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Volumn 61, Issue 1, 2017, Pages

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

Author keywords

Ellagic acid; Ellagitannins; Gut microbiota metabolites; Interindividual variability; Urolithins

Indexed keywords

3,8-DIHYDROXY-6H-DIBENZO(B,D)PYRAN-6-ONE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; COUMARIN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; TANNIN;

EID: 84977563497     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500901     Document Type: Review
Times cited : (364)

References (147)
  • 2
    • 84896886888 scopus 로고    scopus 로고
    • Metabolic fate of ellagitannins: implications for health, and research perspectives for innovative functional foods
    • García-Muñoz, C., Vaillant, F., Metabolic fate of ellagitannins: implications for health, and research perspectives for innovative functional foods. Crit. Rev. Food Sci. Nutr. 2014, 54, 1584–1598.
    • (2014) Crit. Rev. Food Sci. Nutr. , vol.54 , pp. 1584-1598
    • García-Muñoz, C.1    Vaillant, F.2
  • 3
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeation in drug discovery and development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. V., Feeney, P. J., Experimental and computational approaches to estimate solubility and permeation in drug discovery and development settings. Adv. Drug Deliv. Rev. 1997, 23, 3–25.
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.V.3    Feeney, P.J.4
  • 4
    • 4544345237 scopus 로고    scopus 로고
    • The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivates by the colonic microflora of healthy humans
    • Cerdá, B., Espín, J. C., Parra, S., Martínez, P. et al., The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivates by the colonic microflora of healthy humans. Eur. J. Nutr. 2004, 43, 205–220.
    • (2004) Eur. J. Nutr. , vol.43 , pp. 205-220
    • Cerdá, B.1    Espín, J.C.2    Parra, S.3    Martínez, P.4
  • 5
    • 79951754055 scopus 로고    scopus 로고
    • UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals
    • González-Barrio, R., Truchado, P., Ito, H., Espín, J. C. et al., UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals. J. Agric. Food Chem. 2011, 59, 1152–1162.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 1152-1162
    • González-Barrio, R.1    Truchado, P.2    Ito, H.3    Espín, J.C.4
  • 6
    • 0002448372 scopus 로고
    • Chemistry and biochemistry of some mammalian secretions and excretions
    • Lederer, E., Chemistry and biochemistry of some mammalian secretions and excretions. J. Chem. Soc. 1949, 2115–2125.
    • (1949) J. Chem. Soc. , pp. 2115-2125
    • Lederer, E.1
  • 7
    • 85039895928 scopus 로고
    • Isolation of two benzocoumarins from ‘Clover Stone’, a type of renal calculus found in sheep
    • Pope, G. S., Isolation of two benzocoumarins from ‘Clover Stone’, a type of renal calculus found in sheep. Biochem. J. 1964, 93, 744–747.
    • (1964) Biochem. J. , vol.93 , pp. 744-747
    • Pope, G.S.1
  • 8
    • 84899547040 scopus 로고    scopus 로고
    • Natural dibenzo-α-pyranones and their bioactivities
    • Mao, Z., Sum, W., Fu, L., Luo, H. et al., Natural dibenzo-α-pyranones and their bioactivities. Molecules 2014, 19, 5088–5108.
    • (2014) Molecules , vol.19 , pp. 5088-5108
    • Mao, Z.1    Sum, W.2    Fu, L.3    Luo, H.4
  • 9
    • 85027957692 scopus 로고    scopus 로고
    • Natural dibezo[b,d]pyran-6-ones: structural diversity, and biological activity
    • Garadz, Y. L., Garadz, M. M., Natural dibezo[b,d]pyran-6-ones: structural diversity, and biological activity. Chem. Nat. Compd. 2016, 52, 1–18.
    • (2016) Chem. Nat. Compd , vol.52 , pp. 1-18
    • Garadz, Y.L.1    Garadz, M.M.2
  • 10
    • 0018953488 scopus 로고
    • The metabolism of ellagic acid in the rat
    • Doyle, B., Griffiths, L. A., The metabolism of ellagic acid in the rat. Xenobiotica 1980, 10, 247–256.
    • (1980) Xenobiotica , vol.10 , pp. 247-256
    • Doyle, B.1    Griffiths, L.A.2
  • 11
    • 0037219635 scopus 로고    scopus 로고
    • Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice
    • Cerdá, B., Llorach, R., Cerón, J. J., Espín, J. C. et al., Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur. J. Nutr. 2003, 42, 18–28.
    • (2003) Eur. J. Nutr. , vol.42 , pp. 18-28
    • Cerdá, B.1    Llorach, R.2    Cerón, J.J.3    Espín, J.C.4
  • 12
    • 12344282206 scopus 로고    scopus 로고
    • Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability
    • Cerdá, B., Tomás-Barberán, F. A., Espín, J. C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability. J. Agric. Food Chem. 2005, 53, 227–235.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 227-235
    • Cerdá, B.1    Tomás-Barberán, F.A.2    Espín, J.C.3
  • 13
  • 14
    • 84946397477 scopus 로고    scopus 로고
    • Identifying the limits for ellagic acid bioavailability: a crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts
    • González-Sarrías, A., García-Villalba, R., Núñez-Sánchez, M. A., Tomé-Carneiro, J. et al., Identifying the limits for ellagic acid bioavailability: a crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts. J. Funct. Foods 2015, 19, 225–235.
    • (2015) J. Funct. Foods , vol.19 , pp. 225-235
    • González-Sarrías, A.1    García-Villalba, R.2    Núñez-Sánchez, M.A.3    Tomé-Carneiro, J.4
  • 15
    • 84944754690 scopus 로고    scopus 로고
    • New insights into the bioavailability of red raspberry anthocyanins and ellagitannins
    • Ludwing, I. A., Mena, P., Calani, L., Borges, G. et al., New insights into the bioavailability of red raspberry anthocyanins and ellagitannins. Free Radic. Biol. Med. 2015, 89, 758–769.
    • (2015) Free Radic. Biol. Med. , vol.89 , pp. 758-769
    • Ludwing, I.A.1    Mena, P.2    Calani, L.3    Borges, G.4
  • 16
    • 33645369150 scopus 로고    scopus 로고
    • Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial
    • Cerdá, B., Soto, C., Albadalejo, M. D., Martínez, P. et al., Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial. Eur. J. Nutr. 2006, 60, 245–253.
    • (2006) Eur. J. Nutr. , vol.60 , pp. 245-253
    • Cerdá, B.1    Soto, C.2    Albadalejo, M.D.3    Martínez, P.4
  • 17
    • 84908374936 scopus 로고    scopus 로고
    • Pilot walnut intervention study of urolithin bioavailability in human volunteers
    • Pfundstein, B., Haubner, R., Würtele, G., Gehres, N. et al., Pilot walnut intervention study of urolithin bioavailability in human volunteers. J. Agric. Food Chem. 2014, 62, 10264–10273.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 10264-10273
    • Pfundstein, B.1    Haubner, R.2    Würtele, G.3    Gehres, N.4
  • 18
    • 84941360292 scopus 로고    scopus 로고
    • Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans
    • Yang, J., Lee, R., Henning, S. M., Thames, G. et al., Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans. Food Chem. 2016, 194, 1300–1303.
    • (2016) Food Chem , vol.194 , pp. 1300-1303
    • Yang, J.1    Lee, R.2    Henning, S.M.3    Thames, G.4
  • 19
    • 84938782551 scopus 로고    scopus 로고
    • Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers
    • Li, Z., Henning, S. M., Lee, R. P., Lu, Q. Y. et al., Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct. 2015, 6, 2487–2495.
    • (2015) Food Funct , vol.6 , pp. 2487-2495
    • Li, Z.1    Henning, S.M.2    Lee, R.P.3    Lu, Q.Y.4
  • 20
    • 84901940928 scopus 로고    scopus 로고
    • Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients
    • Nuñez-Sánchez, M. A., García-Villalba, R., Monedero-Saiz, T., García-Talavera, N. V. et al., Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. Mol. Nutr. Food Res. 2014, 58, 1199–1211.
