Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages

  Ma, Zhongming ^a   Siebert, Adam P ^a   Cheung, King Ho ^a   Lee, Robert J ^a   Johnson, Brian ^b   Cohen, Akiva S ^a,b   Vingtdeux, Valérie ^c   Marambaud, Philippe ^c   Foskett, J Kevin ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Alzheimer's disease; Mutagenesis; Neurodegeneration; Polymorphism; Selectivity

Indexed keywords

CALCIUM HOMEOSTASIS MODULATOR 1; CALCIUM ION; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ACTION POTENTIAL; ALLOSTERISM; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CALCIUM HOMEOSTASIS; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; ELECTRIC POTENTIAL; EXTRACELLULAR CALCIUM; GENE DELETION; GENETIC CONSERVATION; ION CURRENT; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ALZHEIMER DISEASE; ANIMALS; BINDING SITES; CALCIUM; CALCIUM CHANNELS; CELL MEMBRANE; ELECTROPHYSIOLOGY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IONS; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUTAGENESIS; NEURODEGENERATIVE DISEASES; NEURONS; OOCYTES; POLYMORPHISM, GENETIC; TIME FACTORS; XENOPUS;

MUS;

EID: 84863910505     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204023109     Document Type: Article

References (41)

1. 2+homeostasis, Abeta levels, and Alzheimer's disease risk. Cell 133:1149-1161.
2. Lambert JC, et al. (2010) The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: A meta-analysis study. J Alzheimers Dis 22:247-255.
3. Ebihara L (1996) Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes. Biophys J 71:742-748.
4. Bahima L, et al. (2006) Endogenous hemichannels play a role in the release of ATP from Xenopus oocytes. J Cell Physiol 206:95-102. (Pubitemid 41740721)
5. Sather WA, McCleskey EW (2003) Permeation and selectivity in calcium channels. Annu Rev Physiol 65:133-159. (Pubitemid 38249150)
6. Owsianik G, Talavera K, Voets T, Nilius B (2006) Permeation and selectivity of TRP channels. Annu Rev Physiol 68:685-717.
7. Prakriya M, et al. (2006) Orai1 is an essential pore subunit of the CRAC channel. Nature 443:230-233. (Pubitemid 44387613)
8. Zhou Y, Ramachandran S, Oh-Hora M, Rao A, Hogan PG (2010) Pore architecture of the ORAI1 store-operated calcium channel. Proc Natl Acad Sci USA 107:4896-4901.
9. Moreno-Ortega AJ, Ruiz-Nuño A, García AG, Cano-Abad MF (2010) Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1. Biochem Biophys Res Commun 391:722-726.
10. 2+ signaling, cell death and stroke. Trends Neurosci 29:75-81.
11. Lu B, et al. (2010) Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron 68:488-499.
12. 2+-inhibited cation (MIC) channels. J Gen Physiol 119:487-507.
13. Kozak JA, Cahalan MD (2003) MIC channels are inhibited by internal divalent cations but not ATP. Biophys J 84:922-927.
14. Ma Z, Lou XJ, Horrigan FT (2006) Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol 127:309-328.
15. Benninger C, Kadis J, Prince DA (1980) Extracellular calcium and potassium changes in hippocampal slices. Brain Res 187:165-182. (Pubitemid 10150924)
16. Heinemann U, Pumain R (1980) Extracellular calcium activity changes in cat sensorimotor cortex induced by iontophoretic application of aminoacids. Exp Brain Res 40:247-250. (Pubitemid 10022994)
17. 2+ in pyramidal layers of the rat's hippocampus. Can J Physiol Pharmacol 60:1643-1657.
18. 2+ concentrations in the hippocampus. Can J Physiol Pharmacol 60:1658-1671.
19. Nicholson C, Bruggencate GT, Steinberg R, Stöckle H (1977) Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci USA 74:1287-1290. (Pubitemid 8065652)
20. Pumain R, Heinemann U (1985) Stimulus- and amino acid-induced calcium and potassium changes in rat neocortex. J Neurophysiol 53:1-16. (Pubitemid 15174271)
21. Pumain R, Kurcewicz I, Louvel J (1983) Fast extracellular calcium transients: Involvement in epileptic processes. Science 222:177-179. (Pubitemid 13008794)
22. Borst JG, Sakmann B (1999) Depletion of calcium in the synaptic cleft of a calyx-type synapse in the rat brainstem. J Physiol 521:123-133.
23. 2+ depletion contributes to fast activitydependent modulation of synaptic transmission in the brain. Neuron 37:287-297.
24. Stanley EF (2000) Presynaptic calcium channels and the depletion of synaptic cleft calcium ions. J Neurophysiol 83:477-482.
25. Egelman DM, Montague PR (1999) Calcium dynamics in the extracellular space of mammalian neural tissue. Biophys J 76:1856-1867. (Pubitemid 29266343)
26. Vassilev PM, Mitchel J, Vassilev M, Kanazirska M, Brown EM (1997) Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft. Biophys J 72:2103-2116. (Pubitemid 27184437)
27. Heinemann U, Konnerth A, Pumain R, Wadman WJ (1986) Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue. Adv Neurol 44: 641-661.
28. 2+] induced by anoxia in neonatal rabbit medulla. Am J Physiol 264:R761-R769.
29. 2+ levels following cortical compression contusion trauma in rats. J Cereb Blood Flow Metab 13:183-192.
30. 2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol 95:837-866.
31. Wang T, Wang J, Cottrell JE, Kass IS (2004) Small physiologic changes in calcium and magnesium alter excitability and burst firing of CA1 pyramidal cells in rat hippocampal slices. J Neurosurg Anesthesiol 16:201-209. (Pubitemid 38890609)
32. Xiong ZG, MacDonald JF (1999) Sensing of extracellular calcium by neurones. Can J Physiol Pharmacol 77:715-721.
33. Lu B, et al. (2007) The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell 129:371-383. (Pubitemid 46574966)
34. Wei WL, et al. (2007) TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci USA 104:16323-16328.
35. 2+ in rat hippocampal neurones. J Physiol 549:537-552.
36. Xiong Z, Lu W, MacDonald JF (1997) Extracellular calcium sensed by a novel cation channel in hippocampal neurons. Proc Natl Acad Sci USA 94:7012-7017. (Pubitemid 27281982)
37. Zimmerman AN, Hülsmann WC (1966) Paradoxical influence of calcium ions on the permeability of the cell membranes of the isolated rat heart. Nature 211:646-647.
38. Chinopoulos C, Adam-Vizi V (2006) Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J 273:433-450.
39. Deshpande LS, Limbrick DD, Jr., Sombati S, DeLorenzo RJ (2007) Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. J Pharmacol Exp Ther 322:443-452. (Pubitemid 47105801)
40. Meberg PJ, Miller MW (2003) Culturing hippocampal and cortical neurons. Methods Cell Biol 71:111-127.
41. Foskett JK (1988) Simultaneous Nomarski and fluorescence imaging during video microscopy of cells. Am J Physiol 255:C566-C571.