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Volumn 8, Issue 6, 2016, Pages 863-879

The interplay between DNA methylation, folate and neurocognitive development

Author keywords

5 hydroxymethylation; Barker hypothesis; DNMT1; DNMT3A; homocysteine; MeCP2; TET

Indexed keywords

FOLIC ACID;

EID: 84978222453     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi-2016-0003     Document Type: Review
Times cited : (65)

References (143)
  • 1
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324(5929), 929-930 (2009)
    • (2009) Science , vol.324 , Issue.5929 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 2
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324(5929), 930-935 (2009)
    • (2009) Science , vol.324 , Issue.5929 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 3
    • 84879663784 scopus 로고    scopus 로고
    • Global epigenomic reconfiguration during mammalian brain development
    • Lister R, Mukamel E, Nery JR et al. Global epigenomic reconfiguration during mammalian brain development. Science 341(6146), 1237905 (2013)
    • (2013) Science , vol.341 , Issue.6146 , pp. 1237905
    • Lister, R.1    Mukamel, E.2    Nery, J.R.3
  • 4
    • 10844241534 scopus 로고    scopus 로고
    • The developmental origins of chronic adult disease
    • Barker DJP. The developmental origins of chronic adult disease. Acta Paediatr. Suppl. 93(446), 26-33 (2004)
    • (2004) Acta Paediatr. Suppl , vol.93 , Issue.446 , pp. 26-33
    • Barker, D.J.P.1
  • 5
    • 55949137722 scopus 로고    scopus 로고
    • Persistent epigenetic differences associated with prenatal exposure to famine in humans
    • Heijmans BT, Tobi EW, Stein AD et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl Acad. Sci. USA 105(44), 17046-17049 (2008)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.44 , pp. 17046-17049
    • Heijmans, B.T.1    Tobi, E.W.2    Stein, A.D.3
  • 6
    • 0022621648 scopus 로고
    • Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales
    • Barker D. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 327(8489), 1077-1081 (1986)
    • (1986) Lancet , vol.327 , Issue.8489 , pp. 1077-1081
    • Barker, D.1
  • 7
    • 84923326770 scopus 로고    scopus 로고
    • DNA methylation signatures link prenatal famine exposure to growth and metabolism
    • Tobi EW, Goeman JJ, Monajemi R et al. DNA methylation signatures link prenatal famine exposure to growth and metabolism. Nat. Commun. 5, 5592 (2014)
    • (2014) Nat. Commun , vol.5 , pp. 5592
    • Tobi, E.W.1    Goeman, J.J.2    Monajemi, R.3
  • 8
    • 79957511968 scopus 로고    scopus 로고
    • Womens compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects
    • McNulty B, Pentieva K, Marshall B et al. Womens compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects. Hum. Reprod. 26(6), 1530-1536 (2011)
    • (2011) Hum. Reprod , vol.26 , Issue.6 , pp. 1530-1536
    • McNulty, B.1    Pentieva, K.2    Marshall, B.3
  • 9
    • 84947559592 scopus 로고    scopus 로고
    • Pediatric cancer epigenome and the influence of folate
    • Yiu TT, Li W. Pediatric cancer epigenome and the influence of folate. Epigenomics 7(6), 961-973 (2015)
    • (2015) Epigenomics , vol.7 , Issue.6 , pp. 961-973
    • Yiu, T.T.1    Li, W.2
  • 10
    • 84862258323 scopus 로고    scopus 로고
    • Prenatal nutrition, epigenetics and schizophrenia risk: Can we test causal effects
    • Kirkbride JB, Susser E, Kundakovic M et al. Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects? Epigenomics 4(3), 303-315 (2012)
    • (2012) Epigenomics , vol.4 , Issue.3 , pp. 303-315
    • Kirkbride, J.B.1    Susser, E.2    Kundakovic, M.3
  • 11
    • 84879788031 scopus 로고    scopus 로고
    • Neural tube defects-disorders of neurulation and related embryonic processes
    • Copp AJ, Greene NDE. Neural tube defects-disorders of neurulation and related embryonic processes. Wiley Interdiscip. Rev. Dev. Biol. 2(2), 213-227 (2013)
    • (2013) Wiley Interdiscip. Rev. Dev. Biol , vol.2 , Issue.2 , pp. 213-227
    • Copp, A.J.1    Greene, N.D.E.2
  • 12
    • 0031657015 scopus 로고    scopus 로고
    • Open or closed?. A world of difference: A history of homocysteine research
    • Eskes TK. Open or closed? A world of difference: a history of homocysteine research. Nutr. Rev. 56(8), 236-244 (1998)
    • (1998) Nutr. Rev , vol.56 , Issue.8 , pp. 236-244
    • Eskes, T.K.1
  • 13
    • 0027080461 scopus 로고
    • Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation
    • Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327(26), 1832-1835 (1992)
    • (1992) N. Engl. J. Med , vol.327 , Issue.26 , pp. 1832-1835
    • Czeizel, A.E.1    Dudás, I.2
  • 15
    • 0025863475 scopus 로고
    • Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
    • MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338(8760), 131-137 (1991)
    • (1991) Lancet , vol.338 , Issue.8760 , pp. 131-137
    • MRC Vitamin Study Research Group1
  • 16
    • 79961071065 scopus 로고    scopus 로고
    • Folic acid in obstetric practice: A review
    • Talaulikar VS, Arulkumaran S. Folic acid in obstetric practice: a review. Obstet. Gynecol. Surv. 66(4), 240-247 (2011)
    • (2011) Obstet. Gynecol. Surv , vol.66 , Issue.4 , pp. 240-247
    • Talaulikar, V.S.1    Arulkumaran, S.2
  • 18
    • 79953718498 scopus 로고    scopus 로고
    • Folic acid food fortificationits history, effect, concerns, and future directions
    • Crider KS, Bailey LB, Berry RJ. Folic acid food fortificationits history, effect, concerns, and future directions. Nutrients 3(3), 370-384 (2011)
    • (2011) Nutrients , vol.3 , Issue.3 , pp. 370-384
    • Crider, K.S.1    Bailey, L.B.2    Berry, R.J.3
  • 19
    • 84978200432 scopus 로고    scopus 로고
    • Development of the nervous system
    • Standing S (Ed.). Elsevier, Edinburgh, Scotland
    • Collins P. Development of the nervous system. In: Gray's Anatomy. Standing S (Ed.). Elsevier, Edinburgh, Scotland, 241-274 (2005)
    • (2005) Gray's Anatomy , vol.241-244
    • Collins, P.1
  • 20
    • 0004210529 scopus 로고    scopus 로고
    • (6th Edition). Sinauer Associates, MA, USA, 271