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 1199-1211
    • Nuñez-Sánchez, M.A.1    García-Villalba, R.2    Monedero-Saiz, T.3    García-Talavera, N.V.4
  • 21
    • 46749097580 scopus 로고    scopus 로고
    • Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects
    • Seeram, N. P., Zhang, Y., McKeever, R., Henning, S. M. et al., Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J. Med. Food 2008, 11, 390–394.
    • (2008) J. Med. Food , vol.11 , pp. 390-394
    • Seeram, N.P.1    Zhang, Y.2    McKeever, R.3    Henning, S.M.4
  • 22
    • 84942834400 scopus 로고    scopus 로고
    • Effect of daily intake of pomegranate juice on fecal microbiota and feces metabolites from healthy volunteers
    • Mosele, J. I., Gosalbes, M. J., Maciá, A., Rubió, L. et al., Effect of daily intake of pomegranate juice on fecal microbiota and feces metabolites from healthy volunteers. Mol. Nutr. Food Res. 2015, 59, 1942–1953.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 1942-1953
    • Mosele, J.I.1    Gosalbes, M.J.2    Maciá, A.3    Rubió, L.4
  • 23
    • 77950640680 scopus 로고    scopus 로고
    • Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy
    • González-Barrio, R., Borges, G., Mullen, W., Crozier, A., Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J. Agric. Food Chem. 2010, 58, 3933–3939.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 3933-3939
    • González-Barrio, R.1    Borges, G.2    Mullen, W.3    Crozier, A.4
  • 24
    • 38049054118 scopus 로고    scopus 로고
    • Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans
    • Espín, J. C., González-Barrio, R., Cerdá, B., López-Bote, C. et al., Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. J. Agric. Food Chem. 2007, 55, 10476–10485.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 10476-10485
    • Espín, J.C.1    González-Barrio, R.2    Cerdá, B.3    López-Bote, C.4
  • 25
    • 22544459923 scopus 로고    scopus 로고
    • Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds
    • Cerdá, B., Periago, P., Espín, J. C., Tomás-Barberán, F. A., Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. J. Agric. Food Chem. 2005, 53, 5571–5576.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 5571-5576
    • Cerdá, B.1    Periago, P.2    Espín, J.C.3    Tomás-Barberán, F.A.4
  • 26
    • 84938848667 scopus 로고    scopus 로고
    • Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production
    • Romo-Vaquero, M., García-Villalba, R., González-Sarrías, A., Beltrán, D. et al., Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production. J. Funct. Foods 2015, 17, 785–791.
    • (2015) J. Funct. Foods , vol.17 , pp. 785-791
    • Romo-Vaquero, M.1    García-Villalba, R.2    González-Sarrías, A.3    Beltrán, D.4
  • 27
    • 84884468326 scopus 로고    scopus 로고
    • Time course production of urolithins from ellagic acid by human gut microbiota
    • García-Villalba, R., Beltrán, D., Espín, J. C., Selma, M. V. et al., Time course production of urolithins from ellagic acid by human gut microbiota. J. Agric. Food Chem. 2013, 61, 8797–8806.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 8797-8806
    • García-Villalba, R.1    Beltrán, D.2    Espín, J.C.3    Selma, M.V.4
  • 28
    • 84925796074 scopus 로고    scopus 로고
    • Chemical composition of defatted strawberry and raspberry seeds and the effect of these dietary ingredients on polyphenol metabolites, intestinal function, and selected serum parameters in rats
    • Kosmala, M., Zdunczyk, Z., Juskiewicz, J., Jurgonski, A. et al., Chemical composition of defatted strawberry and raspberry seeds and the effect of these dietary ingredients on polyphenol metabolites, intestinal function, and selected serum parameters in rats. J. Agric. Food Chem. 2015, 63, 2989–2996.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 2989-2996
    • Kosmala, M.1    Zdunczyk, Z.2    Juskiewicz, J.3    Jurgonski, A.4
  • 29
    • 34948873551 scopus 로고    scopus 로고
    • Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland
    • Seeram, N. P., Aronson, W. J., Zhang, Y., Henning, S. M. et al., Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J. Agric. Food Chem. 2007, 55, 7732–7737.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 7732-7737
    • Seeram, N.P.1    Aronson, W.J.2    Zhang, Y.3    Henning, S.M.4
  • 30
    • 84892770341 scopus 로고    scopus 로고
    • Absorption, metabolism, and effects at transcriptome level of a standardized french oak wood extract, Robuvit, in healthy volunteers: pilot study
    • Natella, F., Leoni, G., Maldini, M., Natarelli, L. et al., Absorption, metabolism, and effects at transcriptome level of a standardized french oak wood extract, Robuvit, in healthy volunteers: pilot study. J. Agric. Food Chem. 2014, 62, 443–453.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 443-453
    • Natella, F.1    Leoni, G.2    Maldini, M.3    Natarelli, L.4
  • 31
    • 84888025436 scopus 로고    scopus 로고
    • Diversity of urinary excretion patterns of main ellagitannins’ colonic metabolites after ingestion of tropical highland blackberry (Rubus adenotrichus) juice
    • García-Muñoz, C., Hernández, L., Pérez, A., Vaillant, F., Diversity of urinary excretion patterns of main ellagitannins’ colonic metabolites after ingestion of tropical highland blackberry (Rubus adenotrichus) juice. Food Res. Inter. 2014, 55, 161–169.
    • (2014) Food Res. Inter. , vol.55 , pp. 161-169
    • García-Muñoz, C.1    Hernández, L.2    Pérez, A.3    Vaillant, F.4
  • 32
    • 84866411779 scopus 로고    scopus 로고
    • Urolithins are the main urinary microbial-derived phenolic metabolites discriminating a moderate consumption of nuts in free-living subjects with diagnosed metabolic syndrome
    • Tulipani, S., Urpi-Sarda, M., García-Villalba, R., Rabassa, M. et al., Urolithins are the main urinary microbial-derived phenolic metabolites discriminating a moderate consumption of nuts in free-living subjects with diagnosed metabolic syndrome. J. Agric. Food Chem. 2012, 60, 8930–8940.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 8930-8940
    • Tulipani, S.1    Urpi-Sarda, M.2    García-Villalba, R.3    Rabassa, M.4
  • 33
    • 80051976641 scopus 로고    scopus 로고
    • Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies
    • González-Barrio, R., Edwards, C. A., Crozier, A., Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies. Drug Metab. Dispos. 2011, 39, 1680–1688.
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1680-1688
    • González-Barrio, R.1    Edwards, C.A.2    Crozier, A.3
  • 34
    • 43649099198 scopus 로고    scopus 로고
    • Safety evaluation of an oak-flavored milk powder containing ellagitannins upon oral administration in the rat
    • Azorín-Ortuño, M., Urbán, C., Cerón, J. J., Tecles, F. et al., Safety evaluation of an oak-flavored milk powder containing ellagitannins upon oral administration in the rat. J. Agric. Food Chem. 2008, 56, 2857–2865.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 2857-2865
    • Azorín-Ortuño, M.1    Urbán, C.2    Cerón, J.J.3    Tecles, F.4
  • 35
    • 84862192813 scopus 로고    scopus 로고
    • Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans
    • Truchado, P., Larrosa, M., García-Conesa, M. T., Cerdá, B. et al., Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans. J. Agric. Food. Chem. 2012, 60, 5749–5754.
    • (2012) J. Agric. Food. Chem. , vol.60 , pp. 5749-5754
    • Truchado, P.1    Larrosa, M.2    García-Conesa, M.T.3    Cerdá, B.4
  • 36
    • 84903291718 scopus 로고    scopus 로고
    • Strawberry ellagitannins thwarted the positive effects of dietary fructooligosaccharides in rat cecum
    • Fotschki, B., Milala, J., Jurgonski, A., Karlinska, E. et al., Strawberry ellagitannins thwarted the positive effects of dietary fructooligosaccharides in rat cecum. J. Agric. Food Chem. 2014, 62, 5871–5880.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 5871-5880
    • Fotschki, B.1    Milala, J.2    Jurgonski, A.3    Karlinska, E.4
  • 37
    • 38949106503 scopus 로고    scopus 로고
    • Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats
    • Ito, H., Iguchi, A., Hatano, T., Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats. J. Agric. Food Chem. 2008, 56, 393–400.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 393-400
    • Ito, H.1    Iguchi, A.2    Hatano, T.3
  • 38
    • 33749494522 scopus 로고    scopus 로고
    • Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours
    • Seeram, N. P., Henning, S. M., Zhang, Y., Suchard, M. et al., Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J. Nutr. 2006, 136, 2481–2485.
