NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: Roles for K+ efflux and Ca2+ influx

American Journal of Physiology - Cell Physiology

Volumn 311, Issue 1, 2016, Pages C83-C100

  Katsnelson, Michael A ^a   Lozada Soto, Kristen M ^a   Russo, Hana M ^a   Miller, Barbara A ^b   Dubyak, George R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENN STATE CHILDREN S HOSPITAL   (United States)

Author keywords

Caspase 1; Cell death; Dendritic cell; IL 1; Ion channels

Indexed keywords

CALCIUM ION; CRYOPYRIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEUCYLLEUCINE METHYL ESTER; NIGERICIN; POTASSIUM ION; APOPTOSIS REGULATORY PROTEIN; CALCIUM; CASP11 PROTEIN, MOUSE; CASPASE; DIPEPTIDE; IL1B PROTEIN, MOUSE; INFLAMMASOME; LEUCYL-LEUCINE-METHYL ESTER; NLRP3 PROTEIN, MOUSE; POTASSIUM; PYCARD PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CALCIUM TRANSPORT; CELL DEATH; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN SECRETION; PYROPTOSIS; UBIQUITINATION; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CELL CULTURE; DEFICIENCY; DENDRITIC CELL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; KINETICS; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PATHOLOGY; PERMEABILITY;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM; CALCIUM SIGNALING; CASPASE 1; CASPASES; CELLS, CULTURED; DENDRITIC CELLS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMASOMES; INTERLEUKIN-1BETA; KINETICS; LYSOSOMES; MICE, INBRED C57BL; MICE, KNOCKOUT; NECROSIS; NIGERICIN; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PERMEABILITY; POTASSIUM; TRPM CATION CHANNELS; UBIQUITINATION;

EID: 84983666649     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00298.2015     Document Type: Article

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