Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort

Paediatric and Perinatal Epidemiology

Volumn 23, Issue 3, 2009, Pages 199-206

  Julvez, Jordi ^b,c,d   Fortuny, Joan ^e,f   Mendez, Michelle ^b,c,d   Torrent, Maties ^g   Ribas Fitó, Núria ^b,c,d   Sunyer, Jordi ^a,b,c,d,e  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^e CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^f UNIVERSITAT POMPEU FABRA   (Spain)

^g Menorca Health Area ^*  (Spain)

Author keywords

Childhood; Maternal folate supplements; Neurobehavioural outcomes

Indexed keywords

CALCIUM; FOLIC ACID; IRON; VITAMIN;

ARTICLE; ATTENTION; BREAST FEEDING; CHILD; CLINICAL ASSESSMENT; COGNITION; COGNITIVE DEVELOPMENT; COHORT ANALYSIS; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; FETUS DEVELOPMENT; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN EXPERIMENT; MATERNAL CARE; MINERAL INTAKE; MOTOR DEVELOPMENT; MOTOR PERFORMANCE; NERVOUS SYSTEM DEVELOPMENT; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; PARITY; POPULATION RESEARCH; PRESCHOOL CHILD; PREVALENCE; PROSPECTIVE STUDY; PSYCHOLOGIST; QUESTIONNAIRE; SCORING SYSTEM; SMOKING; SOCIAL COMPETENCE; SOCIAL STATUS; VERBAL BEHAVIOR; VITAMIN SUPPLEMENTATION; CHILD DEVELOPMENT; DIETARY SUPPLEMENT; INFANT; MATERNAL NUTRITION; NEURAL TUBE DEFECTS; NEUROLOGIC EXAMINATION; PHYSIOLOGY; PREGNANCY; PRENATAL CARE; PRENATAL EXPOSURE; PROCEDURES; SOCIOECONOMICS; SPAIN; TIME FACTOR;

CHILD DEVELOPMENT; CHILD, PRESCHOOL; COHORT STUDIES; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; INFANT; NEURAL TUBE DEFECTS; NEUROLOGIC EXAMINATION; PREGNANCY; PRENATAL CARE; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; SOCIOECONOMIC FACTORS; SPAIN; TIME FACTORS; VITAMINS;

EID: 63449111562     PISSN: 02695022     EISSN: 13653016     Source Type: Journal    
DOI: 10.1111/j.1365-3016.2009.01032.x     Document Type: Article

References (34)