    • (2006) J. Nutr. , vol.136 , pp. 2481-2485
    • Seeram, N.P.1    Henning, S.M.2    Zhang, Y.3    Suchard, M.4
  • 39
    • 84892427401 scopus 로고    scopus 로고
    • Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals
    • Haddad, E. H., Gaban-Chong, N., Oda, K., Sabaté, J. Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals. Nutr. J. 2014, 13, 1–9.
    • (2014) Nutr. J. , vol.13 , pp. 1-9
    • Haddad, E.H.1    Gaban-Chong, N.2    Oda, K.3    Sabaté, J.4
  • 40
    • 84959858829 scopus 로고    scopus 로고
    • Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid
    • García-Villalba, R., Espín, J. C., Tomás-Barberán, F. A., Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid. J. Chromatogr. A. 2016, 1428, 162–175.
    • (2016) J. Chromatogr. A. , vol.1428 , pp. 162-175
    • García-Villalba, R.1    Espín, J.C.2    Tomás-Barberán, F.A.3
  • 41
    • 84887986296 scopus 로고    scopus 로고
    • A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men prostate cancer before radical prostatectomy
    • Freedland, S. J., Carducci, M., Kroeger, N., Partin, A. et al., A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men prostate cancer before radical prostatectomy. Cancer Prev. Res. 2013, 6, 1120–1127.
    • (2013) Cancer Prev. Res. , vol.6 , pp. 1120-1127
    • Freedland, S.J.1    Carducci, M.2    Kroeger, N.3    Partin, A.4
  • 42
    • 84868613767 scopus 로고    scopus 로고
    • Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glycosides
    • Braune, A., Blaut, M., Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glycosides. Appl. Env. Microbiol. 2012, 78, 8151–8153.
    • (2012) Appl. Env. Microbiol. , vol.78 , pp. 8151-8153
    • Braune, A.1    Blaut, M.2
  • 44
    • 84920698765 scopus 로고    scopus 로고
    • Bioactive compounds produced by gut microbial tannase: implications for colorectal cancer development
    • De Felipe, F. L., de las Rivas, B., Muñoz, R., Bioactive compounds produced by gut microbial tannase: implications for colorectal cancer development. Front. Microbiol. 2014, 5, 1–4.
    • (2014) Front. Microbiol. , vol.5 , pp. 1-4
    • De Felipe, F.L.1    de las Rivas, B.2    Muñoz, R.3
  • 45
    • 68249114506 scopus 로고    scopus 로고
    • Interaction between phenolics and gut microbiota: role in human health
    • Selma, M. V., Espín, J. C., Tomás-Barberán, F. A., Interaction between phenolics and gut microbiota: role in human health. J. Agric. Food Chem. 2009, 57, 6485–6501.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 6485-6501
    • Selma, M.V.1    Espín, J.C.2    Tomás-Barberán, F.A.3
  • 46
    • 84905049318 scopus 로고    scopus 로고
    • Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species
    • Selma, M. V, Beltrán, D., García-Villalba, R., Espín, J. C. et al., Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. Food Funct. 2014, 5, 1779–1784.
    • (2014) Food Funct. , vol.5 , pp. 1779-1784
    • Selma, M.V.1    Beltrán, D.2    García-Villalba, R.3    Espín, J.C.4
  • 47
    • 84904500536 scopus 로고    scopus 로고
    • Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut
    • Selma, M. V., Tomas-Barberan, F. A., Beltran, D., Garcia-Villalba, R. et al., Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut. Int. J. Syst. Evol. Microbiol. 2014, 64, 2346–2352.
    • (2014) Int. J. Syst. Evol. Microbiol. , vol.64 , pp. 2346-2352
    • Selma, M.V.1    Tomas-Barberan, F.A.2    Beltran, D.3    Garcia-Villalba, R.4
  • 48
    • 12244305578 scopus 로고    scopus 로고
    • Enantioselective synthesis of S-Equol from dihydrodaidzein by a newly isolated anaerobic human intestinal bacterium
    • Wang, X., Hur, H., Lee, J. H., Kim, K. T. et al., Enantioselective synthesis of S-Equol from dihydrodaidzein by a newly isolated anaerobic human intestinal bacterium Appl. Environ. Microbiol. 2005, 71, 214–219.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 214-219
    • Wang, X.1    Hur, H.2    Lee, J.H.3    Kim, K.T.4
  • 49
    • 77955617234 scopus 로고    scopus 로고
    • Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol
    • Jin, J. S., Kitahara, M., Sakamoto, M., Hattori, M. et al., Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol. Int. J. Syst. Evol. Microbiol. 2010, 60, 1721–1724.
    • (2010) Int. J. Syst. Evol. Microbiol. , vol.60 , pp. 1721-1724
    • Jin, J.S.1    Kitahara, M.2    Sakamoto, M.3    Hattori, M.4
  • 50
    • 62149133476 scopus 로고    scopus 로고
    • Isolation of a human intestinal bacterium capable of daidzein and genistein conversion
    • Matthies, A., Blaut, M., Braune, A., Isolation of a human intestinal bacterium capable of daidzein and genistein conversion. Appl. Environ. Microbiol. 2009, 75, 1740–1744.
    • (2009) Appl. Environ. Microbiol. , vol.75 , pp. 1740-1744
    • Matthies, A.1    Blaut, M.2    Braune, A.3
  • 51
    • 33745670638 scopus 로고    scopus 로고
    • The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
    • Possemiers, S., Bolca, S., Grootaert, C., Heyerick, A. et al., The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J. Nutr. 2006, 136, 1862–1867.
    • (2006) J. Nutr. , vol.136 , pp. 1862-1867
    • Possemiers, S.1    Bolca, S.2    Grootaert, C.3    Heyerick, A.4
  • 52
    • 26844567074 scopus 로고    scopus 로고
    • Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans
    • Clavel, T., Henderson, G., Alpert, C., Philippe, C. et al., Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans. Appl. Environ. Microbiol. 2005, 71, 6077–6085.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 6077-6085
    • Clavel, T.1    Henderson, G.2    Alpert, C.3    Philippe, C.4
  • 54
    • 84904437984 scopus 로고    scopus 로고
    • Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status
    • Tomás-Barberán, F. A., García-Villalba, R., González-Sarrías, A., Selma, M. V. et al., Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. J. Agric. Food Chem. 2014, 62, 6535–6538.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 6535-6538
    • Tomás-Barberán, F.A.1    García-Villalba, R.2    González-Sarrías, A.3    Selma, M.V.4
  • 55
    • 84873368632 scopus 로고    scopus 로고
    • In vivo and in vitro metabolism of trans-resveratrol by human gut
    • Bode, L. M., Bunzel, D., Huch, M., Cho, G. et al., In vivo and in vitro metabolism of trans-resveratrol by human gut. Am. J. Clin. Nutr. 2013, 97, 295–309.
    • (2013) Am. J. Clin. Nutr. , vol.97 , pp. 295-309
    • Bode, L.M.1    Bunzel, D.2    Huch, M.3    Cho, G.4
  • 56
    • 47049107667 scopus 로고    scopus 로고
    • Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella
    • Maruo, T., Sakamoto, M., Ito, C., Toda, T. et al., Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella. Int. J. Syst. Evol. Microbiol. 2008, 58, 1221–1227.
    • (2008) Int. J. Syst. Evol. Microbiol. , vol.58 , pp. 1221-1227
    • Maruo, T.1    Sakamoto, M.2    Ito, C.3    Toda, T.4
  • 57
    • 84938536520 scopus 로고    scopus 로고
    • In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells
    • Wang, Y., Qiu, Z., Zhou, B., Liu, C. et al., In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol. In Vitro. 2015, 29, 1107–1115.
    • (2015) Toxicol. In Vitro. , vol.29 , pp. 1107-1115
    • Wang, Y.1    Qiu, Z.2    Zhou, B.3    Liu, C.4
  • 59
    • 77953122894 scopus 로고    scopus 로고
    • The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota
    • Bialonska, D., Ramnani, P., Kasimsetty, S. G., Muntha, K. R. et al., The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int. J. Food Microbiol. 2010, 140, 175–182.
