Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism

Journal of Biological Chemistry

Volumn 289, Issue 39, 2014, Pages 27246-27263

  Boyd Tressler, Andrea ^a   Penuela, Silvia ^b   Laird, Dale W ^b   Dubyak, George R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMOTHERAPY; DISEASES; NUCLEOTIDES; T-CELLS; TUMORS;

ADENINE NUCLEOTIDE; C-TERMINAL DOMAINS; CASPASE INHIBITORS; CHEMOTHERAPEUTIC DRUGS; FUNCTIONAL ACTIVATION; LYMPHOCYTIC LEUKEMIA; PARACRINE INTERACTIONS; PURINERGIC RECEPTORS;

CELL SIGNALING;

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; DOXORUBICIN; ETOPOSIDE; MEMBRANE PROTEIN; PANNEXIN 1; STAUROSPORINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; CASPASE INHIBITOR; GAP JUNCTION PROTEIN; NERVE PROTEIN; PANX1 PROTEIN, HUMAN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; CHANNEL GATING; CONTROLLED STUDY; HUMAN; HUMAN CELL; JURKAT CELL LINE; PARACRINE SIGNALING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOBLAST; T LYMPHOCYTE; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SECRETION (PROCESS);

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE INHIBITORS; CONNEXINS; HUMANS; JURKAT CELLS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84907916542     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.590240     Document Type: Article

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