    • Gilbert SF. Developmental Biology (6th Edition). Sinauer Associates, MA, USA, 271 (2000)
    • (2000) Developmental Biology
    • Gilbert, S.F.1
  • 21
    • 0034190659 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review
    • Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am. J. Epidemiol. 151(9), 862-877 (2000)
    • (2000) Am. J. Epidemiol , vol.151 , Issue.9 , pp. 862-877
    • Botto, L.D.1    Yang, Q.2
  • 22
    • 0032884078 scopus 로고    scopus 로고
    • Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development
    • Piedrahita JA, Oetama B, Bennett GD et al. Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat. Genet. 23(2), 228-232 (1999)
    • (1999) Nat. Genet , vol.23 , Issue.2 , pp. 228-232
    • Piedrahita, J.A.1    Oetama, B.2    Bennett, G.D.3
  • 23
    • 4143082484 scopus 로고    scopus 로고
    • Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose and timing of maternal folate supplementation
    • Spiegelstein O, Mitchell LE, Merriweather MY et al. Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose and timing of maternal folate supplementation. Dev. Dyn. 231(1), 221-231 (2004)
    • (2004) Dev. Dyn , vol.231 , Issue.1 , pp. 221-231
    • Spiegelstein, O.1    Mitchell, L.E.2    Merriweather, M.Y.3
  • 24
    • 0032796617 scopus 로고    scopus 로고
    • The role of folate transport and metabolism in neural tube defect risk
    • Barber RC, Lammer EJ, Shaw GM et al. The role of folate transport and metabolism in neural tube defect risk. Mol. Genet. Metab. 66(1), 1-9 (1999)
    • (1999) Mol. Genet. Metab , vol.66 , Issue.1 , pp. 1-9
    • Barber, R.C.1    Lammer, E.J.2    Shaw, G.M.3
  • 25
    • 0032568871 scopus 로고    scopus 로고
    • Embryonic folate metabolism and mouse neural tube defects
    • Fleming A, Copp AJ. Embryonic folate metabolism and mouse neural tube defects. Science 280(5372), 2107-2109 (1998)
    • (1998) Science , vol.280 , Issue.5372 , pp. 2107-2109
    • Fleming, A.1    Copp, A.J.2
  • 26
    • 79953186061 scopus 로고    scopus 로고
    • Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice
    • Beaudin AE, Abarinov EV, Noden DM et al. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am. J. Clin. Nutr. 93(4), 789-798 (2011)
    • (2011) Am. J. Clin. Nutr , vol.93 , Issue.4 , pp. 789-798
    • Beaudin, A.E.1    Abarinov, E.V.2    Noden, D.M.3
  • 27
    • 84455160888 scopus 로고    scopus 로고
    • Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice
    • Beaudin AE, Abarinov EV, Malysheva O et al. Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am. J. Clin. Nutr. 95(1), 109-114 (2012)
    • (2012) Am. J. Clin. Nutr , vol.95 , Issue.1 , pp. 109-114
    • Beaudin, A.E.1    Abarinov, E.V.2    Malysheva, O.3
  • 28
    • 84882987556 scopus 로고    scopus 로고
    • A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development
    • Christensen KE, Deng L, Leung KY. A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development. Hum. Mol. Genet. 22(8), 3705-3719 (2013)
    • (2013) Hum. Mol. Genet , vol.22 , Issue.8 , pp. 3705-3719
    • Christensen, K.E.1    Deng, L.2    Leung, K.Y.3
  • 29
    • 63249085436 scopus 로고    scopus 로고
    • Analysis of the MTHFD1 promoter and risk of neural tube defects
    • Carroll N, Pangilinan F, Molloy AM et al. Analysis of the MTHFD1 promoter and risk of neural tube defects. Hum. Genet. 125(3), 247-256 (2009)
    • (2009) Hum. Genet , vol.125 , Issue.3 , pp. 247-256
    • Carroll, N.1    Pangilinan, F.2    Molloy, A.M.3
  • 30
    • 84867176545 scopus 로고    scopus 로고
    • DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition
    • Ivanova E, Chen JH, Segonds-Pichon A et al. DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition. Epigenetics 7(10), 1200-1210 (2012)
    • (2012) Epigenetics , vol.7 , Issue.10 , pp. 1200-1210
    • Ivanova, E.1    Chen, J.H.2    Segonds-Pichon, A.3
  • 31
    • 33748433110 scopus 로고    scopus 로고
    • Integrity of the methylation cycle is essential for mammalian neural tube closure
    • Dunlevy LPE, Burren KA, Mills K et al. Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res. Part A Clin. Mol. Teratol. 76(7), 544-552 (2006)
    • (2006) Birth Defects Res. Part A Clin. Mol. Teratol , vol.76 , Issue.7 , pp. 544-552
    • Dunlevy, L.P.E.1    Burren, K.A.2    Mills, K.3
  • 32
    • 0031026635 scopus 로고    scopus 로고
    • Effects of methionine on the cytoplasmic distribution of actin and tubulin during neural tube closure in rat embryos
    • Moephuli SR, Klein NW, Baldwin MT et al. Effects of methionine on the cytoplasmic distribution of actin and tubulin during neural tube closure in rat embryos. Proc. Natl Acad. Sci. USA 94(2), 543-548 (1997)
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.2 , pp. 543-548
    • Moephuli, S.R.1    Klein, N.W.2    Baldwin, M.T.3
  • 33
    • 23644455654 scopus 로고    scopus 로고
    • Inhibition of transmethylation disturbs neurulation in chick embryos
    • Afman LA, Blom HJ, Drittij MJ et al. Inhibition of transmethylation disturbs neurulation in chick embryos. Dev. Brain Res. 158(1-2), 59-65 (2005)
    • (2005) Dev. Brain Res , vol.158 , Issue.1-2 , pp. 59-65
    • Afman, L.A.1    Blom, H.J.2    Drittij, M.J.3
  • 34
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3), 247-257 (1999)
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3
  • 35
    • 77951949256 scopus 로고    scopus 로고
    • Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects
    • Wang L, Wang F, Guan J et al. Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am. J. Clin. Nutr. 91(5), 1359-1367 (2010)
    • (2010) Am. J. Clin. Nutr , vol.91 , Issue.5 , pp. 1359-1367
    • Wang, L.1    Wang, F.2    Guan, J.3
  • 36
    • 79960141859 scopus 로고    scopus 로고
    • Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects
    • Chang H, Zhang T, Zhang Z et al. Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects. J. Nutr. Biochem. 22(12), 1172-1177 (2011)
    • (2011) J. Nutr. Biochem , vol.22 , Issue.12 , pp. 1172-1177
    • Chang, H.1    Zhang, T.2    Zhang, Z.3
  • 37
    • 33749685522 scopus 로고    scopus 로고
    • Vitamin B12, folic acid, and the nervous system
    • Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 5(11), 949-960 (2006)
    • (2006) Lancet Neurol , vol.5 , Issue.11 , pp. 949-960
    • Reynolds, E.1
  • 38
    • 33846877601 scopus 로고    scopus 로고
    • Nutrition and the developing brain: Nutrient priorities and measurement
    • Georgieff MK. Nutrition and the developing brain: nutrient priorities and measurement. Am. J. Clin. Nutr. 85(2), S614-S620 (2007)
    • (2007) Am. J. Clin. Nutr , vol.85 , Issue.2 , pp. S614-S620
    • Georgieff, M.K.1
  • 39
    • 84890564111 scopus 로고    scopus 로고
    • Nutrition and neurodevelopment in children: Focus on NUTRIMENTHE project
    • Anjos T, Altmäe S, Emmett P et al. Nutrition and neurodevelopment in children: focus on NUTRIMENTHE project. Eur. J. Nutr. 52(8), 1825-1842 (2013)
    • (2013) Eur. J. Nutr , vol.52 , Issue.8 , pp. 1825-1842
    • Anjos, T.1    Altmäe, S.2    Emmett, P.3
  • 40
    • 84868091781 scopus 로고    scopus 로고
    • Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells
    • Akchiche N, Bossenmeyer-Pourié C, Kerek R et al. Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells. FASEB J. 26(10), 3980-3992 (2012)
    • (2012) FASEB J , vol.26 , Issue.10 , pp. 3980-3992
    • Akchiche, N.1    Bossenmeyer-Pourié, C.2    Kerek, R.3
  • 41
    • 22544476559 scopus 로고    scopus 로고
    • Folate deficiency inhibits proliferation of adult hippocampal progenitors
    • Kruman II, Mouton PR, Emokpae R et al. Folate deficiency inhibits proliferation of adult hippocampal progenitors. Neuroreport 16(10), 1055-1059 (2005)
    • (2005) Neuroreport , vol.16 , Issue.10 , pp. 1055-1059
    • Kruman, I.I.1    Mouton, P.R.2    Emokpae, R.3
  • 42
    • 33947538533 scopus 로고    scopus 로고
    • Gestational Vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats
    • Blaise SA, Nédélec E, Schroeder H et al. Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats. Am. J. Pathol. 170(2), 667-679 (2007)
    • (2007) Am. J. Pathol , vol.170 , Issue.2 , pp. 667-679
    • Blaise, S.A.1    Nédélec, E.2    Schroeder, H.3
  • 43
    • 0346726171 scopus 로고    scopus 로고
    • Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain
    • Craciunescu CN, Brown EC, Mar M-H et al. Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. J. Nutr. 134(1), 162-166 (2004)
    • (2004) J. Nutr , vol.134 , Issue.1 , pp. 162-166
    • Craciunescu, C.N.1    Brown, E.C.2    Mar, M.-H.3
  • 44
    • 84894462313 scopus 로고    scopus 로고
    • Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid
    • Barua S, Kuizon S, Chadman KK et al. Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid. Epigenetics Chromatin. 7(1), 3 (2014)
    • (2014) Epigenetics Chromatin , vol.7 , Issue.1 , pp. 3
    • Barua, S.1    Kuizon, S.2    Chadman, K.K.3
  • 45
    • 63449111562 scopus 로고    scopus 로고
    • Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort
    • Julvez J, Fortuny J, Mendez M et al. Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort. Paediatr. Perinat. Epidemiol. 23(3), 199-206 (2009)
    • (2009) Paediatr. Perinat. Epidemiol , vol.23 , Issue.3 , pp. 199-206
    • Julvez, J.1    Fortuny, J.2    Mendez, M.3
  • 46
    • 77951477003 scopus 로고    scopus 로고
    • Higher maternal plasma folate but not Vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9-to-10 year-old children in South India
    • Phase III, Krishnaveni GV, Srinivasan K et al. Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9-to-10 year-old children in South India. J. Nutr. 140(5), 1014-1022 (2010)
    • (2010) J. Nutr , vol.140 , Issue.5 , pp. 1014-1022
    • Phase, I.I.I.1    Krishnaveni, G.V.2    Srinivasan, K.3
  • 47
    • 84879375502 scopus 로고    scopus 로고
    • Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: The mother-child cohort "Rhea" study in Crete, Greece
    • Chatzi L, Papadopoulou E, Koutra K et al. Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother-child cohort "Rhea" study in Crete, Greece. Public Health Nutr. 15(09), 1728-1736 (2012)
    • (2012) Public Health Nutr , vol.15 , Issue.9 , pp. 1728-1736
    • Chatzi, L.1    Papadopoulou, E.2    Koutra, K.3
  • 48
    • 84978229177 scopus 로고    scopus 로고
    • Folic acid supplements in pregnancy and severe language delay in children
    • Roth C, Magnus P, Schjølberg S et al. Folic acid supplements in pregnancy and severe language delay in children. Obstet. Gynecol. Surv. 67(2), 79-80 (2012)
    • (2012) Obstet. Gynecol. Surv , vol.67 , Issue.2 , pp. 79-80
    • Roth, C.1    Magnus, P.2    Schjølberg, S.3
  • 49
    • 84862247194 scopus 로고    scopus 로고
    • Maternal intake of methyl-donor nutrients and child cognition at 3 years of age
    • Villamor E, Rifas-Shiman SL, Gillman MW et al. Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. Paediatr. Perinat. Epidemiol. 26(4), 328-335 (2012)
    • (2012) Paediatr. Perinat. Epidemiol , vol.26 , Issue.4 , pp. 328-335
    • Villamor, E.1    Rifas-Shiman, S.L.2    Gillman, M.W.3
  • 50
    • 33646067730 scopus 로고    scopus 로고
    • Ontogeny of the human central nervous system: What is happening when?. Early Hum
    • De Graaf-Peters VB, Hadders-Algra M. Ontogeny of the human central nervous system: what is happening when? Early Hum. Dev. 82(4), 257-266 (2006)
    • (2006) Dev , vol.82 , Issue.4 , pp. 257-266
    • De Graaf-Peters, V.B.1    Hadders-Algra, M.2
  • 51
    • 0016173037 scopus 로고
    • Adverse effects on infant development associated with maternal folic acid deficiency
    • Gross RL, Newberne PM, Reid JVO. Adverse effects on infant development associated with maternal folic acid deficiency. Nutr. Rep. Int. 10(5), 241-248 (1974)
    • (1974) Nutr. Rep. Int , vol.10 , Issue.5 , pp. 241-248
    • Gross, R.L.1    Newberne, P.M.2    Reid, J.V.O.3
  • 52
    • 84921536022 scopus 로고    scopus 로고
    • Effect of folic acid supplementation during pregnancy on growth and cognitive development of the offspring: A pilot follow-up investigation of children of FASSTT study participants
    • (Epub ahead of print)
    • Pentieva K, McGarel C, McNulty B et al. Effect of folic acid supplementation during pregnancy on growth and cognitive development of the offspring: a pilot follow-up investigation of children of FASSTT study participants. Proc. Nutr. Soc. doi:10.1017/S0029665112001966 (2012) (Epub ahead of print)