    • (2010) Int. J. Food Microbiol. , vol.140 , pp. 175-182
    • Bialonska, D.1    Ramnani, P.2    Kasimsetty, S.G.3    Muntha, K.R.4
  • 60
    • 77954657360 scopus 로고    scopus 로고
    • Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism
    • Larrosa, M., González-Sarrías, A., Yáñez-Gascón, M. J., Selma, M. V. et al., Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J. Nutr. Biochem. 2010, 21, 717–725.
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 717-725
    • Larrosa, M.1    González-Sarrías, A.2    Yáñez-Gascón, M.J.3    Selma, M.V.4
  • 61
    • 84934451277 scopus 로고    scopus 로고
    • A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp- population in the gut microbiota of mice
    • Anhe, F. F., Roy, D., Pilon, G., Dudonné, S. et al., A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp- population in the gut microbiota of mice. Gut. 2015, 64, 872–883.
    • (2015) Gut. , vol.64 , pp. 872-883
    • Anhe, F.F.1    Roy, D.2    Pilon, G.3    Dudonné, S.4
  • 62
    • 84938323859 scopus 로고    scopus 로고
    • Validated method for the characterization and quantification of extractable and non-extractable ellagitannins after acid hydrolysis in pomegranate fruits, juices and extracts
    • García-Villalba, R., Espín, J. C., Aaby, K., Alasalvar, C. et al., Validated method for the characterization and quantification of extractable and non-extractable ellagitannins after acid hydrolysis in pomegranate fruits, juices and extracts. J. Agric. Food Chem. 2015, 63, 6555–6566.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 6555-6566
    • García-Villalba, R.1    Espín, J.C.2    Aaby, K.3    Alasalvar, C.4
  • 63
    • 84856231117 scopus 로고    scopus 로고
    • Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit Quorum Sensing in Yersinia enterocolitica: phenotypic response and associated molecular changes
    • Giménez-Bastida, J. A., Truchado, P., Larrosa, M., Espín, J. C. et al., Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit Quorum Sensing in Yersinia enterocolitica: phenotypic response and associated molecular changes. Food Chem. 2012, 132, 1465–1474.
    • (2012) Food Chem. , vol.132 , pp. 1465-1474
    • Giménez-Bastida, J.A.1    Truchado, P.2    Larrosa, M.3    Espín, J.C.4
  • 64
    • 85027927719 scopus 로고    scopus 로고
    • Enterotypes of the human gut microbiome
    • Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D. et al., Enterotypes of the human gut microbiome. Nature. 2011, 473, 174–180.
    • (2011) Nature. , vol.473 , pp. 174-180
    • Arumugam, M.1    Raes, J.2    Pelletier, E.3    Le Paslier, D.4
  • 65
    • 84952982818 scopus 로고    scopus 로고
    • Talking microbes: when gut bacteria interacts with diet and host organs
    • Cani, P. D., Everand, A., Talking microbes: when gut bacteria interacts with diet and host organs. Mol. Nutr. Food Res. 2016, 60, 58–66.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 58-66
    • Cani, P.D.1    Everand, A.2
  • 66
    • 77649297783 scopus 로고    scopus 로고
    • Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice
    • González-Sarrías, A., Giménez-Bastida, J. A., García-Conesa, M. T., Gómez-Sánchez, M. B. et al., Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol. Nutr. Food Res. 2010, 54, 311–322.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 311-322
    • González-Sarrías, A.1    Giménez-Bastida, J.A.2    García-Conesa, M.T.3    Gómez-Sánchez, M.B.4
  • 67
    • 84889072982 scopus 로고    scopus 로고
    • Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome
    • Puupponen-Pimiä, R., Seppänen-Laakso, T., Kankainen, M., Maukonen, J. et al., Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Mol. Nutr. Food Res. 2013, 57, 2258–2263.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 2258-2263
    • Puupponen-Pimiä, R.1    Seppänen-Laakso, T.2    Kankainen, M.3    Maukonen, J.4
  • 68
    • 84966393306 scopus 로고    scopus 로고
    • The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism
    • Selma, M. V., Romo-Vaquero, M., García-Villalba, R., González-Sarrías, A. et al., The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism. Food Funct. 2015. doi: 10.1039/C5FO01100K.
    • (2015) Food Funct.
    • Selma, M.V.1    Romo-Vaquero, M.2    García-Villalba, R.3    González-Sarrías, A.4
  • 69
    • 84954381324 scopus 로고    scopus 로고
    • Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome
    • Mora-Cubillos, X., Tulipani, S., Garcia-Aloy, M., Bulló, M. et al., Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. Mol. Nutr. Food Res. 2015, 59, 2480–2490.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 2480-2490
    • Mora-Cubillos, X.1    Tulipani, S.2    Garcia-Aloy, M.3    Bulló, M.4
  • 70
    • 84881442331 scopus 로고    scopus 로고
    • Pomegranate juice augments memory and fMRI activity in middle-aged and older adults with mild memory complaints
    • Bookheimer, S. Y., Renner, B. A., Ekstrom, A., Li, Z.et al., Pomegranate juice augments memory and fMRI activity in middle-aged and older adults with mild memory complaints. Evid. Based Complement. Alternat. Med. 2013, 2013, 946298.
    • (2013) Evid. Based Complement. Alternat. Med. , vol.2013 , pp. 946298
    • Bookheimer, S.Y.1    Renner, B.A.2    Ekstrom, A.3    Li, Z.4
  • 72
    • 84939780334 scopus 로고    scopus 로고
    • Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination?
    • Gasperotti, M., Passamonti, S., Tramer, F., Masuero, D. et al., Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination? ACS Chem. Neurosci. 2015, 6, 1341–1352.
    • (2015) ACS Chem. Neurosci. , vol.6 , pp. 1341-1352
    • Gasperotti, M.1    Passamonti, S.2    Tramer, F.3    Masuero, D.4
  • 74
    • 84929253606 scopus 로고    scopus 로고
    • Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions
    • Sala, R., Mena, P., Savi, M., Brighenti, F. et al., Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions. J. Funct. Foods. 2015, 15, 97–105.
    • (2015) J. Funct. Foods. , vol.15 , pp. 97-105
    • Sala, R.1    Mena, P.2    Savi, M.3    Brighenti, F.4
  • 75
    • 84941686142 scopus 로고    scopus 로고
    • The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells
    • Giorgio, C., Mena, P., Del Rio, D., Brighenti, F. et al., The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells. Mol. Nutr. Food Res. 2015, 59, 2155–2167.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 2155-2167
    • Giorgio, C.1    Mena, P.2    Del Rio, D.3    Brighenti, F.4
  • 76
    • 84966534214 scopus 로고    scopus 로고
    • Antioatherogenic effects of ellagic acid and urolithins in vitro
    • Mele, L., Mena, P., Piomontese, A., Marino, A. et al., Antioatherogenic effects of ellagic acid and urolithins in vitro. Arch. Biochem. Biophys. 2016. doi:10.1016/j.abb.2016.02.017.
    • (2016) Arch. Biochem. Biophys.
    • Mele, L.1    Mena, P.2    Piomontese, A.3    Marino, A.4
  • 77
    • 84952684929 scopus 로고    scopus 로고
    • Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key associated molecular hallmarks: microRNA-cell specific induction of CDKN1A (p21) as a common mechanism involved
    • González-Sarrías, A., Núñez-Sánchez, M. A., Tomé-Carneiro, J., Tomás-Barberán, F. A. et al., Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key associated molecular hallmarks: microRNA-cell specific induction of CDKN1A (p21) as a common mechanism involved. Mol. Nutr. Food Res. 2015. doi: 10.1002/mnfr.201500780.
    • (2015) Mol. Nutr. Food Res.
    • González-Sarrías, A.1    Núñez-Sánchez, M.A.2    Tomé-Carneiro, J.3    Tomás-Barberán, F.A.4
  • 78
    • 84903906709 scopus 로고    scopus 로고
    • Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells
    • González-Sarrías, A., Giménez-Bastida, J. A., Núñez-Sánchez, M. A., Larrosa, M. et al., Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells. Eur. J. Nutr. 2014, 53, 853–864.
