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Volumn 3, Issue 3, 2011, Pages 370-384

Folic acid food fortification-its history, effect, concerns, and future directions

Author keywords

Cancer; Epigenetics; Flour fortification; Folic acid; Neural tube defects

Indexed keywords

DNA; FOLIC ACID;

EID: 79953718498     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu3030370     Document Type: Review
Times cited : (446)

References (100)
  • 2
    • 0016782417 scopus 로고
    • Nutritional stability of various naturally occurring monoglutamate derivatives of folic acid
    • O'Broin, J.D.; Temperley, I.J.; Brown, J.P.; Scott, J.M. Nutritional stability of various naturally occurring monoglutamate derivatives of folic acid. Am. J. Clin. Nutr. 1975, 28, 438-444.
    • (1975) Am. J. Clin. Nutr , vol.28 , pp. 438-444
    • O'Broin, J.D.1    Temperley, I.J.2    Brown, J.P.3    Scott, J.M.4
  • 4
    • 85057943345 scopus 로고    scopus 로고
    • Folate biochemical pathways and their regulation
    • 2nd ed.; Bailey, L.B., Ed.; CRC Press, Taylor & Francis Group: Gainesville, FL, USA
    • Stover, P.J. Folate biochemical pathways and their regulation. In Folate in Health and Disease, 2nd ed.; Bailey, L.B., Ed.; CRC Press, Taylor & Francis Group: Gainesville, FL, USA, 2009; pp. 49-74.
    • (2009) Folate In Health and Disease , pp. 49-74
    • Stover, P.J.1
  • 5
    • 65349147023 scopus 로고    scopus 로고
    • The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects
    • Molloy, A.M.; Brody, L.C.; Mills, J.L.; Scott, J.M.; Kirke, P.N. The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects. Birth Defects Res. A Clin. Mol. Teratol. 2009, 85, 285-294.
    • (2009) Birth Defects Res. a Clin. Mol. Teratol , vol.85 , pp. 285-294
    • Molloy, A.M.1    Brody, L.C.2    Mills, J.L.3    Scott, J.M.4    Kirke, P.N.5
  • 6
    • 55449086410 scopus 로고    scopus 로고
    • Survival and disability in a cohort of neural tube defect births in Dublin, Ireland
    • Sutton, M.; Daly, L.E.; Kirke, P.N. Survival and disability in a cohort of neural tube defect births in Dublin, Ireland. Birth Defects Res. A Clin. Mol. Teratol. 2008, 82, 701-709.
    • (2008) Birth Defects Res. a Clin. Mol. Teratol , vol.82 , pp. 701-709
    • Sutton, M.1    Daly, L.E.2    Kirke, P.N.3
  • 9
    • 0023791890 scopus 로고
    • Periconceptional use of multivitamins and the occurrence of neural tube defects
    • Mulinare, J.; Cordero, J.F.; Erickson, J.D.; Berry, R.J. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988, 260, 3141-3145.
    • (1988) JAMA , vol.260 , pp. 3141-3145
    • Mulinare, J.1    Cordero, J.F.2    Erickson, J.D.3    Berry, R.J.4
  • 10
    • 0024385912 scopus 로고
    • Dietary folate as a risk factor for neural-tube defects: Evidence from a case-control study in Western Australia
    • Bower, C.; Stanley, F.J. Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med. J. Aust. 1989, 150, 613-619.
    • (1989) Med. J. Aust , vol.150 , pp. 613-619
    • Bower, C.1    Stanley, F.J.2
  • 11
    • 0025863475 scopus 로고
    • Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
    • MRC Vitamin Study Research Group
    • MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991, 338, 131-137.
    • (1991) Lancet , vol.338 , pp. 131-137
  • 12
    • 0027080461 scopus 로고
    • Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation
    • Czeizel, A.E.; Dudas, I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 1992, 327, 1832-1835.
    • (1992) N. Engl. J. Med , vol.327 , pp. 1832-1835
    • Czeizel, A.E.1    Dudas, I.2
  • 13
    • 0026413973 scopus 로고
    • Use of folic acid for prevention of spina bifida and other neural tube defects-1983-1991
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Use of folic acid for prevention of spina bifida and other neural tube defects-1983-1991. MMWR Morb. Mortal. Wkly. Rep. 1991, 40, 513-516.
