Maternal folate status in early pregnancy and child emotional and behavioral problems: The generation R study

American Journal of Clinical Nutrition

Volumn 95, Issue 6, 2012, Pages 1413-1421

  Steenweg de Graaff, Jolien ^a   Roza, Sabine J ^a   Steegers, Eric A P ^a   Hofman, Albert ^a   Verhulst, Frank C ^a   Jaddoe, Vincent W V ^a   Tiemeier, Henning ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID;

ADULT; ARTICLE; BEHAVIOR DISORDER; CHILD BEHAVIOR CHECKLIST; EMOTIONAL DISORDER; FEMALE; FIRST TRIMESTER PREGNANCY; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; VITAMIN SUPPLEMENTATION;

ADULT; AFFECTIVE SYMPTOMS; CHILD BEHAVIOR DISORDERS; CHILD, PRESCHOOL; COHORT STUDIES; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENOTYPE; HUMANS; INFANT, NEWBORN; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NUTRITIONAL STATUS; POLYMORPHISM, GENETIC; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL CARE; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; RISK FACTORS; YOUNG ADULT;

EID: 84861569891     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.111.030791     Document Type: Article

References (49)

1. Bailey LB, Gregory JF III. Folate metabolism and requirements. J Nutr 1999;129:779-82. (Pubitemid 29162370)
2. Molloy AM, Brody LC, Mills JL, Scott JM, Kirke PN. The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects. Birth Defects Res A Clin Mol Teratol 2009;85:285-94.
3. de Bree A, Verschuren WM, Bjorke-Monsen AL, van der Put NM, Heil SG, Trijbels FJ, Blom HJ. Effect of the methylenetetrahydrofolate reductase 677C/T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 2003;77:687-93. (Pubitemid 36258581)
4. Crider KS, Zhu JH, Hao L, Yang QH, Yang TP, Gindler J, Maneval DR, Quinlivan EP, Li Z, Bailey LB, et al. MTHFR 677C → T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am J Clin Nutr 2011;93:1365-72.
5. Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993;86:703-8.
6. Steegers-Theunissen RP, Boers GH, Trijbels FJ, Finkelstein JD, Blom HJ, Thomas CM, Borm GF, Wouters MG, Eskes TK. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism 1994;43:1475-80. (Pubitemid 24382696)
7. Blom HJ, Smulders Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis 2011;34:75-81.
8. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7.
9. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-5. (Pubitemid 23003073)
10. Julvez J, Fortuny J, Mendez M, Torrent M, Ribas-Fito N, Sunyer J. Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort. Paediatr Perinat Epidemiol 2009;23:199-206.
11. Wehby GL, Murray JC. The effects of prenatal use of folic acid and other dietary supplements on early child development. Matern Child Health J 2008;12:180-7. (Pubitemid 351149586)
12. Roza SJ, van Batenburg-Eddes T, Steegers EA, Jaddoe VW, Mackenbach JP, Hofman A, Verhulst FC, Tiemeier H. Maternal folic acid supplement use in early pregnancy and child behavioural problems: the Generation R Study. Br J Nutr 2010;103:445-52.
13. Veena SR, Krishnaveni GV, Srinivasan K, Wills AK, Muthayya S, Kurpad AV, Yajnik CS, Fall CH. Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9- to 10- year-old children in South India. J Nutr 2010;140:1014-22.
14. Schlotz W, Jones A, Phillips DI, Gale CR, Robinson SM, Godfrey KM. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatry 2010;51:594-602.
15. Pilsner JR, Hu H, Wright RO, Kordas K, Ettinger AS, Sánchez BN, Cantonwine D, Lazarus AL, Cantoral A, Schnaas L, et al. Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City. Am J Clin Nutr 2010;92:226-34.
16. del Río Garcia C, Torres-Sanchez L, Chen J, Schnaas L, Hernández C, Osorio E, Portillo MG, López-Carrillo L. Maternal MTHFR 677C.T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment. Nutr Neurosci 2009;12:13-20.
17. Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tancredi DJ, Tassone F, Hertz-Picciotto I. Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology 2011;22: 476-85.
18. Jaddoe VW, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Verhulst FC,Witteman JC, Hofman A. The Generation R Study: design and cohort profile. Eur J Epidemiol 2006;21:475-84. (Pubitemid 44259554)
19. Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. The Generation R Study: design and cohort update 2010. Eur J Epidemiol 2010;25:823-41.
20. Jaddoe VW, Bakker R, van Duijn CM, van der Heijden AJ, Lindemans J, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, et al. The Generation R Study Biobank: a resource for epidemiological studies in children and their parents. Eur J Epidemiol 2007;22: 917-23.
21. Health Council of the Netherlands. Towards an optimal use of folic acid. The Hague: Health Council of the Netherlands, 2008; publication no. 2008/02 (in Dutch).
