Open or closed? A world of difference: A history of homocysteine research

Nutrition Reviews

Volumn 56, Issue 8, 1998, Pages 236-244

  Eskes, T K A B ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE; METHIONINE; MULTIVITAMIN;

AMINO ACID BLOOD LEVEL; BIRTH DEFECT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EMBRYO DEVELOPMENT; FOLIC ACID DEFICIENCY; GENE MUTATION; HUMAN; HYPERHOMOCYSTEINEMIA; INBORN ERROR OF METABOLISM; NETHERLANDS; NEURAL TUBE; NEURAL TUBE DEFECT; NONHUMAN; NUTRITIONAL STATUS; RANDOMIZED CONTROLLED TRIAL; RAT; REVIEW; VASCULAR DISEASE;

EID: 0031657015     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1998.tb01755.x     Document Type: Review

References (54)

1. Eskes TKAB. Abortus artificialis, gronden en beleid. Ned T Geneesk 1976;120:815-6
2. Lenz W, Knapp K. Thalidomide embryopathy. Arch Environ Health 1962;5:100
3. Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 1971;284:878-81
4. Gehring WJ. The homeobox: a key to the understanding of development? Cell 1985;40:3-5
5. Den Ouden AL, Hirasing RA, Buitendijk SE, et al. Prevalentie, klinisch beeld en prognose van neurale buisdefecten in Nederland. Ned T Geneesk 1996;140:2092-5
6. Stein Z, Susser M, Saenper G, Marolla F, eds. Famine and human development: the Dutch hunger winter of 1944-1945. New York: Oxford University Press, 1975
7. Susser E, Neugebauer R, Hoek HW, et al. Schizophrenia after prenatal famine. Arch Gen Psychiatry 1996;53:25-31
8. Hibbard BM. The role of folic acid in pregnancy with particular reference to anaemia, abruption, and abortion. J Obstet Gynaecol Br Cwlth 1964;71:529-42
9. Hibbard BM, Smithells RW. Folic acid metabolism and human embryopathy. Lancet 1965;1:1254
10. Smithells RW, Sheppard S, Schorah CJ, et al. Possible prevention of neural tube defects by periconceptional vitamin supplementation. Lancet 1980;1:339-40
11. Mooij PNM, Steegers-Theunissen RPM, Thomas CMG, et al. Periconceptional vitamin profiles are not suitable for identifying women at risk for neural tube defects. J Nutr 1993;123:197-203
12. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, et al. Maternal hyperhomocysteinemia: a risk factor for neural tube defects? Metabolism 1994;43:1475-80
13. Boers GHJ, Smals AGH, Trijbels JMF, et al. Heterozygosity for homocystinuria in peripheral and cerebral occlusive arterial disease. N Engl J Med 1985;313:709-15
14. Mudd SH, Finkelstein JD, Irrewerre F, Laster L. Homocystinuria: an enzymatic defect. Science 1964;143:1443-5
15. Finkelstein JD. Methionine metabolism in mammals. J Nutr 1990;1:228-37
16. Du Vigneaud VE. Trail of research in sulfur chemistry and metabolism and related fields. Ithaca, NY: Cornell University Press, 1952
17. Steegers-Theunissen RPM, Boers GHJ, Trijbels JMF, Eskes TKAB. Neural tube defects and derangement of homocysteine metabolism. N Engl J Med 1991;324:199-200
18. Wouters MGAJ, Boers GHJ, Blom HJ, et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993;60:820-5
19. Van Aerts LAGJM, Blom HJ, Deabreu RA, et al. Prevention of neural tube defects by and toxicity of L-homocysteine in cultured postimplantation rat embryos. Teratology 1994;50:348-60
20. Heby O. DNA methylation and polyamines in embryonic development and cancer. Int J Dev Biol 1995;39:737-57
21. Rosenquist TH, Ratashak SA, Selhub J. Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc Natl Acad Sci USA 1996;93:15227-32
22. Finnell RH, Bennett GD, Lacey SW, et al. Inactivation of the folate binding protein genes: implications for the role of homocysteine in neural tube defects [Abstract]. 2nd International Conference on Homocysteine Metabolism. Nijmegen, The Netherlands, April 26-29, 1998
23. Engbersen AMT, Franken DG, Boers GHJ, et al. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet 1995;56:142-50
24. Kang SS, Wong PWK, Susmano A, et al. Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. Am J Hum Genet 1991;48:536-45
25. Van der Put NMJ, Steegers-Theunissen RPM, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995;346:1070-1