    • (1991) MMWR Morb. Mortal. Wkly. Rep , vol.40 , pp. 513-516
  • 14
    • 0027117866 scopus 로고
    • Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm. Rep. 1992, 41, 1-7.
    • (1992) MMWR Recomm. Rep , vol.41 , pp. 1-7
  • 16
    • 65649095591 scopus 로고    scopus 로고
    • Folic acid for the prevention of neural tube defects: U.S. Preventive Services Task Force recommendation statement
    • U.S. Preventive Services Task Force
    • U.S. Preventive Services Task Force. Folic acid for the prevention of neural tube defects: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 2009, 150, 626-631.
    • (2009) Ann. Intern. Med , vol.150 , pp. 626-631
  • 17
    • 33745107633 scopus 로고    scopus 로고
    • Disparities in rates of unintended pregnancy in the United States, 1994 and 2001
    • Finer, L.B.; Henshaw, S.K. Disparities in rates of unintended pregnancy in the United States, 1994 and 2001. Perspect. Sex. Reprod. Health 2006, 38, 90-96.
    • (2006) Perspect. Sex. Reprod. Health , vol.38 , pp. 90-96
    • Finer, L.B.1    Henshaw, S.K.2
  • 18
    • 2442436792 scopus 로고    scopus 로고
    • Evidence for suboptimal use of periconceptional folic acid supplements globally
    • Ray, J.G.; Singh, G.; Burrows, R.F. Evidence for suboptimal use of periconceptional folic acid supplements globally. BJOG 2004, 111, 399-408.
    • (2004) BJOG , vol.111 , pp. 399-408
    • Ray, J.G.1    Singh, G.2    Burrows, R.F.3
  • 21
    • 53349096756 scopus 로고    scopus 로고
    • Did national folic acid fortification reduce socioeconomic and racial disparities in folate status in the US?
    • Dowd, J.B.; Aiello, A.E. Did national folic acid fortification reduce socioeconomic and racial disparities in folate status in the US? Int. J. Epidemiol. 2008, 37, 1059-1066.
    • (2008) Int. J. Epidemiol , vol.37 , pp. 1059-1066
    • Dowd, J.B.1    Aiello, A.E.2
  • 22
    • 85020855418 scopus 로고    scopus 로고
    • Report of the Workshop of Wheat Flour Fortification: Cuernavaca, Mexico. Available online, (accessed on August 21, 2010)
    • Flour Fortification Initiative. Report of the Workshop of Wheat Flour Fortification: Cuernavaca, Mexico. Available online: http://www.sph.emory.edu/wheatflour/CKPAFF/index.htm (accessed on August 21, 2010).
    • Flour Fortification Initiative
  • 23
    • 77955692711 scopus 로고    scopus 로고
    • Additional Opportunities to Prevent Neural Tube Defects with Folic Acid Fortification
    • Centers for Disease Control and Prevention. CDC Grand Rounds
    • Centers for Disease Control and Prevention. CDC Grand Rounds: Additional Opportunities to Prevent Neural Tube Defects with Folic Acid Fortification. MMWR Morb. Mortal. Wkly. Rep. 2010, 59, 980-984.
    • (2010) MMWR Morb. Mortal. Wkly. Rep , vol.59 , pp. 980-984
  • 24
    • 79953724204 scopus 로고    scopus 로고
    • Annex D-A procedure for estimating feasible fortification levels for a mass fortification programme, 1st ed.; Allen, L., de Benoist, B., Dary, O., Hurrell, R., Eds.; World Health Organization: Portland, OR, USA
    • Annex D-A procedure for estimating feasible fortification levels for a mass fortification programme. In Guidelines on Food Fortification with Micronutrients, 1st ed.; Allen, L., de Benoist, B., Dary, O., Hurrell, R., Eds.; World Health Organization: Portland, OR, USA, 2006; pp. 294-312.
    • (2006) Guidelines On Food Fortification With Micronutrients , pp. 294-312
  • 25
    • 0001716641 scopus 로고    scopus 로고
    • Food standards: Amendment of standards of identity for enriched grain products to require addition of folic acid. Final Rule. 21 CFR Parts 136, 137, and 139
    • Food and Drug Administration
    • Food and Drug Administration. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Final Rule. 21 CFR Parts 136, 137, and 139. Fed. Regist. 1996, 61, 8781-8789.
