Vitamin B12, folic acid, and the nervous system

Lancet Neurology

Volumn 5, Issue 11, 2006, Pages 949-960

  Reynolds, Edward ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYANOCOBALAMIN; FOLIC ACID; FOLIC ACID DERIVATIVE; HOMOCYSTEINE; METHIONINE; METHIONINE SYNTHASE; NUCLEOTIDE;

AGING; ALZHEIMER DISEASE; ANEMIA; CHILDHOOD; CLINICAL TRIAL; DEMENTIA; DEPRESSION; DISSOCIATION; DNA METHYLATION; DRUG FORMULATION; EPIGENETICS; EPILEPSY; FOLATE METABOLISM; FOLIC ACID DEFICIENCY; GENOME; HUMAN; MEGALOCYTOSIS; MOOD DISORDER; MORPHOLOGY; MULTIINFARCT DEMENTIA; MULTIPLE SCLEROSIS; NERVOUS SYSTEM; NEURAL TUBE DEFECT; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; REVIEW; VITAMIN DEFICIENCY; VITAMIN METABOLISM;

ANIMALS; FOLIC ACID; HUMANS; METABOLIC DISEASES; MODELS, BIOLOGICAL; MULTIPLE SCLEROSIS; NERVOUS SYSTEM; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 33749685522     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(06)70598-1     Document Type: Review

References (150)

1. Leichtenstern O. Progressive perniciöse anämie bei tabeskranken. Dtsch Med Wochenschr 10 (1884) 849-850
2. Lichtheim L. Zur kenntniss der perniciösen anämie. Munch Med Wochenschr 34 (1887) 301-306
3. Russell J., Batten F., and Collier J. Subacute combined degeneration of the spinal cord. Brain 23 (1900) 39-110
4. Woltmann H. The nervous symptoms in pernicious anaemia: an analysis of 150 cases. Am J Med Sci 157 (1919) 400-409
5. Ahrens R. Neurologic aspects of primary anaemia. Arch Neurol Psychiatry 28 (1932) 92-109
6. Kinnier Wilson S. Neurology (1941), Arnold, London 1339-1358
7. Chanarin I. The megaloblastic anaemias (1969), Blackwell, Oxford
8. Schwartz S., Kaplan S., and Armstrong B. The long-term evaluation of folic acid in the treatment of pernicious anaemia. J Lab Clin Med 35 (1950) 894-898
9. Hall B., and Watkins C. Experience with pteroylglutamic (synthetic folic) acid in the treatment of pernicious anaemia. J Lab Clin Med 32 (1947) 622-634
10. Reynolds E. Folic acid, vitamin B12 and the nervous system: historical aspects. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry, and internal medicine (1979), Raven Press, New York 1-5
11. In: Botez M., and Reynolds E. (Eds). Folic acid in Neurology, Psychiatry and Internal Medicine (1979), Raven Press, New York
12. In: Carmel R., and Jacobsen D. (Eds). Homocysteine in health and disease (2001), Cambridge University Press, Cambridge
13. In: Bailey L. (Ed). Folate in health and disease (1995), Marcel Dekker, New York
14. In: Massaro E., and Rogers J. (Eds). Folate and human development (2002), Humana Press, Totowa, New Jersey
15. Reynolds E. Folic acid, ageing, depression, and dementia. BMJ 324 (2002) 1512-1515
16. Morris M. Homocysteine and Alzheimer's disease. Lancet Neurol 2 (2003) 425-428
17. Lucock M. Is folic acid the ultimate functional food component for disease prevention?. BMJ 328 (2004) 211-214
18. Iskandar B., Nelson A., Resnick D., et al. Folic acid supplementation enhances repair in the adult central nervous system. Ann Neurol 56 (2004) 221-227
19. Ravaglia G., Forti P., Maioli F., et al. Homocystine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 82 (2005) 636-643
20. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuro-Psychopharmacol Biol Psychiatry 29 (2005) 1103-1112
21. Durga J., van Boxtel M., Schouten E., Bots M., Kok F., and Verhoef P. Folate and the methylenetetrahydrofolate reductase 677C-T mutation correlate with cognitive performance. Neurobiol Aging 27 (2006) 334-343
22. Dickinson C. Does folic acid harm people with vitamin B12 deficiency?. Q J Med 88 (1995) 357-364
23. Reynolds E. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 72 (2002) 767-771