22. Bakker R, Timmermans S, Steegers EA, Hofman A, Jaddoe VW. Folic acid supplements modify the adverse effects of maternal smoking on fetal growth and neonatal complications. J Nutr 2011;141:2172-9.
23. Molloy AM, Mills JL, McPartlin J, Kirke PN, Scott JM, Daly S. Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C/T variant. Am J Obstet Gynecol 2002;186:499-503. (Pubitemid 34234164)
24. Achenbach TM, Rescorla LA. Manual for the ASEBA preschool forms & profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families, 2000.
25. Thuesen BH, Husemoen LL, Ovesen L, Jorgensen T, Fenger M, Linneberg A. Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 2010;103: 1195-204.
26. Nilsen RM, Vollset SE, Gjessing HK, Magnus P, Meltzer HM, Haugen M, Ueland PM. Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study. Am J Clin Nutr 2006;84:1134-41. (Pubitemid 44730385)
27. Timmermans S, Jaddoe VW, Mackenbach JP, Hofman A, Steegers-Theunissen RP, Steegers EA. Determinants of folic acid use in early pregnancy in a multi-ethnic urban population in The Netherlands: the Generation R study. Prev Med 2008;47:427-32.
28. Van den Bergh BR, Mulder EJ, Mennes M, Glover V. Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neurosci Biobehav Rev 2005;29:237-58. (Pubitemid 40461742)
29. Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry 2010; 51:134-43.
30. de Beurs E. Brief symptom inventory. Leiden, Netherlands: Pits Publishers, 2004.
31. Derogatis LR, Melisaratos N. The brief symptom inventory: an introductory report. Psychol Med 1983;13:595-605. (Pubitemid 13019024)
32. Cents RA, Tiemeier H, Luijk MP, Jaddoe VW, Hofman A, Verhulst FC, Lambregtse-van den Berg MP. Grandparental anxiety and depression predict young children's internalizing and externalizing problems: the generation R study. J Affect Disord 2011;128:95-105.
33. Velders FP, Dieleman G, Henrichs J, Jaddoe VW, Hofman A, Verhulst FC, Hudziak JJ, Tiemeier H. Prenatal and postnatal psychological symptoms of parents and family functioning: the impact on child emotional and behavioural problems. Eur Child Adolesc Psychiatry 2011;20:341-50.
34. Simpson JL, Bailey LB, Pietrzik K, Shane B, Holzgreve W. Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part I - folate, vitamin B12, vitamin B6. J Matern Fetal Neonatal Med 2010;23:1323-43.
35. Hague WM. Homocysteine and pregnancy. Best Pract Res Clin Obstet Gynaecol 2003;17:459-69. (Pubitemid 36722171)
36. Walter S, Tiemeier H. Variable selection: current practice in epidemiological studies. Eur J Epidemiol 2009;24:733-6.
37. Craciunescu CN, Brown EC, Mar MH, Albright CD, Nadeau MR, Zeisel SH. Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. J Nutr 2004;134:162-6. (Pubitemid 38057441)
38. Burdge GC, Lillycrop KA. Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease. Annu Rev Nutr 2010;30:315-39.
39. Blom HJ, Shaw GM, den Heijer M, Finnell RH. Neural tube defects and folate: case far from closed. Nat Rev Neurosci 2006;7:724-31. (Pubitemid 44267496)
40. Kim KC, Friso S, Choi SW. DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem 2009;20:917-26.
41. Costello EJ, Compton SN, Keeler G, Angold A. Relationships between poverty and psychopathology: a natural experiment. JAMA 2003;290: 2023-9. (Pubitemid 37430585)
42. Li Q, Yan H, Zeng L, Cheng Y, Liang W, Dang S, Wang Q, Tsuji I. Effects of maternal multimicronutrient supplementation on the mental development of infants in rural western China: follow-up evaluation of a double-blind, randomized, controlled trial. Pediatrics 2009;123: e685-92.
43. James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB, Yi P, Tafoya DL, Swenson DH, Wilson VL, et al. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 1999;70:495-501.
44. Zhang C, Xie B, Fang Y, Cheng W, Du Y, Wang D, Yu S. Influence of maternal MTHFR A1298C polymorphism on the risk in offspring of schizophrenia. Brain Res 2010;1320:130-4.
45. Glaser B, Ades AE, Lewis S, Emmet P, Lewis G, Smith GD, Zammit S. Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort. Schizophr Res 2010;120:177-83.
46. Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004;33:30-42. (Pubitemid 38528650)
47. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9. (Pubitemid 26006560)
48. de Walle HE, Cornel MC, de Jong-van den Berg LT. Three years after the dutch folic acid campaign: growing socioeconomic differences. Prev Med 2002;35:65-9. (Pubitemid 34762087)
49. Meijer WM, de Walle HE. Verschillen in foliumzuurbeleid en prevalentie van neuralebuisdefecten in europa; aanbevelingen voor voedselverrijking in een EUROCAT-rapport. (Differences in folic-acid policy and the prevalence of neural-tube defects in Europe; recommendations for food fortification in a EUROCAT report.) Ned Tijdschr Geneeskd 2005;149:2561-4 (in Dutch).