    • (2014) Eur. J. Nutr. , vol.53 , pp. 853-864
    • González-Sarrías, A.1    Giménez-Bastida, J.A.2    Núñez-Sánchez, M.A.3    Larrosa, M.4
  • 79
    • 84929486032 scopus 로고    scopus 로고
    • Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells
    • Cho, H., Jung, H., Lee, H., Yi, H. C. et al., Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells. Food Funct. 2015, 6, 1675–1683.
    • (2015) Food Funct. , vol.6 , pp. 1675-1683
    • Cho, H.1    Jung, H.2    Lee, H.3    Yi, H.C.4
  • 81
    • 67649214140 scopus 로고    scopus 로고
    • Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytocrhrome P450 1A1
    • González-Sarrías, A., Azorín-Ortuño, M., Yáñez-Gascón, M. J., Tomás-Barberán, F. A. et al., Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytocrhrome P450 1A1. J. Agric. Food Chem. 2009, 57, 5623–5632.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 5623-5632
    • González-Sarrías, A.1    Azorín-Ortuño, M.2    Yáñez-Gascón, M.J.3    Tomás-Barberán, F.A.4
  • 82
    • 84861684487 scopus 로고    scopus 로고
    • Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells
    • Giménez-Bastida, J. A., González-Sarrías, A., Larrosa, M., Tomás-Barberán, F. et al., Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells. Mol. Nutr. Food Res. 2012, 56, 784–796.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 784-796
    • Giménez-Bastida, J.A.1    González-Sarrías, A.2    Larrosa, M.3    Tomás-Barberán, F.4
  • 83
    • 84906066484 scopus 로고    scopus 로고
    • Influence of gut microbiota-derived ellagitannins′ metabolites urolithins on pro-inflammatory activities of human neutrophils
    • Piwowarski, J. P., Granica, S., Kiss, A. K., Influence of gut microbiota-derived ellagitannins′ metabolites urolithins on pro-inflammatory activities of human neutrophils. Planta Med. 2014, 80, 887–895.
    • (2014) Planta Med. , vol.80 , pp. 887-895
    • Piwowarski, J.P.1    Granica, S.2    Kiss, A.K.3
  • 84
    • 84905560024 scopus 로고    scopus 로고
    • Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials
    • Piwowarski, J. P., Granica, S., Zwierzynska, M., Stefanska, J. et al., Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. J. Ethnopharmacol. 2014, 155, 801–809.
    • (2014) J. Ethnopharmacol. , vol.155 , pp. 801-809
    • Piwowarski, J.P.1    Granica, S.2    Zwierzynska, M.3    Stefanska, J.4
  • 85
    • 77956196994 scopus 로고    scopus 로고
    • NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts
    • González-Sarrías, A., Larrosa, M., Tomás-Barberán, F. A., Dolara, P. et al. C., NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts. Br. J. Nutr. 2010, 104, 503–512.
    • (2010) Br. J. Nutr. , vol.104 , pp. 503-512
    • González-Sarrías, A.1    Larrosa, M.2    Tomás-Barberán, F.A.3    Dolara, P.4    et al, C.5
  • 86
    • 84866381930 scopus 로고    scopus 로고
    • Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts
    • Giménez-Bastida, J. A., Larrosa, M., González-Sarrías, A., Tomás-Barberán, F. et al., Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts. J. Agric. Food Chem. 2012, 60, 8866–8876.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 8866-8876
    • Giménez-Bastida, J.A.1    Larrosa, M.2    González-Sarrías, A.3    Tomás-Barberán, F.4
  • 87
    • 80052596190 scopus 로고    scopus 로고
    • In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A
    • Ishimoto, H., Shibata, M., Myojin, Y., Ito, H. et al., In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg. Med. Chem. Lett. 2011, 21, 5901–5904.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5901-5904
    • Ishimoto, H.1    Shibata, M.2    Myojin, Y.3    Ito, H.4
  • 88
    • 33646507529 scopus 로고    scopus 로고
    • Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions
    • Gallardo, C., Jiménez, L., García-Conesa, M. T., Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions. Food Chem. 2006, 99, 455–463.
    • (2006) Food Chem. , vol.99 , pp. 455-463
    • Gallardo, C.1    Jiménez, L.2    García-Conesa, M.T.3
  • 89
    • 70449085306 scopus 로고    scopus 로고
    • Urolithins, intestinal microbial metabolites of pomegranate-ellagitannins, exhibit potent antioxidant activity in a cell-based assay
    • Bialonska, D., Kasimsetty, S. G., Khan, S. I., Ferreira, D., Urolithins, intestinal microbial metabolites of pomegranate-ellagitannins, exhibit potent antioxidant activity in a cell-based assay. J. Agric. Food Chem. 2009, 57, 10181–10186.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 10181-10186
    • Bialonska, D.1    Kasimsetty, S.G.2    Khan, S.I.3    Ferreira, D.4
  • 90
    • 84880435708 scopus 로고    scopus 로고
    • In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells
    • Qiu, Z., Zhou, B., Jin, L., Yu, H. et al., In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem. Toxicol. 2013, 59, 428–437.
    • (2013) Food Chem. Toxicol. , vol.59 , pp. 428-437
    • Qiu, Z.1    Zhou, B.2    Jin, L.3    Yu, H.4
  • 91
    • 84944463822 scopus 로고    scopus 로고
    • In vitro bioaccessibility, human gut microbiota metabolites and hepatoprotective potential of chebulic ellagitannins: a case of Padma Hepaten (®) formulation
    • Olennikov, D. N., Kashchenko, N. I., Chirikova, N. K., In vitro bioaccessibility, human gut microbiota metabolites and hepatoprotective potential of chebulic ellagitannins: a case of Padma Hepaten (®) formulation. Nutrients. 2015, 7, 8456–8477.
    • (2015) Nutrients. , vol.7 , pp. 8456-8477
    • Olennikov, D.N.1    Kashchenko, N.I.2    Chirikova, N.K.3
  • 92
    • 79960738872 scopus 로고    scopus 로고
    • Metabolites of the ellagitannin geraniin and their antioxidant activities
    • Ito, M., Metabolites of the ellagitannin geraniin and their antioxidant activities. Planta Med. 2011, 77, 1110–1115.
    • (2011) Planta Med. , vol.77 , pp. 1110-1115
    • Ito, M.1
  • 93
    • 84871770770 scopus 로고    scopus 로고
    • Pomegranate: a fruit that ameliorates metabolic syndrome
    • Medjakovic, S., Jungbauer, A., Pomegranate: a fruit that ameliorates metabolic syndrome. Food Funct. 2013, 4, 19–39.
    • (2013) Food Funct. , vol.4 , pp. 19-39
    • Medjakovic, S.1    Jungbauer, A.2
  • 94
    • 84929152744 scopus 로고    scopus 로고
    • Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination
    • Rosenblat, M., Volkova, N., Borochov-Neori, H., Judeinstein, S. et al., Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination. Food Funct. 2015, 6, 1496–1509.
    • (2015) Food Funct. , vol.6 , pp. 1496-1509
    • Rosenblat, M.1    Volkova, N.2    Borochov-Neori, H.3    Judeinstein, S.4
  • 95
    • 84963647506 scopus 로고    scopus 로고
    • Urolithin A, C and D, but not iso-Urolithin A and Urolithin B, attenuate triglyceride accumulation in primary cultures of human adipocytes
    • Kang, I., Kim, Y. E., Tomás-Barberán, F. A., Espín, J. C. et al., Urolithin A, C and D, but not iso-Urolithin A and Urolithin B, attenuate triglyceride accumulation in primary cultures of human adipocytes. Mol. Nutr. Food Res. 2016. doi:10.1002/mnfr.201500796.
    • (2016) Mol. Nutr. Food Res.
    • Kang, I.1    Kim, Y.E.2    Tomás-Barberán, F.A.3    Espín, J.C.4
  • 96
    • 33645457770 scopus 로고    scopus 로고
    • Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities
    • Larrosa, M., González-Sarrías, A., García-Conesa, M. T., Tomás-Barberán, F. A. et al., Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities. J. Agric. Food Chem. 2006, 54, 1611–1620.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 1611-1620
    • Larrosa, M.1    González-Sarrías, A.2    García-Conesa, M.T.3    Tomás-Barberán, F.A.4
  • 97
    • 84884745946 scopus 로고    scopus 로고
    • Modelling the posible bioactivity of ellagitannin-derived metabolites. In silico tools to evaluate their potential xenoestrogenic behavior
    • Dellafiora, L., Mena, P., Cozzini, P., Brighenti, F. et al., Modelling the posible bioactivity of ellagitannin-derived metabolites. In silico tools to evaluate their potential xenoestrogenic behavior. Food Funct. 2013, 4, 1442–1451.