    • (2012) Proc. Nutr. Soc
    • Pentieva, K.1    McGarel, C.2    McNulty, B.3
  • 53
    • 65349137788 scopus 로고    scopus 로고
    • Maternal MTHFR 677CT genotype and dietary intake of folate and Vitamin B(12): Their impact on child neurodevelopment
    • Del Río Garcia C, Torres-Sánchez L, Chen J et al. Maternal MTHFR 677CT genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment. Nutr. Neurosci. 12(1), 13-20 (2009)
    • (2009) Nutr. Neurosci , vol.12 , Issue.1 , pp. 13-20
    • Del Río, G.C.1    Torres-Sánchez, L.2    Chen, J.3
  • 54
    • 77449157341 scopus 로고    scopus 로고
    • Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study
    • Roza SJ, van Batenburg-Eddes T, Steegers EAP et al. Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study. Br. J. Nutr. 103(3), 445-452 (2010)
    • (2010) Br. J. Nutr , vol.103 , Issue.3 , pp. 445-452
    • Roza, S.J.1    Van Batenburg-Eddes, T.2    Steegers, E.A.P.3
  • 55
    • 84861569891 scopus 로고    scopus 로고
    • Maternal folate status in early pregnancy and child emotional and behavioral problems: The Generation R Study
    • Steenweg-de Graaff J, Roza SJ, Steegers EA et al. Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study. Am. J. Clin. Nutr. 95(6), 1413-1421 (2012)
    • (2012) Am. J. Clin. Nutr , vol.95 , Issue.6 , pp. 1413-1421
    • Steenweg-De Graaff, J.1    Roza, S.J.2    Steegers, E.A.3
  • 56
    • 84873692512 scopus 로고    scopus 로고
    • Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children
    • Surén P, Roth C, Bresnahan M et al. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA 309(6), 570-577 (2013)
    • (2013) JAMA , vol.309 , Issue.6 , pp. 570-577
    • Surén, P.1    Roth, C.2    Bresnahan, M.3
  • 58
    • 37849037738 scopus 로고    scopus 로고
    • How environmental and genetic factors combine to cause autism: A redox/ methylation hypothesis
    • Deth R, Muratore C, Benzecry J et al. How environmental and genetic factors combine to cause autism: a redox/ methylation hypothesis. Neurotoxicology 29(1), 190-201 (2008)
    • (2008) Neurotoxicology , vol.29 , Issue.1 , pp. 190-201
    • Deth, R.1    Muratore, C.2    Benzecry, J.3
  • 59
    • 0027493364 scopus 로고
    • Evidence for multi-site closure of the neural tube in humans
    • Van Allen MI, Kalousek DK, Chernoff GF et al. Evidence for multi-site closure of the neural tube in humans. Am. J. Med. Genet. 47, 723-743 (1993)
    • (1993) Am. J. Med. Genet , vol.47 , pp. 723-743
    • Van Allen, M.I.1    Kalousek, D.K.2    Chernoff, G.F.3
  • 61
    • 0015965793 scopus 로고
    • Neurons in rhesus monkey visual cortex: Systematic relation between time of origin and eventual disposition
    • Rakic P. Neurons in rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition. Science 183(4123), 425-427 (1974)
    • (1974) Science , vol.183 , Issue.4123 , pp. 425-427
    • Rakic, P.1
  • 62
    • 84899091504 scopus 로고    scopus 로고
    • Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
    • Wen L, Li XX, Yan L et al. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biol. 15(3), R49 (2014)
    • (2014) Genome Biol , vol.15 , Issue.3 , pp. R49
    • Wen, L.1    Li, X.X.2    Yan, L.3
  • 63
    • 77956648493 scopus 로고    scopus 로고
    • Pioneer factors in embryonic stem cells and differentiation
    • Smale ST. Pioneer factors in embryonic stem cells and differentiation. Curr. Opin. Genet. Dev. 20(5), 519-526 (2010)
    • (2010) Curr. Opin. Genet. Dev , vol.20 , Issue.5 , pp. 519-526
    • Smale, S.T.1
  • 64
    • 84892690160 scopus 로고    scopus 로고
    • Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions
    • Feldmann A, Ivanek R, Murr R et al. Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions. PLoS Genet. 9(12), e1003994 (2013)
    • (2013) PLoS Genet , vol.9 , Issue.12 , pp. e1003994
    • Feldmann, A.1    Ivanek, R.2    Murr, R.3
  • 65
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: Establishing competence for gene expression
    • Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 25(21), 2227-2241 (2011)
    • (2011) Genes Dev , vol.25 , Issue.21 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 66
    • 84902313706 scopus 로고    scopus 로고
    • Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells
    • Wheldon LM, Abakir A, Ferjentsik Z et al. Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells. Cell Rep. 7(5), 1353-1361 (2014)
    • (2014) Cell Rep , vol.7 , Issue.5 , pp. 1353-1361
    • Wheldon, L.M.1    Abakir, A.2    Ferjentsik, Z.3
  • 67
    • 84881178902 scopus 로고    scopus 로고
    • Tet1 regulates adult hippocampal neurogenesis and cognition
    • Zhang RR, Cui QY, Murai K et al. Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell. 13(2), 237-245 (2013)
    • (2013) Cell Stem Cell , vol.13 , Issue.2 , pp. 237-245
    • Zhang, R.R.1    Cui, Q.Y.2    Murai, K.3
  • 68
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5-hydroxymethylcytosine in the human brain
    • Jin SG, Wu X, Li AX et al. Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res. 39(12), 5015-5024 (2011)
    • (2011) Nucleic Acids Res , vol.39 , Issue.12 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3
  • 69
    • 84874252793 scopus 로고    scopus 로고
    • Dynamics of 5-hydroxymethylcytosine and chromatin marks in mammalian neurogenesis
    • Hahn MA, Qiu R, Wu X et al. Dynamics of 5-hydroxymethylcytosine and chromatin marks in mammalian neurogenesis. Cell Rep. 3(2), 291-300 (2013)
    • (2013) Cell Rep , vol.3 , Issue.2 , pp. 291-300
    • Hahn, M.A.1    Qiu, R.2    Wu, X.3
  • 70
    • 84927696607 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine: A stable or transient DNA modification
    • Hahn MA, Szabo PE, Pfeifer GP et al. 5-Hydroxymethylcytosine: a stable or transient DNA modification? Genomics 10(5), 314-323 (2014)
    • (2014) Genomics , vol.10 , Issue.5 , pp. 314-323
    • Hahn, M.A.1    Szabo, P.E.2    Pfeifer, G.P.3
  • 71
    • 84886035297 scopus 로고    scopus 로고
    • A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