    • (1996) Fed. Regist , vol.61 , pp. 8781-8789
  • 26
    • 36849081815 scopus 로고    scopus 로고
    • Reassessing folic acid consumption patterns in the United States (1999-2004): Potential effect on neural tube defects and overexposure to folate
    • Quinlivan, E.P.; Gregory, J.F., III. Reassessing folic acid consumption patterns in the United States (1999-2004): potential effect on neural tube defects and overexposure to folate. Am. J. Clin. Nutr. 2007, 86, 1773-1779.
    • (2007) Am. J. Clin. Nutr , vol.86 , pp. 1773-1779
    • Quinlivan, E.P.1    Gregory III, J.F.2
  • 27
    • 34248359482 scopus 로고    scopus 로고
    • Race-ethnicity differences in folic acid intake in women of childbearing age in the United States after folic acid fortification: Findings from the National Health and Nutrition Examination Survey, 2001-2002
    • Yang, Q.H.; Carter, H.K.; Mulinare, J.; Berry, R.J.; Friedman, J.M.; Erickson, J.D. Race-ethnicity differences in folic acid intake in women of childbearing age in the United States after folic acid fortification: findings from the National Health and Nutrition Examination Survey, 2001-2002. Am. J. Clin. Nutr. 2007, 85, 1409-1416.
    • (2007) Am. J. Clin. Nutr , vol.85 , pp. 1409-1416
    • Yang, Q.H.1    Carter, H.K.2    Mulinare, J.3    Berry, R.J.4    Friedman, J.M.5    Erickson, J.D.6
  • 28
    • 0034664105 scopus 로고    scopus 로고
    • Total folate in enriched cereal-grain products in the United States following fortification
    • Rader, J.I.; Weaver, C.M.; Angyal, G. Total folate in enriched cereal-grain products in the United States following fortification. Food Chem. 2000, 70, 275-289.
    • (2000) Food Chem , vol.70 , pp. 275-289
    • Rader, J.I.1    Weaver, C.M.2    Angyal, G.3
  • 29
    • 0034905547 scopus 로고    scopus 로고
    • Fortification contributed greatly to vitamin and mineral intakes in the United States, 1989-1991
    • Berner, L.A.; Clydesdale, F.M.; Douglass, J.S. Fortification contributed greatly to vitamin and mineral intakes in the United States, 1989-1991. J. Nutr. 2001, 131, 2177-2183.
    • (2001) J. Nutr , vol.131 , pp. 2177-2183
    • Berner, L.A.1    Clydesdale, F.M.2    Douglass, J.S.3
  • 30
    • 34247122192 scopus 로고    scopus 로고
    • Wheat flour fortification is unlikely to benefit the neediest in Guatemala
    • Imhoff-Kunsch, B.; Flores, R.; Dary, O.; Martorell, R. Wheat flour fortification is unlikely to benefit the neediest in Guatemala. J. Nutr. 2007, 137, 1017-1022.
    • (2007) J. Nutr , vol.137 , pp. 1017-1022
    • Imhoff-Kunsch, B.1    Flores, R.2    Dary, O.3    Martorell, R.4
  • 31
    • 48249135749 scopus 로고    scopus 로고
    • Establishing safe and potentially efficacious fortification contents for folic acid and vitamin B12
    • Dary, O. Establishing safe and potentially efficacious fortification contents for folic acid and vitamin B12. Food Nutr. Bull. 2008, 29, S214-S224.
    • (2008) Food Nutr. Bull , vol.29
    • Dary, O.1
  • 32
    • 84884836751 scopus 로고    scopus 로고
    • Folic acid fortification: Neural tube defect risk reduction-a global perspective
    • 2nd ed.; Bailey, L.B., Ed.; CRC Press: Boca Raton, FL, USA
    • Berry, R.J.; Mulinare, J.; Hamner, H.C. Folic acid fortification: neural tube defect risk reduction-a global perspective. In Folate in Health and Disease, 2nd ed.; Bailey, L.B., Ed.; CRC Press: Boca Raton, FL, USA, 2010; pp. 179-204.
