Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity

Cancer Research

Volumn 70, Issue 3, 2010, Pages 855-858

  Aymeric, Laetitia ^a,b,c   Apetoh, Lionel ^a,b,c   Ghiringhelli, François ^a,b,c,d   Tesniere, Antoine ^b,c,e   Martins, Isabelle ^b,c,e   Kroemer, Guido ^b,c,e   Smyth, Mark J ^f   Zitvogel, Laurence ^a,b,c  

^a INSERM   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d CENTRE GEORGES FRANÇOIS LECLERC   (France)

^e Institut Gustave Roussy   (France)

^f PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTHRACYCLINE; CADMIUM; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CISPLATIN; CRYOPYRIN; DOXORUBICIN; ETOPOSIDE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 33; MITOMYCIN C; MITOXANTRONE; OXALIPLATIN; PURINERGIC P2X7 RECEPTOR; STAUROSPORINE; THAPSIGARGIN; TOLL LIKE RECEPTOR 4;

ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL POLARITY; CELLULAR IMMUNITY; COLON CANCER; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFECT; DRUG EFFICACY; HUMAN; IMMUNOGENICITY; IMMUNOSTIMULATION; INFLAMMATION; INNATE IMMUNITY; IONIZING RADIATION; LYMPHOCYTE DIFFERENTIATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SARCOMA; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOMA; TUMOR CELL DESTRUCTION; TUMOR IMMUNITY; TUMOR MODEL; TUMOR REGRESSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; DENDRITIC CELLS; HUMANS; IMMUNITY; INTERFERON-GAMMA; NEOPLASMS; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION;

EID: 76249128304     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3566     Document Type: Review

References (26)

1. Casares N, Pequignot M, Tesniere A, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med 2005;202:1691-701.
2. Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. Nat Rev Immunol 2008;8:59-73.
3. Obeid M, Tesniere A, Ghiringhelli F, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007; 13:54-61.
4. Panaretakis T, Joza N, Modjtahedi N, et al. The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ 2008;15:1499-509.
5. Panaretakis T, Kepp O, Brockmeier U, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J 2009;28:578-90.
6. Apetoh L, Ghiringhelli F, Tesniere A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007;13:1050-9.
7. Ghiringhelli F, Apetoh L, Tesniere A, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors. Nat Med 2009;15:1170-8.
8. Shankaran V, Ikeda H, Bruce A, et al. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001;410:1107-11.
9. Koebel CM, Vermi W, Swann JB, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007;450:903-7.
10. Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007;117:1137-46.
11. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE. Nod-like proteins in immunity, inflammation and disease. Nat Immunol 2006;7:1250-7.
12. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001;1:135-45.
13. Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ 2007;14:10-22.
14. Kanneganti TD, Ozören N, Body-Malapel M, et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/ Nalp3. Nature 2006;440:233-6.
15. Mariathasan S, Weiss D, Newton K, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006;440:228-32.
16. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006;440:237-41.
17. Sutterwala FS, Ogura Y, Szczepanik M, et al. Critical role for NALP3/ CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 2006;24:317-27.
18. Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004;20:319-25.
19. Brydges S, Kastner D. The systemic autoinflammatory diseases: inborn errors of the innate immune system. Curr Top Microbiol Immunol 2006;305:127-60.
20. Kanneganti TD, Body-Malapel M, Amer A, et al. Critical role for Cryopyrin/ Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006;281:36560-8.
21. Ogura Y, Sutterwala F, Flavell R. The inflammasome: first line of the immune response to cell stress. Cell 2006;126:659-62.
22. Di Virgilio F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci 2007;28:465-72.
23. Martins I, Tesniere A, Kepp O, et al. Chemotherapy induces ATP release from tumor cells. Cell Cycle 2009;8:3723-8.
24. Qin Z, Schwartzkopff J, Pradera F, et al. A critical requirement of interferon γ-mediated angiostasis for tumor rejection by CD8+ T cells. Cancer Res 2003;63:4095-100.
25. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala F, Flavell R. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008;453:1122-6.
26. Ichinohe T, Lee H, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 2009;206:79-87.