    • Iurlaro M, Ficz G, Oxley D et al. A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol. 14(10), R119 (2013)
    • (2013) Genome Biol , vol.14 , Issue.10 , pp. R119
    • Iurlaro, M.1    Ficz, G.2    Oxley, D.3
  • 72
    • 84874771985 scopus 로고    scopus 로고
    • Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
    • Spruijt CG, Gnerlich F, Smits AH et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 152(5), 1146-1159 (2013)
    • (2013) Cell , vol.152 , Issue.5 , pp. 1146-1159
    • Spruijt, C.G.1    Gnerlich, F.2    Smits, A.H.3
  • 73
    • 84879663784 scopus 로고    scopus 로고
    • Global epigenomic reconfiguration during mammalian brain development
    • Lister R, Mukamel EA, Nery JR et al. Global epigenomic reconfiguration during mammalian brain development. Science 341(6146), 1237905 (2013)
    • (2013) Science , vol.341 , Issue.6146 , pp. 1237905
    • Lister, R.1    Mukamel, E.A.2    Nery, J.R.3
  • 74
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • Feng J, Zhou Y, Campbell SL et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat. Neurosci. 13(4), 423-430 (2010)
    • (2010) Nat. Neurosci , vol.13 , Issue.4 , pp. 423-430
    • Feng, J.1    Zhou, Y.2    Campbell, S.L.3
  • 75
    • 77956139754 scopus 로고    scopus 로고
    • Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    • LaPlant Q, Vialou V, Covington HE et al. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat. Neurosci. 13(9), 1137-1143 (2010)
    • (2010) Nat. Neurosci , vol.13 , Issue.9 , pp. 1137-1143
    • LaPlant, Q.1    Vialou, V.2    Covington, H.E.3
  • 76
    • 84928534828 scopus 로고    scopus 로고
    • MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome
    • Chen L, Chen K, Lavery LA et al. MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome. Proc. Natl Acad. Sci. USA 112(17), 201505909 (2015)
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , Issue.17 , pp. 201505909
    • Chen, L.1    Chen, K.2    Lavery, L.A.3
  • 77
    • 84928533445 scopus 로고    scopus 로고
    • Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
    • Gabel HW, Kinde B, Stroud H et al. Disruption of DNA-methylation-dependent long gene repression in Rett syndrome. Nature 522(7554), 89-93 (2015)
    • (2015) Nature , vol.522 , Issue.7554 , pp. 89-93
    • Gabel, H.W.1    Kinde, B.2    Stroud, H.3
  • 78
    • 0035221585 scopus 로고    scopus 로고
    • Developmental science and the media: Early brain development
    • Thompson R, Nelson C. Developmental science and the media: early brain development. Am. Psychol. 56(1), 5-15 (2001)
    • (2001) Am. Psychol , vol.56 , Issue.1 , pp. 5-15
    • Thompson, R.1    Nelson, C.2
  • 79
    • 0018376668 scopus 로고
    • Synaptic density in human frontal cortex-Developmental changes and effects of aging
    • Peter RH. Synaptic density in human frontal cortex-developmental changes and effects of aging. Brain Res. 163(2), 195-205 (1979)
    • (1979) Brain Res , vol.163 , Issue.2 , pp. 195-205
    • Peter, R.H.1
  • 80
    • 0002382687 scopus 로고    scopus 로고
    • Sensory experience and the fine-tuning of synaptic connections
    • Kandel ER, Schwartz JH, Jessell TM (Eds). McGraw-Hill, New York, USA
    • Kandel ER, Jessell TM, Sanes JR. Sensory experience and the fine-tuning of synaptic connections. In: Principles of Neural Science. Kandel ER, Schwartz JH, Jessell TM (Eds). McGraw-Hill, New York, USA, 1115-1130 (2000)
    • (2000) Principles of Neural Science , pp. 1115-1130
    • Kandel, E.R.1    Jessell, T.M.2    Sanes, J.R.3
  • 81
    • 84978231436 scopus 로고
    • The cerebral cortex of man A clinical study of localization of function
    • Penfield W, Rasmussen T. The cerebral cortex of man. A clinical study of localization of function. Acad. Med. 25, 375 (1950)
    • (1950) Acad. Med , vol.25 , pp. 375
    • Penfield, W.1    Rasmussen, T.2
  • 82
    • 13844301056 scopus 로고    scopus 로고
    • Sexual differentiation of the vertebrate nervous system
    • Morris JA, Jordan CL, Breedlove SM. Sexual differentiation of the vertebrate nervous system. Nat. Neurosci. 7(10), 1034-1039 (2004)
    • (2004) Nat. Neurosci , vol.7 , Issue.10 , pp. 1034-1039
    • Morris, J.A.1    Jordan, C.L.2    Breedlove, S.M.3
  • 83
    • 84895530878 scopus 로고    scopus 로고
    • Cognitive function: Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients
    • De Jager CA, Dye L, De Bruin E et al. Cognitive function: criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutr. Rev. 72(3), 162-179 (2014)
    • (2014) Nutr. Rev , vol.72 , Issue.3 , pp. 162-179
    • De Jager, C.A.1    Dye, L.2    De Bruin, E.3
  • 84
    • 84881437672 scopus 로고    scopus 로고
    • Brain imaging and human nutrition: Which measures to use in intervention studies
    • Sizonenko SV, Babiloni C, de Bruin EA et al. Brain imaging and human nutrition: which measures to use in intervention studies? Br. J. Nutr. 110(Suppl.), S1-S30 (2013)
    • (2013) Br. J. Nutr , vol.110 , pp. S1-S30
    • Sizonenko, S.V.1    Babiloni, C.2    De Bruin, E.A.3
  • 86
    • 0024430616 scopus 로고
    • Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
    • Wilkinson DG, Bhatt S, Cook M et al. Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 341(6241), 405-409 (1989)
    • (1989) Nature , vol.341 , Issue.6241 , pp. 405-409
    • Wilkinson, D.G.1    Bhatt, S.2    Cook, M.3
  • 87
    • 84864311315 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
    • Bocker MT, Tuorto F, Raddatz G et al. Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nat. Commun. 3, 818 (2012)
    • (2012) Nat. Commun , vol.3 , pp. 818
    • Bocker, M.T.1    Tuorto, F.2    Raddatz, G.3
  • 88
    • 84890441146 scopus 로고    scopus 로고
    • Role of BDNF epigenetics in activitydependent neuronal plasticity
    • Karpova NN. Role of BDNF epigenetics in activitydependent neuronal plasticity. Neuropharmacology 76(Pt C), 709-718 (2014)
    • (2014) Neuropharmacology , vol.76 , pp. 709-718
    • Karpova, N.N.1
  • 89
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: Provocative insights from epigenomics
    • Suzuki MM, Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 9(6), 465-476 (2008)