    • (2010) Folate In Health and Disease , pp. 179-204
    • Berry, R.J.1    Mulinare, J.2    Hamner, H.C.3
  • 33
    • 79959222760 scopus 로고    scopus 로고
    • SOR/96-527. Available online, (accessed on September 27, 2008)
    • Canada Gazette Food and Drugs Regulations. SOR/96-527. Available online: http://canadagazette.gc.ca/partII/1998/19981125/html/sor550-e.html (accessed on September 27, 2008).
    • Canada Gazette Food and Drugs Regulations
  • 34
    • 3142738068 scopus 로고    scopus 로고
    • The Costa Rican experience: Reduction of neural tube defects following food fortification programs
    • Chen, L.T.; Rivera, M.A. The Costa Rican experience: reduction of neural tube defects following food fortification programs. Nutr. Rev. 2004, 62, S40-S43.
    • (2004) Nutr. Rev , vol.62
    • Chen, L.T.1    Rivera, M.A.2
  • 35
    • 3142673553 scopus 로고    scopus 로고
    • Folic acid fortification of wheat flour: Chile
    • discussion S49
    • Hertrampf, E.; Cortes, F. Folic acid fortification of wheat flour: Chile. Nutr. Rev. 2004, 62, S44-S48; discussion S49.
    • (2004) Nutr. Rev , vol.62
    • Hertrampf, E.1    Cortes, F.2
  • 36
    • 43249108669 scopus 로고    scopus 로고
    • Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa
    • Sayed, A.R.; Bourne, D.; Pattinson, R.; Nixon, J.; Henderson, B. Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa. Birth Defects Res. A Clin. Mol. Teratol. 2008, 82, 211-216.
    • (2008) Birth Defects Res. a Clin. Mol. Teratol , vol.82 , pp. 211-216
    • Sayed, A.R.1    Bourne, D.2    Pattinson, R.3    Nixon, J.4    Henderson, B.5
  • 38
    • 0035919139 scopus 로고    scopus 로고
    • Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects
    • Honein, M.A.; Paulozzi, L.J.; Mathews, T.J.; Erickson, J.D.; Wong, L.Y. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001, 285, 2981-2986.
    • (2001) JAMA , vol.285 , pp. 2981-2986
    • Honein, M.A.1    Paulozzi, L.J.2    Mathews, T.J.3    Erickson, J.D.4    Wong, L.Y.5
  • 42
    • 0037153743 scopus 로고    scopus 로고
    • Association of neural tube defects and folic acid food fortification in Canada
    • Ray, J.; Meier, C.; Vermeulen, M.; Boss, S.; Wyatt, P.; Cole, D. Association of neural tube defects and folic acid food fortification in Canada. Lancet 2002, 360, 2047-2048.
    • (2002) Lancet , vol.360 , pp. 2047-2048
    • Ray, J.1    Meier, C.2    Vermeulen, M.3    Boss, S.4    Wyatt, P.5    Cole, D.6
  • 43
    • 0036057549 scopus 로고    scopus 로고
    • Incidence of open neural tube defects in Nova Scotia after folic acid fortification
    • Persad, V.L.; van den Hof, M.C.; Dube, J.M.; Zimmer, P. Incidence of open neural tube defects in Nova Scotia after folic acid fortification. Can. Med. Assoc. J. 2002, 167, 241-245.
    • (2002) Can. Med. Assoc. J , vol.167 , pp. 241-245
    • Persad, V.L.1    van den Hof, M.C.2    Dube, J.M.3    Zimmer, P.4
  • 46
    • 78449235688 scopus 로고    scopus 로고
    • Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
    • Lopez-Camelo, J.S.; Castilla, E.E.; Orioli, I.M. Folic acid flour fortification: impact on the frequencies of 52 congenital anomaly types in three South American countries. Am. J. Med. Genet. A 2010, 152A, 2444-2458.
    • (2010) Am. J. Med. Genet. A , vol.152 A , pp. 2444-2458
    • Lopez-Camelo, J.S.1    Castilla, E.E.2    Orioli, I.M.3
  • 47
    • 63149166599 scopus 로고    scopus 로고
    • Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
    • Molloy, A.M.; Kirke, P.N.; Troendle, J.F.; Burke, H.; Sutton, M.; Brody, L.C.; Scott, J.M.; Mills, J.L. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics 2009, 123, 917-923.