1. Greenblatt JM, Huffman LC, Reiss AL. Folic acid in neurodevelopment and child psychiatry. Progress in Neuro-Psychopharmacology & Biological Psychiatry 1994 18 : 647 660.
2. Tamura T, Goldenberg RL, Chapman VR, Johnston KE, Ramey SL, Nelson KG. Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age. Pediatrics 2005 116 : 703 708.
3. Gross RL, Newberne PM, Reid JVO. Adverse effects on infant development associated with maternal folic acid deficiency. Nutrition Reports International 1974 10 : 241 248.
4. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991 338 : 131 137.
5. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. New England Journal of Medicine 1992 24 : 1832 1835.
6. Martínez-Frías ML, Rodríguez-Pinilla E, Bermejo E. Analysis of the Spanish situation regarding folic acid/calcic folinate consumption for birth defects prevention. Medicina Clinica 2003 121 : 772 775.
7. Dobó M, Czeizel AE. Long-term somatic and mental development of children after periconceptional multivitamin supplementation. European Journal of Pediatrics 1998 157 : 719 723.
8. Wehby GL, Murray JC. The effects of prenatal use of folic acid and other dietary supplements on early child development. Maternal and Child Health Journal 2008 12 : 180 187.
9. Ordoñez LA. Biochemical functions of folate in the central nervous system. In : Folic Acid in Neurology, Psychiatry and Internal Medicine. Editors : Botez MI, Reynolds EH. New York : Raven Press, 1979 pp. 129 145.
10. Wagner C. Biochemical role of folate in cellular metabolism. In : Folate in Health and Disease. Editor : Bayley LB. New York : Marcel Dekker, 1995 pp. 23 42.
11. Craciunescu CN, Brown EC, Mar MH, Albright CD, Nadeau MR, Zeisel SH. Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. Journal of Nutrition 2004 134 : 162 166.
12. Ribas-Fitó N, Torrent M, Carrizo D, Muñoz-Ortiz L, Júlvez J, Grimalt JO, et al. In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers. American Journal of Epidemiology 2006 164 : 955 962.
13. Julvez J, Ribas-Fitó N, Torrent M, Forns M, Garcia-Esteban R, Sunyer J. Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort. International Journal of Epidemiology 2007 36 : 825 832.
14. Polk S, Sunyer J, Muñoz-Ortiz L, Barnes M, Torrent M, Figueroa C, et al. A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezing. American Journal of Respiratory and Critical Care Medicine 2004 170 : 273 278.
15. McCarthy D. Manual for the McCarthy Scales of Children's Abilities. New York : Pa: Psychological Corp, 1972 Spanish Adaptation: Madrid, Spain, Pa: TEA Ediciones, S.A., 1996).
16. Julvez J, Ribas-Fitó N, Forns M, Garcia-Esteban R, Torrent M, Sunyer J. Attention behaviour and hyperactivity at age 4 and duration of breast-feeding. Acta Paediatrica 2007 96 : 842 847.
17. Levin S, Elzey FF, Lewis M. California Preschool Social Competency Manual. San Francisco, CA : Pa: Consulting Pychologist Press, 1969.
18. Julvez J, Forns M, Ribas-Fitó N, Mazon C, Torrent M, Garcia-Esteban R, et al. Psychometric characteristics of the California Preschool Social Competence Scale in a Spanish population sample. Early Education and Development 2008 19 : 795 815.
19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Washington, DC : American Psychiatric Association, 1994.
20. Jacobson JL, Jacobson SW. Methodological issues in research on developmental exposure to neurotoxic agents. Neurotoxicology and Teratology 2005 27 : 395 406.
21. Spanish Pharmacist Association. Catálogo de Especialidades Farmeceutica. Madrid : Spanish Pharmacist Association, 2006.
22. Ribas-Fitó N, Júlvez J, Torrent M, Grimalt JO, Sunyer J. Beneficial effects of breastfeeding on cognition regardless of DDT concentrations at birth. American Journal of Epidemiology 2007 166 : 1198 1202.
23. Forster DA, Wills G, Denning A, Bolger M. The use of folic acid and other vitamins before and during pregnancy in a group of women in Melbourne, Australia. Midwifery doi. 10.1016/j.midw.2007.01.019.
24. Nilsen RM, Vollset SE, Gjessing HK, Magnus P, Meltzer HM, Haugen M, et al. Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study. American Journal of Clinical Nutrition 2006 84 : 1134 1141.
25. Kolb B, Wishaw IQ. Human Neuropsychology, 4th edn. Editors : Atkinson RC, Lindzey G, Thompson RF. New York : W.H. Freeman and Company, 1996.
26. Arakawa T, Minzuno T, Honda Y, Tamura T, Sakai K. Brain function of infants fed on milk from mothers with low serum folate levels. Tohoku Journal of Experimental Medicine 1969 97 : 391 397.
27. Brown AS, Susser ES, Butler PD, Richardson Andrews R, Kaufmann CA, Gorman JM. Neurobiological plausibility of prenatal nutritional deprivation as a risk factor for schizophrenia. Journal of Nervous and Mental Disease 1996 184 : 71 85.
28. Bryan J, Osendarp S, Hughes D, Calvaresi E, Baghurst K, van Klinken JW. Nutrients for cognitive development in school-aged children. Nutrition Reviews 2004 62 : 295 306.
29. Bodnar LM, Wisner KL. Nutrition and depression: implications for improving mental health among childbearing-aged women. Biological Psychiatry 2005 58 : 679 685.
30. Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007 369 : 208 216.
31. Lindeman RD, Romero LJ, Koehler KM, Liang HC, LaRue A, Baumgartner RN, et al. Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: correlations with cognitive and affective functions. Journal of the American College of Nutrition 2000 19 : 68 76.
32. Martínez-Frías ML, Rodríguez-Pinilla E, Bermejo E, Grupo Periférico del ECEMC. Tobacco smoking during pregnancy in Spain: an analysis according to years, autonomous communities and maternal characteristics. Medinica Clinica 2005 29 : 86 92.
33. De la Torre MJ, Martín-Calama J, Hernandez-Aguilar MT, Spanish Committee on Human Lactation, Spanish Paediatric Association. Breast-feeding in Spain. Public Health Nutrition 2001 4 : 1347 1351.
34. Gadow KD, Sprafkin J, Nolan EE. DSM-IV symptoms in community and clinic preschool children. Journal of the American Academy of Child and Adolescent Psychiatry 2001 40 : 1383 1392.