    • (2008) Nat. Rev. Genet , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 90
    • 0242300612 scopus 로고    scopus 로고
    • DNA methylationrelated chromatin remodeling in activity-dependent BDNF gene regulation
    • Martinowich K, Hattori D, Wu H et al. DNA methylationrelated chromatin remodeling in activity-dependent BDNF gene regulation. Science (80) 302(5646), 890-893 (2003)
    • (2003) Science (80) , vol.302 , Issue.5646 , pp. 890-893
    • Martinowich, K.1    Hattori, D.2    Wu, H.3
  • 91
    • 0242332183 scopus 로고    scopus 로고
    • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    • Chen WG, Chang Q, Lin Y et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302(5646), 885-889 (2003)
    • (2003) Science , vol.302 , Issue.5646 , pp. 885-889
    • Chen, W.G.1    Chang, Q.2    Lin, Y.3
  • 92
    • 84864949487 scopus 로고    scopus 로고
    • Functional significance of isoform diversification in the protocadherin gamma gene cluster
    • Chen WV, Alvarez FJ, Lefebvre JL et al. Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron 75(3), 402-409 (2012)
    • (2012) Neuron , vol.75 , Issue.3 , pp. 402-409
    • Chen, W.V.1    Alvarez, F.J.2    Lefebvre, J.L.3
  • 93
    • 45549101475 scopus 로고    scopus 로고
    • Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-α gene cluster
    • Kawaguchi M, Toyama T, Kaneko R, Hirayama T, Kawamura Y, Yagi T. Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-α gene cluster. J. Biol. Chem. 283, 1064-1075 (2008)
    • (2008) J. Biol. Chem , vol.283 , pp. 1064-1075
    • Kawaguchi, M.1    Toyama, T.2    Kaneko, R.3    Hirayama, T.4    Kawamura, Y.5    Yagi, T.6
  • 95
    • 84856959987 scopus 로고    scopus 로고
    • Imprinted gene dosage is critical for the transition to independent life
    • Charalambous M, Ferron SR, da Rocha ST et al. Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 15, 209-221 (2012)
    • (2012) Cell Metab , vol.15 , pp. 209-221
    • Charalambous, M.1    Ferron, S.R.2    Da Rocha, S.T.3
  • 96
    • 0035930660 scopus 로고    scopus 로고
    • Dnmt3L and the establishment of maternal genomic imprints
    • Bourc'his D, Xu GL, Lin CS et al. Dnmt3L and the establishment of maternal genomic imprints. Science 294(5551), 2536-2539 (2001)
    • (2001) Science , vol.294 , Issue.5551 , pp. 2536-2539
    • Bourc'His, D.1    Xu, G.L.2    Lin, C.S.3
  • 97
    • 0036333103 scopus 로고    scopus 로고
    • Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
    • Hata K, Okano M, Lei H et al. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129(8), 1983-1993 (2002)
    • (2002) Development , vol.129 , Issue.8 , pp. 1983-1993
    • Hata, K.1    Okano, M.2    Lei, H.3
  • 98
    • 0035234557 scopus 로고    scopus 로고
    • Genomic imprinting: Parental influence on the genome
    • Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat. Rev. Genet. 2(1), 21-32 (2001)
    • (2001) Nat. Rev. Genet , vol.2 , Issue.1 , pp. 21-32
    • Reik, W.1    Walter, J.2
  • 99
    • 34250160167 scopus 로고    scopus 로고
    • Mechanisms regulating imprinted genes in clusters
    • Edwards CA, Ferguson-Smith AC. Mechanisms regulating imprinted genes in clusters. Curr. Opin. Cell Biol. 19(3), 281-289 (2007)
    • (2007) Curr. Opin. Cell Biol , vol.19 , Issue.3 , pp. 281-289
    • Edwards, C.A.1    Ferguson-Smith, A.C.2
  • 100
    • 0029935327 scopus 로고    scopus 로고
    • Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes
    • Tucker KL, Beard C, Dausman J et al. Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev. 10(8), 1008-1020 (1996)
    • (1996) Genes Dev , vol.10 , Issue.8 , pp. 1008-1020
    • Tucker, K.L.1    Beard, C.2    Dausman, J.3
  • 101
    • 84860909449 scopus 로고    scopus 로고
    • DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: Results of a pilot randomized controlled trial
    • Cooper WN, Khulan B, Owens S et al. DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial. FASEB J. 26(5), 1782-1790 (2012)
    • (2012) FASEB J , vol.26 , Issue.5 , pp. 1782-1790
    • Cooper, W.N.1    Khulan, B.2    Owens, S.3
  • 102
    • 70349999407 scopus 로고    scopus 로고
    • DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific
    • Tobi EW, Lumey LH, Talens RP et al. DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific. Hum. Mol. Genet. 18(21), 4046-4053 (2009)
    • (2009) Hum. Mol. Genet , vol.18 , Issue.21 , pp. 4046-4053
    • Tobi, E.W.1    Lumey, L.H.2    Talens, R.P.3
  • 103
    • 0031426323 scopus 로고    scopus 로고
    • Genomic imprinting in the brain
    • Keverne EB. Genomic imprinting in the brain. Curr. Opin. Neurobiol. 7(4), 463-468 (1997)
    • (1997) Curr. Opin. Neurobiol , vol.7 , Issue.4 , pp. 463-468
    • Keverne, E.B.1
  • 104
    • 33645455075 scopus 로고    scopus 로고
    • Imprinting defects on human chromosome 15
    • Horsthemke B, Buiting K. Imprinting defects on human chromosome 15. Cytogenet. Genome Res. 113(1-4), 292-299 (2006)
    • (2006) Cytogenet. Genome Res , vol.113 , Issue.1-4 , pp. 292-299
    • Horsthemke, B.1    Buiting, K.2
  • 105
    • 72949087949 scopus 로고    scopus 로고
    • Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome
    • Relkovic D, Doe CM, Humby T et al. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome. Eur. J. Neurosci. 31(1), 156-164 (2010)
    • (2010) Eur. J. Neurosci , vol.31 , Issue.1 , pp. 156-164
    • Relkovic, D.1    Doe, C.M.2    Humby, T.3
  • 106
    • 77956192737 scopus 로고    scopus 로고
    • Genomic imprinting and human disease
    • Hirasawa R, Feil R. Genomic imprinting and human disease. Essays Biochem. 48, 187-200 (2010)
    • (2010) Essays Biochem , vol.48 , pp. 187-200
    • Hirasawa, R.1    Feil, R.2
  • 107
    • 0028267714 scopus 로고
    • Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice
    • Goto K, Numata M, Komura JI, Ono T, Bestor TH, Kondo H. Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice. Differentiation 56, 39-44 (1994)
    • (1994) Differentiation , vol.56 , pp. 39-44
    • Goto, K.1    Numata, M.2    Komura, J.I.3    Ono, T.4    Bestor, T.H.5    Kondo, H.6
  • 108
    • 0035109547 scopus 로고    scopus 로고
    • DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals
    • Fan G, Beard C, Chen RZ et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21(3), 788-797 (2001)
    • (2001) J. Neurosci , vol.21 , Issue.3 , pp. 788-797
    • Fan, G.1    Beard, C.2    Chen, R.Z.3
  • 109
    • 0031937282 scopus 로고    scopus 로고
    • Programming by early nutrition: An experimental approach
    • Lucas A. Programming by early nutrition: an experimental approach. J. Nutr. 128(Suppl. 2), S401-S406 (1998)
    • (1998) J. Nutr , vol.128 , pp. S401-S406
    • Lucas, A.1
  • 110
    • 37649011327 scopus 로고    scopus 로고
    • DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
    • Sinclair KD, Allegrucci C, Singh R et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc. Natl Acad. Sci. USA 104(49), 19351-19356 (2007)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.49 , pp. 19351-19356
    • Sinclair, K.D.1    Allegrucci, C.2    Singh, R.3
  • 111
    • 65549155328 scopus 로고    scopus 로고
    • Epigenetic mechanisms for nutrition determinants of later health outcomes
    • Zeisel SH. Epigenetic mechanisms for nutrition determinants of later health outcomes. Am. J. Clin. Nutr. 89(5), 1488-1493 (2009)
    • (2009) Am. J. Clin. Nutr , vol.89 , Issue.5 , pp. 1488-1493
    • Zeisel, S.H.1
  • 113
    • 79954701341 scopus 로고    scopus 로고
    • Epigenetics and the brain: Transcriptome sequencing reveals new depths to genomic imprinting
    • Kelsey G. Epigenetics and the brain: transcriptome sequencing reveals new depths to genomic imprinting. Bioessays 33(5), 362-367 (2011)
    • (2011) Bioessays , vol.33 , Issue.5 , pp. 362-367
    • Kelsey, G.1
  • 114
    • 77958526499 scopus 로고    scopus 로고
    • Epigenetic regulation of the neural transcriptome: The meaning of the marks
    • Meaney MJ, Ferguson-Smith AC. Epigenetic regulation of the neural transcriptome: the meaning of the marks. Nat. Neurosci. 13(11), 1313-1318 (2010)
    • (2010) Nat. Neurosci , vol.13 , Issue.11 , pp. 1313-1318
    • Meaney, M.J.1    Ferguson-Smith, A.C.2
  • 115
    • 34247469843 scopus 로고    scopus 로고
    • Epigenetic regulation of neural gene expression and neuronal function
    • Supplement 5
    • Feng J, Fouse S, Fan G. Epigenetic regulation of neural gene expression and neuronal function. Pediatr. Res. 61(Part 2 Suppl. 5), 58-63 (2007)
    • (2007) Pediatr. Res , vol.61 , pp. 58-63
    • Feng, J.1    Fouse, S.2    Fan, G.3
  • 116
    • 60149108896 scopus 로고    scopus 로고
    • Gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina
    • Lefebvre JL, Zhang Y, Meister M et al. gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development 135(24), 4141-4151 (2008)
    • (2008) Development , vol.135 , Issue.24 , pp. 4141-4151
    • Lefebvre, J.L.1    Zhang, Y.2    Meister, M.3
  • 117
    • 13944269194 scopus 로고    scopus 로고
    • Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons
    • Esumi S, Kakazu N, Taguchi Y et al. Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons. Nat. Genet. 37(2), 171-176 (2005)
    • (2005) Nat. Genet , vol.37 , Issue.2 , pp. 171-176
    • Esumi, S.1    Kakazu, N.2    Taguchi, Y.3
  • 118
    • 0035001936 scopus 로고    scopus 로고
    • The complete human olfactory subgenome
    • Glusman G, Yanai I, Rubin I et al. The complete human olfactory subgenome. Genome Res. 11(5), 685-702 (2001)
    • (2001) Genome Res , vol.11 , Issue.5 , pp. 685-702
    • Glusman, G.1    Yanai, I.2    Rubin, I.3
  • 119
    • 84907599079 scopus 로고    scopus 로고
    • Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription
    • Colquitt B, Markenscoff-Papadimitriou E, Duffié R et al. Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription. Neuron 83(4), 823-838 (2014)
    • (2014) Neuron , vol.83 , Issue.4 , pp. 823-838
    • Colquitt, B.1    Markenscoff-Papadimitriou, E.2    Duffié, R.3
  • 120
    • 84928705254 scopus 로고    scopus 로고
    • Brain feminization requires active repression of masculinization via DNA methylation
    • Nugent BM, Wright CL, Shetty AC et al. Brain feminization requires active repression of masculinization via DNA methylation. Nat. Neurosci. 18(5), 690-697 (2015)
    • (2015) Nat. Neurosci , vol.18 , Issue.5 , pp. 690-697
    • Nugent, B.M.1    Wright, C.L.2    Shetty, A.C.3
  • 121
    • 84893740377 scopus 로고    scopus 로고
    • Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
    • Guo JU, Su Y, Shin JH et al. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat. Neurosci. 17(2), 215-222 (2014)
    • (2014) Nat. Neurosci , vol.17 , Issue.2 , pp. 215-222
    • Guo, J.U.1    Su, Y.2    Shin, J.H.3
  • 122
    • 84899153582 scopus 로고    scopus 로고
    • Widespread differences in cortex DNA methylation of the "language gene" CNTNAP2 between humans and chimpanzees
    • Schneider E, El Hajj N, Richter S et al. Widespread differences in cortex DNA methylation of the "language gene" CNTNAP2 between humans and chimpanzees. Epigenetics 9(4), 533-545 (2014)
    • (2014) Epigenetics , vol.9 , Issue.4 , pp. 533-545
    • Schneider, E.1    El Hajj, N.2    Richter, S.3
  • 123
    • 84924405857 scopus 로고    scopus 로고
    • DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects
    • Rochtus A, Izzi B, Vangeel E et al. DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects. Epigenetics 10(1), 37-41 (2015)
    • (2015) Epigenetics , vol.10 , Issue.1 , pp. 37-41
    • Rochtus, A.1    Izzi, B.2    Vangeel, E.3
  • 124
    • 84892406215 scopus 로고    scopus 로고
    • Epigenetic profiles in children with a neural tube defect; A case-control study in two populations
    • Stolk L, Bouwland-Both MI, Van Mill NH et al. Epigenetic profiles in children with a neural tube defect; a case-control study in two populations. PLoS ONE 8(11), 1-8 (2013)
    • (2013) PLoS ONE , vol.8 , Issue.11 , pp. 1-8
    • Stolk, L.1    Bouwland-Both, M.I.2    Van Mill, N.H.3
  • 125
    • 5444246895 scopus 로고    scopus 로고
    • A mixed epigenetic/ genetic model for oligogenic inheritance of autism with a limited role for UBE3A
    • Jiang YH, Sahoo T, Michaelis RC et al. A mixed epigenetic/ genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am. J. Med. Genet. 131, 1-10 (2004)