24. Surtees R. Cobalamin and folate responsive disorders. In: Baxter P. (Ed). Vitamin responsive conditions in paediatric neurology: international review of child neurology series (2001), MacKeith Press, London 96-108
25. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71 (2000) 121-138
26. Carmel R., Green R., Rosenblatt D., and Watkins D. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program 1 (2003) 62-81
27. Koury M., and Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr 24 (2004) 105-131
28. Reynolds E. Neurological aspects of folate and vitamin B12 metabolism. In: Hoffbrand A. (Ed). Clinics in haematology volume 5 (1976), Saunders, London 661-696
29. Shorvon S., Carney M., Chanarin I., and Reynolds E. The neuropsychiatry of megaloblastic anaemia. BMJ 281 (1980) 1036-1038
30. Lindenbaum J., Healton E., Savage D., et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anaemia or macrocytosis. N Engl J Med 318 (1988) 1720-1728
31. Healton E., Savage D., Brust J., Garrett T., and Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine 70 (1991) 229-245
32. Savage D., and Lindenbaum J. Neurological complications of acquired cobalamin deficiency: clinical aspects. Bailliere's Clin Haematol 8 (1996) 657-678
33. Sigal S., Hall C., and Antel J. Plasma R binder deficiency and neurologic disease. N Engl J Med 317 (1987) 1330-1332
34. Reynolds E., Bottiglieri T., Laundy M., et al. Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein: new cause of an old syndrome. Arch Neurol 50 (1993) 739-742
35. Fine E., Soria E., Paroski M., Petryk D., and Thomasula L. The neurophysiological profile of vitamin B12 deficiency. Muscle Nerve 13 (1990) 158-164
36. Zucker D., Livingston R., Nakra R., and Clayton P. B12 deficiency and psychiatric disorders: case report and literature review. Biol Psychiatry 16 (1981) 197-205
37. Waters A., and Mollin D. Studies on the folic acid activity of human serum. J Clin Pathol 14 (1961) 335-344
38. Reynolds E. Interrelationships between the neurology of folate and vitamin B12, deficiency. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 501-515
39. Layzer R. Myeloneurophathy after prolonged exposure to nitrous oxide. Lancet 2 (1978) 1227-1230
40. Admir H., Krzysztof G., Sanborn K., and Thys D. Severe neurologic deficit after nitrous oxide anaesthesia. Anaesthesiology 83 (1995) 863-866
41. Riedel B., Fiskerstrand T., Refsum H., and Ueland P. Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase. Biochem J 341 (1999) 133-138
42. Amess J., Burkman J., Rees G., Nancekievill D., and Mollin D. Megaloblastic haemopoiesis in patients receiving nitrous oxide. Lancet 2 (1978) 339-342
43. Nunn J. Clinical aspects of the interaction between nitrous oxide and vitamin B12. Br J Anaesth 59 (1987) 3-13
44. Reynolds E., Linnell J., and Faludy J. Multiple sclerosis associated with vitamin B12 deficiency. Arch Neurol 48 (1991) 808-811
45. Crellin R., Bottiglieri T., and Reynolds E. Multiple sclerosis and macrocytosis. Acta Neurol Scand 81 (1990) 388-391
46. Reynolds E., Bottiglieri T., Laundy H., Crellin R., and Kirker S. Vitamin B12 metabolism in multiple sclerosis. Arch Neurol 49 (1992) 649-652
47. Sandyk R., and Awerbuch G. Vitamin B12 and its relationship to age of onset of multiple sclerosis. Int J Neurosci 71 (1993) 93-99
48. Besler H., and Comogleu S. Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci 6 (2003) 189-196
49. Vrethem M., Mattsson E., Hebelka H., et al. Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid. Mult Scler 9 (2003) 239-245
50. Reynolds E. Multiple sclerosis and vitamin B12 metabolism. J Neuroimmunol 40 (1992) 225-230
