600699     Document Type: Article

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