    • (2009) Pediatrics , vol.123 , pp. 917-923
    • Molloy, A.M.1    Kirke, P.N.2    Troendle, J.F.3    Burke, H.4    Sutton, M.5    Brody, L.C.6    Scott, J.M.7    Mills, J.L.8
  • 48
    • 48249084968 scopus 로고    scopus 로고
    • The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status
    • Selhub, J.; Jacques, P.F.; Dallal, G.; Choumenkovitch, S.; Rogers, G. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food. Nutr. Bull. 2008, 29, S67-S73.
    • (2008) Food. Nutr. Bull , vol.29
    • Selhub, J.1    Jacques, P.F.2    Dallal, G.3    Choumenkovitch, S.4    Rogers, G.5
  • 49
    • 0028863219 scopus 로고
    • Folate levels and neural tube defects. Implications for prevention
    • Daly, L.E.; Kirke, P.N.; Molloy, A.; Weir, D.G.; Scott, J.M. Folate levels and neural tube defects. Implications for prevention. JAMA 1995, 274, 1698-1702.
    • (1995) JAMA , vol.274 , pp. 1698-1702
    • Daly, L.E.1    Kirke, P.N.2    Molloy, A.3    Weir, D.G.4    Scott, J.M.5
  • 50
    • 74049089339 scopus 로고    scopus 로고
    • Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006
    • Yang, Q.; Cogswell, M.E.; Hamner, H.C.; Carriquiry, A.; Bailey, L.B.; Pfeiffer, C.M.; Berry, R.J. Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006. Am. J. Clin. Nutr. 2010, 91, 64-72.
    • (2010) Am. J. Clin. Nutr , vol.91 , pp. 64-72
    • Yang, Q.1    Cogswell, M.E.2    Hamner, H.C.3    Carriquiry, A.4    Bailey, L.B.5    Pfeiffer, C.M.6    Berry, R.J.7
  • 51
    • 77957949167 scopus 로고    scopus 로고
    • Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    • Clarke, R.; Halsey, J.; Lewington, S.; Lonn, E.; Armitage, J.; Manson, J.E.; Bonaa, K.H.; Spence, J.D.; Nygard, O.; Jamison, R.; et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch. Intern. Med. 2010, 170, 1622-1631.
    • (2010) Arch. Intern. Med , vol.170 , pp. 1622-1631
    • Clarke, R.1    Halsey, J.2    Lewington, S.3    Lonn, E.4    Armitage, J.5    Manson, J.E.6    Bonaa, K.H.7    Spence, J.D.8    Nygard, O.9    Jamison, R.10
  • 52
    • 85088739199 scopus 로고    scopus 로고
    • Cognitive impairment in older Americans in the age of folic acid fortification
    • Berry, R.J.; Carter, H.K.; Yang, Q. Cognitive impairment in older Americans in the age of folic acid fortification. Am. J. Clin. Nutr. 2007, 86, 267-269.
    • (2007) Am. J. Clin. Nutr , vol.86 , pp. 267-269
    • Berry, R.J.1    Carter, H.K.2    Yang, Q.3
  • 53
    • 0014938703 scopus 로고
    • Toxicity of folic acid given in pharmacological doses to healthy volunteers
    • Hunter, R.; Barnes, J.; Oakeley, H.F.; Matthews, D.M. Toxicity of folic acid given in pharmacological doses to healthy volunteers. Lancet 1970, 1, 61-63.
    • (1970) Lancet , vol.1 , pp. 61-63
    • Hunter, R.1    Barnes, J.2    Oakeley, H.F.3    Matthews, D.M.4
  • 55
    • 0015215916 scopus 로고
    • Lack of toxicity of folic acid given in pharmacological doses to healthy volunteers
    • Hellstrom, L. Lack of toxicity of folic acid given in pharmacological doses to healthy volunteers. Lancet 1971, 1, 59-61.
    • (1971) Lancet , vol.1 , pp. 59-61
    • Hellstrom, L.1
  • 56
    • 0015057484 scopus 로고
    • Toxicity of folic acid
    • Richens, A. Toxicity of folic acid. Lancet 1971, 1, 912.
    • (1971) Lancet , vol.1 , pp. 912
    • Richens, A.1
  • 57
    • 0015915658 scopus 로고
    • Folic acid: Lack of toxicity
    • Sheehy, T.W. Folic acid: lack of toxicity. Lancet 1973, 1, 37.
