N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Lin, Pei Hsuan ^a   Lin, Hsien Yi ^a   Kuo, Cheng Chin ^a   Yang, Liang Tung ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cell death; Gasdermin A3; Mitochondria; Mitochondrial permeability transition; Reactive oxygen species

Indexed keywords

GASDERMIN A3; HEAT SHOCK PROTEIN 90; PROTEIN TOM70; PROTEIN TRAP1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CARRIER PROTEIN; GSDMA3 PROTEIN, MOUSE; PROTEIN; TOM70 PROTEIN, MOUSE; TRAP-1 PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL DIFFERENTIATION; CHANNEL GATING; CONTROLLED STUDY; EPIDERMIS CELL; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TARGETING SIGNAL; NEGATIVE FEEDBACK; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; ANIMAL; GENETICS; HOMEOSTASIS; METABOLISM; MITOCHONDRION; MOUSE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; HOMEOSTASIS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84935031669     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0152-0     Document Type: Article

References (45)

1. Lippens S, Hoste E, Vandenabeele P, Agostinis P, Declercq W. Cell death in the skin. Apoptosis Int J Programmed Cell Death. 2009;14(4):549-69.
2. Hao K, Bosse Y, Nickle DC, Pare PD, Postma DS, Laviolette M, et al. Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet. 2012;8(11):e1003029.
3. Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, et al. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer. 2009;48(3):261-71.
4. Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics. 2007;89(5):618-29.
5. Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mammalian Genome Off J Int Mammalian Genome Soc. 2000;11(9):718-24.
6. Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, et al. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene. 2007;26(45):6488-98.
7. Lluis A, Schedel M, Liu J, Illi S, Depner M, von Mutius E, et al. Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol. 2011;127(6):1587-94. e1586, 2011.
8. Yu J, Kang MJ, Kim BJ, Kwon JW, Song YH, Choi WA, et al. Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr Pulmonol. 2011;46(7):701-8.
9. Lunny DP, Weed E, Nolan PM, Marquardt A, Augustin M, Porter RM. Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland. J Invest Dermatol. 2005;124(3):615-21.
10. Runkel F, Marquardt A, Stoeger C, Kochmann E, Simon D, Kohnke B, et al. The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Genomics. 2004;84(5):824-35.
11. Kumar S, Rathkolb B, Budde BS, Nurnberg P, de Angelis MH, Aigner B, et al. Gsdma3(I359N) is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis. J Dermatol Sci. 2012;67(3):190-2.
12. Lei M, Yang T, Lai X, Bai X, Qiu W, Lian X, et al. Upregulation of interfollicular epidermal and hair infundibulum beta-catenin expression in Gsdma3 mutant mice. Acta Histochem. 2013;115(1):63-9.
13. Lei MX, Gao X, Yang L, Yang T, Lian XH. Gsdma3 gene is needed for the induction of apoptosis-driven catagen during mouse hair follicle cycle. Histochem Cell Biol. 2011;136(3):335-43.
14. Li J, Zhou Y, Yang T, Wang N, Lian X, Yang L. Gsdma3 is required for hair follicle differentiation in mice. Biochem Biophys Res Commun. 2010;403(1):18-23.
15. Tanaka S, Tamura M, Aoki A, Fujii T, Komiyama H, Sagai T, et al. A new Gsdma3 mutation affecting anagen phase of first hair cycle. Biochem Biophys Res Commun. 2007;359(4):902-7.
16. Lei M, Bai X, Yang T, Lai X, Qiu W, Yang L, et al. Gsdma3 is a new factor needed for TNF-alpha-mediated apoptosis signal pathway in mouse skin keratinocytes. Histochem Cell Biol. 2012;138(3):385-96.
17. Porter RM, Jahoda CA, Lunny DP, Henderson G, Ross J, McLean WH, et al. Defolliculated (dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles. J Invest Dermatol. 2002;119(1):32-7.
18. Ruge F, Glavini A, Gallimore AM, Richards HE, Thomas CP, O'Donnell VB, et al. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. J Invest Dermatol. 2011;131(3):572-9.
19. Zhou Y, Jiang X, Gu P, Chen W, Zeng X, Gao X. Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation. Am J Pathol. 2012;180(2):763-74.
20. Tsujimoto Y, Nakagawa T, Shimizu S. Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta. 2006;1757(9-10):1297-300.
21. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281(5381):1309-12.
22. Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell. 2005;16(2):927-42.
23. Shoshan-Barmatz V, Keinan N, Abu-Hamad S, Tyomkin D, Aram L. Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c. AIF Smac/Diablo Biochimica Biophysica Acta. 2010;1797(6-7):1281-91.
24. Tsoi H, Li L, Chen ZS, Lau KF, Tsui SK, Chan HY. The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. Biochem J. 2014;464(3):439-47.
25. Kuo CC, Kuo CW, Liang CM, Liang SM. A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells. Proteomics. 2005;5(4):894-906.
26. Young JC, Hoogenraad NJ, Hartl FU. Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell. 2003;112(1):41-50.
27. Altieri DC, Stein GS, Lian JB, Languino LR. TRAP-1, the mitochondrial Hsp90. Biochim Biophys Acta. 2012;1823(3):767-73.
28. Montesano GN, Chirico G, Pirozzi G, Costantino E, Landriscina M, Esposito F. Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. Stress. 2007;10(4):342-50.
29. Loor G, Kondapalli J, Iwase H, Chandel NS, Waypa GB, Guzy RD, et al. Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta. 2011;1813(7):1382-94.
30. Ott M, Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis Int J Programmed Cell Death. 2007;12(5):913-22.
31. Galluzzi L, Kroemer G. Necroptosis: a specialized pathway of programmed necrosis. Cell. 2008;135(7):1161-3.
32. Altieri DC. Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis. Cell Mol Life Sci CMLS. 2013;70(14):2463-72.
33. Westermann B. Bioenergetic role of mitochondrial fusion and fission. Biochim Biophys Acta. 2012;1817(10):1833-8.
34. Brix J, Dietmeier K, Pfanner N. Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70. J Biol Chem. 1997;272(33):20730-5.
35. Fan AC, Bhangoo MK, Young JC. Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import. J Biol Chem. 2006;281(44):33313-24.
36. Le Bras M, Clement MV, Pervaiz S, Brenner C. Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol. 2005;20(1):205-19.
37. Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, et al. Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun. 2013;4:2139.
38. Sciacovelli M, Guzzo G, Morello V, Frezza C, Zheng L, Nannini N, et al. The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab. 2013;17(6):988-99.
39. Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee MJ, Lee S, et al. Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis. Proc Natl Acad Sci U S A. 2013;110(17):E1604-12.
40. Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell. 2007;131(2):257-70.
41. Hua G, Zhang Q, Fan Z. Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis. J Biol Chem. 2007;282(28):20553-60.
42. Honda HM, Ping P. Mitochondrial permeability transition in cardiac cell injury and death. Cardiovascular drugs and therapy / sponsored by the international society of cardiovascular. Pharmacotherapy. 2006;20(6):425-32.
43. Eckhart L, Lippens S, Tschachler E, Declercq W. Cell death by cornification. Biochim Biophys Acta. 2013;1833(12):3471-80.
44. Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, et al. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal. 2013;6(261):ra8.
45. Grether-Beck S, Felsner I, Brenden H, Krutmann J. Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes. J Biol Chem. 2003;278(48):47498-507.