51. Grant H., Hoffbrand A., and Wells D. Folate deficiency and neurological disease. Lancet 2 (1965) 763-767
52. Reynolds E., Chanarin I., and Matthews D. Neuropsychiatric aspects of anti-convulsant megaloblastic anaemia. Lancet 1 (1968) 394-397
53. Reynolds E. Mental effects of anticonvulsants, and folic acid metabolism. Brain 91 (1968) 197-214
54. Reynolds E., Rothfeld P., and Pincus J. Neurological disease associated with folate deficiency. BMJ 2 (1973) 398-400
55. Manzoor M., and Runcie J. Folate-responsive neuropathy: a report of ten cases. BMJ 1 (1976) 1176-1178
56. Botez M., Fontaine F., Botez T., and Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Eur Neurol 16 (1977) 230-246
57. Pincus J. Folic acid deficiency: a cause of subacute combined degeneration. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 427-433
58. Botez M., Peyronnard J., and Charron L. Polyneuropathies responsive to folic acid therapy. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 401-412
59. Shorvon S., and Reynolds E. Folate deficiency and peripheral neuropathy. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 413-421
60. Bottiglieri T., Crellin R., and Reynolds E. Folate and neuropsychiatry. In: Bailey L. (Ed). Folate in health and disease (1995), Marcel Dekker, New York 435-462
61. Engelborghs S., Vloeberghs E., Maertens K., et al. Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia. Int J Geriatr Psychiatry 19 (2004) 365-370
62. Clarke R., Grimley Evans J., Schneede J., et al. Vitamin B12 and folate deficiency in later life. Age Ageing 33 (2004) 34-41
63. Reynolds E., Preece J., Bailey J., and Coppen A. Folate deficiency in depressive illness. Brit J Psychiatry 117 (1970) 287-292
64. Lewis S., Lawlor D., Davey Smith G., et al. The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. Mol Psychiatry 11 (2006) 352-360
65. Ramos M., Allen L., Mungas D., et al. Low folate status is associated with impaired cognitive function and dementia in the Sacramento area Latino study on aging. Am J Clin Nutr 82 (2005) 1346-1352
66. Sneath P., Chanarin I., Hodkinson H., McPhearson C., and Reynolds E. Folate status in a geriatric population and its relation to dementia. Age Ageing 2 (1973) 177-182
67. Carney M., and Sheffield B. Associations of subnormal folate and vitaminB12 values and effects of replacement therapy. J Nerv Ment Dis 150 (1970) 404-411
68. Starr J., Pattie A., Whiteman M., Deary I., and Whalley L. Vitamin B12, serum folate, and cognitive change between 11 and 79 years. J Neurol Neurosurg Psychiatry 76 (2005) 291-292
69. Bottiglieri T., Reynolds E., and Laundy M. Folate in CSF and age. J Neurol Neurosurg Psychiatry 69 (2000) 562
70. Serot J., Barbe F., Arning E., et al. Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry 76 (2005) 1585-1587
71. Seshadri S., Beiser A., Selhub J., et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346 (2002) 476-483
72. Wahlin T., Wahlin A., Winblad B., and Backman L. The influence of serum vitamin B12 and folate status on cognitive functioning in very old age. Biol Psychol 56 (2001) 247-265
73. Goodwin J., Goodwin J., and Garry P. Association between nutritional status and cognitive functioning in a healthy elderly population. JAMA 249 (1983) 2917-2921
74. Hassing L., Wahlin A., Winblad B., and Backman L. Further evidence on the effects of vitamin B12 and folate levels on episodic memory functioning; a population-based study of healthy very old adults. Biol Psychiatry 45 (1999) 1472-1480
75. McIlroy S., Dynan K., Lawson J., Patterson C., and Passmore A. Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. Stroke 3 (2002) 2351-2356