    • (1973) Lancet , vol.1 , pp. 37
    • Sheehy, T.W.1
  • 60
    • 78651267683 scopus 로고    scopus 로고
    • Contributions of enriched cereal-grain products, ready-to-eat cereals, and supplements to folic acid and vitamin B-12 usual intake and folate and vitamin B-12 status in US children: National Health and Nutrition Examination Survey (NHANES), 2003-2006
    • Yeung, L.F.; Cogswell, M.E.; Carriquiry, A.L.; Bailey, L.B.; Pfeiffer, C.M.; Berry, R.J. Contributions of enriched cereal-grain products, ready-to-eat cereals, and supplements to folic acid and vitamin B-12 usual intake and folate and vitamin B-12 status in US children: National Health and Nutrition Examination Survey (NHANES), 2003-2006. Am. J. Clin. Nutr. 2011, 93, 172-185.
    • (2011) Am. J. Clin. Nutr , vol.93 , pp. 172-185
    • Yeung, L.F.1    Cogswell, M.E.2    Carriquiry, A.L.3    Bailey, L.B.4    Pfeiffer, C.M.5    Berry, R.J.6
  • 61
    • 0029067620 scopus 로고
    • Does folic acid harm people with vitamin B12 deficiency?
    • Dickinson, C.J. Does folic acid harm people with vitamin B12 deficiency? QJM 1995, 88, 357-364.
    • (1995) QJM , vol.88 , pp. 357-364
    • Dickinson, C.J.1
  • 62
    • 0038239366 scopus 로고    scopus 로고
    • Low vitamin B-12 concentrations in patients without anemia: The effect of folic acid fortification of grain
    • Mills, J.L.; Von Kohorn, I.; Conley, M.R.; Zeller, J.; Cox, C.; Williamson, R.E.; Dufour, D.R. Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain. Am. J. Clin. Nutr. 2003, 77, 1474-1477.
    • (2003) Am. J. Clin. Nutr , vol.77 , pp. 1474-1477
    • Mills, J.L.1    von Kohorn, I.2    Conley, M.R.3    Zeller, J.4    Cox, C.5    Williamson, R.E.6    Dufour, D.R.7
  • 63
    • 7444254369 scopus 로고    scopus 로고
    • The relationship between serum cobalamin concentration and mean red cell volume at varying concentrations of serum folate
    • Metz, J.; McNeil, A.R.; Levin, M. The relationship between serum cobalamin concentration and mean red cell volume at varying concentrations of serum folate. Clin. Lab. Haematol. 2004, 26, 323-325.
    • (2004) Clin. Lab. Haematol , vol.26 , pp. 323-325
    • Metz, J.1    McNeil, A.R.2    Levin, M.3
  • 64
    • 35148874118 scopus 로고    scopus 로고
    • Proportion of individuals with low serum vitamin B-12 concentrations without macrocytosis is higher in the post folic acid fortification period than in the pre folic acid fortification period
    • Wyckoff, K.F.; Ganji, V. Proportion of individuals with low serum vitamin B-12 concentrations without macrocytosis is higher in the post folic acid fortification period than in the pre folic acid fortification period. Am. J. Clin. Nutr. 2007, 86, 1187-1192.
    • (2007) Am. J. Clin. Nutr , vol.86 , pp. 1187-1192
    • Wyckoff, K.F.1    Ganji, V.2
  • 65
    • 77956324727 scopus 로고    scopus 로고
    • Folate and Cancer. Epidemiological Perspective
    • 2nd ed.; Bailey, L.B., Eds.; CRC Press, Taylor & Francis Group: Boca Raton, FL, USA
    • Chen, J.; Xu, X.; Liu, A.; Ulrich, C.M. Folate and Cancer. Epidemiological Perspective. In Folate in Health and Disease, 2nd ed.; Bailey, L.B., Eds.; CRC Press, Taylor & Francis Group: Boca Raton, FL, USA, 2009; pp. 205-233.
    • (2009) Folate In Health and Disease , pp. 205-233
    • Chen, J.1    Xu, X.2    Liu, A.3    Ulrich, C.M.4
  • 69
    • 0030846298 scopus 로고    scopus 로고
    • Tying it all together: Epigenetics, genetics, cell cycle, and cancer
    • Baylin, S.B. Tying it all together: Epigenetics, genetics, cell cycle, and cancer. Science 1997, 277, 1948-1949.
