Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Nature Communications

Volumn 7, Issue , 2016, Pages

  Karmakar, Mausita ^a   Katsnelson, Michael A ^a   Dubyak, George R ^a   Pearlman, Eric ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; POTASSIUM; PURINERGIC P2X7 RECEPTOR; CARRIER PROTEIN; IL1B PROTEIN, HUMAN; IL1B PROTEIN, MOUSE; NLRP3 PROTEIN, HUMAN; NLRP3 PROTEIN, MOUSE; PURINERGIC P2X RECEPTOR ANTAGONIST;

BACTERIUM; CELLS AND CELL COMPONENTS; GENE EXPRESSION; MOLECULAR ANALYSIS; POLYMORPHISM; PROTEIN; SECRETION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL KERATITIS; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOSOL; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; LEUKOCYTE ACTIVATION; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PNEUMOCOCCAL INFECTION; POTASSIUM CELL LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; ATOMIC ABSORPTION SPECTROMETRY; BACTERIAL EYE INFECTION; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOLOGY; KERATITIS; KNOCKOUT MOUSE; METABOLISM; SECRETION (PROCESS); STREPTOCOCCUS INFECTION; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); MURINAE; STREPTOCOCCUS PNEUMONIAE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE INFECTIONS, BACTERIAL; FLOW CYTOMETRY; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; KERATITIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; NEUTROPHILS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; POTASSIUM; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7; SPECTROPHOTOMETRY, ATOMIC; STREPTOCOCCAL INFECTIONS;

EID: 84958230881     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10555     Document Type: Article

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