76. Clarke R., Collins R., and Lewington S. Homocysteine and risk of heart disease and stroke: a meta-analysis. JAMA 288 (2002) 2015-2022
77. Spence J. Homocysteine: call off the funeral. Stroke 37 (2006) 281-282
78. Nilsson K., Gustafson L., Faldt R., et al. Hyperhomocysteinaemia: a common finding in a psychogeriatric population. Eur J Clin Invest 26 (1996) 853-859
79. Riggs K., Spiro A., Tucker K., and Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 63 (1996) 306-314
80. McCaddon A., Davies G., Hudson P., Tandy S., and Cattell H. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 13 (1998) 235-239
81. Leblhuber F., Walli J., Artner-Dworzak E., et al. Hyperhomocysteinemia in dementia. J Neural Transm 107 (2000) 1469-1474
82. Morris M., Jacques P., Rosenberg I., and Selhub J. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 73 (2001) 927-933
83. McCaddon A., Hudson P., Davies G., Hughes A., Williams J., and Wilkinson C. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord 12 (2001) 309-313
84. Ravaglia G., Forti P., Maioli F., et al. Homocystine and cognitive function in healthy elderly community dwellers in Italy. Am J Clin Nutr 77 (2003) 668-673
85. Teunissen C., Blom A., van Boxtel P., et al. Homocysteine: a mark of the cognitive performance? A longitudinal follow-up study. J Nutr Health Aging 7 (2003) 153-159
86. Almeida O., Lautenschlager N., Flicker L., et al. Association between homocysteine, depression, and cognitive function in community-dwelling older women from Australia. J Am Geriatr Soc 52 (2004) 327-328
87. Quadri P., Fragiacomo C., Pezzati R., et al. Homocysteine, folate and vitamin B12 in mild cognitive impairment, Alzheimer's disease, and vascular dementia. Am J Clin Nutr 80 (2004) 114-122
88. Mizrahi E., Bowirrat A., Jacoben D., et al. Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel. J Neurol Sci 227 (2004) 109-113
89. Quadri P., Fragiacomo C., Pezzati R., Zanda E., Tettamanti M., and Lucca U. Homocysteine and B-vitamins in mild cognitive impairment and dementia. Clin Chem Lab Med 43 (2005) 1096-1100
90. Wang H.-X., Wahlin A., Basun H., Fastbom J., Winblad B., and Frattelioni L. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology 56 (2001) 1188-1194
91. Duthie S., Whalley L., Collins A., Leaper S., Berger K., and Deary I. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 75 (2002) 908-913
92. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357 (2001) 169-175
93. Clarke R., Smith A., Jobst K., et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55 (1998) 1449-1455
94. den Heijer T., Vermeer S., Clarke R., et al. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain 126 (2003) 170-175
95. Prins N., Den Heijer T., Hofman A., et al. Homocysteine and cognitive function in the elderly: the Rotterdam scan study. Neurology 59 (2002) 1375-1380
96. Snowdon D., Tully C., Smith C., Riley K., and Markesbery W. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the nun Study. Am J Clin Nutr 71 (2000) 993-998
97. Bottiglieri T., Laundy M., Crellin R., Toone B., Carney M., and Reynolds E. Homocysteine, folate, methylation and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 69 (2000) 228-232
98. Fava M., Borus J., Alpert J., Nierenberg A., Rosenbaum J., and Bottiglieri T. Folate, vitamin B12, and homocysteine in major depressive disorder. Am J Psychiatry 154 (1997) 426-428
99. Reif A., Pfuhlmann B., and Lesch K. Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychosis. Prog Neuro-Psychopharmacol Biol Psychiatry 29 (2005) 1162-1168
100. Goff D., Bottiglieri T., Arning E., et al. Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry 161 (2004) 1705-1708
101. Muntjewerff J., Kahn R., Blom H., and den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry 11 (2006) 143-149