    • (1997) Science , vol.277 , pp. 1948-1949
    • Baylin, S.B.1
  • 70
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin, S.B.; Herman, J.G. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000, 16, 168-174.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 72
    • 0035895249 scopus 로고    scopus 로고
    • Cancer epigenetics takes center stage
    • Feinberg, A.P. Cancer epigenetics takes center stage. Proc. Natl. Acad. Sci. USA 2001, 98, 392-394.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 392-394
    • Feinberg, A.P.1
  • 73
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in Cancer
    • Esteller, M. Epigenetics in Cancer. N. Engl. J. Med. 2008, 358, 1148-1159.
    • (2008) N. Engl. J. Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 76
    • 84976369565 scopus 로고    scopus 로고
    • Folate and carcinogenesis basic mechanisms
    • 2nd ed.; Bailey, L.B., Eds.; CRC Press, Taylor & Francis Group: Boca Raton, FL, USA
    • Ciappio, E.; Mason, J.B. Folate and carcinogenesis basic mechanisms. In Folate in Health and Disease, 2nd ed.; Bailey, L.B., Eds.; CRC Press, Taylor & Francis Group: Boca Raton, FL, USA, 2009; pp. 235-262.
    • (2009) Folate In Health and Disease , pp. 235-262
    • Ciappio, E.1    Mason, J.B.2
  • 79
    • 0347123629 scopus 로고    scopus 로고
    • Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    • Waterland, R.A.; Jirtle, R.L. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 2004, 20, 63-68.
    • (2004) Nutrition , vol.20 , pp. 63-68
    • Waterland, R.A.1    Jirtle, R.L.2
  • 80
    • 70350223852 scopus 로고    scopus 로고
    • Folic Acid
    • CRC Press, Taylor & Francis Group: Boca Raton, FL, USA
    • Bailey, L. Folic Acid. Handbook of Vitamins; CRC Press, Taylor & Francis Group: Boca Raton, FL, USA, 2007.
    • (2007) Handbook of Vitamins
    • Bailey, L.1
  • 81
    • 34047122671 scopus 로고    scopus 로고
    • Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appear in serum
    • Sweeney, M.; McPartlin, J.; Scott, J. Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appear in serum. BMC Public Health 2007, 7, 41.
    • (2007) BMC Public Health , vol.7 , pp. 41
    • Sweeney, M.1    McPartlin, J.2    Scott, J.3
  • 82
    • 33846058996 scopus 로고    scopus 로고
    • Multivitamin-multimineral supplements: Who uses them?
    • C.L. Multivitamin-multimineral supplements: who uses them? Am. J. Clin. Nutr. 2007, 85, 277S-279S.
    • (2007) Am. J. Clin. Nutr , vol.85
  • 83
    • 0030962568 scopus 로고    scopus 로고
    • Unmetabolized folic acid in serum: Acute studies in subjects consuming fortified food and supplements
    • Kelly, P.; McPartlin, J.; Goggins, M.; Weir, D.G.; Scott, J.M. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am. J. Clin. Nutr. 1997, 65, 1790-1795.
    • (1997) Am. J. Clin. Nutr , vol.65 , pp. 1790-1795
    • Kelly, P.1    McPartlin, J.2    Goggins, M.3    Weir, D.G.4    Scott, J.M.5
  • 84
    • 32844473443 scopus 로고    scopus 로고
    • Postprandial serum folic acid response to multiple doses of folic acid in fortified bread
    • Sweeney, M.R.; McPartlin, J.; Weir, D.G.; Daly, L.; Scott, J.M. Postprandial serum folic acid response to multiple doses of folic acid in fortified bread. Br. J. Nutr. 2006, 95, 145-151.
    • (2006) Br. J. Nutr , vol.95 , pp. 145-151
    • Sweeney, M.R.1    McPartlin, J.2    Weir, D.G.3    Daly, L.4    Scott, J.M.5
  • 86
    • 79955004113 scopus 로고    scopus 로고
    • Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults
    • doi:10.1016/j.metabol.2010.06.020
    • Obeid, R.; Kirsch, S.H.; Kasoha, M.; Eckert, R.; Herrmann, W. Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults. Metabolism 2010, doi:10.1016/j.metabol.2010.06.020.