    • (2013) Food Funct. , vol.4 , pp. 1442-1451
    • Dellafiora, L.1    Mena, P.2    Cozzini, P.3    Brighenti, F.4
  • 98
    • 79957854023 scopus 로고    scopus 로고
    • Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites
    • Verzelloni, E., Pellacani, C., Tagliazucchi, D., Tagliaferri, S. et al., Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites. Mol. Nutr. Food Res. 2011, 55, 35–43.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 35-43
    • Verzelloni, E.1    Pellacani, C.2    Tagliazucchi, D.3    Tagliaferri, S.4
  • 99
    • 84890839286 scopus 로고    scopus 로고
    • Ellagitannin oligomers and a neolignan from pomegranate arils and their inhibitory effects on the formation of advanced glycation end products
    • Ito, H., Li, P., Koreishi, M., Nagatomo, A. et al., Ellagitannin oligomers and a neolignan from pomegranate arils and their inhibitory effects on the formation of advanced glycation end products. Food Chem. 2014, 152, 323–330.
    • (2014) Food Chem. , vol.152 , pp. 323-330
    • Ito, H.1    Li, P.2    Koreishi, M.3    Nagatomo, A.4
  • 100
    • 84908124678 scopus 로고    scopus 로고
    • Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging carbonyl species
    • Liu, W., Ma, H., Frost, L., Yuan, T. et al., Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging carbonyl species. Food Funct. 2014, 5, 2996–3004.
    • (2014) Food Funct. , vol.5 , pp. 2996-3004
    • Liu, W.1    Ma, H.2    Frost, L.3    Yuan, T.4
  • 101
    • 84955570396 scopus 로고    scopus 로고
    • Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites
    • Yuan, T., Ma, H., Liu, W., Niesen, D. B., Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem. Neurosci. 2016, 7, 26–33.
    • (2016) ACS Chem. Neurosci. , vol.7 , pp. 26-33
    • Yuan, T.1    Ma, H.2    Liu, W.3    Niesen, D.B.4
  • 102
    • 84908399641 scopus 로고    scopus 로고
    • Pomegranate from Oman alleviates the brain oxidative damage in transgenic mouse model of Alzheimer's disease
    • Subash, S., Essa, M. M., Al-Asmi, A., Al-Adawi, S. et al., Pomegranate from Oman alleviates the brain oxidative damage in transgenic mouse model of Alzheimer's disease. J. Tradit. Complement. Med. 2014, 4, 232–238.
    • (2014) J. Tradit. Complement. Med. , vol.4 , pp. 232-238
    • Subash, S.1    Essa, M.M.2    Al-Asmi, A.3    Al-Adawi, S.4
  • 103
    • 84922215237 scopus 로고    scopus 로고
    • Long-term (15 mo) dietary supplementation with pomegranates from Oman attenuates cognitive and behavioral deficits in a transgenic mice model of Alzheimer's disease
    • Subash, S., Braidy, N., Essa, M. M., Zayana, A. B. et al., Long-term (15 mo) dietary supplementation with pomegranates from Oman attenuates cognitive and behavioral deficits in a transgenic mice model of Alzheimer's disease. Nutrition. 2015, 31, 223–229.
    • (2015) Nutrition. , vol.31 , pp. 223-229
    • Subash, S.1    Braidy, N.2    Essa, M.M.3    Zayana, A.B.4
  • 104
    • 77954687492 scopus 로고    scopus 로고
    • Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
    • Dell'agli, M., Galli, G. V., Bulgari, M., Basilico, N. et al., Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malar. J. 2010, 9, 208.
    • (2010) Malar. J. , vol.9 , pp. 208
    • Dell'agli, M.1    Galli, G.V.2    Bulgari, M.3    Basilico, N.4
  • 105
    • 0141556575 scopus 로고    scopus 로고
    • Hyaluronidase inhibitory active 6H-dibenzo[b,d]pyran-6-ones from the feces of Trogopterus xanthipes
    • Jeong, S. J., Kim, N. Y., Kim, D. H., Kang, T. H., et al., Hyaluronidase inhibitory active 6H-dibenzo[b,d]pyran-6-ones from the feces of Trogopterus xanthipes. Planta Med. 2000, 66, 76–77.
    • (2000) Planta Med. , vol.66 , pp. 76-77
    • Jeong, S.J.1    Kim, N.Y.2    Kim, D.H.3    Kang, T.H.4
  • 106
    • 84866409583 scopus 로고    scopus 로고
    • Ellagic acid and polyhydroxilated urolithins are potent catalytic inhibitors of human topoisomerase II: an in vitro study
    • Furlanetto, V., Zagotto, G., Pasquale, R., Moro, S. et al., Ellagic acid and polyhydroxilated urolithins are potent catalytic inhibitors of human topoisomerase II: an in vitro study. J. Agric. Food Chem. 2012, 60, 9162–9170.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 9162-9170
    • Furlanetto, V.1    Zagotto, G.2    Pasquale, R.3    Moro, S.4
  • 107
    • 84907541193 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[o]chromen-6-one derivatives as potential cholinesterase inhibitors
    • Gulcan, H. O., Unlu, S., Esiringu, I., Ercetin, T. et al., Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[o]chromen-6-one derivatives as potential cholinesterase inhibitors. Bioorg. Med. Chem. 2014, 22, 5141–5154.
    • (2014) Bioorg. Med. Chem. , vol.22 , pp. 5141-5154
    • Gulcan, H.O.1    Unlu, S.2    Esiringu, I.3    Ercetin, T.4
  • 108
    • 84942834606 scopus 로고    scopus 로고
    • MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer in response to pomegranate extracts consumption: critical issues to discern between modulatory effects and potential artefacts
    • Núñez-Sánchez, M. A., Dávalos, A., González-Sarrías, A., Casas-Agustench, P. et al., MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer in response to pomegranate extracts consumption: critical issues to discern between modulatory effects and potential artefacts. Mol. Nutr. Food Res. 2015, 59, 1973–1986.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 1973-1986
    • Núñez-Sánchez, M.A.1    Dávalos, A.2    González-Sarrías, A.3    Casas-Agustench, P.4
  • 109
    • 1642464724 scopus 로고    scopus 로고
    • Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects
    • Lotito, S. B., Frei, B., Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects. Free Radic. Biol. Med. 2004, 36, 201–211.
    • (2004) Free Radic. Biol. Med. , vol.36 , pp. 201-211
    • Lotito, S.B.1    Frei, B.2
  • 111
    • 84947998972 scopus 로고    scopus 로고
    • Food polyphenosl fail to cause biologically relevant reduction of COX-2 activity
    • Willenberg, I., Meschede, A. K., Gueler, F., Jang, M. S. et al., Food polyphenosl fail to cause biologically relevant reduction of COX-2 activity. PLoS One. 2015, 10, e0139147.
    • (2015) PLoS One. , vol.10
    • Willenberg, I.1    Meschede, A.K.2    Gueler, F.3    Jang, M.S.4
  • 112
    • 30744445986 scopus 로고    scopus 로고
    • High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart
    • Frankenfeld, C. L., Atkinson, C., Thomas, W. K., Gonzalez, A. et al., High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart. Br. J. Nutr. 2005, 94, 873–876.
    • (2005) Br. J. Nutr. , vol.94 , pp. 873-876
    • Frankenfeld, C.L.1    Atkinson, C.2    Thomas, W.K.3    Gonzalez, A.4
  • 113
    • 84898009943 scopus 로고    scopus 로고
    • Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein
    • Frankenfeld, C. L., Atkinson, C., Wähälä, K., Lampe, J. W., Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein. Eur. J. Clin. Nutr. 2014, 68, 526–530.