26. Whitehead AS, Gallagher P, Mills JL, et al. A genetic defect in 5,10-methylenetetrahydrofolate reductase in neural tube defects. QJM 1995;88:763-6
27. Van der Put NMJ, van den Heuvel LP Steegers-Theunissen RPM, et al. Decreased methylenetetrahydrofolate reductase due to the 677 C→T mutation in families with spina bifida offspring. J Mol Med 1996;74:691-4
28. Simopoulos AP, Herbert V, Jacobson B. Genetic nutrition. New York: Macmillan, 1993
29. Van der Put NMJ, Gabreëls F, Stevens E, et al. Decreased methylenetetrahydrofolate reductase activity due to the 1298 A C mutation in families with NTD affected offspring. Am J Hum Genet (in press)
30. Van der Put NMJ, Eskes TKAB, Blom HJ. Is the common 677 C T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A mega-analysis. QJM 1997;90:111-5
31. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7
32. Czeizel AE, Dudás I. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327: 1832-5
33. Klok ER, TijmstraTJ, Cornel MC, et al. Wat vrouwen er zelf van vinden. Med Contact 1994;49:1245-7
34. Hook EB, Czeizel AE. Can theratanasia explain the protective effect of folic acid supplementation on birth defects? Lancet 1997;350:513-5
35. Bausch-Goldbohm RA, Hulshof KFAM, Brants HAM, et al. De inneming van foliumzuur door verschillende bevolkingsgroepen in Nederland voor en na verrijking van bepaalde voedingsmiddelen. Voedselconsumptiepeiling 1992. Rapport TNO Voeding, vol 95,184 Zeist 1995
36. Cuskelly GJ, McNulty H, Scott JM. Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 1996;347: 657-9
37. Fezondheidsraad/voedingsraad. Advice on folic acid supplementation in relation to neural tube defects. The Hague: Health Council, 1993
38. Van de Pal-de Bruin KM, Buitendijk SE, Ouden den AL, Verloove-Vanhorick SP. Effecten van de foliumzuurcampagne. Concept 29, Augustus 1996: TNO
39. Wiersma TJ. Foliumzuur voor alle vrouwen die een kind wensen: een onjuist advies. Ned T Geneesk 1994;138:315-8
40. Brugman E, van de Pal-de Bruin KM, den Ouden AL, et al. Foliumzuurgebruik bij zwangerschapswens: de reactie van de huisarts. Ned T Geneesk 1997;141:1653-7
41. Schaapveld K, Hirasing RA. Recente ontwikkelingen in de preventieve gezondheids-zorg. Ned T Geneesk 1997;141:1909-12
42. Nelen WLDM, Steegers EAP, Eskes TKAB, Blom HJ. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 1997;350:861
43. Shaw GM, Lammer EJ, Wasserman CR, et al. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 1995;346:393-6
44. Wong WY, Eskes TKAB, Kuijpers-Jagtman A, et al. Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia [Abstract]. 2nd International Conference on Homocysteine Metabolism. Nijmegen, The Netherlands, April 26-29, 1998
45. Shaw GM, O'Mally CD, Wasserman CR, et al. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995;59:536-45
46. Haagmans MLM, Kapusta L, Steegers EAP, et al. Congenital heart defects: association with maternal hyperhomocysteinemia [Abstract]. Association of European Pediatric Cardiologists. XXXIII Annual General Meeting, Dublin, Ireland, June 10-13, 1998
47. Den-Ku Li, Daling JR, Mueller BA, et al. Periconceptional multivitamin use in relation to the risk of congenital urinary tract anomalies. Epidemiology 1995;6:212-8
48. Czeizel AE. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet 1996;62:179-83
49. Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149-55
50. Goddijn-Wessel TAW, Wouters MGAJ, Molen EF, et al. Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur J Obstet Gynecol Reprod Biol 1996;66:23-9
51. Van der Molen EF, Nelen WLDM, Heil SG, et al. The mutation 677 C→T of the methylenetetrahydrofolate reductase (MTHFR) gene as a possible risk factor for placental vasculopathy [Abstract]. 2nd International Conference on Homocysteine Metabolism. Nijmegen, The Netherlands, April 26-29, 1998
52. Barker DJ. The fetal and infant origins of adult disease. Br Med J 1990;301:1111
53. Van der Mooren JM, Wouters MGAJ, Blom HJ, et al. Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women. Eur J Clin Invest 1994;24:733-6
54. Oakley GP. Folic acid: preventable spina bifida and anencephaly [Editorial]. JAMA1993;269:1292-3