    • (2004) Am. J. Med. Genet , vol.131 , pp. 1-10
    • Jiang, Y.H.1    Sahoo, T.2    Michaelis, R.C.3
  • 126
    • 44349191455 scopus 로고    scopus 로고
    • Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster
    • Sahoo T, del Gaudio D, German JR et al. Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster. Nat. Genet. 40(6), 719-721 (2008)
    • (2008) Nat. Genet , vol.40 , Issue.6 , pp. 719-721
    • Sahoo, T.1    Del Gaudio, D.2    German, J.R.3
  • 127
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir RE, Van den Veyver IB, Wan M et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23(2), 185-188 (1999)
    • (1999) Nat. Genet , vol.23 , Issue.2 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3
  • 128
    • 77955803943 scopus 로고    scopus 로고
    • Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain
    • Nguyen A, Rauch TA, Pfeifer GP et al. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J. 24, 3036-3051 (2010)
    • (2010) FASEB J , vol.24 , pp. 3036-3051
    • Nguyen, A.1    Rauch, T.A.2    Pfeifer, G.P.3
  • 129
    • 84894535118 scopus 로고    scopus 로고
    • Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders
    • Zhu L, Wang X, Li X-L et al. Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders. Hum. Mol. Genet. 23(6), 1563-1578 (2014)
    • (2014) Hum. Mol. Genet , vol.23 , Issue.6 , pp. 1563-1578
    • Zhu, L.1    Wang, X.2    Li, X.-L.3
  • 130
    • 84892954147 scopus 로고    scopus 로고
    • Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum
    • Zhubi A, Chen Y, Dong E, Cook EH, Guidotti a, Grayson DR. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl. Psychiatry 4(1), e349 (2014)
    • (2014) Transl. Psychiatry , vol.4 , Issue.1 , pp. e349
    • Zhubi, A.1    Chen, Y.2    Dong, E.3    Cook, E.H.4    Guidotti, A.5    Grayson, D.R.6
  • 131
    • 34247095504 scopus 로고    scopus 로고
    • Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation
    • Nagarajan RP, Hogart AR, Gwye Y, Martin MR, LaSalle JM. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 1(4), 37-41 (2006)
    • (2006) Epigenetics , vol.1 , Issue.4 , pp. 37-41
    • Nagarajan, R.P.1    Hogart, A.R.2    Gwye, Y.3    Martin, M.R.4    LaSalle, J.M.5
  • 132
    • 84874340720 scopus 로고    scopus 로고
    • Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum
    • James SJ, Shpyleva S, Melnyk S et al. Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum. Transl. Psychiatry 3, e232 (2013)
    • (2013) Transl. Psychiatry , vol.3 , pp. e232
    • James, S.J.1    Shpyleva, S.2    Melnyk, S.3
  • 133
    • 71149104488 scopus 로고    scopus 로고
    • Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
    • Gregory SG, Connelly JJ, Towers AJ et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med. 7, 62 (2009)
    • (2009) BMC Med , vol.7 , pp. 62
    • Gregory, S.G.1    Connelly, J.J.2    Towers, A.J.3
  • 134
    • 0027486670 scopus 로고
    • Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome
    • McConkie-Rosell, , Lachiewicz M, Spiridigliozzi G et al. Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome. Am. J. Hum. Genet. 53(4), 800-809 (1993)
    • (1993) Am. J. Hum. Genet , vol.53 , Issue.4 , pp. 800-809
    • McConkie-Rosell, L.M.1    Spiridigliozzi, G.2
  • 135
    • 0030138905 scopus 로고    scopus 로고
    • Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island
    • Gu Y, Shen Y, Gibbs RA, Nelson DL. Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nat. Genet. 13(1), 109-113 (1996)
    • (1996) Nat. Genet , vol.13 , Issue.1 , pp. 109-113
    • Gu, Y.1    Shen, Y.2    Gibbs, R.A.3    Nelson, D.L.4
  • 136
    • 84869504738 scopus 로고    scopus 로고
    • The ever growing complexity of placental epigenetics-Role in adverse pregnancy outcomes and fetal programming
    • Novakovic B, Saffery R. The ever growing complexity of placental epigenetics-role in adverse pregnancy outcomes and fetal programming. Placenta 33(12), 959-970 (2012)
    • (2012) Placenta , vol.33 , Issue.12 , pp. 959-970
    • Novakovic, B.1    Saffery, R.2
  • 139
    • 80053304450 scopus 로고    scopus 로고
    • High density DNA methylation array with single CpG site resolution
    • Bibikova M, Barnes B, Tsan C et al. High density DNA methylation array with single CpG site resolution. Genomics 98(4), 288-295 (2011)
    • (2011) Genomics , vol.98 , Issue.4 , pp. 288-295
    • Bibikova, M.1    Barnes, B.2    Tsan, C.3
  • 140
    • 84886111619 scopus 로고    scopus 로고
    • DNA methylation age of human tissues and cell types
    • Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 14(10), R115 (2013)
    • (2013) Genome Biol , vol.14 , Issue.10 , pp. R115
    • Horvath, S.1
  • 141
    • 84900824657 scopus 로고    scopus 로고
    • Reference-free cell mixture adjustments in analysis of DNA methylation data
    • Houseman EA, Molitor J, Marsit CJ. Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics 30(10), 1431-1439 (2014)
    • (2014) Bioinformatics , vol.30 , Issue.10 , pp. 1431-1439
    • Houseman, E.A.1    Molitor, J.2    Marsit, C.J.3
  • 142
    • 84927657839 scopus 로고    scopus 로고
    • Application of a low cost array-based technique-TAB-Array-for quantifying and mapping both 5 mC and 5 hmC at single base resolution in human pluripotent stem cells
    • Nazor KL, Boland MJ, Bibikova M et al. Application of a low cost array-based technique-TAB-Array-for quantifying and mapping both 5 mC and 5 hmC at single base resolution in human pluripotent stem cells. Genomics 104(5), 358-367 (2014)
    • (2014) Genomics , vol.104 , Issue.5 , pp. 358-367
    • Nazor, K.L.1    Boland, M.J.2    Bibikova, M.3
  • 143
    • 84879428840 scopus 로고    scopus 로고
    • Impact of continuing folic acid after the first trimester of pregnancy: Findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters
    • McNulty B, McNulty H, Marshall B et al. Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters. Am. J. Clin. Nutr. 98(1), 92-98 (2013)
    • (2013) Am. J. Clin. Nutr , vol.98 , Issue.1 , pp. 92-98
    • McNulty, B.1    McNulty, H.2    Marshall, B.3


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