    • (2014) Eur. J. Clin. Nutr. , vol.68 , pp. 526-530
    • Frankenfeld, C.L.1    Atkinson, C.2    Wähälä, K.3    Lampe, J.W.4
  • 114
    • 84869488302 scopus 로고    scopus 로고
    • Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States
    • Atkinson, C., Newton, K. M., Yong, M., Stanczyk, F. Z. et al., Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States. Metabolism. 2012, 61, 1678–1682.
    • (2012) Metabolism. , vol.61 , pp. 1678-1682
    • Atkinson, C.1    Newton, K.M.2    Yong, M.3    Stanczyk, F.Z.4
  • 115
    • 84959925870 scopus 로고    scopus 로고
    • Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
    • Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M. et al., Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial. Am. J. Clin. Nutr. 2016. doi: 10.3945/ajcn.115.125690.
    • (2016) Am. J. Clin. Nutr.
    • Hazim, S.1    Curtis, P.J.2    Schär, M.Y.3    Ostertag, L.M.4
  • 116
    • 33847689036 scopus 로고    scopus 로고
    • Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries
    • Jackman, K. A., Woodman, O. L., Chrissobolis, S., Sobey, C. G., Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Res. 2007, 1141, 99–107.
    • (2007) Brain Res. , vol.1141 , pp. 99-107
    • Jackman, K.A.1    Woodman, O.L.2    Chrissobolis, S.3    Sobey, C.G.4
  • 117
    • 0034013311 scopus 로고    scopus 로고
    • Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    • Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N. et al., Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clin. Nutr. 2000, 71, 1062–1076.
    • (2000) Am. J. Clin. Nutr. , vol.71 , pp. 1062-1076
    • Aviram, M.1    Dornfeld, L.2    Rosenblat, M.3    Volkova, N.4
  • 118
    • 4644359293 scopus 로고    scopus 로고
    • Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia
    • Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., et al., Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J. Med. Food 2004, 7, 305–308.
    • (2004) J. Med. Food , vol.7 , pp. 305-308
    • Esmaillzadeh, A.1    Tahbaz, F.2    Gaieni, I.3    Alavi-Majd, H.4
  • 119
    • 84906515878 scopus 로고    scopus 로고
    • Pomegranate juice consumption increases GSH levels and reduces lipid and protein oxidation in human blood
    • Matthaiou, C. M., Goutzourelas, N., Stagos, D., Sarafoglou, E. et al., Pomegranate juice consumption increases GSH levels and reduces lipid and protein oxidation in human blood. Food Chem. Toxicol. 2014, 73, 1–6.
    • (2014) Food Chem. Toxicol. , vol.73 , pp. 1-6
    • Matthaiou, C.M.1    Goutzourelas, N.2    Stagos, D.3    Sarafoglou, E.4
  • 120
    • 84862281773 scopus 로고    scopus 로고
    • One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial
    • Shema-Didi, L., Sela, S., Ore, L., Shapiro, G. et al., One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial. Free Radic. Biol. Med. 2012, 53, 297–304.
    • (2012) Free Radic. Biol. Med. , vol.53 , pp. 297-304
    • Shema-Didi, L.1    Sela, S.2    Ore, L.3    Shapiro, G.4
  • 121
    • 84982227970 scopus 로고    scopus 로고
    • Lipid profile changes after pomegranate consumption: a systematic review and meta-analysis of randomized controlled trials
    • Shaebkar 2016
    • Sahebkar, A., Simental-Mendía, L. E., Giorgini, P., Ferri, C. et al., Lipid profile changes after pomegranate consumption: a systematic review and meta-analysis of randomized controlled trials. Phytomedicine. 2016. doi: 10.1016/j.phymed.2015.Shaebkar 2016.
    • (2016) Phytomedicine.
    • Sahebkar, A.1    Simental-Mendía, L.E.2    Giorgini, P.3    Ferri, C.4
  • 122
    • 0038284925 scopus 로고    scopus 로고
    • Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic
    • Cerdá, B., Cerón, J. J., Tomás-Barberán, F. A., Espín, J. C., Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J. Agric. Food Chem. 2003, 51, 3493–3501.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 3493-3501
    • Cerdá, B.1    Cerón, J.J.2    Tomás-Barberán, F.A.3    Espín, J.C.4
  • 123
    • 84901401713 scopus 로고    scopus 로고
    • Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC–ESI-MS/MS
    • Gasperotti, M., Masuero, D., Gella, G., Mattivi, F. et al., Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC–ESI-MS/MS Talanta. 2014, 128, 221–230.
    • (2014) Talanta. , vol.128 , pp. 221-230
    • Gasperotti, M.1    Masuero, D.2    Gella, G.3    Mattivi, F.4
  • 124
    • 84865476110 scopus 로고    scopus 로고
    • Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake
    • van der Hooft, J. J. J., de Vos, R. C. H., Mihaleva, V., Bino, R. J. et al., Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake. Anal. Chem. 2012, 84, 7263–7271.
    • (2012) Anal. Chem. , vol.84 , pp. 7263-7271
    • van der Hooft, J.J.J.1    de Vos, R.C.H.2    Mihaleva, V.3    Bino, R.J.4
  • 125
    • 33751260936 scopus 로고    scopus 로고
    • Absorption, metabolism, and antioxidant effect of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers
    • Mertens-Talcott, S. U., Jilma-Stohlawetz, P., Rios, J., Hingorani, L., Derendorf, H., Absorption, metabolism, and antioxidant effect of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J. Agric. Food Chem. 2006, 54, 8956–8961.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 8956-8961
    • Mertens-Talcott, S.U.1    Jilma-Stohlawetz, P.2    Rios, J.3    Hingorani, L.4    Derendorf, H.5
  • 126
    • 67651022312 scopus 로고    scopus 로고
    • Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins
    • González-Sarrías, A., Espín, J. C., Tomás-Barberán, F. A., García-Conesa, M. T., Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. Mol. Nutr. Food Res. 2009, 53, 686–698.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 686-698
    • González-Sarrías, A.1    Espín, J.C.2    Tomás-Barberán, F.A.3    García-Conesa, M.T.4
  • 127
    • 84949991156 scopus 로고    scopus 로고
    • Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism
    • González-Sarrías, A., Núñez-Sánchez, M. A., García-Villalba, R., Tomás-Barberán, F. A. et al., Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism. Eur. J. Nutr. 2015. doi: 10.1007/s00394-015-1131-7.
    • (2015) Eur. J. Nutr.
    • González-Sarrías, A.1    Núñez-Sánchez, M.A.2    García-Villalba, R.3    Tomás-Barberán, F.A.4
  • 128
    • 84929485270 scopus 로고    scopus 로고
    • The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells
    • González-Sarrías, A., Tomé-Carneiro, J., Bellesia, A., Tomás-Barberán, F. A. et al., The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells. Food Funct. 2015, 6, 1460–1469.
    • (2015) Food Funct. , vol.6 , pp. 1460-1469
    • González-Sarrías, A.1    Tomé-Carneiro, J.2    Bellesia, A.3    Tomás-Barberán, F.A.4
  • 129
    • 77249148358 scopus 로고    scopus 로고
    • Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins
    • Kasimsetty, S. G., Bialonska, D., Reddy, M. K., Ma, G. et al., Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. J. Agric. Food Chem. 2010, 58, 2180–2187.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 2180-2187
    • Kasimsetty, S.G.1    Bialonska, D.2    Reddy, M.K.3    Ma, G.4
  • 130
    • 84929939273 scopus 로고    scopus 로고
    • The ellagic acid derivative 4,4′-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16
    • Ramírez de Molina, A., Vargas, T., Molina, S., Sánchez, J. et al., The ellagic acid derivative 4,4′-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16. J. Pharmacol. Exp. Ther. 2015, 353, 433–444.