    • (2010) Metabolism
    • Obeid, R.1    Kirsch, S.H.2    Kasoha, M.3    Eckert, R.4    Herrmann, W.5
  • 87
    • 77955479796 scopus 로고    scopus 로고
    • Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged ≥60 y in the United States
    • Bailey, R.L.; Mills, J.L.; Yetley, E.A.; Gahche, J.J.; Pfeiffer, C.M.; Dwyer, J.T.; Dodd, K.W.; Sempos, C.T.; Betz, J.M.; Picciano, M.F. Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged ≥60 y in the United States. Am. J. Clin. Nutr. 2010, 92, 383-389.
    • (2010) Am. J. Clin. Nutr , vol.92 , pp. 383-389
    • Bailey, R.L.1    Mills, J.L.2    Yetley, E.A.3    Gahche, J.J.4    Pfeiffer, C.M.5    Dwyer, J.T.6    Dodd, K.W.7    Sempos, C.T.8    Betz, J.M.9    Picciano, M.F.10
  • 88
    • 78651330055 scopus 로고    scopus 로고
    • Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood
    • Obeid, R.; Kasoha, M.; Kirsch, S.H.; Munz, W.; Herrmann, W. Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood. Am. J. Clin. Nutr. 2010, 92, 1287-1288.
    • (2010) Am. J. Clin. Nutr , vol.92 , pp. 1287-1288
    • Obeid, R.1    Kasoha, M.2    Kirsch, S.H.3    Munz, W.4    Herrmann, W.5
  • 89
    • 77953061018 scopus 로고    scopus 로고
    • Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors
    • Morris, M.S.; Jacques, P.F.; Rosenberg, I.H.; Selhub, J. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am. J. Clin. Nutr. 2010, 91, 1733-1744.
    • (2010) Am. J. Clin. Nutr , vol.91 , pp. 1733-1744
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 90
    • 33745668282 scopus 로고    scopus 로고
    • Scientific Advisory Committee on Nutrition, The Stationary Office: Norwich, UK
    • Scientific Advisory Committee on Nutrition. Folate and Disease Prevention; The Stationary Office: Norwich, UK, 2006.
    • (2006) Folate and Disease Prevention
  • 91
    • 53849113457 scopus 로고    scopus 로고
    • Food Safety Authority of Ireland, Available online, (accessed on October 1, 2010)
    • Food Safety Authority of Ireland. Report of the National Committee on Folic Acid Food Fortification. Available online: http://www.fsai.ie/WorkArea/DownloadAsset.aspx?id=770 (accessed on October 1, 2010).
    • Report of the National Committee On Folic Acid Food Fortification
  • 92
    • 77956620554 scopus 로고    scopus 로고
    • Food Standards Australia New Zealand (FSANZ), Available online, (accessed on July 10, 2009)
    • Food Standards Australia New Zealand (FSANZ). Final Assessment Report. Proposal P295: Consideration for Mandatory Fortification with Folic Acid. Available online: http://www.foodstandards.gov.au/_srcfiles/FAR_P295_Folic_Acid_Fortification_%20Attachs_1_6.pdf (accessed on July 10, 2009).
    • Final Assessment Report. Proposal P295: Consideration For Mandatory Fortification With Folic Acid
  • 93
    • 85020921014 scopus 로고    scopus 로고
    • Towards an optimal use of folic acid
    • Health Council of the Netherlands, Health Council of the Netherlands: Hague, The Netherlands
    • Health Council of the Netherlands. Towards an optimal use of folic acid. In Health Council of the Netherlands; Health Council of the Netherlands: Hague, The Netherlands, 2008.
    • (2008) Health Council of the Netherlands
  • 95
    • 85020857740 scopus 로고    scopus 로고
    • Food Safety Authority of Ireland, Available online, (accessed on October 1, 2010)
    • Food Safety Authority of Ireland. Mandatory Folic Acid Fortification of Bread Recommended. Available online: http://www.fsai.ie/news_centre/press_releases/18072006.html (accessed on October 1, 2010).
    • Mandatory Folic Acid Fortification of Bread Recommended
  • 99
    • 85020868112 scopus 로고    scopus 로고
    • Available online, (accessed on October 8, 2010)
    • K. Added risk, any way you slice it. Available online: http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10577220 (accessed on October 8, 2010).
    • Added Risk, Any Way You Slice It


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