102. Reynolds E., Gallagher B., Mattson R., Bowers M., and Johnson A. Relationship between serum and cerebrospinal fluid folate. Nature 240 (1972) 155-157
103. Hommes O., Hollinger J., Jansen M., Schoofs M., Vanderweil T., and Kok J. Convulsant properties of folate compounds; some considerations and speculations. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 285-316
104. Hommes O., Obbens E., and Wijfels C. Epileptogenic activity of sodium-folate and the blood brain barrier in the rat. J Neurol Sci 19 (1973) 63-71
105. Miller A., Goff D., and Webster R. Predisposition of laboratory animals to epileptogenic activity of folic acid. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 331-334
106. Davis J., and Watkins J. Facilitatory and direct excitatory effects of folate and folinate on single neurons of cat cerebral cortex. Biochem Pharmacol 22 (1973) 1667-1668
107. Spaans F. No effect of folic acid supplement on CSF folate and serum vitamin B12 in patients on anticonvulsants. Epilepsia 11 (1970) 403-411
108. Rivey M., Schottelius D., and Berg M. Phenytoin-folic acid: a review. Drug Intell Clin Pharm 18 (1984) 292-301
109. Papakostas G., Petersen T., Lebowitz B., et al. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol 8 (2005) 1-6
110. Botez M., Botez T., Leveille J., Beilmann P., and Cadotte M. Neuropsychological correlates of folic acid deficiency; facts and hypotheses. In: Botez M., and Reynolds E. (Eds). Folic acid in neurology, psychiatry and internal medicine (1979), Raven Press, New York 435-461
111. Coppen A., Chaudhry S., and Swade C. Folic acid enhances lithium prophylaxis. J Affect Disord 10 (1986) 9-13
112. Godfrey P., Toone B., Carney M., et al. Enhancement of recovery from psychiatric illness by methyl folate. Lancet 336 (1990) 392-395
113. Passeri M., Cuciniotta D., Abate G., Senin U., and Ventura A. Oral 5-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study. Ageing Clin Exp Res 5 (1993) 63-71
114. Coppen A., and Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial. J Affect Disord 60 (2000) 121-130
115. Reynolds E., Carney M., and Toone B. Methylation and mood. Lancet 2 (1984) 196-198
116. Bottiglieri T., Hyland K., and Reynolds E. The clinical potential of ademethionine (S-adenosylmethionine) in neurological disorders. Drugs 48 (1994) 1137-1152
117. Mitchell L., Adzick N., Melchionne J., Pasquariello P., Sutton L., and Whitehead A. Spina bifida. Lancet 364 (2004) 1885-1895
118. Eichholzer M., Tönz O., and Zimmermann R. Folic acid: a public-health challenge. Lancet 367 (2006) 1352-1361
119. Ray J., and Blom H. Vitamin B12 insufficiency and the risk of foetal neural tube defects. Q J Med 96 (2003) 289-295
120. Rosenquist T., Ratashak S., and Selhub J. Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc Natl Acad Sci USA 93 (1996) 1527-1532
121. MRC Vitamin Study Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338 (1991) 131-137
122. Czeizel A., and Dudas I. Prevention of the first occurrence of neural tube defects by peri-conceptional vitamin supplementation. N Engl J Med 327 (1992) 1832-1835
123. US Department Health and Human Services, Food and Drug Administration. Food standards: amendments of the standards of identity for enriched grain products to require addition of folic acid. Federal Register 61 (1996) 8781-8807
124. Quinlivan E., and Gregory J. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 77 (2003) 221-225
125. Choumenkovitch S., Selhub J., Wilson P., Rader J., Rosenberg I., and Jacques P. Folic acid intake from fortification in United States exceeds predictions. J Nutr 132 (2002) 2792-2798