    • (2015) J. Pharmacol. Exp. Ther , vol.353 , pp. 433-444
    • Ramírez de Molina, A.1    Vargas, T.2    Molina, S.3    Sánchez, J.4
  • 131
    • 77950671986 scopus 로고    scopus 로고
    • Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling
    • Sharma, M., Li, L., Celver, J., Killian, C. et al., Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. J. Agric. Food Chem. 2010, 58, 3965–3969.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 3965-3969
    • Sharma, M.1    Li, L.2    Celver, J.3    Killian, C.4
  • 132
    • 84877295491 scopus 로고    scopus 로고
    • The gut microbiota ellagic acid-derived metabolite urolithin A, and its sulfate conjugate, are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP)
    • González-Sarrías, A., Miguel, V., Merino, G., Lucas, R. et al., The gut microbiota ellagic acid-derived metabolite urolithin A, and its sulfate conjugate, are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP). J. Agric. Food Chem. 2013, 61, 4352–4359.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 4352-4359
    • González-Sarrías, A.1    Miguel, V.2    Merino, G.3    Lucas, R.4
  • 133
    • 70449124410 scopus 로고    scopus 로고
    • Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rvl prostate cancer cells
    • Kasimsetty, S. G., Bialonska, D., Reddy, M. K., Thornton, C. et al., Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rvl prostate cancer cells. J. Agric. Food Chem. 2009, 57, 10636–10644.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 10636-10644
    • Kasimsetty, S.G.1    Bialonska, D.2    Reddy, M.K.3    Thornton, C.4
  • 134
    • 84890569966 scopus 로고    scopus 로고
    • Extract from Epilobium sp. herbs, their components and gut microbiota metabolites of Epilobium ellagitannins, urolithins, inhibit hormone-dependent prostate cancer cells-(LNCaP) proliferation and PSA secretion
    • Stolarczyk, M., Piwowarski, J. P., Granica, S., Stefanska, J. et al., Extract from Epilobium sp. herbs, their components and gut microbiota metabolites of Epilobium ellagitannins, urolithins, inhibit hormone-dependent prostate cancer cells-(LNCaP) proliferation and PSA secretion. Phytother. Res. 2013, 27, 1842–1848.
    • (2013) Phytother. Res. , vol.27 , pp. 1842-1848
    • Stolarczyk, M.1    Piwowarski, J.P.2    Granica, S.3    Stefanska, J.4
  • 135
    • 84908134440 scopus 로고    scopus 로고
    • Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells
    • Sánchez-González, C., Ciudad, C. J., Noé, V., Izquierdo-Pulido, M., Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells. Food Funct. 2014, 5, 2922–2930.
    • (2014) Food Funct. , vol.5 , pp. 2922-2930
    • Sánchez-González, C.1    Ciudad, C.J.2    Noé, V.3    Izquierdo-Pulido, M.4
  • 136
    • 84877932636 scopus 로고    scopus 로고
    • Pomegranate juice metabolites, ellagic acid and urolithin A, synergistically inhibit androgen-independent prostate cancer cell growth via distinct effects on cell cycle control and apoptosis
    • Vicinanza, R., Zhang, Y., Henning, S. M., Heber, D., Pomegranate juice metabolites, ellagic acid and urolithin A, synergistically inhibit androgen-independent prostate cancer cell growth via distinct effects on cell cycle control and apoptosis. Evid. Based Complement. Altern. Med. 2013, 2013, 247504
    • (2013) Evid. Based Complement. Altern. Med. , vol.2013 , pp. 247504
    • Vicinanza, R.1    Zhang, Y.2    Henning, S.M.3    Heber, D.4
  • 137
    • 84887643090 scopus 로고    scopus 로고
    • Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions
    • Kallio, T., Kallio, J., Jaakkola, M., Maki, M. et al., Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions. J. Agric. Food Chem. 2013, 61, 10720–10729.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 10720-10729
    • Kallio, T.1    Kallio, J.2    Jaakkola, M.3    Maki, M.4
  • 138
    • 77649212752 scopus 로고    scopus 로고
    • Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro
    • Adams, L. S., Zhang, Y., Seeram, N. P., Heber, D. et al., Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev. Res. (Phila.) 2010, 3, 108–113.
    • (2010) Cancer Prev. Res. (Phila. , vol.3 , pp. 108-113
    • Adams, L.S.1    Zhang, Y.2    Seeram, N.P.3    Heber, D.4
  • 139
    • 82955186865 scopus 로고    scopus 로고
    • Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors
    • Cozza, G., Gianoncelli, A., Bonvini, P., Zorzi, E. et al., Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors. ChemMedChem. 2011, 6, 2273–2286.
    • (2011) ChemMedChem. , vol.6 , pp. 2273-2286
    • Cozza, G.1    Gianoncelli, A.2    Bonvini, P.3    Zorzi, E.4
  • 140
    • 80755181126 scopus 로고    scopus 로고
    • Epigenetic modulation of mechanisms involved in inflammation: influence of selected polyphenolic substances on histone acetylation state
    • Kiss, A. K., Granica, S., Stolarczyk, M., Melzig, M. F., Epigenetic modulation of mechanisms involved in inflammation: influence of selected polyphenolic substances on histone acetylation state. Food Chem. 2012, 131, 1015–1020.
    • (2012) Food Chem. , vol.131 , pp. 1015-1020
    • Kiss, A.K.1    Granica, S.2    Stolarczyk, M.3    Melzig, M.F.4
  • 141
    • 84940773386 scopus 로고    scopus 로고
    • Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages
    • Piwowarski, J. P., Kiss, A. K., Granica, S., Moeslinger, T., Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages. Mol. Nutr. Food Res. 2015, 59, 2168–2177.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 2168-2177
    • Piwowarski, J.P.1    Kiss, A.K.2    Granica, S.3    Moeslinger, T.4
  • 142
    • 84884414792 scopus 로고    scopus 로고
    • Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A-C
    • Nealmongkol, P., Tangdenpaisal, K., Sitthimonchai, S., Ruchirawat, S., et al., Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A-C. Tetrahedron. 2013, 69, 9277–9283.
    • (2013) Tetrahedron. , vol.69 , pp. 9277-9283
    • Nealmongkol, P.1    Tangdenpaisal, K.2    Sitthimonchai, S.3    Ruchirawat, S.4
  • 143
    • 0035212246 scopus 로고    scopus 로고
    • Antioxidative effects of dibenzo-α-pyrones in fruits of Trapa natans on lipid peroxidation
    • Shirataki, Y., Toda, S., Antioxidative effects of dibenzo-α-pyrones in fruits of Trapa natans on lipid peroxidation. Nat. Med. 2001, 55, 247–250.
    • (2001) Nat. Med. , vol.55 , pp. 247-250
    • Shirataki, Y.1    Toda, S.2
  • 144
    • 84857856425 scopus 로고    scopus 로고
    • Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay
    • Ishimoto, H., Tai, A., Yoshimura, M., Amakura, Y. et al. Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay. Biosci. Biotechnol. Biochem. 2012, 76, 395–399.
    • (2012) Biosci. Biotechnol. Biochem. , vol.76 , pp. 395-399
    • Ishimoto, H.1    Tai, A.2    Yoshimura, M.3    Amakura, Y.4
  • 145
    • 84951023230 scopus 로고    scopus 로고
    • Comparative docking study of “dukung anak” phytonutrient compounds with anti-cholesterol properties
    • Rozano, L., Zawawi, M. R. A., Ahmad, M. A., Jaganath, I. B., Comparative docking study of “dukung anak” phytonutrient compounds with anti-cholesterol properties. J. Teknol. 2015, 77, 37–43.
    • (2015) J. Teknol. , vol.77 , pp. 37-43
    • Rozano, L.1    Zawawi, M.R.A.2    Ahmad, M.A.3    Jaganath, I.B.4
  • 146
    • 68849102666 scopus 로고    scopus 로고
    • Antiplasmodial activity of Punica granatum L. fruit rind
    • Dell'Agli, M., Galli, G. V., Corbett, Y., Taramelli, D. et al., Antiplasmodial activity of Punica granatum L. fruit rind. J. Ethnopharmacol. 2009, 125, 279–285.
    • (2009) J. Ethnopharmacol. , vol.125 , pp. 279-285
    • Dell'Agli, M.1    Galli, G.V.2    Corbett, Y.3    Taramelli, D.4
  • 147
    • 84871625953 scopus 로고    scopus 로고
    • Inhibitory effect of ellagitannin metabolites on IgE-mediated allergic responses in RBL-2H3 cells
    • Nagano, T., Ito, H., Okamoto, T., Inhibitory effect of ellagitannin metabolites on IgE-mediated allergic responses in RBL-2H3 cells. Biosci. Biotechnol. Biochem. 2012, 76, 2310–2312.
    • (2012) Biosci. Biotechnol. Biochem. , vol.76 , pp. 2310-2312
    • Nagano, T.1    Ito, H.2    Okamoto, T.3


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