126. Shane B. Folate fortification: enough already?. Am J Clin Nutr 77 (2003) 8-9
127. Report of the Committee on Medical Aspects of Food and Nutrition Policy. Folic Acid and the Prevention of Disease (2000), Stationery Office, London
128. Rosenblatt D., and Fenton W. Inherited disorders of folate and cobalamin transport and metabolism. In: Scriver C., Beaudet A., Sly W., and Calle D. (Eds). The Metabolic Basis of Inherited Disease. 8th edn. (2001), McGraw-Hill, New York 3897-3933
129. Whitehead V. Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol 134 (2006) 125-136
130. Ogier de Baulny H., Gerard M., Saudubray J., and Zittoun J. Remethylation defects: guidelines for clinical diagnosis and treatment. Eur J Pediatr 157 (1998) S77-S83
131. Ramaekers V., and Blau N. Cerebral folate deficiency. Dev Med Child Neurol 46 (2004) 843-851
132. Ramaekers V., Rothenberg P., Sequeira J., et al. Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med 352 (2005) 1985-1991
133. Oakley G. Let's increase folic acid fortification and include vitamin B12. Am J Clin Nutr 65 (1997) 1889-1890
134. Van der Westhuvzen J., Fernandes-Costa F., and Metz J. Cobalamin inactivation by nitrous oxide produces severe neurological impairment in fruit bats: protection by methionine and aggravation by folates. Life Sci 31 (1982) 2001-2010
135. Friso S., and Choi S.-W. Gene nutrient interactions and DNA methylation. J Nutr 132 (2002) 2382S-2387S
136. Mattson M., and Shea T. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26 (2003) 137-146
137. Nagy Z., Smith M., Esiri M., Barnetson L., and Smith A. Hyperhomocysteinaemia in Alzheimer's disease and expression of cell cycle markers in the brain. J Neurol Neurosurg Psychiatry 69 (2000) 565-566
138. Irizarry M., Gurol M., Raju S., et al. Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease. Neurology 65 (2005) 1402-1408
139. Lumb M., Perry J., Deacon R., and Chanarin I. Changes in plasma folate levels in rats inhaling nitrous oxide. Scand J Haematol 26 (1981) 61-64
140. Scott J., Dinn J., Wilson N., and Weir D. Pathogenesis of subacute combined degeneration: a result of methyl group deficiency. Lancet 2 (1981) 334-337
141. Scott J., Molloy A., Kennedy D., Kennedy S., and Weir D. Effects of the disruption of transmethylation in the central nervous system; an animal model. Act Neurol Scand 154 (1994) 27S-31S
142. Surtees R., Leonard J., and Austin S. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet 338 (1991) 1550-1554
143. Surtees R. Demyelination and inborn errors of the single carbon transfer pathway. Eur J Pediatr 157 (1998) 118S-121S
144. Kruman I., Kumaravel T., Lohani A., et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 22 (2002) 1752-1762
145. Bottiglieri T., Godfrey P., Flynn T., Carney M., Toone B., and Reynolds E. Cerebrospinal fluid S-adenosylmethionine in depression and dementia; effects of treatment with parenteral and oral S-adenosylmethionine. J Neurol Neurosurg Psychiatry 53 (1990) 1096-1098
146. McCaddon A., Regland B., Hudson P., and Davies G. Functional vitamin B(12) deficiency and Alzheimer disease. Neurology 58 (2002) 1395-1399
147. McCaddon A., Hudson P., Hill D., et al. Alzheimer's disease and total plasma aminothiols. Biol Psychiatry 53 (2003) 254-260
148. Fuso A., Seminara L., Cavallaro R., D'Anselmi F., and Scarpa S. S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 28 (2005) 195-204
149. Gortz P., Hoinkes A., Fleischer W., et al. Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J Neurol Sci 218 (2004) 109-114
150. Rampersaud G., Kauwell G., Hutson A., Cerda J., and Bailey L. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 72 (2000) 998-1003